Detailed information for compound 722698

Basic information

Technical information
  • TDR Targets ID: 722698
  • Name: 3-(3-methoxyphenyl)-5-thiophen-2-yl-1,2,4-oxa diazole
  • MW: 258.296 | Formula: C13H10N2O2S
  • H donors: 0 H acceptors: 2 LogP: 3.15 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)c1noc(n1)c1cccs1
  • InChi: 1S/C13H10N2O2S/c1-16-10-5-2-4-9(8-10)12-14-13(17-15-12)11-6-3-7-18-11/h2-8H,1H3
  • InChiKey: NWPANAJPHRXMQR-UHFFFAOYSA-N  


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Synonyms

  • 3-(3-methoxyphenyl)-5-(2-thienyl)-1,2,4-oxadiazole
  • BAS 10847445
  • SMR000047269
  • ZINC02440132
  • MLS000083721
  • 3-(3-Methoxy-phenyl)-5-thiophen-2-yl-[1,2,4]oxadiazole

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens v-rel avian reticuloendotheliosis viral oncogene homolog A No references
Homo sapiens mitogen-activated protein kinase 1 Starlite/ChEMBL No references
Homo sapiens nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Caenorhabditis elegans Protein SKN-1, isoform B Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani mitogen-activated protein kinase 4 Get druggable targets OG5_126781 All targets in OG5_126781
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans MAP kinase implicated in PKC1-controlled signalling pathway Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K04371 extracellular signal-regulated kinase 1/2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 Get druggable targets OG5_126781 All targets in OG5_126781
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania donovani mitogen activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Giardia lamblia Kinase, CMGC MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Leishmania mexicana mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania braziliensis mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase Get druggable targets OG5_126781 All targets in OG5_126781
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Leishmania mexicana mitogen-activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi MAP kinase sur-1 Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Trypanosoma brucei gambiense protein kinase, putative,tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei gambiense mitogen-activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium parvum MAPK, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen activated protein kinase 2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium hominis MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 1 360 aa 361 aa 33.2 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable hydrolase 0.0031 0.0101 0.061
Trichomonas vaginalis D-aminoacylase, putative 0.0031 0.0101 0.0644
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0086 0.1141
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0085 0.0105
Trypanosoma brucei importin beta-1 subunit, putative 0.009 0.0536 0.1468
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0049 0.031
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0321 0.032
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0086 0.0105
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0073 0.0411 0.2625
Echinococcus multilocularis beta LACTamase domain containing family member 0.0031 0.0101 0.01
Entamoeba histolytica hypothetical protein 0.0019 0.0014 0.0174
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0033 0.012 0.0551
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0024 0.0017
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0328 0.0881
Brugia malayi RNA, U transporter 1 0.0256 0.1753 0.2158
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0062 0.0328 0.0881
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0328 0.2092
Onchocerca volvulus Alhambra homolog 0.0029 0.0085 0.033
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0014 0.0013
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0086 0.0495
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0328 0.2092
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0029 0.0086 0.0235
Onchocerca volvulus 0.0023 0.0046 0.0079
Brugia malayi hypothetical protein 0.0087 0.0514 0.0632
Onchocerca volvulus Fatty acid synthase homolog 0.0234 0.1596 0.9984
Loa Loa (eye worm) hypothetical protein 0.0023 0.0042 0.0052
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0042 0.0041
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0014 0.0013
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0101 0.0258
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.013 0.0831
Echinococcus granulosus expressed protein 0.0366 0.2562 0.2561
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.025 0.0308
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0062 0.0328 0.0897
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0031 0.0101 0.01
Schistosoma mansoni hypothetical protein 0.096 0.6925 0.6925
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0029 0.0086 0.0496
Brugia malayi Cathepsin L-like precursor 0.0035 0.013 0.016
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0132 0.0846 0.2317
Echinococcus granulosus chromobox protein 1 0.0059 0.0311 0.0311
Trichomonas vaginalis penicillin-binding protein, putative 0.0031 0.0101 0.0644
Trypanosoma brucei Fatty acid elongase 0.0514 0.3649 1
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0067 0.0366 0.1003
Loa Loa (eye worm) hypothetical protein 0.0048 0.0227 0.0279
Onchocerca volvulus 0.0035 0.013 0.0617
Loa Loa (eye worm) steroid hormone receptor 0.0023 0.0042 0.0052
Plasmodium falciparum long chain polyunsaturated fatty acid elongation enzyme, putative 0.0137 0.0882 0.2417
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0037 0.0102
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0154 0.0189
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0046 0.0609
Echinococcus multilocularis mitogen activated protein kinase 0.0062 0.0328 0.0327
Mycobacterium ulcerans polyketide synthase MbtC 0.0033 0.0115 0.0649
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0321 0.0878
Mycobacterium ulcerans hypothetical protein 0.0031 0.0101 0.0537
Schistosoma mansoni hypothetical protein 0.0517 0.3675 0.3674
Schistosoma mansoni hypothetical protein 0.0087 0.0514 0.0513
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.013 0.0831
Brugia malayi photoreceptor-specific nuclear receptor 0.0023 0.0042 0.0052
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0014 0.0016
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.1362 0.1676
Brugia malayi Fatty acid elongation protein 3 0.0514 0.3649 0.4491
Entamoeba histolytica cysteine protease, putative 0.0018 0.0007 0.0084
Brugia malayi Hypothetical 34.1 kDa protein C40H1.4 in chromosome III 0.0127 0.0805 0.099
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0321 0.2272
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0014 0.0016
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0029 0.0086 0.0218
Loa Loa (eye worm) hypothetical protein 0.0031 0.0101 0.0124
Onchocerca volvulus Cathepsin L homolog 0.0035 0.013 0.0617
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0087 0.0512 0.1402
Echinococcus multilocularis FTZ F1 alpha 0.0023 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0031 0.0101 0.0124
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0023 0.0042 0.0052
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0023 0.0042 0.0052
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0018 0.0007 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.012 0.0766
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0029 0.0086 0.042
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0037 0.0037
Echinococcus granulosus chromobox protein 1 0.0059 0.0311 0.0311
Plasmodium vivax GNS1/SUR4 domain containing protein 0.0514 0.3649 1
Mycobacterium tuberculosis Probable lipase LipE 0.0031 0.0101 0.061
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0023 0.0042 0.0052
Plasmodium vivax importin-beta 2, putative 0.009 0.0536 0.1468
Echinococcus multilocularis importin subunit beta 1 0.009 0.0536 0.0536
Echinococcus multilocularis cathepsin L cysteine protease 0.0035 0.013 0.013
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0033 0.0083
Trypanosoma cruzi cruzipain precursor, putative 0.0132 0.0846 0.2304
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0246 0.0674
Echinococcus granulosus cathepsin l cysteine peptidase 0.0035 0.013 0.013
Schistosoma mansoni cathepsin F (C01 family) 0.0035 0.013 0.013
Brugia malayi fatty acid elongation protein 3 0.0127 0.0805 0.099
Entamoeba histolytica Ran family GTPase 0.0022 0.0037 0.0495
Trichomonas vaginalis chromobox protein, putative 0.0059 0.0311 0.1989
