Detailed information for compound 719179

Basic information

Technical information
  • TDR Targets ID: 719179
  • Name: 1-(3-methoxyphenyl)-3-(4-methyl-1,3-thiazol-2 -yl)urea
  • MW: 263.316 | Formula: C12H13N3O2S
  • H donors: 2 H acceptors: 2 LogP: 2.22 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)NC(=O)Nc1scc(n1)C
  • InChi: 1S/C12H13N3O2S/c1-8-7-18-12(13-8)15-11(16)14-9-4-3-5-10(6-9)17-2/h3-7H,1-2H3,(H2,13,14,15,16)
  • InChiKey: ZGPMKDLFSIUJQP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(3-methoxyphenyl)-3-(4-methylthiazol-2-yl)urea
  • 1-(3-methoxyphenyl)-3-(4-methyl-2-thiazolyl)urea
  • 1-(3-Methoxy-phenyl)-3-(4-methyl-thiazol-2-yl)-urea
  • BAS 09079756
  • ZINC00137575
  • ST030685

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0142 0.1666 0.4526
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0455 0.0455
Echinococcus multilocularis chromobox protein 2 0.0011 0.0027 0.0016
Echinococcus multilocularis dna polymerase eta 0.0043 0.043 0.042
Schistosoma mansoni thyroid hormone receptor 0.001 0.001 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0371 0.122
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.001 0.001
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0094 0.1062 0.4233
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0094 0.1062 0.1053
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0243 0.0233
Brugia malayi Pre-SET motif family protein 0.0208 0.2494 1
Schistosoma mansoni kinase 0.0048 0.0483 0.0483
Echinococcus multilocularis chromobox protein 1 0.0069 0.0753 0.0743
Echinococcus multilocularis dna polymerase kappa 0.0019 0.012 0.0109
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0229 0.0717
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0085 0.0075
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0268 0.0666
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0047 0.0055
Trypanosoma brucei unspecified product 0.0013 0.0047 0.0055
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0047 0.0055
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0075 0.0064
Schistosoma mansoni hypothetical protein 0.0035 0.0318 0.0318
Echinococcus granulosus caspase 2 0.0031 0.027 0.0259
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0268 0.1983
Leishmania major hypothetical protein, conserved 0.0053 0.0554 0.1457
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0011 0.0027 0.0065
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0065
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.012 0.0257
Onchocerca volvulus 0.0011 0.0027 0.0057
Trypanosoma brucei unspecified product 0.0019 0.012 0.0257
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0408 0.1351
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.001 0.001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0455 0.0445
Onchocerca volvulus 0.0011 0.0027 0.0057
Loa Loa (eye worm) hypothetical protein 0.0031 0.027 0.1043
Schistosoma mansoni hypothetical protein 0.034 0.4155 0.4155
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.012 0.0257
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0519 0.2049
Loa Loa (eye worm) hypothetical protein 0.0035 0.0318 0.124
Trypanosoma brucei DNA polymerase eta, putative 0.0043 0.043 0.1114
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0272 0.0262
Trypanosoma brucei mitochondrial DNA polymerase beta 0.03 0.3649 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.012 0.0257
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0045 0.0067
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0414 0.1069
Echinococcus multilocularis caspase 2 0.0031 0.027 0.0259
Brugia malayi serine/threonine-protein kinase plk-2 0.0094 0.1062 0.4233
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0015 0.0067 0.0057
Brugia malayi hypothetical protein 0.0053 0.0554 0.2189
Brugia malayi Pre-SET motif family protein 0.0031 0.0272 0.1053
Schistosoma mansoni thyroid hormone receptor 0.001 0.001 0.001
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0753 0.257
Schistosoma mansoni hypothetical protein 0.0011 0.0027 0.0027
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.0554 0.4335
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.012 0.0257
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0045 0.0067
Loa Loa (eye worm) hypothetical protein 0.0031 0.0272 0.1053
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.015 0.0438
Echinococcus granulosus geminin 0.034 0.4155 0.4149
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0371 0.127
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.0554 1
Brugia malayi CXXC zinc finger family protein 0.0057 0.0595 0.2352
Leishmania major mitochondrial DNA polymerase beta 0.03 0.3649 1
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0318 0.124
Trichomonas vaginalis set domain proteins, putative 0.0237 0.2853 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.012 0.0257
Brugia malayi hypothetical protein 0.0031 0.027 0.1043
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0065
Trypanosoma brucei PAB1-binding protein , putative 0.0053 0.0554 0.1457
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0467 0.156
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1062 0.3664
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0101 0.0264
Loa Loa (eye worm) hypothetical protein 0.0031 0.027 0.1043
Schistosoma mansoni DNA polymerase eta 0.0043 0.043 0.043
Brugia malayi Heterochromatin protein 1 0.0069 0.0753 0.2989
Brugia malayi chromobox protein homolog 3 0.0039 0.0371 0.1453
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.001 0.001
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0094 0.0094
Leishmania major DNA polymerase eta, putative 0.0043 0.043 0.1114
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.012 0.0257
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.012 0.0257
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0065
Echinococcus granulosus chromobox protein 1 0.0069 0.0753 0.0743
Brugia malayi ImpB/MucB/SamB family protein 0.0043 0.043 0.169
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.001 0.001
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.012 0.0257
Echinococcus multilocularis geminin 0.034 0.4155 0.4149
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.001 0.001
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.1666 0.4526
Loa Loa (eye worm) CHromoDomain protein family member 0.0015 0.0067 0.0228
