Detailed information for compound 713164

Basic information

Technical information
  • TDR Targets ID: 713164
  • Name: 1-methyl-4-[2-(5-methyl-2-nitrophenoxy)ethyl] piperazine
  • MW: 279.335 | Formula: C14H21N3O3
  • H donors: 0 H acceptors: 2 LogP: 1.94 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1CCN(CC1)CCOc1cc(C)ccc1[N+](=O)[O-]
  • InChi: 1S/C14H21N3O3/c1-12-3-4-13(17(18)19)14(11-12)20-10-9-16-7-5-15(2)6-8-16/h3-4,11H,5-10H2,1-2H3
  • InChiKey: LCENFUGIKOOFAS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-methyl-4-[2-(5-methyl-2-nitro-phenoxy)ethyl]piperazine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni z-protein (S1r protein) 0.0038 0.0194 0.0124
Trypanosoma cruzi hypothetical protein, conserved 0.0652 0.8155 0.8155
Loa Loa (eye worm) hypothetical protein 0.004 0.0211 0.0141
Plasmodium vivax hypothetical protein, conserved 0.0215 0.2486 0.5709
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.005 0.0342 0.0342
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0541 0.671 0.668
Echinococcus multilocularis axis inhibition protein axin 0.0038 0.0194 0.0124
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.005 0.0342 0.5
Loa Loa (eye worm) hypothetical protein 0.0038 0.0194 0.0124
Plasmodium falciparum phd finger protein, putative 0.003 0.0092 0.005
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0794 1 1
Schistosoma mansoni chromobox protein 0.0071 0.0614 0.0547
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0175 0.0105
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0355 0.4302 0.4302
Giardia lamblia NADH oxidase lateral transfer candidate 0.005 0.0342 0.0252
Brugia malayi Bromodomain containing protein 0.003 0.0092 0.0021
Plasmodium falciparum glutathione reductase 0.005 0.0342 0.064
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.005 0.0342 0.0342
Plasmodium vivax glutathione reductase, putative 0.0143 0.1558 0.3515
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0194 0.0124
Trichomonas vaginalis CAMK family protein kinase 0.0289 0.3452 0.3452
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0522 0.0455
Giardia lamblia Sirtuin type 2 0.0215 0.2486 0.2417
Echinococcus multilocularis beta adrenergic receptor kinase 0.0039 0.0206 0.0136
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0373 0.0304
Entamoeba histolytica hypothetical protein 0.0038 0.0194 0.0194
Echinococcus multilocularis regulator of G protein signaling 0.0038 0.0194 0.0124
Loa Loa (eye worm) hypothetical protein 0.0038 0.0194 0.0124
Echinococcus granulosus beta-adrenergic receptor kinase 0.0039 0.0206 0.0136
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0373 0.0304
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0522 0.0455
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.005 0.0342 0.0273
Schistosoma mansoni chromatin regulatory protein sir2 0.0794 1 1
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0092 0.0021
Echinococcus granulosus axis inhibition protein axin 0.0038 0.0194 0.0124
Brugia malayi jmjC domain containing protein 0.01 0.0991 0.0927
Loa Loa (eye worm) PXA domain-containing protein 0.0038 0.0194 0.0124
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0194 0.0194
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0327 0.3943 0.8837
Echinococcus multilocularis Regulator of G protein signaling 20 0.0038 0.0194 0.0124
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0194 0.0194
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.029 0.0221
Leishmania major trypanothione reductase 0.0143 0.1558 0.1558
Schistosoma mansoni chromobox protein 0.0071 0.0614 0.0547
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0175 0.0105
Loa Loa (eye worm) glutathione reductase 0.0143 0.1558 0.1498
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0075 0.0671 0.0671
Loa Loa (eye worm) RNA binding protein 0.0064 0.0522 0.0455
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0075 0.0671 0.0671
Echinococcus multilocularis chromobox protein 1 0.0071 0.0614 0.0547
Trichomonas vaginalis CAMK family protein kinase 0.0289 0.3452 0.3452
Leishmania major hypothetical protein, conserved 0.0652 0.8155 0.8155
Giardia lamblia Hypothetical protein 0.0794 1 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0355 0.4302 0.4302
Brugia malayi PXA domain containing protein 0.0038 0.0194 0.0124
Mycobacterium ulcerans hypothetical protein 0.0075 0.0671 0.0502
Brugia malayi regulator of G-protein signaling egl-10 0.0038 0.0194 0.0124
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.029 0.0221
