TDR Targets

Basic information

Technical information

TDR Targets ID: 722324
Name: N-(2-methyl-5-nitrophenyl)-2-[[5-(phenoxymeth yl)-4-prop-2-enyl-1,2,4-triazol-3-yl]sulfanyl ]acetamide
MW: 439.488 | Formula: C21H21N5O4S
H donors: 1 H acceptors: 5 LogP: 3.61 Rotable bonds: 11
Rule of 5 violations (Lipinski): 1
SMILES: C=CCn1c(SCC(=O)Nc2cc(ccc2C)[N+](=O)[O-])nnc1COc1ccccc1
InChi: 1S/C21H21N5O4S/c1-3-11-25-19(13-30-17-7-5-4-6-8-17)23-24-21(25)31-14-20(27)22-18-12-16(26(28)29)10-9-15(18)2/h3-10,12H,1,11,13-14H2,2H3,(H,22,27)
InChiKey: SFNJERMGNLSFRH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[[4-allyl-5-(phenoxymethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-(2-methyl-5-nitro-phenyl)acetamide
2-[[4-allyl-5-(phenoxymethyl)-1,2,4-triazol-3-yl]thio]-N-(2-methyl-5-nitrophenyl)acetamide
2-[[4-allyl-5-(phenoxymethyl)-1,2,4-triazol-3-yl]thio]-N-(2-methyl-5-nitro-phenyl)acetamide
N-(2-methyl-5-nitro-phenyl)-2-[[5-(phenoxymethyl)-4-prop-2-enyl-1,2,4-triazol-3-yl]sulfanyl]ethanamide
STK130777

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0058	0.0595	0.2156
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0011	0.0022	0.0022
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0015	0.0075	0.0069
Loa Loa (eye worm)	hypothetical protein	0.003	0.0258	0.1056
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0024	0.0182	0.0592
Trypanosoma cruzi	DNA polymerase eta, putative	0.0032	0.0285	0.0757
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0258	0.0258
Loa Loa (eye worm)	RecQ helicase	0.0021	0.0141	0.0564
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0258	0.0258
Echinococcus multilocularis	bloom syndrome protein	0.0021	0.0141	0.0135
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0044	0.0433	0.1788
Toxoplasma gondii	histone lysine methyltransferase SET1	0.011	0.1244	1
Echinococcus multilocularis	dnaJ subfamily B	0.082	1	1
Brugia malayi	CXXC zinc finger family protein	0.0058	0.0595	0.2468
Onchocerca volvulus		0.003	0.0252	0.0899
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.0006	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0022	0.0065
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0015	0.0075	0.0075
Trichomonas vaginalis	chromobox protein, putative	0.0068	0.072	0.257
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.0388	0.135
Mycobacterium ulcerans	arylamine N-acetyltransferase Nat	0.0652	0.7921	1
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0018	0.0108	0.0318
Schistosoma mansoni	chromobox protein	0.0068	0.072	0.072
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.013	0.0313
Schistosoma mansoni	hypothetical protein	0.0017	0.0095	0.0095
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.0014	0.0058	0.0691
Schistosoma mansoni	cpg binding protein	0.0061	0.0636	0.0636
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.013	0.0313
Trypanosoma cruzi	polo-like protein kinase, putative	0.0092	0.1017	0.2858
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0022	0.0065
Schistosoma mansoni	hypothetical protein	0.0017	0.0095	0.0095
Echinococcus multilocularis	chromodomain helicase DNA binding protein 4	0.0014	0.0062	0.0056
Schistosoma mansoni	DNA polymerase eta	0.0046	0.0454	0.0454
Onchocerca volvulus		0.0011	0.0022	0.0057
Trypanosoma brucei	polo-like protein kinase	0.0092	0.1017	0.2858
Brugia malayi	hypothetical protein	0.0035	0.0312	0.128
Plasmodium falciparum	chromodomain-helicase-DNA-binding protein 1 homolog, putative	0.0011	0.0022	0.00000000082963
Echinococcus multilocularis	apoptotic protease activating factor 1	0.003	0.0255	0.0249
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.003	0.0258	0.1935
Schistosoma mansoni	cpg binding protein	0.0061	0.0636	0.0636
Echinococcus granulosus	chromodomain helicase DNA binding protein 1	0.0011	0.0022	0.0016
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0038	0.0353	0.1269
Brugia malayi	CHD4 protein	0.0014	0.0062	0.0235
Echinococcus granulosus	cpg binding protein	0.0061	0.0636	0.063
Brugia malayi	F/Y-rich N-terminus family protein	0.0019	0.0115	0.0457
Loa Loa (eye worm)	helicase	0.0011	0.0022	0.0065
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0123	0.1405	0.1405
Trypanosoma brucei	DNA polymerase kappa, putative	0.0014	0.0054	0.0094
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0433	0.0433
Schistosoma mansoni	hypothetical protein	0.0017	0.0095	0.0095
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0092	0.1017	1
Echinococcus granulosus	chromobox protein 2	0.0011	0.0022	0.0016
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.0006	0.0006
Entamoeba histolytica	deoxycytidyl transferase, putative	0.002	0.013	0.1094
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0293	0.3503	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0024	0.0182	0.0592
Echinococcus multilocularis	chromobox protein 1	0.0068	0.072	0.0714
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.013	0.0313
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.013	0.0313
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0017	0.0095	0.0089
Schistosoma mansoni	chromobox protein	0.0011	0.0022	0.0022