Loa Loa (eye worm) hypothetical protein 0.0911 0.6567 0.8084
Echinococcus granulosus netrin receptor unc 5 0.0038 0.0156 0.0156
Echinococcus granulosus cathepsin L cysteine protease 0.0018 0.0007 0.0006
Echinococcus multilocularis ecdysone induced protein 78C 0.0023 0.0042 0.0042
Mycobacterium leprae Conserved hypothetical protein 0.0029 0.0086 0.0501
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0086 0.0419
Entamoeba histolytica cysteine proteinase 2 0.0018 0.0007 0.0084
Schistosoma mansoni chromobox protein 0.0059 0.0311 0.0311
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0085 0.0233
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0018 0.0017
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0138 0.0889 0.6707
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0023 0.0042 0.0042
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0072 0.0072
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0007 0.0084
Brugia malayi Cathepsin L-like precursor 0.0035 0.013 0.016
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0101 0.0258
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.025 0.1598
Brugia malayi Cathepsin L-like precursor 0.0023 0.0046 0.0056
Brugia malayi Immunoglobulin I-set domain containing protein 0.0038 0.0156 0.0192
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0126 0.08 0.6022
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0006 0.0005
Leishmania major importin beta-1 subunit, putative 0.0073 0.0411 0.1125
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0138 0.0889 0.6776
Trichomonas vaginalis importin beta-1, putative 0.0073 0.0411 0.2625
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0086 0.05
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0031 0.0101 0.061
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0031 0.0101 0.01
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.0563 0.0562
Loa Loa (eye worm) hypothetical protein 0.0033 0.012 0.0147
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0131 0.0836 0.0836
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.013 0.0831
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0029 0.0086 0.042
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.013 0.0831
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0037 0.0085
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0018 0.0021
Loa Loa (eye worm) hypothetical protein 0.0023 0.0042 0.0052
Mycobacterium tuberculosis Hypothetical protein 0.0039 0.0163 0.1091
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0029 0.0086 0.042
Schistosoma mansoni retinoic acid receptor RXR 0.0023 0.0042 0.0042
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0121 0.0761 0.2072
Echinococcus granulosus Ankyrin 0.0038 0.0157 0.0157
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0037 0.0046
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0046 0.0294
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0048 0.0227 0.0227
Brugia malayi Calcitonin receptor-like protein seb-1 0.0076 0.0436 0.0537
Loa Loa (eye worm) hypothetical protein 0.0029 0.0086 0.0105
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0029 0.0086 0.0496
Schistosoma mansoni coup transcription factor 0.0023 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0023 0.0046 0.0056
Mycobacterium ulcerans esterase/lipase LipP 0.0031 0.0101 0.0537
Trypanosoma cruzi major cysteine proteinase, putative 0.0104 0.0638 0.1733
Echinococcus multilocularis protein dispatched 1 0.0058 0.0303 0.0303
Loa Loa (eye worm) CXXC zinc finger family protein 0.0059 0.0312 0.0384
Loa Loa (eye worm) hypothetical protein 0.0049 0.0238 0.0292
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0074 0.0418 0.3064
Entamoeba histolytica cysteine protease, putative 0.0018 0.0007 0.0084
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0023 0.0042 0.0042
Leishmania major fatty acid elongase, putative 0.0127 0.0805 0.2205
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.1973 0.1973
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0029 0.0086 0.0496
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0014 0.0013
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0023 0.0042 0.0042
Schistosoma mansoni hypothetical protein 0.0024 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0062 0.0335 0.0411
Toxoplasma gondii ABC1 family protein 0.0031 0.0101 0.0275
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0086 0.0105
Brugia malayi Cytochrome P450 family protein 0.0047 0.022 0.027
Loa Loa (eye worm) hypothetical protein 0.002 0.0022 0.0026
Echinococcus granulosus cathepsin L 0.0018 0.0007 0.0006
Brugia malayi ecdysteroid receptor 0.0023 0.0042 0.0052
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0246 0.0674
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0018 0.0018
Brugia malayi fatty acid elongation protein 3 0.0127 0.0805 0.099
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0042 0.0042
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0169 0.0169
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0029 0.0086 0.042
Echinococcus multilocularis chromobox protein 1 0.0059 0.0311 0.0311
Trypanosoma cruzi cysteine peptidase, putative 0.0035 0.013 0.0339
Entamoeba histolytica cysteine protease, putative 0.0035 0.013 0.1733
Loa Loa (eye worm) hypothetical protein 0.0038 0.0157 0.0193
Schistosoma mansoni ap endonuclease 0.0038 0.0154 0.0153
Loa Loa (eye worm) TK/EPH protein kinase 0.0084 0.0495 0.0609
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0036 0.0138 0.067
Echinococcus multilocularis thyroid hormone receptor alpha 0.0153 0.1003 0.1003
Giardia lamblia Histone acetyltransferase GCN5 0.0077 0.0442 1
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0014 0.0013
Brugia malayi MH2 domain containing protein 0.0125 0.0794 0.0977
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0169 0.0169
Trypanosoma cruzi fatty acid elongase, putative 0.0127 0.0805 0.2192
Trypanosoma brucei hypothetical protein, conserved 0.0031 0.0101 0.0275
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0046 0.0293
Brugia malayi Cathepsin L-like precursor 0.0035 0.013 0.016
Loa Loa (eye worm) hypothetical protein 0.0127 0.0805 0.099
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.013 0.0831
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0073 0.0411 0.2625
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0014 0.0013
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.013 0.0831
Schistosoma mansoni ran 0.0022 0.0037 0.0037
Mycobacterium ulcerans polyketide synthase Pks9 0.0086 0.0507 0.3734
Leishmania major cathepsin L-like protease 0.0132 0.0846 0.2317
Echinococcus granulosus zinc finger protein 0.0031 0.0101 0.0101
Mycobacterium ulcerans polyketide synthase MbtD 0.004 0.0169 0.1074
Loa Loa (eye worm) hypothetical protein 0.0023 0.0042 0.0052
Leishmania major cathepsin L-like protease 0.0035 0.013 0.0356
Brugia malayi jmjC domain containing protein 0.004 0.0169 0.0207
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0154 0.042
Echinococcus granulosus cathepsin l1 0.0035 0.013 0.013
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0014 0.0086
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0018 0.0022
Echinococcus multilocularis chromobox protein 1 0.0059 0.0311 0.0311
Plasmodium vivax vivapain-3 0.0018 0.0007 0.0017
Brugia malayi nuclear receptor NHR-88 0.0023 0.0042 0.0052
Leishmania major cathepsin L-like protease 0.0035 0.013 0.0356
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0035 0.013 0.013
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0023 0.0042 0.0052
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0132 0.0846 0.2317
Trichomonas vaginalis bromodomain-containing protein, putative 0.0087 0.0512 0.327
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0086 0.0419
Loa Loa (eye worm) MH2 domain-containing protein 0.0125 0.0794 0.0977
Trypanosoma cruzi cysteine peptidase, putative 0.0132 0.0846 0.2304
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0037 0.0102
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0062 0.0328 0.0897
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0047 0.022 0.1475
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0154 0.0153
Echinococcus multilocularis microtubule associated protein 2 0.1378 1 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0023 0.0042 0.0042
Mycobacterium leprae putative cytochrome p450 0.0029 0.0086 0.0501
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0321 0.032
Trypanosoma cruzi fatty acid elongase, putative 0.0137 0.0882 0.2404
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0014 0.0016
Trypanosoma brucei importin beta-1 subunit, putative 0.009 0.0536 0.1468