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0364 0.4416 1
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0794 1 1
Schistosoma mansoni chromatin regulatory protein sir2 0.0215 0.2486 0.2433
Toxoplasma gondii NADPH-glutathione reductase 0.005 0.0342 0.064
Giardia lamblia Transcriptional regulator, Sir2 family 0.0355 0.4302 0.4249
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.005 0.0342 0.0273
Brugia malayi jmjC domain containing protein 0.0037 0.0175 0.0105
Leishmania major dihydrolipoamide dehydrogenase, putative 0.005 0.0342 0.0342
Trichomonas vaginalis chromobox protein, putative 0.0043 0.025 0.025
Mycobacterium ulcerans NAD-dependent deacetylase 0.0355 0.4302 0.6043
Echinococcus multilocularis regulator of G protein signaling 7 0.0038 0.0194 0.0124
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.005 0.0342 0.0342
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0541 0.671 0.671
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.005 0.0342 0.0273
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0247 0.0177
Schistosoma mansoni axis inhibition protein axin 0.0038 0.0194 0.0124
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0289 0.3452 0.3406
Brugia malayi PHD-finger family protein 0.003 0.0092 0.0021
Echinococcus granulosus thioredoxin glutathione reductase 0.0143 0.1558 0.1498
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0061 0.0061
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0364 0.4416 1
Echinococcus multilocularis regulator of G protein signaling 3 0.0038 0.0194 0.0124
Brugia malayi RNA, U transporter 1 0.0082 0.0761 0.0695
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0143 0.1558 0.2985
Echinococcus granulosus axis inhibition protein axin 0.0038 0.0194 0.0124
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0355 0.4302 0.4261
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0215 0.2486 0.2486
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.025 0.047
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0355 0.4302 0.4302
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.005 0.0342 0.0342
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.029 0.0221
Brugia malayi NAD-dependent deacetylase SIRT1 0.0541 0.671 0.6687
Brugia malayi Heterochromatin protein 1 0.0071 0.0614 0.0547
Loa Loa (eye worm) hypothetical protein 0.0541 0.671 0.6687
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0075 0.0671 0.0808
Echinococcus multilocularis chromatin regulatory protein sir2 0.0794 1 1
Plasmodium falciparum thioredoxin reductase 0.005 0.0342 0.064
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0038 0.0194 0.0124
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.029 0.0221
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0075 0.0671 0.0502
Loa Loa (eye worm) hypothetical protein 0.0038 0.0194 0.0124
Loa Loa (eye worm) transcriptional regulator 0.0794 1 1
Schistosoma mansoni chromatin regulatory protein sir2 0.0794 1 1
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0522 0.0455
Toxoplasma gondii histone deacetylase SIR2 0.0355 0.4302 1
Loa Loa (eye worm) heterochromatin protein 1 0.0071 0.0614 0.0547
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0092 0.0021
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0215 0.2486 0.2433
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0355 0.4302 0.4302
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0039 0.0206 0.0136
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0522 0.0455
Echinococcus granulosus expressed protein 0.0746 0.9378 0.9373
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.005 0.0342 0.5
Schistosoma mansoni glutaminase 0.0555 0.6895 0.6873
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0327 0.3943 0.8837
Mycobacterium tuberculosis Probable reductase 0.0327 0.3943 0.8837
Trichomonas vaginalis CAMK family protein kinase 0.0289 0.3452 0.3452
Brugia malayi serine/threonine-protein kinase plk-2 0.0289 0.3452 0.3406
Plasmodium vivax thioredoxin reductase, putative 0.0143 0.1558 0.3515
Trichomonas vaginalis CAMK family protein kinase 0.0289 0.3452 0.3452
Echinococcus granulosus chromobox protein 1 0.0071 0.0614 0.0547
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0039 0.0206 0.0136
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.005 0.0342 0.064
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0541 0.671 0.671
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0614 0.0614
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.005 0.0342 0.0342
