Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adrenoceptor alpha 1B | Starlite/ChEMBL | References |
Homo sapiens | adrenoceptor alpha 1A | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin 1a (5-HT1a) receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Adrenergic receptor alpha-1 | Starlite/ChEMBL | References |
Homo sapiens | adrenoceptor alpha 1D | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | bifunctional protein NCOAT | 0.0319 | 0.7459 | 1 |
Mycobacterium ulcerans | lipoprotein LpqI | 0.0231 | 0.5179 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.3458 | 0.1568 |
Echinococcus multilocularis | serotonin receptor | 0.0164 | 0.3458 | 0.4636 |
Brugia malayi | Hyaluronidase family protein | 0.0319 | 0.7459 | 0.5 |
Echinococcus granulosus | bifunctional protein NCOAT | 0.0319 | 0.7459 | 1 |
Schistosoma mansoni | Hyaluronidase | 0.0319 | 0.7459 | 0.7459 |
Mycobacterium leprae | PROBABLE CONSERVED LIPOPROTEIN LPQI | 0.0231 | 0.5179 | 0.5 |
Trichomonas vaginalis | beta-hexosaminidase, putative | 0.0231 | 0.5179 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0231 | 0.5179 | 1 |
Trichomonas vaginalis | beta-hexosaminidase, putative | 0.0231 | 0.5179 | 1 |
Echinococcus multilocularis | serotonin receptor | 0.0164 | 0.3458 | 0.4636 |
Loa Loa (eye worm) | hyaluronidase | 0.0319 | 0.7459 | 1 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0164 | 0.3458 | 0.4636 |
Schistosoma mansoni | aminopeptidase P homologue (M24 family) | 0.0319 | 0.7459 | 0.7459 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0164 | 0.3458 | 0.3458 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.3458 | 0.1568 |
Mycobacterium tuberculosis | Probable conserved lipoprotein LpqI | 0.0231 | 0.5179 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 5.93 nM | The compound was tested for binding affinity on [3H]- prazosin as specific ligand on Human cloned alpha-1A adrenergic receptor expressed in CHO cells | ChEMBL. | 9888842 |
Ki (binding) | = 5.93 nM | The compound was tested for binding affinity on [3H]- prazosin as specific ligand on Human cloned alpha-1A adrenergic receptor expressed in CHO cells | ChEMBL. | 9888842 |
Ki (binding) | = 11.9 nM | The compound was tested for binding affinity on [3H]- prazosin as specific ligand on Human cloned alpha-1D adrenergic receptor in CHO cells | ChEMBL. | 9888842 |
Ki (binding) | = 11.9 nM | The compound was tested for binding affinity on [3H]- prazosin as specific ligand on Human cloned alpha-1D adrenergic receptor in CHO cells | ChEMBL. | 9888842 |
Ki (binding) | = 13.6 nM | The compound was tested for binding affinity on [3H]- prazosin as specific ligand on Human cloned alpha-1B adrenergic receptor in CHO cells | ChEMBL. | 9888842 |
Ki (binding) | = 13.6 nM | The compound was tested for binding affinity on [3H]- prazosin as specific ligand on Human cloned alpha-1B adrenergic receptor in CHO cells | ChEMBL. | 9888842 |
Ki (binding) | = 54.6 nM | The compound was tested for binding affinity on [3H]- prazosin as specific ligand on alpha-1 adrenergic receptor cells in rat cerebral cortex | ChEMBL. | 9888842 |
Ki (binding) | = 54.6 nM | The compound was tested for binding affinity on [3H]- prazosin as specific ligand on alpha-1 adrenergic receptor cells in rat cerebral cortex | ChEMBL. | 9888842 |
Ki (binding) | = 56.5 nM | The compound was tested for binding affinity on [3H]-8-OH-DPAT as specific ligand on 5-hydroxytryptamine 1A receptor in rat hippocampus | ChEMBL. | 9888842 |
Ki (binding) | = 56.5 nM | The compound was tested for binding affinity on [3H]-8-OH-DPAT as specific ligand on 5-hydroxytryptamine 1A receptor in rat hippocampus | ChEMBL. | 9888842 |
Ratio (binding) | = 1.03 | Ratio of the binding affinities of the compound against 5-HT1A and alpha1-adrenoceptor from rat brain membranes. | ChEMBL. | 9888842 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.