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0046 0.0293
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0031 0.0101 0.0537
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0029 0.0086 0.0496
Loa Loa (eye worm) hypothetical protein 0.0031 0.0101 0.0124
Echinococcus granulosus cytochrome P450 2K1 0.0029 0.0086 0.0086
Mycobacterium tuberculosis Probable polyketide synthase Pks17 0.0032 0.0109 0.0671
Echinococcus granulosus cpg binding protein 0.0065 0.0352 0.0351
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.013 0.083 0.6249
Brugia malayi Cathepsin L-like precursor 0.0035 0.013 0.016
Echinococcus multilocularis cysteine protease 0.0035 0.013 0.013
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0042 0.0052
Schistosoma mansoni hypothetical protein 0.0021 0.0033 0.0033
Echinococcus granulosus nuclear factor of activated T cells 5 0.0374 0.2619 0.2619
Brugia malayi cytochrome P450 0.0029 0.0086 0.0105
Schistosoma mansoni ephrin receptor 0.0066 0.0363 0.0363
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.015 0.0149
Echinococcus granulosus mitogen activated protein kinase 3 0.0062 0.0328 0.0327
Mycobacterium ulcerans hypothetical protein 0.0029 0.0086 0.0419
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0154 0.0954
Schistosoma mansoni hypothetical protein 0.0029 0.0085 0.0085
Echinococcus granulosus histone acetyltransferase KAT2B 0.0087 0.0512 0.0512
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0289 0.1997 0.1996
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0154 1
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0029 0.0086 0.042
Trypanosoma brucei beta-ketoacyl-ACP synthase 0.0033 0.0115 0.0314
Plasmodium falciparum cysteine proteinase falcipain 3 0.0035 0.013 0.0356
Schistosoma mansoni hypothetical protein 0.0049 0.0237 0.0236
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0031 0.0101 0.061
Schistosoma mansoni hypothetical protein 0.0049 0.0237 0.0236
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0131 0.0836 0.0836
Echinococcus multilocularis GPCR, family 2 0.0024 0.0053 0.0053
Loa Loa (eye worm) heterochromatin protein 1 0.0059 0.0311 0.0383
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0132 0.0846 0.2317
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0016
Leishmania major fatty acid elongase, putative 0.0127 0.0805 0.2205
Loa Loa (eye worm) hypothetical protein 0.0023 0.0042 0.0052
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0138 0.0889 0.6748
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0023 0.0042 0.0042
Schistosoma mansoni hypothetical protein 0.0517 0.3675 0.3674
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0007 0.0084
Schistosoma mansoni cathepsin F (C01 family) 0.0035 0.013 0.013
Trypanosoma brucei elongation of very long chain fatty acids protein, putative 0.0137 0.0882 0.2417
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.013 0.0831
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0029 0.0086 0.0496
Loa Loa (eye worm) beta-lactamase 0.0031 0.0101 0.0124
Brugia malayi Cathepsin L-like precursor 0.0035 0.013 0.016
Brugia malayi cathepsin L-like precursor 0.0023 0.0046 0.0056
Plasmodium vivax elongation of very long chain fatty acids protein 3, putative 0.0127 0.0805 0.2205
Onchocerca volvulus Elongation of very long chain fatty acids protein 5 homolog 0.0127 0.0805 0.493
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0033 0.0115 0.0141
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.013 0.0831
Mycobacterium ulcerans polyketide synthase Pks13 0.0194 0.1302 1
Echinococcus multilocularis expressed conserved protein 0.0112 0.0696 0.0695
Loa Loa (eye worm) hypothetical protein 0.0023 0.0046 0.0056
Trypanosoma cruzi cysteine peptidase, putative 0.0132 0.0846 0.2304
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0029 0.0086 0.0496
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0571 0.0571
Brugia malayi Muscleblind-like protein 0.0911 0.6567 0.8084
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0014 0.0013
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0046 0.0293
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0029 0.0086 0.042
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0025 0.006 0.006
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0154 0.2871
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.013 0.0831
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0007 0.0006
Toxoplasma gondii type I fatty acid synthase 0.002 0.0022 0.0059
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0042 0.0052
Echinococcus granulosus sodium channel protein 0.0058 0.0298 0.0298
Onchocerca volvulus 0.0127 0.0805 0.493
Leishmania major beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative 0.0033 0.0115 0.0314
Giardia lamblia Kinase, CMGC MAPK 0.0062 0.0328 0.7162
Toxoplasma gondii 3-oxoacyl-acyl-carrier protein synthase I/II, putative 0.0033 0.0115 0.0314
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0138 0.0889 0.6776
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0024 0.0053 0.0065
Schistosoma mansoni hypothetical protein 0.0024 0.0053 0.0053
Schistosoma mansoni cpg binding protein 0.0059 0.0312 0.0312
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0038 0.0157 0.0157
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0012 0.0033
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0042 0.0052
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0106 0.0656 0.4904
Schistosoma mansoni survival motor neuron protein 0.0058 0.0303 0.0303
Loa Loa (eye worm) fatty acid elongation protein 3 0.0127 0.0805 0.099
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0033 0.004
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0038 0.0156 0.0192
Loa Loa (eye worm) ELO-9 protein 0.0127 0.0805 0.099
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.013 0.083 0.1021
Trichomonas vaginalis D-aminoacylase, putative 0.0031 0.0101 0.0644
Mycobacterium tuberculosis Conserved protein 0.0039 0.0163 0.1091
Leishmania major cysteine peptidase A (CPA) 0.0035 0.013 0.0356
Onchocerca volvulus 0.013 0.0829 0.5083
Brugia malayi hypothetical protein 0.0019 0.0014 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.012 0.0766
Loa Loa (eye worm) hypothetical protein 0.0021 0.0033 0.004
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.013 0.083 0.6249
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0571 0.0571
Loa Loa (eye worm) hypothetical protein 0.0286 0.1973 0.2429
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0014 0.0013
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0029 0.0086 0.042
Entamoeba histolytica hypothetical protein 0.0019 0.0014 0.0174
Echinococcus granulosus tumor protein p63 0.0408 0.2873 0.2872
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0101 0.0275
Plasmodium vivax vivapain-1 0.0018 0.0007 0.0017
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0037 0.0102
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0023 0.0042 0.0055
Loa Loa (eye worm) hypothetical protein 0.0038 0.0156 0.0192
Loa Loa (eye worm) hypothetical protein 0.0033 0.0121 0.0148
Schistosoma mansoni elongation of fatty acids protein 1 0.0127 0.0805 0.0804
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0022 0.0034 0.0092
Echinococcus multilocularis tumor protein p63 0.0408 0.2873 0.2872
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0024 0.0053 0.0053
Mycobacterium leprae PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) 0.0041 0.0175 0.1198
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0023 0.0042 0.0042
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.004 0.0168 0.0168
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0038 0.0156 0.0156
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0046 0.0293
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0022 0.0034 0.0008
Loa Loa (eye worm) cytochrome P450 family protein 0.0047 0.022 0.027
Toxoplasma gondii histone lysine methyltransferase SET1 0.0123 0.0781 0.2138
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0062 0.0328 0.0881
Toxoplasma gondii HEAT repeat-containing protein 0.009 0.0536 0.1468
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0014 0.0016
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0014 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0014 0.0086
Schistosoma mansoni chromobox protein 0.0059 0.0311 0.0311
Brugia malayi PXA domain containing protein 0.0019 0.0014 0.0016
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0029 0.0086 0.042
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0016
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0029 0.0086 0.0496
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0023 0.0042 0.0052