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0194 0.0124
Echinococcus granulosus snurportin 1 0.0308 0.3691 0.3646
Echinococcus granulosus regulator of G protein signaling 3 0.0038 0.0194 0.0124
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0211 0.0211
Brugia malayi hypothetical protein 0.0038 0.0194 0.0124
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.01 0.0991 0.0927
Mycobacterium tuberculosis Probable oxidoreductase 0.0364 0.4416 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0794 1 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.005 0.0342 0.0273
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.029 0.0221
Schistosoma mansoni chromatin regulatory protein sir2 0.0541 0.671 0.6687
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0373 0.0304
Brugia malayi TAR-binding protein 0.0064 0.0522 0.0455
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0355 0.4302 0.4302
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.029 0.0221
Trichomonas vaginalis CAMK family protein kinase 0.0143 0.1556 0.1556
Schistosoma mansoni jumonji domain containing protein 0.0079 0.0725 0.0659
Plasmodium vivax hypothetical protein, conserved 0.003 0.0092 0.005
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0522 0.0455
Schistosoma mansoni chromatin regulatory protein sir2 0.0215 0.2486 0.2433
Giardia lamblia Kinase, PLK 0.0289 0.3452 0.3392
Echinococcus multilocularis axis inhibition protein axin 0.0038 0.0194 0.0124
Toxoplasma gondii histone deacetylase SIR2-like 0.0215 0.2486 0.5709
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0614 0.0614
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0522 0.0455
Echinococcus granulosus regulator of G protein signaling 3 0.0038 0.0194 0.0124
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0522 0.0455
Trypanosoma cruzi polo-like protein kinase, putative 0.0289 0.3452 0.3452
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0355 0.4302 0.4302
Leishmania major dihydrolipoamide dehydrogenase, putative 0.005 0.0342 0.0342
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.005 0.0342 0.0342
Echinococcus multilocularis chromobox protein 1 0.0071 0.0614 0.0547
Brugia malayi RNA binding protein 0.0064 0.0522 0.0455
Mycobacterium tuberculosis Conserved protein 0.0075 0.0671 0.0808
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0194 0.0194
Echinococcus granulosus chromatin regulatory protein sir2 0.0794 1 1
Schistosoma mansoni hypothetical protein 0.0308 0.3691 0.3646
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0092 0.0021
Echinococcus multilocularis citrate lyase subunit beta protein 0.0075 0.0671 0.0604
Brugia malayi A-kinase anchor protein 10, precursor 0.0038 0.0194 0.0124
Brugia malayi hypothetical protein 0.0038 0.0194 0.0124
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.029 0.0221
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0159 0.0089
Echinococcus granulosus regulator of G protein signaling 7 0.0038 0.0194 0.0124
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.005 0.0342 0.0273
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0308 0.3691 0.3646
Trichomonas vaginalis mercuric reductase, putative 0.005 0.0342 0.0342
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0289 0.3452 0.3452
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0327 0.3943 0.8837
Echinococcus granulosus regulator of G protein signaling 7 0.0038 0.0194 0.0124
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.029 0.0221
Brugia malayi PXA domain containing protein 0.0038 0.0194 0.0124
Loa Loa (eye worm) hypothetical protein 0.0038 0.0194 0.0124
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0215 0.2486 0.2433
Schistosoma mansoni serine/threonine protein kinase 0.0289 0.3452 0.3406
Schistosoma mansoni chromatin regulatory protein sir2 0.0794 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0061 0.0061
Trichomonas vaginalis glutaminase, putative 0.0555 0.6895 0.6895
Trichomonas vaginalis CAMK family protein kinase 0.0289 0.3452 0.3452
Echinococcus multilocularis regulator of G protein signaling 7 0.0038 0.0194 0.0124
Mycobacterium ulcerans Sir2-like regulatory protein 0.0215 0.2486 0.3273
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0038 0.0194 0.0124
Loa Loa (eye worm) hypothetical protein 0.003 0.0092 0.0021
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0541 0.671 0.6687
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0522 0.0455
Trichomonas vaginalis CAMK family protein kinase 0.0143 0.1556 0.1556