Brugia malayi	Pre-SET motif family protein	0.003	0.0258	0.1056
Trichomonas vaginalis	DNA helicase recq1, putative	0.0021	0.0141	0.0438
Trichomonas vaginalis	CAMK family protein kinase	0.0045	0.0445	0.1559
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0041	0.0394	0.1069
Echinococcus granulosus	chromodomain helicase DNA binding protein 4	0.0014	0.0062	0.0056
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.013	0.0313
Brugia malayi	Valyl-tRNA synthetase	0.0011	0.0022	0.0065
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.0006	0.0006
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0011	0.0022	0.0022
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0046	0.009
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.002	0.013	0.013
Echinococcus granulosus	bloom syndrome protein	0.0021	0.0141	0.0135
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0155	0.1791	0.2131
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.0108	0.0318
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0046	0.009
Schistosoma mansoni	caspase-7 (C14 family)	0.003	0.0255	0.0255
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0022	0.0065
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.0006	0.0006
Plasmodium vivax	ataxin-2 like protein, putative	0.0054	0.0546	1
Trichomonas vaginalis	helicase, putative	0.0013	0.0046	0.009
Echinococcus multilocularis	Chromobox protein 3	0.0011	0.0022	0.0016
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0014	0.0056	0.028
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0092	0.1017	0.2858
Echinococcus granulosus	apoptotic protease activating factor 1	0.003	0.0255	0.0249
Onchocerca volvulus		0.0231	0.2738	1
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0018	0.011	0.1677
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0017	0.0096	0.0275
Trichomonas vaginalis	DNA polymerase eta, putative	0.002	0.013	0.0401
Brugia malayi	Bloom's syndrome protein homolog	0.0021	0.0141	0.0564
Echinococcus multilocularis	cpg binding protein	0.0061	0.0636	0.063
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.1017	0.3663
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0015	0.0075	0.0069
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0032	0.0285	0.2156
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0258	0.0258
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.002	0.013	0.0313
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0353	0.1219
Plasmodium falciparum	ataxin-2 like protein, putative	0.0054	0.0546	1
Toxoplasma gondii	chromodomain helicase DNA binding protein CHD1/SWI2/SNF2	0.0011	0.0022	0.00000000035603
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0024	0.0181	0.0176
Onchocerca volvulus		0.0041	0.0395	0.1423
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.013	0.0313
Onchocerca volvulus		0.0011	0.0022	0.0057
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.013	0.0313
Leishmania major	DNA polymerase eta, putative	0.0046	0.0454	0.1243
Echinococcus granulosus	chromobox protein 1	0.0068	0.072	0.0714
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0019	0.0118	0.0112
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.013	0.0313
Schistosoma mansoni	hypothetical protein	0.0024	0.0178	0.0178
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0024	0.0182	0.0592
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.002	0.013	0.0401
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.0006	0.0006
Toxoplasma gondii	LsmAD domain-containing protein	0.0054	0.0546	0.4291
Schistosoma mansoni	hypothetical protein	0.0347	0.4167	0.4167
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0216	0.0717
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.0006	0.0006
Brugia malayi	M-phase phosphoprotein, mpp8	0.0011	0.0022	0.0065
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0017	0.0095	0.0089
Echinococcus granulosus	Chromobox protein 3	0.0011	0.0022	0.0016
Schistosoma mansoni	hypothetical protein	0.0017	0.0095	0.0095
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0054	0.0547	0.2268
Trypanosoma brucei	unspecified product	0.002	0.013	0.0313
Schistosoma mansoni	kinase	0.0047	0.046	0.046
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0546	0.2262
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0046	0.009
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0017	0.0095	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0022	0.0065
Plasmodium falciparum	ataxin-2 like protein, putative	0.0054	0.0546	1
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0041	0.0388	0.1399
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0046	0.009
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0203	0.2394	1
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.1017	0.3663
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.005	0.0505	0.1389
Echinococcus multilocularis	chromodomain helicase DNA binding protein 1	0.0011	0.0022	0.0016
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0041	0.0395	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0022	0.0065
Giardia lamblia	Kinase, PLK	0.0092	0.1017	1
Echinococcus multilocularis	GPCR, family 2	0.0017	0.0095	0.0089