Loa Loa (eye worm) hypothetical protein 0.0051 0.0519 0.2049
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1062 0.3664
Mycobacterium ulcerans hypothetical protein 0.0158 0.1867 0.2341
Leishmania major DNA polymerase kappa, putative 0.0019 0.012 0.0257
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.012 0.0257
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0408 0.14
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0272 0.2017
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0188 0.057
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0094 0.1062 0.2858
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0272 0.0272
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0085 0.0302
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.012 0.0257
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.012 0.0257
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0188 0.057
Schistosoma mansoni chromobox protein 0.0011 0.0027 0.0027
Brugia malayi Associated with TFs and helicases family protein 0.0011 0.0027 0.0065
Schistosoma mansoni hypothetical protein 0.0016 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.003 0.0266 0.1029
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0045 0.0067
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0085 0.0075
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0414 0.1069
Brugia malayi SET domain containing protein 0.0014 0.0056 0.0183
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0045 0.0067
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0085 0.0075
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0455 0.0445
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0094 0.1062 0.1053
Brugia malayi hypothetical protein 0.0011 0.0027 0.0065
Echinococcus granulosus dna polymerase eta 0.0043 0.043 0.042
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1062 0.3664
Echinococcus granulosus cpg binding protein 0.006 0.0635 0.0625
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.0075 0.0064
Echinococcus multilocularis GPCR, family 2 0.0016 0.0085 0.0075
Loa Loa (eye worm) hypothetical protein 0.0017 0.0097 0.0347
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.1062 0.2858
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0118 0.1735
Loa Loa (eye worm) helicase 0.0011 0.0027 0.0065
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.1062 0.2858
Brugia malayi hypothetical protein 0.0034 0.0317 0.1234
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.0075 0.0064
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0455 0.0445
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0011 0.0027 0.0027
Schistosoma mansoni cpg binding protein 0.006 0.0635 0.0635
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0075 0.0064
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.012 0.0257
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0011 0.0027 0.00000000037197
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0011 0.0027 0.0016
Loa Loa (eye worm) hypothetical protein 0.0039 0.0371 0.1453
Schistosoma mansoni cpg binding protein 0.006 0.0635 0.0635
Schistosoma mansoni hypothetical protein 0.0031 0.027 0.027
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0272 0.0262
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0188 0.057
Leishmania major DNA polymerase eta, putative 0.0031 0.0268 0.0666
Brugia malayi CHD4 protein 0.0015 0.0067 0.0228
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0011 0.0027 0.0016
Schistosoma mansoni cpg binding protein 0.0057 0.0595 0.0595
Echinococcus multilocularis apoptotic protease activating factor 1 0.0031 0.027 0.0259
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0272 0.0272
Loa Loa (eye worm) RecQ helicase 0.0021 0.015 0.0564
Onchocerca volvulus 0.0031 0.027 0.0912
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0065
Toxoplasma gondii histone lysine methyltransferase SET1 0.0108 0.1244 1
Echinococcus multilocularis bloom syndrome protein 0.0021 0.015 0.014
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0455 0.0455
Onchocerca volvulus 0.003 0.0266 0.09
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.001 0.001
Onchocerca volvulus 0.0057 0.0595 0.2056
Echinococcus multilocularis dnaJ subfamily B 0.0806 1 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0118 0.0108
Mycobacterium ulcerans arylamine N-acetyltransferase Nat 0.0614 0.7586 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0414 0.1069
Echinococcus granulosus chromobox protein 1 0.0069 0.0753 0.0743
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0753 0.257
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0115 0.0421
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.015 0.0438
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0455 0.1788
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0042 0.0414 0.0414
Brugia malayi Cell death protein 3 precursor 0.0031 0.027 0.1043
Echinococcus granulosus chromobox protein 2 0.0011 0.0027 0.0016
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0065
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.001 0.001
Echinococcus granulosus Chromobox protein 3 0.0011 0.0027 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0045 0.0067
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.012 0.0109
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0113 0.0306
Mycobacterium tuberculosis Conserved hypothetical protein 0.0158 0.1867 0.2341
Trichomonas vaginalis helicase, putative 0.0013 0.0045 0.0067
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0045 0.0067
Echinococcus granulosus bloom syndrome protein 0.0021 0.015 0.014
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.012 0.012
Brugia malayi M-phase phosphoprotein, mpp8 0.0011 0.0027 0.0065
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.001 0.001
Onchocerca volvulus Cell death protein 3 homolog 0.0031 0.027 0.0912
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0065
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0062 0.0292
Loa Loa (eye worm) hypothetical protein 0.0043 0.043 0.169
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0121 0.1405 0.1405
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.03 0.3649 1
Echinococcus multilocularis Chromobox protein 3 0.0011 0.0027 0.0016
Entamoeba histolytica serine/threonine protein kinase, putative 0.0094 0.1062 1
Schistosoma mansoni hypothetical protein 0.0016 0.0085 0.0085
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.012 0.044