Plasmodium vivax unspecified product 0.0018 0.0007 0.0017
Entamoeba histolytica cysteine protease, putative 0.0018 0.0007 0.0084
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0108 0.0671 0.5069
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0023 0.0042 0.0052
Plasmodium vivax vivapain-2 0.0035 0.013 0.0356
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.0563 0.0562
Schistosoma mansoni hypothetical protein 0.0847 0.6097 0.6097
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.013 0.083 0.6312
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0571 0.0571
Entamoeba histolytica acyl-CoA synthetase, putative 0.0042 0.0182 0.2429
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0571 0.0571
Brugia malayi GNS1/SUR4 family protein 0.0514 0.3649 0.4491
Brugia malayi CXXC zinc finger family protein 0.0059 0.0312 0.0384
Leishmania major cathepsin L-like protease 0.0132 0.0846 0.2317
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0023 0.0042 0.0052
Onchocerca volvulus 0.023 0.1567 0.9802
Schistosoma mansoni hypothetical protein 0.0023 0.0042 0.0041
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0053 0.0261 0.1852
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0029 0.0086 0.042
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0086 0.0234
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0571 0.0571
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0037 0.0085
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0029 0.0086 0.0496
Mycobacterium ulcerans thioesterase 0.0108 0.0671 0.5028
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0022 0.0034 0.0091
Loa Loa (eye worm) hypothetical protein 0.0023 0.0046 0.0056
Brugia malayi Cathepsin L-like precursor 0.0035 0.013 0.016
Brugia malayi Uncoordinated protein 44 0.0038 0.0156 0.0192
Loa Loa (eye worm) cytochrome P450 0.0029 0.0086 0.0105
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0014 0.0013
Schistosoma mansoni hypothetical protein 0.0049 0.0237 0.0236
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.7068 0.7068
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0029 0.0086 0.042
Loa Loa (eye worm) hypothetical protein 0.0052 0.0259 0.0318
Trypanosoma cruzi fatty acid elongase, putative 0.0127 0.0805 0.2192
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.013 0.0831
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0194 0.1302 0.9899
Leishmania major fatty acid elongase, putative 0.0514 0.3649 1
Brugia malayi Protein kinase domain containing protein 0.0039 0.016 0.0197
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0227 0.0227
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0132 0.0846 0.2317
Onchocerca volvulus 0.0058 0.0303 0.1724
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0309 0.038
Entamoeba histolytica cysteine protease, putative 0.0018 0.0007 0.0084
Plasmodium falciparum 3-oxoacyl-acyl-carrier protein synthase I/II 0.0033 0.0115 0.0314
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.013 0.0831
Loa Loa (eye worm) hypothetical protein 0.0029 0.0085 0.0105
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0087 0.0512 0.1402
Loa Loa (eye worm) bromodomain containing protein 0.0025 0.0062 0.0076
Entamoeba histolytica cysteine proteinase 1, putative 0.0018 0.0007 0.0084
Brugia malayi PHD-finger family protein 0.0029 0.0085 0.0105
Brugia malayi beta-lactamase family protein 0.0031 0.0101 0.0124
Schistosoma mansoni hypothetical protein 0.0058 0.0303 0.0303
Echinococcus granulosus peregrin 0.0038 0.0155 0.0155
Schistosoma mansoni elongation of fatty acids protein 1 0.0137 0.0882 0.0882
Echinococcus granulosus lysine specific demethylase 5A 0.004 0.0169 0.0169
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0018 0.0017
Loa Loa (eye worm) hypothetical protein 0.0031 0.0101 0.0124
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0045 0.0204 0.1405
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0014 0.0013
Mycobacterium leprae Probable lipase LipE 0.0031 0.0101 0.0617
Onchocerca volvulus 0.0127 0.0805 0.493
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0046 0.0293
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0024 0.0053 0.0053
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0042 0.0052
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0042 0.0042
Plasmodium vivax long chain polyunsaturated fatty acid elongation enzyme, putative 0.0137 0.0882 0.2417
Echinococcus granulosus death domain containing protein 0.0038 0.0156 0.0156
Brugia malayi Death domain containing protein 0.0038 0.0156 0.0192
Brugia malayi PXA domain containing protein 0.0019 0.0014 0.0016
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0194 0.1302 0.9899
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0127 0.081 0.081
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0321 0.032
Schistosoma mansoni zinc finger protein 0.0031 0.0101 0.0101
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0132 0.0846 0.2317
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0126 0.08 0.6022
Echinococcus multilocularis cathepsin L 0.0018 0.0007 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.013 0.0831
Mycobacterium ulcerans Type I modular polyketide synthase 0.013 0.083 0.6281
Entamoeba histolytica hypothetical protein 0.0087 0.0514 0.6859
Schistosoma mansoni netrin receptor unc5 0.0038 0.0156 0.0156
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0314 0.0314
Onchocerca volvulus 0.0148 0.0963 0.5941
Trypanosoma cruzi fatty acid elongase, putative 0.0127 0.0805 0.2192
Plasmodium falciparum cysteine proteinase falcipain 1 0.0018 0.0007 0.0017
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0022 0.0034 0.0091
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0024 0.0017
Brugia malayi steroid hormone receptor 0.0023 0.0042 0.0052
Mycobacterium tuberculosis Probable thioesterase TesA 0.0108 0.0671 0.5018
Echinococcus multilocularis geminin 0.0517 0.3675 0.3674
Schistosoma mansoni hypothetical protein 0.0024 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0023 0.0042 0.0052
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0031 0.0101 0.061
Loa Loa (eye worm) hypothetical protein 0.0026 0.0067 0.0082
Loa Loa (eye worm) hypothetical protein 0.002 0.0022 0.0026
Schistosoma mansoni cpg binding protein 0.0065 0.0352 0.0351
Schistosoma mansoni ran 0.0022 0.0037 0.0037
Onchocerca volvulus 0.0029 0.0086 0.0334
Loa Loa (eye worm) acetyltransferase 0.0289 0.1997 0.2457
Leishmania major cathepsin L-like protease 0.0035 0.013 0.0356
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0037 0.0046
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.013 0.0831
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0018 0.0017
Mycobacterium ulcerans lipase LipD 0.0031 0.0101 0.0537
Loa Loa (eye worm) hypothetical protein 0.0023 0.0042 0.0052
Echinococcus granulosus ephrin type A receptor 4 A 0.0066 0.0363 0.0363
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0421 0.0421
Brugia malayi GNS1/SUR4 family protein 0.1123 0.8123 1
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0154 0.0189
Mycobacterium leprae Polyketide synthase Pks13 0.0194 0.1302 1
Loa Loa (eye worm) hypothetical protein 0.009 0.0536 0.0659
Brugia malayi Cathepsin L-like precursor 0.0023 0.0046 0.0056
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0029 0.0086 0.0496
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0014 0.0013
Brugia malayi nuclear hormone receptor 0.0023 0.0042 0.0052
Loa Loa (eye worm) hypothetical protein 0.006 0.0314 0.0386
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0037 0.0037
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0289 0.1997 0.1996
Onchocerca volvulus Bile acid receptor homolog 0.0023 0.0042 0.0055
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0087 0.0512 0.1402
Trypanosoma cruzi fatty acid elongase, putative 0.0514 0.3649 1
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0374 0.2619 0.2619
Brugia malayi latrophilin 2 splice variant baaae 0.0052 0.0259 0.0318
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0014 0.0013
Schistosoma mansoni steroid hormone receptor ad4bp 0.0023 0.0042 0.0042
Mycobacterium tuberculosis Conserved protein 0.0031 0.0101 0.061
Toxoplasma gondii integral membrane protein, GNS1/SUR4 family protein, putative 0.0514 0.3649 1
Loa Loa (eye worm) hypothetical protein 0.0119 0.0749 0.0921
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0038 0.0156 0.0156
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0023 0.0042 0.0052
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0029 0.0086 0.0496
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0046 0.0293
