Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | polyprenyl synthetase superfamily protein | 0.0425 | 0.2773 | 0.2692 |
Echinococcus multilocularis | carbonic anhydrase | 0.016 | 0.0848 | 0.0848 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0042 | 0.0042 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0118 | 0.0064 |
Treponema pallidum | octaprenyl-diphosphate synthase | 0.0608 | 0.4108 | 0.5 |
Mycobacterium ulcerans | polyprenyl synthetase IdsB | 0.0519 | 0.3461 | 0.3285 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.016 | 0.0848 | 0.0798 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0062 | 0.0139 | 0.0082 |
Onchocerca volvulus | Matrilysin homolog | 0.0228 | 0.134 | 1 |
Brugia malayi | Polyprenyl synthetase family protein | 0.0425 | 0.2773 | 0.2773 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0051 | 0.0055 | 0.0055 |
Mycobacterium ulcerans | geranylgeranyl pyrophosphate synthase | 0.1418 | 1 | 1 |
Schistosoma mansoni | patched 1 | 0.0051 | 0.0055 | 0.0055 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0119 | 0.0549 | 0.0549 |
Schistosoma mansoni | glutathione synthetase | 0.0425 | 0.2773 | 0.2773 |
Schistosoma mansoni | carbonic anhydrase-related | 0.016 | 0.0848 | 0.0848 |
Echinococcus granulosus | carbonic anhydrase | 0.016 | 0.0848 | 0.0848 |
Leishmania major | solanesyl-diphosphate synthase, putative | 0.0425 | 0.2773 | 0.2024 |
Leishmania major | farnesyl pyrophosphate synthase | 0.1418 | 1 | 1 |
Giardia lamblia | Farnesyl diphosphate synthase | 0.1418 | 1 | 0.5 |
Mycobacterium ulcerans | geranylgeranyl pyrophosphate synthase | 0.1418 | 1 | 1 |
Entamoeba histolytica | bifunctional short chain isoprenyl diphosphate synthase, putative | 0.0425 | 0.2773 | 1 |
Brugia malayi | CHE-14 protein | 0.0051 | 0.0055 | 0.0055 |
Wolbachia endosymbiont of Brugia malayi | geranylgeranyl pyrophosphate synthase | 0.0519 | 0.3461 | 1 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0051 | 0.0055 | 0.0055 |
Echinococcus multilocularis | protein patched | 0.0051 | 0.0055 | 0.0055 |
Trypanosoma cruzi | polyprenyl synthase, putative | 0.0608 | 0.4108 | 0.4074 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0979 | 0.6808 | 0.6808 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0365 | 0.2337 | 0.2293 |
Loa Loa (eye worm) | matrixin family protein | 0.0241 | 0.1435 | 0.1388 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0286 | 0.1761 | 0.1761 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0192 | 0.1082 | 0.0841 |
Onchocerca volvulus | 0.0065 | 0.0159 | 0.0414 | |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0173 | 0.094 | 0.0888 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0042 | 0.0042 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0139 | 0.0084 |
Loa Loa (eye worm) | polyprenyl synthetase | 0.0425 | 0.2773 | 0.2733 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0159 | 0.0104 |
Mycobacterium leprae | PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) | 0.0425 | 0.2773 | 1 |
Echinococcus multilocularis | farnesyl pyrophosphate synthase | 0.1418 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.0848 | 0.0798 |
Brugia malayi | follicle stimulating hormone receptor | 0.028 | 0.1719 | 0.1719 |
Schistosoma mansoni | carbonic anhydrase | 0.016 | 0.0848 | 0.0848 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0051 | 0.0055 | 0.0055 |
Mycobacterium tuberculosis | Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase) | 0.0519 | 0.3461 | 0.3285 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0268 | 0.1637 | 0.1637 |
Brugia malayi | geranylgeranyl pyrophosphate synthetase | 0.0608 | 0.4108 | 0.4108 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0268 | 0.1637 | 0.1637 |
Mycobacterium tuberculosis | Probable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate | 0.0519 | 0.3461 | 0.3285 |
Trichomonas vaginalis | geranylgeranyl diphosphate synthase, putative | 0.1418 | 1 | 1 |
Entamoeba histolytica | geranylgeranyl pyrophosphate synthetase, putative | 0.0425 | 0.2773 | 1 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0121 | 0.0562 | 0.0562 |