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0794 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0206 0.0136
Loa Loa (eye worm) hypothetical protein 0.0052 0.0373 0.0304
Mycobacterium tuberculosis Probable dehydrogenase 0.0327 0.3943 0.8837
Loa Loa (eye worm) sirtuin 4 0.0215 0.2486 0.2433
Plasmodium vivax NAD-dependent deacetylase, putative 0.0355 0.4302 1
Loa Loa (eye worm) hypothetical protein 0.0326 0.392 0.3877
Echinococcus multilocularis thioredoxin glutathione reductase 0.0143 0.1558 0.1498
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0794 1 1
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0794 1 1
Echinococcus multilocularis peregrin 0.003 0.0092 0.0021
Plasmodium falciparum thioredoxin reductase 0.0143 0.1558 0.3515
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0342 0.0342
Echinococcus granulosus tar DNA binding protein 0.0064 0.0522 0.0455
Entamoeba histolytica hypothetical protein, conserved 0.0215 0.2486 0.2486
Schistosoma mansoni kinase 0.0147 0.1605 0.1546
Entamoeba histolytica serine/threonine protein kinase, putative 0.0289 0.3452 0.3452
Brugia malayi transcriptional regulator, Sir2 family protein 0.0215 0.2486 0.2433
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0075 0.0671 0.0671
Echinococcus granulosus Regulator of G protein signaling 20 0.0038 0.0194 0.0124
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0175 0.0105
Brugia malayi glutathione reductase 0.0143 0.1558 0.1498
Echinococcus multilocularis snurportin 1 0.0308 0.3691 0.3646
Loa Loa (eye worm) glutaminase 2 0.0555 0.6895 0.6873
Loa Loa (eye worm) hypothetical protein 0.0031 0.01 0.0029
Trichomonas vaginalis chromobox protein, putative 0.0043 0.025 0.025
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0038 0.0194 0.0124
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0194 0.0194
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0355 0.4302 1
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0215 0.2486 0.2433
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0247 0.0177
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.01 0.0991 0.0927
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0206 0.0136
Toxoplasma gondii thioredoxin reductase 0.0143 0.1558 0.3515
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0327 0.3943 0.8369
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.005 0.0342 0.064
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0038 0.0194 0.0194
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0522 0.0455
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0194 0.0124
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0194 0.0124
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0194 0.0124
Trypanosoma cruzi trypanothione reductase, putative 0.0143 0.1558 0.1558
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0794 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0289 0.3452 0.3452
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0194 0.0194
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0215 0.2486 0.2486
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0215 0.2486 0.5709
Entamoeba histolytica hypothetical protein 0.0038 0.0194 0.0194
Schistosoma mansoni hypothetical protein 0.003 0.0092 0.0021
Trypanosoma cruzi hypothetical protein, conserved 0.0652 0.8155 0.8155
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0289 0.3452 0.3406
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0038 0.0194 0.0124
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0794 1 1
Echinococcus granulosus citrate lyase subunit beta protein 0.0075 0.0671 0.0604
Leishmania major acetoin dehydrogenase e3 component-like protein 0.005 0.0342 0.0342
Schistosoma mansoni chromatin regulatory protein sir2 0.0355 0.4302 0.4261
Trypanosoma brucei polo-like protein kinase 0.0289 0.3452 0.3406
Loa Loa (eye worm) transcriptional regulator 0.0215 0.2486 0.2433
Entamoeba histolytica hypothetical protein 0.0038 0.0194 0.0194
Loa Loa (eye worm) glutaminase 0.0555 0.6895 0.6873
Brugia malayi glutaminase DH11.1 0.0555 0.6895 0.6873
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0092 0.005
Mycobacterium ulcerans hypothetical protein 0.0075 0.0671 0.0502
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.029 0.0221
Plasmodium falciparum glutathione reductase 0.0143 0.1558 0.3515
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0037 0.017 0.01
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0206 0.0136
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0175 0.0105
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0211 0.0211