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0097 0.0264
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0321 0.032
Entamoeba histolytica hypothetical protein 0.0087 0.0514 0.6859
Brugia malayi MAP kinase sur-1 0.0062 0.0328 0.0403
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0014 0.0013
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0328 0.0327
Leishmania major fatty acid elongase, putative 0.0127 0.0805 0.2205
Leishmania major hypothetical protein, conserved 0.005 0.0246 0.0674
Echinococcus multilocularis protein patched 0.0051 0.025 0.025
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0014 0.0013
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0086 0.0419
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0138 0.0889 0.6707
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0024 0.0017
Brugia malayi Papain family cysteine protease containing protein 0.0035 0.013 0.016
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0029 0.0086 0.042
Loa Loa (eye worm) hypothetical protein 0.0021 0.0033 0.004
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0058 0.0298 0.0817
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0029 0.0086 0.0496
Echinococcus granulosus FTZ F1 alpha 0.0023 0.0042 0.0042
Trypanosoma cruzi cytochrome P450, putative 0.0047 0.022 0.0585
Onchocerca volvulus 0.0023 0.0042 0.0055
Onchocerca volvulus 0.0035 0.013 0.0617
Entamoeba histolytica hypothetical protein 0.0087 0.0514 0.6859
Chlamydia trachomatis 3-oxoacyl-ACP synthase 0.0033 0.0115 1
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0154 0.0982
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0138 0.0889 0.6707
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0321 0.2313
Schistosoma mansoni transcription factor LCR-F1 0.0087 0.0514 0.0513
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0321 0.2272
Echinococcus granulosus snurportin 1 0.096 0.6925 0.6925
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0035 0.013 0.016
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0246 0.0674
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0105 0.0643 0.4812
Onchocerca volvulus 0.0035 0.013 0.0617
Schistosoma mansoni cpg binding protein 0.0065 0.0352 0.0351
Brugia malayi chromobox protein homolog 3 0.0033 0.012 0.0147
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0016
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0246 0.0658
Entamoeba histolytica hypothetical protein 0.0073 0.0411 0.5486
Trichomonas vaginalis ran, putative 0.0022 0.0037 0.0239
Schistosoma mansoni hypothetical protein 0.0052 0.0259 0.0258
Leishmania major fatty acid elongase, putative 0.0514 0.3649 1
Giardia lamblia Methyltransferase like 2 0.0039 0.0163 0.3099
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0095 0.0571 0.0703
Echinococcus multilocularis snurportin 1 0.096 0.6925 0.6925
Loa Loa (eye worm) cysteine protease 0.0035 0.013 0.016
Echinococcus multilocularis cpg binding protein 0.0065 0.0352 0.0351
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0035 0.013 0.0831
Trypanosoma cruzi fatty acid elongase, putative 0.0127 0.0805 0.2192
Leishmania major hypothetical protein, conserved 0.0039 0.0163 0.0446
Schistosoma mansoni methyltransferase-related 0.0039 0.0163 0.0163
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0029 0.0086 0.0218
Brugia malayi hypothetical protein 0.0286 0.1973 0.2429
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0014 0.0016
Trypanosoma cruzi fatty acid elongase, putative 0.0514 0.3649 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.025 0.0308
Brugia malayi hypothetical protein 0.0033 0.0115 0.0141
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.025 0.025
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0035 0.013 0.0356
Echinococcus multilocularis muscleblind protein 0.0911 0.6567 0.6567
Brugia malayi F/Y-rich N-terminus family protein 0.0031 0.01 0.0122
Toxoplasma gondii cytochrome p450 superfamily protein 0.0029 0.0086 0.0235
Trichomonas vaginalis chromobox protein, putative 0.0036 0.0138 0.0884
Trypanosoma brucei Long chain fatty acyl elongase 0.0137 0.0882 0.2417
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.013 0.0831
Leishmania major cytochrome p450-like protein 0.0047 0.022 0.0601
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0086 0.0419
Echinococcus granulosus geminin 0.0517 0.3675 0.3674
Brugia malayi Steroid receptor seven-up type 2 0.0023 0.0042 0.0052
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0087 0.0514 0.0513
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0154 0.102
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0014 0.0086
Loa Loa (eye worm) hypothetical protein 0.0023 0.0042 0.0052
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0023 0.0042 0.0052
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0014 0.0016
Brugia malayi Cytochrome P450 family protein 0.0029 0.0086 0.0105
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.0049 0.0235 0.0289
Onchocerca volvulus 0.0031 0.0101 0.0429
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0246 0.0658
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0097 0.0096
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0034 0.0008
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0014 0.0016
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0033 0.0088
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0049 0.031
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0084 0.0495 0.1354
Mycobacterium tuberculosis Probable esterase LipL 0.0031 0.0101 0.061
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0023 0.0042 0.0042
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0571 0.0571
Schistosoma mansoni hypothetical protein 0.0038 0.0156 0.0156
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0042 0.0042
Giardia lamblia PHD finger protein 15 0.0029 0.0085 0.1182
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0062 0.0328 0.0897
Loa Loa (eye worm) transcription factor SMAD2 0.0125 0.0794 0.0977
Leishmania major fatty acid elongase, putative 0.0127 0.0805 0.2205
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0014 0.0086
Loa Loa (eye worm) cytochrome P450 family protein 0.0108 0.0669 0.0823
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0571 0.0571
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.0749 0.0748
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0033 0.0115 0.0649
Loa Loa (eye worm) hypothetical protein 0.0073 0.0415 0.0511
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0007 0.0006
Echinococcus multilocularis 3 oxoacyl (acyl carrier protein) synthase 0.0033 0.0115 0.0115
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0042 0.0042
Brugia malayi hypothetical protein 0.0148 0.0963 0.1185
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0042 0.0041
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0086 0.1141
Brugia malayi Methyltransferase-like protein 4 0.0039 0.0163 0.02
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0058 0.0298 0.0298
Onchocerca volvulus 0.006 0.0314 0.1794
Mycobacterium ulcerans beta-lactamase 0.0031 0.0101 0.0537
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.015 0.0149
Leishmania major cytochrome p450-like protein 0.0029 0.0086 0.0235
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0029 0.0086 0.042
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0029 0.0086 0.0496
Loa Loa (eye worm) ctsf protein 0.0035 0.013 0.016
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0014 0.0013
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0087 0.0514 0.0513
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.0408 0.0407
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0154 0.2048
Toxoplasma gondii type I fatty acid synthase, putative 0.0139 0.0898 0.2459
Schistosoma mansoni RAR-like nuclear receptor 0.0023 0.0042 0.0042
Loa Loa (eye worm) fibroinase 0.0035 0.013 0.016
Schistosoma mansoni microtubule-associated protein tau 0.1378 1 1
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0029 0.0086 0.042
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0328 0.2092
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0018 0.0007 0.0017
Loa Loa (eye worm) beta-ketoacyl synthase domain-containing protein 0.0033 0.0115 0.0141
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.0408 0.0407
Loa Loa (eye worm) CYP4Cod1 0.0047 0.022 0.027
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0014 0.0013
Brugia malayi Importin beta-1 subunit 0.009 0.0536 0.0659
Echinococcus granulosus ecdysone induced protein 78C 0.0023 0.0042 0.0042
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0007 0.0043
Mycobacterium tuberculosis Conserved protein 0.0031 0.0101 0.061