Brugia malayi | Matrixin family protein | 0.0065 | 0.0159 | 0.0159 |
Schistosoma mansoni | carbonic anhydrase-related | 0.016 | 0.0848 | 0.0848 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0268 | 0.1637 | 0.159 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.016 | 0.0848 | 0.0848 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.028 | 0.1719 | 0.1673 |
Trypanosoma cruzi | farnesyl pyrophosphate synthase, putative | 0.1418 | 1 | 1 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0058 | 0.0108 | 0.0108 |
Brugia malayi | Hemopexin family protein | 0.0093 | 0.0357 | 0.0357 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0268 | 0.1637 | 0.1637 |
Trypanosoma cruzi | solanesyl-diphosphate synthase, putative | 0.0425 | 0.2773 | 0.2732 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0042 | 0.0042 |
Toxoplasma gondii | polyprenyl synthetase superfamily protein | 0.1418 | 1 | 1 |
Schistosoma mansoni | survival motor neuron protein | 0.0058 | 0.0108 | 0.0108 |
Chlamydia trachomatis | geranylgeranyl pyrophosphate synthase | 0.0519 | 0.3461 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0268 | 0.1637 | 0.1589 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.017 | 0.092 | 0.092 |
Onchocerca volvulus | 0.0093 | 0.0357 | 0.2024 | |
Toxoplasma gondii | hypothetical protein | 0.016 | 0.0848 | 0.0745 |
Echinococcus granulosus | carbonic anhydrase | 0.016 | 0.0848 | 0.0848 |
Trypanosoma brucei | solanesyl-diphosphate synthase, putative | 0.0425 | 0.2773 | 0.2732 |
Mycobacterium tuberculosis | Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) | 0.0425 | 0.2773 | 0.2579 |
Schistosoma mansoni | trans-prenyltransferase | 0.0425 | 0.2773 | 0.2773 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0268 | 0.1637 | 0.1589 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.1761 | 0.1716 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0268 | 0.1637 | 0.1637 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.032 | 0.2014 | 0.2014 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0268 | 0.1637 | 0.1637 |
Echinococcus multilocularis | carbonic anhydrase | 0.016 | 0.0848 | 0.0848 |
Plasmodium falciparum | geranylgeranyl pyrophosphate synthase, putative | 0.1418 | 1 | 1 |
Echinococcus granulosus | decaprenyl diphosphate synthase subunit 1 | 0.0425 | 0.2773 | 0.2773 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.016 | 0.0848 | 0.0848 |
Echinococcus granulosus | farnesyl pyrophosphate synthase | 0.1418 | 1 | 1 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0119 | 0.0549 | 0.0549 |
Trichomonas vaginalis | geranylgeranyl pyrophosphate synthase, putative | 0.1418 | 1 | 1 |
Trypanosoma cruzi | polyprenyl synthase, putative | 0.0608 | 0.4108 | 0.4074 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.0848 | 0.0798 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.032 | 0.2014 | 0.2014 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0145 | 0.0737 | 0.5105 |
Schistosoma mansoni | farnesyl pyrophosphate synthase | 0.1418 | 1 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0365 | 0.2337 | 0.2293 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0042 | 0.0042 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0286 | 0.1761 | 0.1761 |
Echinococcus multilocularis | prenyl (decaprenyl) diphosphate synthase | 0.0425 | 0.2773 | 0.2773 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.016 | 0.0848 | 0.0848 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0159 | 0.0104 |
Trichomonas vaginalis | geranylgeranyl pyrophosphate synthase, putative | 0.1418 | 1 | 1 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0079 | 0.0262 | 0.0262 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.0262 | 0.0208 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0173 | 0.094 | 0.0888 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.0762 | 0.0711 |
Echinococcus granulosus | carbonic anhydrase | 0.016 | 0.0848 | 0.0848 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0268 | 0.1637 | 0.159 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.016 | 0.0848 | 0.0848 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0065 | 0.0159 | 0.0104 |