Echinococcus multilocularis regulator of G protein signaling 3 0.0038 0.0194 0.0124
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.005 0.0342 0.0273
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0175 0.0105
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0075 0.0671 0.0502
Trypanosoma brucei SIR2-like protein 4, putative 0.0215 0.2486 0.2433
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0092 0.0021
Treponema pallidum NADH oxidase 0.005 0.0342 0.5
Brugia malayi chromobox protein homolog 3 0.004 0.0211 0.0141
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0039 0.0206 0.0136
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0038 0.0194 0.0124
Mycobacterium ulcerans glutaminase 0.0555 0.6895 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0541 0.671 0.671
Leishmania major sir2-family protein-like protein 0.0215 0.2486 0.2486
Trypanosoma cruzi polo-like protein kinase, putative 0.0289 0.3452 0.3452
Echinococcus multilocularis expressed protein 0.0746 0.9378 0.9373
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0075 0.0671 0.0671
Loa Loa (eye worm) thioredoxin reductase 0.0143 0.1558 0.1498
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0364 0.4416 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0374 0.0306
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0215 0.2486 0.2486
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.005 0.0342 0.064
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.005 0.0342 0.0342
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.005 0.0342 0.064
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.005 0.0342 0.064
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0194 0.0194
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0075 0.0671 0.0502
Loa Loa (eye worm) hypothetical protein 0.0038 0.0194 0.0124
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.005 0.0342 0.0342
Schistosoma mansoni axis inhibition protein axin 0.0038 0.0194 0.0124
Brugia malayi Regulator of G protein signaling domain containing protein 0.0038 0.0194 0.0124
Echinococcus granulosus chromobox protein 1 0.0071 0.0614 0.0547
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0037 0.017 0.01
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0215 0.2486 0.2433
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.005 0.0342 0.5
Brugia malayi Regulator of G protein signaling domain containing protein 0.0038 0.0194 0.0124
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.005 0.0342 0.0342
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0355 0.4302 0.4302
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0038 0.0194 0.0124
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.005 0.0342 0.0273
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0513 0.0445
Leishmania major silent information regulator 2, putative 0.0794 1 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0159 0.0089
Loa Loa (eye worm) RGS-3 protein 0.0038 0.0194 0.0124
Brugia malayi transcriptional regulator, Sir2 family protein 0.0215 0.2486 0.2433
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0541 0.671 0.6687
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0211 0.0354
Trichomonas vaginalis CAMK family protein kinase 0.0289 0.3452 0.3452
Trypanosoma brucei hypothetical protein, conserved 0.0652 0.8155 0.8142
Brugia malayi regulator of G-protein signaling rgs-7 0.0038 0.0194 0.0124
Echinococcus granulosus peregrin 0.003 0.0092 0.0021
Onchocerca volvulus 0.0031 0.01 0.0023
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0794 1 1
Brugia malayi Thioredoxin reductase 0.0143 0.1558 0.1498
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0092 0.005
Trichomonas vaginalis glutathione reductase, putative 0.005 0.0342 0.0342
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0327 0.3943 0.8837
Loa Loa (eye worm) hypothetical protein 0.0038 0.0194 0.0124
Schistosoma mansoni hypothetical protein 0.0036 0.0159 0.0089
Onchocerca volvulus Serine\/threonine kinase homolog 0.0289 0.3452 1
Trypanosoma brucei trypanothione reductase 0.0143 0.1558 0.1498
Loa Loa (eye worm) transcriptional regulator 0.0215 0.2486 0.2433
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0355 0.4302 0.9718
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.005 0.0342 0.0273
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0541 0.671 0.671
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0289 0.3452 0.3406

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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