Detailed information for compound 72110

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 323.386 | Formula: C20H21NO3
  • H donors: 1 H acceptors: 1 LogP: 3.68 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1OC1CCCC1)C1C(=O)Nc2c1cccc2
  • InChi: 1S/C20H21NO3/c1-23-17-11-10-13(12-18(17)24-14-6-2-3-7-14)19-15-8-4-5-9-16(15)21-20(19)22/h4-5,8-12,14,19H,2-3,6-7H2,1H3,(H,21,22)
  • InChiKey: TZXDUVYWNXDILB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens phosphodiesterase 4D, cAMP-specific Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128242 All targets in OG5_128242
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase, isoform F, putative Get druggable targets OG5_128242 All targets in OG5_128242
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_128242 All targets in OG5_128242
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase 4C, putative Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative Get druggable targets OG5_128242 All targets in OG5_128242
Cryptosporidium parvum membrane associated HD superfamily cyclic nucleotide phosphodiesterase domain containing protein Get druggable targets OG5_128242 All targets in OG5_128242
Neospora caninum cAMP-specific phosphodiesterase, putative Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum IPR002073,3'5'-cyclic nucleotide phosphodiesterase,domain-containing Get druggable targets OG5_128242 All targets in OG5_128242
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.007 0.0015 0.0015
Echinococcus granulosus eukaryotic translation initiation factor 4E type 0.0071 0.0024 0.0068
Trypanosoma cruzi eukaryotic translation initiation factor 4E (eIF4E) interacting protein, putative 0.0071 0.0024 0.0026
Schistosoma mansoni P2X receptor subunit 0.029 0.1466 0.1466
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0071 0.0024 0.0026
Toxoplasma gondii eukaryotic initiation factor-4E, putative 0.0071 0.0024 0.0068
Giardia lamblia Guanine phosphoribosyltransferase 0.0095 0.0183 0.26
Trichomonas vaginalis hypothetical protein 0.0071 0.0024 0.0026
Leishmania major hypoxanthine-guanine phosphoribosyltransferase 0.0095 0.0183 0.0525
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.007 0.0015 0.0042
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0096 0.0189 0.0214
Brugia malayi GTP-binding protein, identical 0.0155 0.0576 0.0688
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0156 0.0581 0.1635
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.007 0.0015 0.0015
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.0595 0.348 1
Echinococcus granulosus p2X purinoceptor 4 0.029 0.1466 0.4212
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.007 0.0015 0.0015
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.007 0.0015 0.0015
Leishmania major eukaryotic translation initiation factor 4e, putative 0.0071 0.0024 0.0068
Plasmodium falciparum hypoxanthine-guanine phosphoribosyltransferase 0.0095 0.0183 1
Loa Loa (eye worm) hypothetical protein 0.0168 0.0661 0.0792
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0015 0.0042
Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferase 0.0095 0.0183 0.0183
Echinococcus multilocularis survival motor neuron protein 1 0.0262 0.1286 0.3695
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0024 0.0026
Mycobacterium leprae conserved hypothetical protein 0.0073 0.0037 1
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-3 0.0071 0.0024 0.0026
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0156 0.0581 0.167
Loa Loa (eye worm) hypothetical protein 0.1237 0.7713 0.9437
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0015 0.0042
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0595 0.348 1
Trypanosoma brucei Eukaryotic translation initiation factor 4E-1 0.0595 0.348 1
Onchocerca volvulus 0.0096 0.0189 0.0947
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0071 0.0024 0.0026
Mycobacterium ulcerans hypoxanthine-guanine phosphoribosyltransferase Hpt 0.0095 0.0183 1
Echinococcus granulosus p2X purinoceptor 4 0.029 0.1466 0.4212
Echinococcus multilocularis p2X purinoceptor 4 0.029 0.1466 0.4212
Loa Loa (eye worm) hypothetical protein 0.1307 0.8172 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0015 0.0042
Plasmodium vivax translation initiation factor 4E, putative 0.0071 0.0024 0.0156
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0284 0.1426 0.4071
Brugia malayi Eukaryotic translation initiation factor 4E type 3, putative 0.0071 0.0024 0.0011
Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase 0.0095 0.0183 0.0485
Loa Loa (eye worm) hypothetical protein 0.0262 0.1286 0.1558
Loa Loa (eye worm) eukaryotic translation initiation factor 4E-1 0.0071 0.0024 0.0011
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0284 0.1426 0.4071
Loa Loa (eye worm) hypothetical protein 0.0096 0.0189 0.0214
Leishmania major cAMP-specific phosphodiesterase, putative 0.0284 0.1426 0.4096
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0168 0.0661 0.19
Toxoplasma gondii RNA-directed DNA polymerase 0.0089 0.0145 0.0417
Echinococcus multilocularis hypoxanthine guanine phosphoribosyltransferase 0.0095 0.0183 0.0525
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0024 0.0026
Trichomonas vaginalis hypoxanthine-guanine phosphoribosyltransferase, putative 0.0095 0.0183 0.0485
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0098 0.0202 0.023
Schistosoma mansoni P2X receptor subunit 0.029 0.1466 0.1466
Brugia malayi translation initiation factor 4E 0.0595 0.348 0.4248
Onchocerca volvulus 0.0095 0.0183 0.0911