Trypanosoma cruzi | solanesyl-diphosphate synthase, putative | 0.0425 | 0.2773 | 0.2732 |
Schistosoma mansoni | hypothetical protein | 0.0093 | 0.0357 | 0.0357 |
Echinococcus granulosus | carbonic anhydrase II | 0.0268 | 0.1637 | 0.1637 |
Schistosoma mansoni | geranylgeranyl pyrophosphate synthase | 0.0608 | 0.4108 | 0.4108 |
Trypanosoma brucei | farnesyl pyrophosphate synthase | 0.1418 | 1 | 1 |
Echinococcus multilocularis | expressed conserved protein | 0.0112 | 0.0496 | 0.0496 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0119 | 0.0549 | 0.0549 |
Brugia malayi | hypothetical protein | 0.0286 | 0.1761 | 0.1761 |
Brugia malayi | Matrixin family protein | 0.0065 | 0.0159 | 0.0159 |
Onchocerca volvulus | 0.006 | 0.0118 | 0.0087 | |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0148 | 0.0762 | 0.0762 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0365 | 0.2337 | 0.1543 |
Brugia malayi | Matrixin family protein | 0.0065 | 0.0159 | 0.0159 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0119 | 0.0549 | 0.1979 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0048 | 0.0031 | 0.0031 |
Echinococcus multilocularis | decaprenyl diphosphate synthase subunit 1 | 0.0425 | 0.2773 | 0.2773 |
Trypanosoma cruzi | farnesyl pyrophosphate synthase | 0.1418 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.0848 | 0.0798 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.0549 | 0.0497 |
Loa Loa (eye worm) | polyprenyl synthetase | 0.1418 | 1 | 1 |
Mycobacterium ulcerans | polyprenyl diphosphate synthetase, GrcC1 | 0.0425 | 0.2773 | 0.2579 |
Mycobacterium ulcerans | hypothetical protein | 0.0192 | 0.1082 | 0.0841 |
Schistosoma mansoni | carbonic anhydrase-related | 0.016 | 0.0848 | 0.0848 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.017 | 0.092 | 0.092 |
Echinococcus granulosus | geranylgeranyl pyrophosphate synthase | 0.0608 | 0.4108 | 0.4108 |
Plasmodium vivax | geranylgeranyl pyrophosphate synthase | 0.1418 | 1 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0365 | 0.2337 | 0.2293 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.006 | 0.0118 | 0.0118 |
Mycobacterium tuberculosis | Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) | 0.1418 | 1 | 1 |
Echinococcus multilocularis | protein dispatched 1 | 0.0058 | 0.0108 | 0.0108 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0268 | 0.1637 | 0.1589 |
Trypanosoma cruzi | solanesyl-diphosphate synthase | 0.0425 | 0.2773 | 0.2732 |
Leishmania major | carbonic anhydrase-like protein | 0.0268 | 0.1637 | 0.0769 |
Schistosoma mansoni | hypothetical protein | 0.016 | 0.0848 | 0.0848 |
Leishmania major | polyprenyl synthase, putative | 0.0608 | 0.4108 | 0.3497 |
Echinococcus multilocularis | geranylgeranyl pyrophosphate synthase | 0.0608 | 0.4108 | 0.4108 |
Echinococcus granulosus | prenyl decaprenyl diphosphate synthase | 0.0425 | 0.2773 | 0.2773 |
Loa Loa (eye worm) | matrixin family protein | 0.0145 | 0.0737 | 0.0686 |
Echinococcus multilocularis | carbonic anhydrase | 0.016 | 0.0848 | 0.0848 |
Echinococcus multilocularis | tumor protein p63 | 0.0408 | 0.2652 | 0.2652 |
Plasmodium falciparum | octaprenyl pyrophosphate synthase | 0.0425 | 0.2773 | 0.2104 |
Brugia malayi | Matrixin family protein | 0.0241 | 0.1435 | 0.1435 |
Loa Loa (eye worm) | geranylgeranyl pyrophosphate synthetase | 0.0608 | 0.4108 | 0.4075 |
Echinococcus granulosus | expressed conserved protein | 0.0112 | 0.0496 | 0.0496 |
Brugia malayi | Matrixin family protein | 0.0065 | 0.0159 | 0.0159 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.016 | 0.0848 | 0.0848 |
Entamoeba histolytica | geranylgeranyl pyrophosphate synthase, putative | 0.0425 | 0.2773 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0058 | 0.0108 | 0.0108 |
Echinococcus granulosus | tumor protein p63 | 0.0408 | 0.2652 | 0.2652 |
Onchocerca volvulus | Matrilysin homolog | 0.0065 | 0.0159 | 0.0414 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.