Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lipase, hormone-sensitive | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0253 | 1 | 1 |
Giardia lamblia | Sodium/hydrogen exchanger 3 | 0.0233 | 0.6826 | 0.5 |
Echinococcus granulosus | sodium:hydrogen exchanger | 0.0233 | 0.6826 | 0.6826 |
Echinococcus granulosus | sodium:hydrogen exchanger 2 nhe2 | 0.0233 | 0.6826 | 0.6826 |
Onchocerca volvulus | Sodium\/hydrogen exchanger homolog | 0.0233 | 0.6826 | 1 |
Loa Loa (eye worm) | sodium/hydrogen exchanger 3 family protein | 0.0233 | 0.6826 | 0.1412 |
Loa Loa (eye worm) | sodium/hydrogen exchanger | 0.0233 | 0.6826 | 0.1412 |
Schistosoma mansoni | sodium/hydrogen exchanger 2 (nhe2) | 0.0233 | 0.6826 | 0.1412 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.6826 | 0.1412 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0253 | 1 | 1 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0229 | 0.6304 | 0.6304 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0229 | 0.6304 | 0.6304 |
Leishmania major | hypothetical protein, conserved | 0.0229 | 0.6304 | 0.5 |
Echinococcus granulosus | sodium:hydrogen exchanger | 0.0233 | 0.6826 | 0.6826 |
Brugia malayi | sodium/hydrogen exchanger 3 family protein | 0.0233 | 0.6826 | 1 |
Echinococcus granulosus | sodium:hydrogen exchanger 2 nhe2 | 0.0233 | 0.6826 | 0.6826 |
Echinococcus multilocularis | sodium:hydrogen exchanger 2 (nhe2) | 0.0233 | 0.6826 | 0.6826 |
Echinococcus multilocularis | sodium:hydrogen exchanger 2 (nhe2) | 0.0233 | 0.6826 | 0.6826 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0229 | 0.6304 | 0.5 |
Echinococcus multilocularis | sodium:hydrogen exchanger | 0.0233 | 0.6826 | 0.6826 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.6826 | 0.1412 |
Echinococcus multilocularis | sodium:hydrogen exchanger 2 (nhe2) | 0.0233 | 0.6826 | 0.6826 |
Schistosoma mansoni | sodium/hydrogen exchanger | 0.0233 | 0.6826 | 0.1412 |
Echinococcus multilocularis | sodium:hydrogen exchanger | 0.0233 | 0.6826 | 0.6826 |
Echinococcus multilocularis | hormone sensitive lipase | 0.0253 | 1 | 1 |
Loa Loa (eye worm) | NHE-3 | 0.0233 | 0.6826 | 0.1412 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0229 | 0.6304 | 0.5 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0229 | 0.6304 | 0.5 |
Onchocerca volvulus | Sodium\/hydrogen exchanger homolog | 0.0233 | 0.6826 | 1 |
Onchocerca volvulus | Sodium\/hydrogen exchanger homolog | 0.0233 | 0.6826 | 1 |
Echinococcus granulosus | sodium:hydrogen exchanger 2 nhe2 | 0.0233 | 0.6826 | 0.6826 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.6826 | 0.1412 |
Toxoplasma gondii | kringle domain-containing protein | 0.0229 | 0.6304 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 1 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0253 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3 nM | Inhibition of human recombinant hormone sensitive lipase. | ChEMBL. | 15026062 |
IC50 (binding) | = 3 nM | Inhibition of human recombinant hormone sensitive lipase. | ChEMBL. | 15026062 |
Inhibition (binding) | = 98 % | Inhibition of recombinant human hormone sensitive lipase (HSL) | ChEMBL. | 15026062 |
Inhibition (binding) | = 98 % | Inhibition of recombinant human hormone sensitive lipase (HSL) | ChEMBL. | 15026062 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.