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0092	0.1017	0.3699
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0024	0.0182	0.0592
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.1017	0.3663
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0024	0.0181	0.0176
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.002	0.013	0.0124
Schistosoma mansoni	hypothetical protein	0.082	1	1
Plasmodium vivax	hypothetical protein, conserved	0.0011	0.0022	0.00000000082963
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0015	0.0075	0.0069
Echinococcus granulosus	caspase 2	0.003	0.0255	0.0249
Schistosoma mansoni	chromobox protein	0.0011	0.0022	0.0022
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0293	0.3503	1
Mycobacterium tuberculosis	Arylamine N-acetyltransferase Nat (arylamine acetylase)	0.0652	0.7921	1
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.002	0.013	0.0124
Trichomonas vaginalis	chromobox protein, putative	0.0068	0.072	0.257
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0024	0.0182	0.0592
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0433	0.0433
Echinococcus granulosus	chromobox protein 1	0.0068	0.072	0.0714
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0046	0.009
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.013	0.0313
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0139	0.1597	0.4526
Echinococcus granulosus	dna polymerase kappa	0.002	0.013	0.0124
Schistosoma mansoni	serine/threonine protein kinase	0.0092	0.1017	0.1017
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0058	0.0595	0.2468
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0054	0.0547	0.2268
Echinococcus multilocularis	dna polymerase eta	0.0046	0.0454	0.0449
Echinococcus granulosus	dna polymerase eta	0.0046	0.0454	0.0449
Trichomonas vaginalis	CAMK family protein kinase	0.0045	0.0445	0.1559
Brugia malayi	Cell death protein 3 precursor	0.003	0.0255	0.1043
Schistosoma mansoni	hypothetical protein	0.0024	0.0181	0.0181
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0046	0.009
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0017	0.0095	0.0089
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.1017	0.3663
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0024	0.0182	0.0592
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.013	0.0313
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0338	0.139
Trypanosoma brucei	DNA polymerase kappa, putative	0.0014	0.0054	0.0094
Onchocerca volvulus	Cell death protein 3 homolog	0.003	0.0255	0.0912
Loa Loa (eye worm)	CHromoDomain protein family member	0.0014	0.0062	0.0235
Echinococcus granulosus	histone lysine methyltransferase setb	0.003	0.0258	0.0252
Trypanosoma brucei	PAB1-binding protein , putative	0.0054	0.0546	0.1507
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.013	0.0313
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.013	0.0313
Schistosoma mansoni	hypothetical protein	0.0011	0.0022	0.0022
Echinococcus multilocularis	Chromo domain	0.0011	0.0022	0.0016
Echinococcus granulosus	Chromo domain	0.0011	0.0022	0.0016
Echinococcus multilocularis	chromobox protein 2	0.0011	0.0022	0.0016
Leishmania major	DNA polymerase eta, putative	0.0032	0.0285	0.0757
Schistosoma mansoni	hypothetical protein	0.0347	0.4167	0.4167
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.0006	0.0006
Trypanosoma cruzi	DNA polymerase eta, putative	0.0046	0.0454	0.1243
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0041	0.0394	0.1069
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0433	0.0433
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.0006	0.0006
Brugia malayi	ImpB/MucB/SamB family protein	0.0046	0.0454	0.1878
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0139	0.1597	0.4526
Brugia malayi	Type III restriction enzyme, res subunit family protein	0.0011	0.0022	0.0065
Brugia malayi	Pre-SET motif family protein	0.0203	0.2394	1
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0229	0.0224
Loa Loa (eye worm)	histone methyltransferase	0.0019	0.0118	0.0468
Brugia malayi	Heterochromatin protein 1	0.0068	0.072	0.2989
Toxoplasma gondii	hypothetical protein	0.0047	0.0469	0.3657
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0353	0.1219
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0092	0.1017	0.4232
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0006	0.0006
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0092	0.1017	0.1011
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0216	0.0717
Schistosoma mansoni	blooms syndrome DNA helicase	0.0016	0.0087	0.0087
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.003	0.0258	0.0252
Trypanosoma brucei	unspecified product	0.0014	0.0054	0.0094
Trypanosoma brucei	DNA polymerase kappa, putative	0.0014	0.0054	0.0094
Trichomonas vaginalis	DNA helicase recq, putative	0.0021	0.0141	0.0438
Onchocerca volvulus		0.003	0.0255	0.0912
Echinococcus granulosus	geminin	0.0347	0.4167	0.4163
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0046	0.009
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.013	0.0313
Leishmania major	hypothetical protein, conserved	0.0054	0.0546	0.1507