Trypanosoma brucei Fatty acid elongase 0.0127 0.0805 0.2205
Loa Loa (eye worm) hypothetical protein 0.0018 0.0009 0.0011
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0029 0.0086 0.0496
Mycobacterium ulcerans Type I modular polyketide synthase 0.013 0.083 0.6281
Plasmodium falciparum importin beta, putative 0.009 0.0536 0.1468
Loa Loa (eye worm) hypothetical protein 0.0021 0.0033 0.004
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.0018 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.013 0.0831
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.013 0.0831
Echinococcus granulosus histone acetyltransferase KAT2B 0.0278 0.192 0.1919
Plasmodium falciparum long chain fatty acid elongation enzyme, putative 0.0514 0.3649 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0101 0.0124
Toxoplasma gondii type I fatty acid synthase, putative 0.0092 0.0555 0.1519
Loa Loa (eye worm) hypothetical protein 0.0021 0.0033 0.004
Brugia malayi Bromodomain containing protein 0.0038 0.0155 0.019
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0014 0.0013
Loa Loa (eye worm) hypothetical protein 0.0911 0.6567 0.8084
Brugia malayi Cytochrome P450 family protein 0.0047 0.022 0.027
Brugia malayi ephrin receptor 1 precursor 0.0032 0.0108 0.0133
Brugia malayi fatty acid elongation protein 3 0.0127 0.0805 0.099
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0029 0.0086 0.0218
Brugia malayi jmjC domain containing protein 0.0094 0.0563 0.0692
Echinococcus multilocularis cathepsin L cysteine protease 0.0035 0.013 0.013
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.013 0.0831
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.013 0.083 0.6281
Brugia malayi CHE-14 protein 0.0051 0.025 0.0308
Trypanosoma cruzi fatty acid elongase, putative 0.0514 0.3649 1
Entamoeba histolytica cysteine protease, putative 0.0018 0.0007 0.0084
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0018 0.0018
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.013 0.0831
Echinococcus multilocularis peregrin 0.0038 0.0155 0.0155
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0023 0.0042 0.0042
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0022 0.0034 0.0041
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0042 0.0042
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0037 0.0102
Mycobacterium leprae conserved hypothetical protein 0.0031 0.0101 0.0617
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0154 0.042
Mycobacterium ulcerans polyketide synthase 0.0138 0.0889 0.6748
Leishmania major GTP-binding protein, putative 0.0022 0.0037 0.0102
Loa Loa (eye worm) hypothetical protein 0.0021 0.0033 0.004
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0024 0.0053 0.0053
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0132 0.0846 0.2317
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0062 0.0328 0.0403
Brugia malayi Heterochromatin protein 1 0.0059 0.0311 0.0383
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0029 0.0086 0.0235
Brugia malayi Pre-SET motif family protein 0.003 0.0097 0.0119
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.008 0.0079
Schistosoma mansoni 3-oxoacyl-[ACP] synthase 0.0033 0.0115 0.0115
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0023 0.0042 0.0052
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0029 0.0086 0.0496
Echinococcus multilocularis ephrin type A receptor 4 A 0.0066 0.0363 0.0363
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0168 0.0167
Leishmania major cathepsin L-like protease 0.0035 0.013 0.0356
Schistosoma mansoni elongation of fatty acids protein 1 0.0137 0.0882 0.0882
Schistosoma mansoni cathepsin F (C01 family) 0.0023 0.0046 0.0046
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0154 0.042
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.013 0.0829 0.6241
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0321 0.0878
Schistosoma mansoni elongation of fatty acids protein 1 0.0127 0.0805 0.0804
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0022 0.0034 0.0091
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.0762 0.0762
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0014 0.0013
Brugia malayi hypothetical protein 0.0019 0.0014 0.0016
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0014 0.0013
Entamoeba histolytica cysteine protease, putative 0.0018 0.0007 0.0084
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0154 0.0404
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0014 0.0013
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0046 0.0293
Loa Loa (eye worm) cytochrome P450 family protein 0.0047 0.022 0.027
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0086 0.0234
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0007 0.0006
Leishmania major fatty acid elongase, putative 0.0137 0.0882 0.2417
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0154 0.5
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0029 0.0086 0.042
Schistosoma mansoni hypothetical protein 0.0029 0.0086 0.0086
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0007 0.0008
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0024 0.0053 0.0053
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0154 0.042
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0022 0.0034 0.0091
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.013 0.0831
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0014 0.0013
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0014 0.0013
Leishmania major cathepsin L-like protease 0.0035 0.013 0.0356
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0029 0.0086 0.0496
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0014 0.0013
Loa Loa (eye worm) hypothetical protein 0.0029 0.0086 0.0105
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0132 0.0846 0.2317
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.013 0.0129
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0093 0.0561 0.417
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0024 0.0017
Echinococcus granulosus muscleblind protein 0.0911 0.6567 0.6567
Brugia malayi AMP-binding enzyme family protein 0.0041 0.0177 0.0218
Leishmania major fatty acid elongase, putative 0.0514 0.3649 1
Brugia malayi fatty acid elongation protein 3 0.0127 0.0805 0.099
Entamoeba histolytica cysteine protease, putative 0.0018 0.0007 0.0084
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0246 0.1684 0.2073
Onchocerca volvulus 0.0031 0.0101 0.0429
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.013 0.083 0.6249
Entamoeba histolytica cysteine protease, putative 0.0018 0.0007 0.0084
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0029 0.0086 0.0496
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0007 0.0008
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0029 0.0086 0.0496
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0006 0.0005
Trypanosoma brucei Fatty acid elongase 0.0127 0.0805 0.2205
Onchocerca volvulus 0.0031 0.0101 0.0429
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0086 0.0419
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0097 0.0096
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0163 0.1041
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0196 0.1315 1
Schistosoma mansoni hypothetical protein 0.0024 0.0053 0.0053
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0154 0.0404
Entamoeba histolytica acetyltransferase, GNAT family 0.0077 0.0442 0.5906
Trypanosoma cruzi importin beta-1 subunit, putative 0.0073 0.0411 0.111
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0029 0.0086 0.0496
Brugia malayi Bromodomain containing protein 0.0088 0.0524 0.0645
Loa Loa (eye worm) fatty acid elongation protein 3 0.0514 0.3649 0.4491
Leishmania major fatty acid elongase, putative 0.0127 0.0805 0.2205
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0029 0.0086 0.042
Trichomonas vaginalis penicillin-binding protein, putative 0.0031 0.0101 0.0644
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.013 0.0831
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0016
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0029 0.0086 0.0496
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0016
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0087 0.0512 0.327
Onchocerca volvulus 0.0066 0.0358 0.2072
Schistosoma mansoni thyroid hormone receptor 0.0153 0.1003 0.1003
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0105 0.0643 0.4812
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0085 0.0085
Plasmodium vivax SET domain protein, putative 0.003 0.0097 0.0264
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.096 0.6925 0.8525
Echinococcus granulosus elongation of very long chain fatty acids 0.0127 0.0805 0.0804
