Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | carbonic anhydrase | 0.0054 | 0.3258 | 0.5 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.0134 | 0.9115 | 0.9115 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0044 | 0.2523 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0146 | 1 | 1 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0054 | 0.3258 | 0.3258 |
Echinococcus granulosus | cathepsin b | 0.0134 | 0.9115 | 0.9115 |
Giardia lamblia | Cathepsin B precursor | 0.0044 | 0.2523 | 0.5 |
Echinococcus multilocularis | cathepsin b | 0.0134 | 0.9115 | 0.9115 |
Echinococcus granulosus | cathepsin b | 0.0134 | 0.9115 | 0.9115 |
Leishmania major | carbonic anhydrase-like protein | 0.0146 | 1 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0054 | 0.3258 | 0.3258 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0054 | 0.3258 | 0.3258 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0054 | 0.3258 | 0.3258 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0146 | 1 | 1 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0054 | 0.3258 | 0.3258 |
Echinococcus multilocularis | cathepsin b | 0.0134 | 0.9115 | 0.9115 |
Toxoplasma gondii | hypothetical protein | 0.0054 | 0.3258 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.3258 | 0.3258 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0134 | 0.9115 | 0.8817 |
Echinococcus granulosus | carbonic anhydrase II | 0.0146 | 1 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0146 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0054 | 0.3258 | 0.3258 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0134 | 0.9115 | 0.9115 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0054 | 0.3258 | 0.3258 |
Echinococcus multilocularis | carbonic anhydrase | 0.0054 | 0.3258 | 0.3258 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0054 | 0.3258 | 0.3258 |
Schistosoma mansoni | carbonic anhydrase | 0.0054 | 0.3258 | 0.3258 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.3258 | 0.3258 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0134 | 0.9115 | 0.9115 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.9115 | 0.9115 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.3258 | 0.3258 |
Loa Loa (eye worm) | cathepsin B | 0.0044 | 0.2523 | 0.2523 |
Giardia lamblia | Cathepsin B precursor | 0.0044 | 0.2523 | 0.5 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0054 | 0.3258 | 0.3258 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.001 | 0 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0054 | 0.3258 | 0.3258 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.001 | 0 | 0.5 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0146 | 1 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0146 | 1 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0146 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0146 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.001 | 0 | 0.5 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0044 | 0.2523 | 0.2523 |
Echinococcus multilocularis | carbonic anhydrase | 0.0054 | 0.3258 | 0.3258 |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0146 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.3258 | 0.3258 |
Echinococcus multilocularis | carbonic anhydrase | 0.0054 | 0.3258 | 0.3258 |
Echinococcus granulosus | carbonic anhydrase | 0.0054 | 0.3258 | 0.3258 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0134 | 0.9115 | 0.9115 |
Echinococcus granulosus | carbonic anhydrase | 0.0054 | 0.3258 | 0.3258 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0146 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0044 | 0.2523 | 0.5 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0134 | 0.9115 | 0.9115 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.