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0353	0.1452
Schistosoma mansoni	cpg binding protein	0.0058	0.0595	0.0595
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0547	0.2268
Brugia malayi	latrophilin 2 splice variant baaae	0.0037	0.0338	0.139
Leishmania major	mitochondrial DNA polymerase beta	0.0293	0.3503	1
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0293	0.3503	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0252	0.1029
Brugia malayi	ImpB/MucB/SamB family protein	0.002	0.013	0.0521
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.002	0.013	0.0521
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0433	0.0427
Schistosoma mansoni	hypothetical protein	0.0037	0.0338	0.0338
Brugia malayi	hypothetical protein	0.0054	0.0546	0.2262
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0041	0.0394	0.1069
Schistosoma mansoni	hypothetical protein	0.003	0.0255	0.0255
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0046	0.009
Loa Loa (eye worm)	hypothetical protein	0.003	0.0255	0.1043
Trypanosoma cruzi	PAB1-binding protein , putative	0.0054	0.0546	0.1507
Brugia malayi	serine/threonine-protein kinase plk-2	0.0092	0.1017	0.4232
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0015	0.0075	0.0069
Brugia malayi	Associated with TFs and helicases family protein	0.0011	0.0022	0.0065
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0006	0.0006
Loa Loa (eye worm)	heterochromatin protein 1	0.0068	0.072	0.2989
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0433	0.0427
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.013	0.0313
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0006	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0089	0.0347
Brugia malayi	hypothetical protein	0.0011	0.0022	0.0065
Schistosoma mansoni	chromobox protein	0.0068	0.072	0.072
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0019	0.0118	0.0112
Echinococcus multilocularis	geminin	0.0347	0.4167	0.4163
Leishmania major	DNA polymerase kappa, putative	0.002	0.013	0.0313
Schistosoma mansoni	coup transcription factor	0.001	0.0006	0.0006
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0044	0.0433	0.1788
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.1017	0.3663
Trypanosoma brucei	unspecified product	0.0014	0.0054	0.0094
Trypanosoma cruzi	PAB1-binding protein , putative	0.0054	0.0546	0.1507
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0139	0.1597	0.4526
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.0006	0.0006
Trichomonas vaginalis	set domain proteins, putative	0.0231	0.2738	1
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.0258	0.0252
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.013	0.0313
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0054	0.0547	0.2268
Brugia malayi	Protein cec-1.	0.0011	0.0022	0.0065
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0433	0.0427
Brugia malayi	hypothetical protein	0.003	0.0255	0.1043
Brugia malayi	chromobox protein homolog 3	0.0038	0.0353	0.1452
Echinococcus multilocularis	chromobox protein 1	0.0068	0.072	0.0714
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0017	0.0095	0.0371
Trypanosoma brucei	DNA polymerase eta, putative	0.0046	0.0454	0.1243
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.1017	0.3663
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0046	0.009
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0017	0.0095	0.0371
Echinococcus multilocularis	caspase 2	0.003	0.0255	0.0249
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.0388	0.135
Echinococcus granulosus	GPCR family 2	0.0017	0.0095	0.0089
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0014	0.0062	0.0062
Brugia malayi	SET domain containing protein	0.0013	0.005	0.0185
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0022	0.0065
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0092	0.1017	0.1011
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.1017	0.3663
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0433	0.0427
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0454	0.1878
Mycobacterium ulcerans	hypothetical protein	0.0155	0.1791	0.2131
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0024	0.0182	0.0592
Loa Loa (eye worm)	hypothetical protein	0.003	0.0255	0.1043
Trypanosoma cruzi	polo-like protein kinase, putative	0.0092	0.1017	0.2858
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.013	0.0313
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0041	0.0394	0.1069
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.013	0.0313
Echinococcus multilocularis	dna polymerase kappa	0.002	0.013	0.0124
Brugia malayi	Latrophilin receptor protein 2	0.0017	0.0095	0.0371
Schistosoma mansoni	terminal deoxycytidyl transferase	0.002	0.013	0.013
Plasmodium vivax	SET domain protein, putative	0.003	0.0258	0.451
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0011	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0095	0.0371
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0022	0.0065
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0024	0.0182	0.0592

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 722324