Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | NAD-dependent histone deacetylase Sir2 | 0.0424 | 0.5226 | 0.5226 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.01 | 0.0874 | 0.0874 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0037 | 0.0035 | 0.0035 |
Leishmania major | hypothetical protein, conserved | 0.0224 | 0.2548 | 0.2548 |
Echinococcus granulosus | chromatin regulatory protein sir2 | 0.0779 | 1 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.01 | 0.0874 | 0.0874 |
Trypanosoma brucei | Silent information regulator 2 related protein 1 | 0.0779 | 1 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0252 | 0.2924 | 1 |
Trypanosoma cruzi | Silent information regulator 2 related protein 1 | 0.0779 | 1 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0227 | 0.2584 | 0.6224 |
Schistosoma mansoni | jumonji domain containing protein | 0.008 | 0.0606 | 0.0606 |
Loa Loa (eye worm) | glutathione reductase | 0.0099 | 0.0873 | 0.0841 |
Trichomonas vaginalis | CAMK family protein kinase | 0.01 | 0.0874 | 0.0874 |
Plasmodium vivax | glutathione reductase, putative | 0.0099 | 0.0873 | 0.2102 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0242 | 0.0208 |
Leishmania major | sir2-family protein-like protein | 0.0201 | 0.2233 | 0.2233 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.0434 | 0.0434 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0067 | 0.0434 | 0.04 |
Loa Loa (eye worm) | transcriptional regulator | 0.0201 | 0.2233 | 0.2206 |
Trypanosoma brucei | trypanothione reductase | 0.0099 | 0.0873 | 0.0873 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0043 | 0.0109 | 0.0109 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0037 | 0.0035 | 0.0035 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0224 | 0.2548 | 0.2548 |
Plasmodium falciparum | glutathione reductase | 0.0099 | 0.0873 | 0.2102 |
Echinococcus granulosus | tar DNA binding protein | 0.0067 | 0.0434 | 0.0434 |
Schistosoma mansoni | kinase | 0.0051 | 0.0217 | 0.0217 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0224 | 0.2548 | 0.2548 |
Treponema pallidum | NADH oxidase | 0.0034 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.0434 | 0.0434 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0224 | 0.2548 | 0.2548 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.01 | 0.0874 | 0.0874 |
Mycobacterium tuberculosis | Transcriptional regulatory protein | 0.0344 | 0.4151 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.01 | 0.0874 | 0.0874 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0424 | 0.5226 | 0.5226 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0037 | 0.0035 | 0.0035 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0779 | 1 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0201 | 0.2233 | 0.5379 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0252 | 0.2924 | 0.7043 |
Brugia malayi | transcriptional regulator, Sir2 family protein | 0.0201 | 0.2233 | 0.2233 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0099 | 0.0873 | 0.0873 |
Mycobacterium ulcerans | NAD-dependent deacetylase | 0.0344 | 0.4151 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0099 | 0.0873 | 0.2102 |
Echinococcus granulosus | NAD dependent deacetylase sirtuin 1 | 0.0424 | 0.5226 | 0.5226 |
Brugia malayi | NAD-dependent deacetylase SIRT1 | 0.0424 | 0.5226 | 0.5226 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0201 | 0.2233 | 0.2233 |
Loa Loa (eye worm) | hypothetical protein | 0.0223 | 0.253 | 0.2504 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0252 | 0.2924 | 0.7043 |
Plasmodium falciparum | thioredoxin reductase | 0.0099 | 0.0873 | 0.2102 |
Echinococcus granulosus | NAD dependent deacetylase sirtuin 3 | 0.0779 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0067 | 0.0434 | 0.04 |
Brugia malayi | jmjC domain containing protein | 0.01 | 0.0883 | 0.0883 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0779 | 1 | 1 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0424 | 0.5226 | 0.5226 |
Entamoeba histolytica | NAD-dependent deacetylase 1, putative | 0.0201 | 0.2233 | 0.1489 |
Entamoeba histolytica | Sir2 family transcriptional regulator, putative | 0.0344 | 0.4151 | 0.3591 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0099 | 0.0873 | 0.0873 |
Loa Loa (eye worm) | transcriptional regulator | 0.0779 | 1 | 1 |
Echinococcus multilocularis | NAD dependent deacetylase sirtuin 6 | 0.0201 | 0.2233 | 0.2233 |
Brugia malayi | RNA binding protein | 0.0067 | 0.0434 | 0.0434 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0424 | 0.5226 | 0.5226 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0779 | 1 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0063 | 0.0386 | 0.0352 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0227 | 0.2584 | 0.6224 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.0434 | 0.0434 |
Entamoeba histolytica | Sir2 family transcriptional regulator, putative | 0.0779 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.0434 | 0.0434 |
Trichomonas vaginalis | CAMK family protein kinase | 0.01 | 0.0874 | 0.0874 |
Brugia malayi | glutathione reductase | 0.0099 | 0.0873 | 0.0873 |
Loa Loa (eye worm) | sirtuin 4 | 0.0201 | 0.2233 | 0.2206 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.01 | 0.0874 | 0.0874 |