Schistosoma mansoni nuclear hormone receptor 0.001 0.001 0.001
Schistosoma mansoni chromobox protein 0.0069 0.0753 0.0753
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0188 0.057
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.012 0.012
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.012 0.0257
Schistosoma mansoni hypothetical protein 0.0016 0.0085 0.0085
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.012 0.0109
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0185 0.0175
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.001 0.001
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.012 0.0899
Echinococcus granulosus dna polymerase kappa 0.0019 0.012 0.0109
Schistosoma mansoni chromobox protein 0.0069 0.0753 0.0753
Schistosoma mansoni hypothetical protein 0.0024 0.0189 0.0189
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.0027 0.0027
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0554 0.1457
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0085 0.0302
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0229 0.0717
Schistosoma mansoni hypothetical protein 0.034 0.4155 0.4155
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0554 1
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.0027 0.0027
Schistosoma mansoni hypothetical protein 0.0016 0.0085 0.0085
Schistosoma mansoni coup transcription factor 0.001 0.001 0.001
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0027 0.00000000085814
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0085 0.0302
Trypanosoma brucei unspecified product 0.0013 0.0047 0.0055
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0208 0.2494 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0519 0.2049
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0045 0.0067
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0414 0.1069
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0118 0.0433
Toxoplasma gondii hypothetical protein 0.0048 0.0492 0.3821
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0554 0.1457
Giardia lamblia Kinase, PLK 0.0094 0.1062 1
Echinococcus granulosus Chromo domain 0.0011 0.0027 0.0016
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.053 0.1389
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1062 0.3664
Brugia malayi Valyl-tRNA synthetase 0.0011 0.0027 0.0065
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0408 0.1351
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0014 0.0064 0.0715
Echinococcus multilocularis Chromo domain 0.0011 0.0027 0.0016
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0554 1
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0045 0.0067
Onchocerca volvulus 0.0237 0.2853 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0113 0.0306
Onchocerca volvulus Serine\/threonine kinase homolog 0.0094 0.1062 0.3699
Schistosoma mansoni caspase-7 (C14 family) 0.0031 0.027 0.027
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0085 0.0075
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.012 0.0329
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0519 0.2049
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0371 0.122
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0015 0.0067 0.0057
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.015 0.0564
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.012 0.0257
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1062 0.3664
Echinococcus multilocularis cpg binding protein 0.006 0.0635 0.0625
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0272 0.0272
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0272 0.0262
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.012 0.0257
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0467 0.156
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.012 0.0257
Onchocerca volvulus 0.0042 0.0414 0.1421
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0188 0.057
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0011 0.0027 0.00000000085814
Schistosoma mansoni chromobox protein 0.0011 0.0027 0.0027
Mycobacterium tuberculosis Arylamine N-acetyltransferase Nat (arylamine acetylase) 0.0614 0.7586 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.012 0.0329
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0188 0.057
Echinococcus multilocularis chromobox protein 1 0.0069 0.0753 0.0743
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.03 0.3649 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.043 0.1114
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.012 0.0257
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0047 0.0055
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0753 0.2989
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0188 0.057
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0455 0.0445
Echinococcus granulosus apoptotic protease activating factor 1 0.0031 0.027 0.0259
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0595 0.2352
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.1062 0.1062
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.012 0.044
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.1666 0.4526
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0455 0.0455
Loa Loa (eye worm) hypothetical protein 0.0053 0.0554 0.2189
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0455 0.1788
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1062 0.3664
Loa Loa (eye worm) hypothetical protein 0.0016 0.0085 0.0302
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0045 0.0067
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.012 0.0257
Schistosoma mansoni hypothetical protein 0.0024 0.0185 0.0185
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0188 0.057
Echinococcus granulosus GPCR family 2 0.0016 0.0085 0.0075
Trypanosoma brucei polo-like protein kinase 0.0094 0.1062 0.2858
Schistosoma mansoni hypothetical protein 0.0806 1 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0118 0.0108
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0185 0.0175
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1062 0.3664
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0065
Plasmodium vivax SET domain protein, putative 0.0031 0.0272 0.4653
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0015 0.0067 0.0067
Brugia malayi Protein cec-1. 0.0011 0.0027 0.0065

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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