Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | calcium channel protein, putative,ion transporter, putative | 0.0003 | 0 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0003 | 0 | 0.5 |
Toxoplasma gondii | transporter, cation channel family protein | 0.0003 | 0 | 0.5 |
Trypanosoma cruzi | inositol 1,4,5-trisphosphate receptor, putative | 0.0003 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0003 | 0.00000011473 | 0.00000045363 |
Leishmania major | hypothetical protein, unknown function | 0.0003 | 0 | 0.5 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0003 | 0.0017 | 0.0017 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0003 | 0 | 0.5 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0003 | 0.0017 | 0.0017 |
Schistosoma mansoni | transient receptor potential channel | 0.0003 | 0.00000011473 | 0.00000011473 |
Loa Loa (eye worm) | NADH dehydrogenase subunit 1 | 0.0039 | 0.2529 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0003 | 0 | 0.5 |
Trypanosoma brucei | Voltage-dependent calcium channel subunit, putative | 0.0003 | 0 | 0.5 |
Trypanosoma brucei | inositol 1,4,5-trisphosphate receptor | 0.0003 | 0 | 0.5 |
Toxoplasma gondii | transporter, cation channel family protein | 0.0003 | 0 | 0.5 |
Schistosoma mansoni | NADH dehydrogenase subunit 1 | 0.0039 | 0.2529 | 0.2529 |
Toxoplasma gondii | hypothetical protein | 0.0003 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0003 | 0.0017 | 0.0067 |
Brugia malayi | NADH dehydrogenase subunit 1 | 0.0039 | 0.2529 | 1 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0003 | 0.00000011473 | 0.00000011473 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0003 | 0.0017 | 0.9999 |
Mycobacterium ulcerans | NADH dehydrogenase subunit H | 0.0144 | 1 | 1 |
Onchocerca volvulus | 0.0039 | 0.2529 | 1 | |
Trypanosoma cruzi | Voltage-dependent calcium channel subunit, putative | 0.0003 | 0 | 0.5 |
Brugia malayi | olfactory channel protein osm-9 | 0.0003 | 0.0017 | 0.0067 |
Wolbachia endosymbiont of Brugia malayi | NADH dehydrogenase subunit H | 0.0144 | 1 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0003 | 0 | 0.5 |
Onchocerca volvulus | 0.0039 | 0.2529 | 1 | |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0003 | 0.00000011473 | 0.0001 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase I (chain H) NuoH (NADH-ubiquinone oxidoreductase chain H) | 0.0144 | 1 | 1 |
Toxoplasma gondii | transporter, cation channel family protein | 0.0003 | 0 | 0.5 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0003 | 0.00000011473 | 0.00000011473 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.0003 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0039 | 0.2529 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0144 | 1 | 1 |
Schistosoma mansoni | transient receptor potential channel | 0.0003 | 0.00000011473 | 0.00000011473 |
Loa Loa (eye worm) | hypothetical protein | 0.0003 | 0.00000011473 | 0.00000045363 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.0003 | 0 | 0.5 |
Schistosoma mansoni | transient receptor potential channel | 0.0003 | 0.0017 | 0.0017 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0003 | 0.0017 | 1 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0003 | 0.0017 | 1 |
Brugia malayi | NADH dehydrogenase subunit 1, identical | 0.0039 | 0.2529 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.