Toxoplasma gondii | thioredoxin reductase | 0.0099 | 0.0873 | 0.2102 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0099 | 0.0873 | 0.0873 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0049 | 0.0199 | 0.0199 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0227 | 0.2584 | 0.6224 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0779 | 1 | 1 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0344 | 0.4151 | 0.4151 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0049 | 0.0199 | 0.0199 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0099 | 0.0873 | 0.2102 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0201 | 0.2233 | 0.2233 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.01 | 0.0874 | 0.0874 |
Brugia malayi | Thioredoxin reductase | 0.0099 | 0.0873 | 0.0873 |
Schistosoma mansoni | serine/threonine protein kinase | 0.01 | 0.0874 | 0.0874 |
Giardia lamblia | Sirtuin type 2 | 0.0201 | 0.2233 | 0.2233 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0344 | 0.4151 | 0.4151 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0424 | 0.5226 | 0.5226 |
Trypanosoma brucei | SIR2-like protein 4, putative | 0.0201 | 0.2233 | 0.2233 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.01 | 0.0874 | 0.0874 |
Echinococcus multilocularis | NAD dependent deacetylase sirtuin 7 | 0.0201 | 0.2233 | 0.2233 |
Trypanosoma cruzi | Silent information regulator 2 related protein 1 | 0.0779 | 1 | 1 |
Leishmania major | NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe | 0.0344 | 0.4151 | 0.4151 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0227 | 0.2584 | 0.6224 |
Brugia malayi | TAR-binding protein | 0.0067 | 0.0434 | 0.0434 |
Brugia malayi | transcriptional regulator, Sir2 family protein | 0.0201 | 0.2233 | 0.2233 |
Loa Loa (eye worm) | transcriptional regulator | 0.0201 | 0.2233 | 0.2206 |
Echinococcus granulosus | NAD dependent deacetylase sirtuin 6 | 0.0201 | 0.2233 | 0.2233 |
Entamoeba histolytica | Sir2 family transcriptional regulator, putative | 0.0779 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.01 | 0.0874 | 0.0874 |
Toxoplasma gondii | histone deacetylase SIR2-like | 0.0201 | 0.2233 | 0.5379 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0067 | 0.0434 | 0.0434 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0344 | 0.4151 | 0.4151 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.01 | 0.0883 | 0.0883 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0201 | 0.2233 | 0.2233 |
Mycobacterium tuberculosis | Probable reductase | 0.0227 | 0.2584 | 0.6224 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0099 | 0.0873 | 0.0841 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.01 | 0.0883 | 0.0883 |
Plasmodium falciparum | transcriptional regulatory protein sir2b | 0.0201 | 0.2233 | 0.5379 |
Plasmodium falciparum | transcriptional regulatory protein sir2a | 0.0344 | 0.4151 | 1 |
Giardia lamblia | Transcriptional regulator, Sir2 family | 0.0344 | 0.4151 | 0.4151 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0252 | 0.2924 | 0.7043 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0779 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0034 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0034 | 0 | 0.5 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0201 | 0.2233 | 0.2233 |
Giardia lamblia | Hypothetical protein | 0.0779 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0067 | 0.0434 | 0.04 |
Echinococcus granulosus | NAD dependent deacetylase sirtuin 7 | 0.0201 | 0.2233 | 0.2233 |
Trypanosoma cruzi | Silent information regulator 2 related protein 3 | 0.0344 | 0.4151 | 0.4151 |
Echinococcus multilocularis | chromatin regulatory protein sir2 | 0.0779 | 1 | 1 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0344 | 0.4151 | 0.4151 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.01 | 0.0874 | 0.0842 |
Plasmodium vivax | NAD-dependent deacetylase, putative | 0.0344 | 0.4151 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.01 | 0.0874 | 0.0874 |
Brugia malayi | jmjC domain containing protein | 0.0037 | 0.0035 | 0.0035 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0037 | 0.0035 | 0.0035 |
Trypanosoma brucei | Silent information regulator 2 related protein 3 | 0.0344 | 0.4151 | 0.4151 |
Giardia lamblia | Kinase, PLK | 0.01 | 0.0874 | 0.0874 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0201 | 0.2233 | 0.1489 |
Loa Loa (eye worm) | hypothetical protein | 0.0424 | 0.5226 | 0.5209 |
Echinococcus multilocularis | NAD dependent deacetylase sirtuin 1 | 0.0424 | 0.5226 | 0.5226 |
Trichomonas vaginalis | CAMK family protein kinase | 0.01 | 0.0874 | 0.0874 |
Trichomonas vaginalis | CAMK family protein kinase | 0.01 | 0.0874 | 0.0874 |
Mycobacterium ulcerans | Sir2-like regulatory protein | 0.0201 | 0.2233 | 0.5379 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.0434 | 0.0434 |
Trypanosoma brucei | polo-like protein kinase | 0.01 | 0.0874 | 0.0874 |
Echinococcus granulosus | jumonji domain containing protein | 0.0043 | 0.0109 | 0.0109 |
Toxoplasma gondii | histone deacetylase SIR2 | 0.0344 | 0.4151 | 1 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0424 | 0.5226 | 0.5226 |
Echinococcus multilocularis | NAD dependent deacetylase sirtuin 3 | 0.0779 | 1 | 1 |
Leishmania major | silent information regulator 2, putative | 0.0779 | 1 | 1 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0227 | 0.2584 | 0.7684 |
Echinococcus multilocularis | tar DNA binding protein | 0.0067 | 0.0434 | 0.0434 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0034 | 0 | 0.5 |
Trypanosoma cruzi | Silent information regulator 2 related protein 3 | 0.0344 | 0.4151 | 0.4151 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.01 | 0.0874 | 0.5 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0227 | 0.2584 | 0.6224 |
Leishmania major | trypanothione reductase | 0.0099 | 0.0873 | 0.0873 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.