Schistosoma mansoni P2X receptor subunit 0.0144 0.0503 0.0503
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0156 0.0581 0.0694
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0015 0.0042
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0098 0.0202 0.0581
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0156 0.0581 0.1635
Schistosoma mansoni cell polarity protein 0.0155 0.0576 0.0576
Leishmania major hypothetical protein, conserved 0.007 0.0015 0.0042
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0071 0.0024 0.0026
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0071 0.0024 0.0026
Brugia malayi GTP-binding protein 0.0155 0.0576 0.0688
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0595 0.348 1
Echinococcus granulosus eukaryotic translation initiation factor 4E 0.0595 0.348 1
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0071 0.0024 0.0026
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0015 0.0042
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-4 0.0071 0.0024 0.0026
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0015 0.0042
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.007 0.0015 0.0015
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0168 0.0661 0.19
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0096 0.0189 0.0189
Leishmania major hypothetical protein, conserved 0.0071 0.0024 0.0068
Echinococcus multilocularis eukaryotic translation initiation factor 4E 0.0595 0.348 1
Schistosoma mansoni cell polarity protein 0.0155 0.0576 0.0576
Echinococcus multilocularis p2X purinoceptor 4 0.029 0.1466 0.4212
Trypanosoma cruzi eukaryotic translation initiation factor 4E (eIF4E) interacting protein, putative 0.0071 0.0024 0.0026
Toxoplasma gondii hypoxanthine-xanthine-guanine phosphoribosyl transferase HXGPRT 0.0095 0.0183 0.0525
Trypanosoma cruzi Eukaryotic translation initiation factor 4E type 5, putative 0.0071 0.0024 0.0026
Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferase 0.0095 0.0183 0.0183
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0089 0.0145 0.0376
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0098 0.0202 0.0581
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0015 0.0042
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0071 0.0024 0.0026
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0084 0.0112 0.0281
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0595 0.348 1
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0024 0.0156
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0015 0.0042
Echinococcus granulosus p2X purinoceptor 4 0.029 0.1466 0.4212
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0015 0.0042
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0156 0.0581 0.167
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.007 0.0015 0.0015
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.007 0.0015 0.0042
Toxoplasma gondii eukaryotic initiation factor-4E, putative 0.0595 0.348 1
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0156 0.0581 0.167
Brugia malayi hypothetical protein 0.0262 0.1286 0.1558
Loa Loa (eye worm) eukaryotic translation initiation factor 4E type 3 0.0071 0.0024 0.0011
Echinococcus granulosus hypoxanthine guanine phosphoribosyltransferase 0.0095 0.0183 0.0525
Echinococcus multilocularis ras gtpase 0.0155 0.0576 0.1654
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.007 0.0015 0.0042
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0168 0.0661 0.0661
Leishmania major hypothetical protein, conserved 0.0071 0.0024 0.0068
Schistosoma mansoni hypothetical protein 0.0383 0.2084 0.2084
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.007 0.0015 0.0015
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.0595 0.348 1
Echinococcus granulosus ras gtpase 0.0155 0.0576 0.1654
Giardia lamblia Translation elongation factor 0.0071 0.0024 0.0137
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.007 0.0015 0.0042
Trypanosoma brucei Eukaryotic translation initiation factor 4E-2 0.0071 0.0024 0.0026
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0071 0.0024 0.0026
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0015 0.0042
Echinococcus multilocularis hypoxanthine guanine phosphoribosyltransferase 0.0095 0.0183 0.0525
Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase, putative 0.0095 0.0183 0.2967
Schistosoma mansoni P2X receptor subunit 0.0144 0.0503 0.0503
Trypanosoma brucei telomerase reverse transcriptase 0.0089 0.0145 0.0376
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative 0.0095 0.0183 0.0485
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative 0.0095 0.0183 0.0485
Giardia lamblia Hypothetical protein 0.0071 0.0024 0.0137
Giardia lamblia Hypothetical protein 0.0071 0.0024 0.0137
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0015 0.0042
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0071 0.0024 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0024 0.0026
Leishmania major eukaryotic translation initiation factor eIF-4E, putative 0.0595 0.348 1
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0595 0.348 1
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.007 0.0015 0.0042
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0015 0.0042
Leishmania major telomerase reverse transcriptase, putative 0.0089 0.0145 0.0417
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0168 0.0661 0.19
Loa Loa (eye worm) GTP-binding protein 0.0155 0.0576 0.0688
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0156 0.0581 0.167