Echinococcus granulosus cathepsin l1 0.0023 0.0046 0.0046
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.1973 0.1973
Loa Loa (eye worm) hypothetical protein 0.0066 0.0358 0.044
Toxoplasma gondii fatty acid elongase 0.0137 0.0882 0.2417
Echinococcus multilocularis sodium channel protein 0.0058 0.0298 0.0298
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0014 0.0086
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative 0.0033 0.0115 0.0314
Onchocerca volvulus 0.0059 0.0312 0.1782
Trypanosoma brucei protein kinase, putative 0.0062 0.0328 0.0897
Entamoeba histolytica cysteine protease, putative 0.0018 0.0007 0.0084
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0014 0.0086
Echinococcus multilocularis mitogen activated protein kinase 3 0.0062 0.0328 0.0327
Mycobacterium ulcerans fatty acid synthase Fas 0.0041 0.0175 0.1124
Echinococcus granulosus expressed conserved protein 0.0112 0.0696 0.0695
Trichomonas vaginalis set domain proteins, putative 0.023 0.1566 1
Echinococcus multilocularis Ankyrin 0.0038 0.0157 0.0157
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0086 0.0495
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.013 0.0831
Leishmania major hypothetical protein, conserved 0.0031 0.0101 0.0275
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0033 0.0088
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0138 0.0889 0.6748
Schistosoma mansoni bromodomain containing protein 0.0076 0.0435 0.0434
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.0749 0.0921
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0246 0.0674
Echinococcus granulosus cathepsin L cysteine proteinase 0.0035 0.013 0.013
Leishmania major fatty acid elongase, putative 0.0127 0.0805 0.2205
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.025 0.025
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.013 0.0831
Onchocerca volvulus 0.0234 0.1598 1
Echinococcus granulosus mitogen activated protein kinase 0.0062 0.0328 0.0327
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0022 0.0034 0.0008
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0086 0.0105
Leishmania major fatty acid elongase, putative 0.0127 0.0805 0.2205
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0014 0.0013
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0072 0.0072
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0246 0.0674
Echinococcus granulosus histone lysine methyltransferase setb 0.0048 0.0227 0.0227
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0086 0.0234
Trichomonas vaginalis esterase, putative 0.0031 0.0101 0.0644
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0046 0.0293
Entamoeba histolytica cysteine proteinase, putative 0.0035 0.013 0.1733
Loa Loa (eye worm) fatty acid synthase 0.0128 0.0817 0.1005
Echinococcus granulosus dnaJ subfamily B 0.0847 0.6097 0.6097
Echinococcus multilocularis dnaJ subfamily B 0.0847 0.6097 0.6097
Mycobacterium ulcerans thioesterase TesA 0.0108 0.0671 0.5028
Trypanosoma cruzi fatty acid elongase, putative 0.0137 0.0882 0.2404
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0086 0.05
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0105 0.0643 0.4856
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0023 0.0042 0.0042
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0042 0.0052
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0169 0.0207
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0033 0.0115 0.0297
Loa Loa (eye worm) fatty acid elongation protein 3 0.0127 0.0805 0.099
Loa Loa (eye worm) hypothetical protein 0.0148 0.0963 0.1185
Plasmodium vivax vivapain-2 0.0035 0.013 0.0356
Echinococcus granulosus cysteine protease 0.0018 0.0007 0.0006
Trypanosoma cruzi cytochrome P450, putative 0.0047 0.022 0.0585
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0035 0.013 0.013
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0095 0.0571 0.0703
Mycobacterium ulcerans Type I modular polyketide synthase 0.013 0.083 0.6281
Trichomonas vaginalis D-aminoacylase, putative 0.0031 0.0101 0.0644
Echinococcus multilocularis muscleblind protein 1 0.0911 0.6567 0.6567
Echinococcus granulosus GPCR family 2 0.0024 0.0053 0.0053
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.004 0.0169 0.1137
Toxoplasma gondii GNS1/SUR4 family protein 0.0514 0.3649 1
Onchocerca volvulus Elongation of very long chain fatty acids protein homolog 0.0127 0.0805 0.493
Onchocerca volvulus 0.0035 0.013 0.0617
Onchocerca volvulus Protein ultraspiracle homolog 0.0023 0.0042 0.0055
Onchocerca volvulus 0.0035 0.013 0.0617
Onchocerca volvulus Cathepsin L homolog 0.0035 0.013 0.0617
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0014 0.0086
Echinococcus granulosus elongation of very long chain fatty acids 0.0137 0.0882 0.0882
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0086 0.0419
Echinococcus granulosus beta LACTamase domain containing family member 0.0031 0.0101 0.01
Onchocerca volvulus 0.0026 0.0067 0.0214
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0035 0.013 0.016
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0023 0.0042 0.0042
Entamoeba histolytica cysteine protease, putative 0.0018 0.0007 0.0084
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0018 0.0017
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0014 0.0016
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0085 0.0233
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0007 0.0043
Onchocerca volvulus 0.0035 0.013 0.0617
Trypanosoma cruzi fatty acid elongase, putative 0.0514 0.3649 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0023 0.0042 0.0042
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0076 0.0436 0.0537
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0029 0.0086 0.042
Leishmania major cytochrome p450-like protein 0.0029 0.0086 0.0235
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0085 0.0233
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0023 0.0042 0.0042
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0035 0.013 0.0356
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0042 0.0042
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.004 0.0168 0.0207
Echinococcus multilocularis elongation of very long chain fatty acids 0.0127 0.0805 0.0804
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0062 0.0328 0.0897
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0303 0.0373
Mycobacterium ulcerans polyketide synthase 0.013 0.083 0.6281
Brugia malayi acetyltransferase, GNAT family protein 0.0289 0.1997 0.2457
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0023 0.0042 0.0052
Plasmodium falciparum fatty acid elongation protein, GNS1/SUR4 family, putative 0.0514 0.3649 1
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0328 0.2092
Echinococcus multilocularis 0.0029 0.0086 0.0086
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0132 0.0846 0.2317
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0007 0.0084
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0042 0.0052
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0023 0.0042 0.0042
Leishmania major fatty acid elongase, putative 0.0127 0.0805 0.2205
Echinococcus granulosus jumonji domain containing protein 0.004 0.0168 0.0167
Echinococcus multilocularis elongation of very long chain fatty acids 0.0137 0.0882 0.0882
Loa Loa (eye worm) GNS1/SUR4 family protein 0.0514 0.3649 0.4491
Plasmodium falciparum phd finger protein, putative 0.0029 0.0085 0.0233
Brugia malayi Pre-SET motif family protein 0.0202 0.1362 0.1676
Schistosoma mansoni ankyrin 23/unc44 0.0038 0.0156 0.0156
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0023 0.0042 0.0052
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0132 0.0846 0.2317
Loa Loa (eye worm) acyl carrier protein 0.006 0.0314 0.0386
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0023 0.0042 0.0052
Loa Loa (eye worm) hypothetical protein 0.0076 0.0436 0.0537
Onchocerca volvulus 0.0035 0.013 0.0617
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0046 0.0294
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0031 0.0101 0.0124
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0132 0.0846 0.2317
Echinococcus multilocularis expressed protein 0.0366 0.2562 0.2561
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0022 0.0034 0.0008
Schistosoma mansoni hypothetical protein 0.0049 0.0237 0.0236
Echinococcus multilocularis zinc finger protein 0.0031 0.0101 0.0101
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0029 0.0086 0.042
Mycobacterium leprae Probable polyketide synthase Pks1 0.0138 0.0889 0.6776
Brugia malayi Latrophilin receptor protein 2 0.0024 0.0053 0.0065
