Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lipase, hormone-sensitive | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0253 | 0.4889 | 0.4889 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0083 | 0.1098 | 0.1064 |
Loa Loa (eye worm) | raf kinase | 0.0481 | 0.9948 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0253 | 0.4889 | 0.4889 |
Loa Loa (eye worm) | hypothetical protein | 0.032 | 0.6382 | 0.6261 |
Brugia malayi | Trypsin family protein | 0.032 | 0.6382 | 0.648 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.006 | 0.0582 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.032 | 0.6382 | 0.6261 |
Loa Loa (eye worm) | TKL/RAF/RAF protein kinase | 0.0274 | 0.5348 | 0.5176 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.006 | 0.0582 | 0.5 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.006 | 0.0582 | 0.5 |
Echinococcus granulosus | hormone sensitive lipase | 0.0253 | 0.4889 | 0.4869 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0334 | 0.6688 | 0.6688 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0253 | 0.4889 | 0.4889 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0483 | 1 | 1 |
Chlamydia trachomatis | glutamine binding protein | 0.006 | 0.0582 | 0.5 |
Echinococcus multilocularis | hormone sensitive lipase | 0.0253 | 0.4889 | 0.4869 |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 0.4889 | 0.4695 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.006 | 0.0582 | 0.5 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0083 | 0.1098 | 0.1064 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.006 | 0.0582 | 0.5 |
Onchocerca volvulus | 0.032 | 0.6382 | 1 | |
Echinococcus multilocularis | raf serine:threonine protein kinase | 0.0483 | 1 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0083 | 0.1098 | 0.1064 |
Onchocerca volvulus | 0.0291 | 0.5735 | 0.8915 | |
Brugia malayi | Raf kinase | 0.0466 | 0.9625 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0052 | 0.0412 | 0.0412 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0035 | 0.0039 | 0.0039 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.032 | 0.6382 | 0.6382 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 19 nM | Inhibition of human recombinant hormone sensitive lipase. | ChEMBL. | 15026062 |
IC50 (binding) | = 19 nM | Inhibition of human recombinant hormone sensitive lipase. | ChEMBL. | 15026062 |
Inhibition (binding) | = 98 % | Inhibition of recombinant human hormone sensitive lipase (HSL) | ChEMBL. | 15026062 |
Inhibition (binding) | = 98 % | Inhibition of recombinant human hormone sensitive lipase (HSL) | ChEMBL. | 15026062 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.