Trypanosoma cruzi Eukaryotic translation initiation factor 4E type 5, putative 0.0071 0.0024 0.0026
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0595 0.348 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0015 0.0042
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0089 0.0145 0.0376
Echinococcus multilocularis p2X purinoceptor 4 0.029 0.1466 0.4212
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0156 0.0581 0.1635
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0015 0.0042
Leishmania major xanthine phosphoribosyltransferase 0.0095 0.0183 0.0525
Echinococcus multilocularis expressed protein 0.0414 0.2287 0.6571
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0595 0.348 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0073 0.0037 1
Toxoplasma gondii hypothetical protein 0.0071 0.0024 0.0068
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.007 0.0015 0.0015
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0071 0.0024 0.0026
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0156 0.0581 0.0581
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0071 0.0024 0.0026
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0156 0.0581 1
Plasmodium vivax telomerase reverse transcriptase, putative 0.0089 0.0145 0.2301
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0071 0.0024 0.0026
Trypanosoma brucei Eukaryotic translation initiation factor 4E-3 0.0071 0.0024 0.0026
Plasmodium falciparum telomerase reverse transcriptase 0.0089 0.0145 0.7755
Brugia malayi Telomerase reverse transcriptase 0.0238 0.1124 0.136
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0336 0.1771 1
Trypanosoma brucei RNA helicase, putative 0.0383 0.2084 0.5971
Brugia malayi Phosphoribosyl transferase domain containing protein 0.0095 0.0183 0.0206
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0098 0.0202 0.023
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.007 0.0015 0.0015
Echinococcus multilocularis L aminoadipate semialdehyde 0.0096 0.0189 0.0543
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0168 0.0661 0.19
Plasmodium falciparum eukaryotic translation initiation factor 4E 0.0071 0.0024 0.0527
Schistosoma mansoni eukaryotic translation initiation factor 4e 0.0595 0.348 0.348
Echinococcus granulosus L aminoadipate semialdehyde 0.0096 0.0189 0.0543
Leishmania major eukaryotic translation initiation factor-like protein 0.0595 0.348 1
Leishmania major hypothetical protein, conserved 0.007 0.0015 0.0042
Echinococcus granulosus survival motor neuron protein 1 0.0262 0.1286 0.3695
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0015 0.0042
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0156 0.0581 0.167
Echinococcus granulosus hypoxanthine guanine phosphoribosyltransferase 0.0095 0.0183 0.0525
Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase 0.0095 0.0183 0.0485
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.007 0.0015 0.0042
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative 0.0095 0.0183 0.0485
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0168 0.0661 0.19
Mycobacterium leprae conserved hypothetical protein 0.0073 0.0037 1
Leishmania major eukaryotic translation initiation factor-like 0.0595 0.348 1
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.007 0.0015 0.0042
Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase, putative 0.0095 0.0183 0.0485
Loa Loa (eye worm) translation initiation factor 4E 0.0595 0.348 0.4248
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0168 0.0661 1
Giardia lamblia hypothetical protein 0.0071 0.0024 0.0137
Trypanosoma brucei Eukaryotic translation initiation factor 4E type 5 0.0071 0.0024 0.0026
Loa Loa (eye worm) PDE1B protein 0.0156 0.0581 0.0694
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.1307 0.8172 1
Echinococcus granulosus expressed protein 0.0414 0.2287 0.6571
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.007 0.0015 0.0042
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative 0.0095 0.0183 0.0485
Brugia malayi eukaryotic translation initiation factor 4E-1 0.0071 0.0024 0.0011
Leishmania major eukaryotic translation initiation factor, putative 0.0071 0.0024 0.0068
Plasmodium falciparum eukaryotic translation initiation factor 4E, putative 0.0071 0.0024 0.0527
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0071 0.0024 0.0026
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0156 0.0581 0.167
Mycobacterium tuberculosis Hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (imp pyrophosphor 0.0073 0.0036 0.9769
Trypanosoma brucei Eukaryotic translation initiation factor 4E-4 0.0071 0.0024 0.0026
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-4 0.0071 0.0024 0.0026
Mycobacterium tuberculosis Conserved hypothetical protein 0.0073 0.0037 1
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0071 0.0024 0.0026
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0156 0.0581 0.167
Giardia lamblia Telomerase catalytic subunit 0.0089 0.0145 0.2016

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 6 uM Inhibition of guinea pig macrophage Phosphodiesterase 4 ChEMBL. 9871649
IC50 (binding) = 6 uM Inhibition of guinea pig macrophage Phosphodiesterase 4 ChEMBL. 9871649
Ki (binding) > 3.7 uM Displacement of [3H]-rolipram binding to guinea pig brain membrane ChEMBL. 9871649
Ki (binding) > 3.7 uM Displacement of [3H]-rolipram binding to guinea pig brain membrane ChEMBL. 9871649

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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