Loa Loa (eye worm) hypothetical protein 0.0029 0.0086 0.0105
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.0065
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.1124 0.1123
Toxoplasma gondii cathepsin CPL 0.0035 0.013 0.0356
Trichomonas vaginalis hypothetical protein 0.0017 0 0.0003
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0072 0.0072
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0033 0.0115 0.0649
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0016
Mycobacterium tuberculosis Probable lipase LipD 0.0031 0.0101 0.061
Trichomonas vaginalis chromobox protein, putative 0.0059 0.0311 0.1989
Onchocerca volvulus Netrin receptor homolog 0.0038 0.0156 0.0783
Echinococcus multilocularis cysteine protease 0.0035 0.013 0.013
Schistosoma mansoni patched 1 0.0051 0.025 0.025
Loa Loa (eye worm) AMP-binding enzyme family protein 0.013 0.0829 0.102
Echinococcus granulosus importin subunit beta 1 0.009 0.0536 0.0536
Brugia malayi Bromodomain containing protein 0.0047 0.0219 0.0269
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0031 0.0101 0.0124
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0014 0.0013
Leishmania major cathepsin L-like protease 0.0132 0.0846 0.2317
Loa Loa (eye worm) fatty acid elongation protein 3 0.0127 0.0805 0.099
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.1124 0.1123
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0018 0.0021
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0014 0.0013
Loa Loa (eye worm) hypothetical protein 0.0031 0.0101 0.0124
Schistosoma mansoni fatty acid acyl transferase-related 0.0137 0.0882 0.0882
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.0749 0.0748
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0014 0.0013
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0029 0.0086 0.042
Schistosoma mansoni hypothetical protein 0.0131 0.0836 0.0836
Echinococcus multilocularis netrin receptor unc 5 0.0038 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0073 0.041 0.0504
Trypanosoma cruzi cysteine peptidase, putative 0.0132 0.0846 0.2304
Loa Loa (eye worm) hypothetical protein 0.0219 0.1487 0.183
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0086 0.0507 0.3787
Loa Loa (eye worm) hypothetical protein 0.0055 0.0277 0.0341
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0006 0.0005
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0085 0.0085
Mycobacterium tuberculosis Conserved protein 0.0031 0.0101 0.061
Entamoeba histolytica cysteine protease, putative 0.0018 0.0007 0.0084
Schistosoma mansoni cytochrome P450 0.0029 0.0086 0.0086
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0086 0.0419
Loa Loa (eye worm) hypothetical protein 0.0035 0.013 0.016
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0154 0.0982
Entamoeba histolytica hypothetical protein 0.0087 0.0514 0.6859
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.0749 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0042 0.0052
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0085 0.0085
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0019 0.0012 0.0033
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0023 0.0042 0.0052
Brugia malayi beta-lactamase 0.0031 0.0101 0.0124
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0321 0.2272
Brugia malayi Cytochrome P450 family protein 0.0108 0.0669 0.0823
Entamoeba histolytica hypothetical protein 0.0019 0.0014 0.0174
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0029 0.0086 0.042
Onchocerca volvulus Elongation of very long chain fatty acids protein homolog 0.0127 0.0805 0.493
Onchocerca volvulus 0.004 0.0168 0.086
Echinococcus granulosus 3 oxoacyl acyl carrier protein synthase 0.0033 0.0115 0.0115
Toxoplasma gondii exonuclease III APE 0.0038 0.0154 0.042
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0132 0.0846 0.2317
Schistosoma mansoni ap endonuclease 0.0038 0.0154 0.0153
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0007 0.0084
Brugia malayi Cathepsin L-like cysteine proteinase 0.0023 0.0046 0.0056
Brugia malayi beta-lactamase family protein 0.0031 0.0101 0.0124
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0328 0.0881
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0023 0.0042 0.0042
Leishmania major long chain polyunsaturated fatty acid elongation enzyme-like protein 0.0137 0.0882 0.2417
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0076 0.0436 0.0537
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0035 0.013 0.0831
Schistosoma mansoni thyroid hormone receptor 0.0153 0.1003 0.1003
Entamoeba histolytica cysteine protease, putative 0.0018 0.0007 0.0084
Onchocerca volvulus Cathepsin F homolog 0.0035 0.013 0.0617
Entamoeba histolytica cysteine protease, putative 0.0018 0.0007 0.0084
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0154 0.0153
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0029 0.0086 0.0496
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0042 0.0052
Plasmodium falciparum histone acetyltransferase GCN5 0.0077 0.0442 0.1212
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0029 0.0086 0.042
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0086 0.0507 0.3734
Leishmania major fatty acid elongase, putative 0.0127 0.0805 0.2205
Trichomonas vaginalis chromobox protein, putative 0.0036 0.0138 0.0884
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0041 0.0175 0.1186
Loa Loa (eye worm) GNS1/SUR4 family protein 0.1123 0.8123 1
Brugia malayi PHD-finger family protein 0.0036 0.0142 0.0174
Trypanosoma brucei cytochrome P450, putative 0.0047 0.022 0.0601
Loa Loa (eye worm) hypothetical protein 0.005 0.0246 0.0303
Loa Loa (eye worm) latrophilin receptor protein 2 0.0024 0.0053 0.0065
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0033 0.0115 0.0297
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0018 0.0017
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.013 0.083 0.6312
Schistosoma mansoni importin beta-1 0.009 0.0536 0.0536
Echinococcus granulosus Protein patched homolog 1 0.0051 0.025 0.025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.013 0.0831
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0022 0.0034 0.0008
Entamoeba histolytica cysteine proteinase, putative 0.0035 0.013 0.1733
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0014 0.0013
Brugia malayi hypothetical protein 0.005 0.0246 0.0303
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0018 0.0005 0.0011
Brugia malayi AMP-binding enzyme family protein 0.013 0.0829 0.102

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 2.183 um PUBCHEM_BIOASSAY: Name: High Throughput Screen to Identify Compounds that increase expression of NF-kB in Human Neuronal Cells - Dose Response. (Class of assay: confirmatory) [Related pubchem assays: 1239 ] ChEMBL. No reference
EC50 (binding) = 7.255 um PUBCHEM_BIOASSAY: Luminescence Biochemical Dose Response HTS to Identify Inhibitors of Luciferase. (Class of assay: confirmatory) [Related pubchem assays: 1663 (Primary HTS), 1678 (Summary of Project)] ChEMBL. No reference
EC50 (functional) 67.602 uM PubChem BioAssay. Counterscreen for agonists of the daf-12 abnormal Dauer Formation: Luminescence-based cell-based dose response screening assay to identify agonists of the Liver-X-Receptor (LXR). (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) = 13.7 uM PubChem BioAssay. Dose Response Confirmation of SKN-1 Inhibitor hits in a fluorescence ratio assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) = 42.41 uM PubChem BioAssay. Dose ResponseConfirmation of SKN-1 Inhibitor hits in a fluorescence ratio assay - Set 2. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.1032 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 0.5012 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.2995 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 2.1331 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 2.2387 uM PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 2.8184 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.6964 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 7.0795 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Firefly Luciferase. (Class of assay: confirmatory) [Related pubchem assays: 2309 (Probe Summary for Inhibitors and Stabilizers of Firefly Luciferase)] ChEMBL. No reference
Potency (functional) 10.3225 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.5821 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature. (Class of assay: confirmatory) [Related pubchem assays: 902 ] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 84.9214 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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