Detailed information for compound 737248

Basic information

Technical information
  • TDR Targets ID: 737248
  • Name: 2-[[5-(4-bromophenyl)-4-methyl-1,2,4-triazol- 3-yl]sulfanyl]-N-(2-methoxyphenyl)acetamide
  • MW: 433.322 | Formula: C18H17BrN4O2S
  • H donors: 1 H acceptors: 3 LogP: 3.5 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1NC(=O)CSc1nnc(n1C)c1ccc(cc1)Br
  • InChi: 1S/C18H17BrN4O2S/c1-23-17(12-7-9-13(19)10-8-12)21-22-18(23)26-11-16(24)20-14-5-3-4-6-15(14)25-2/h3-10H,11H2,1-2H3,(H,20,24)
  • InChiKey: QVRIIXSYQZZOIB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[5-(4-bromophenyl)-4-methyl-1,2,4-triazol-3-yl]thio]-N-(2-methoxyphenyl)acetamide
  • 2-[[5-(4-bromophenyl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-(2-methoxyphenyl)ethanamide
  • CBKinase1_002766
  • BAS 02255295
  • AG-690/40753594
  • STK139799
  • CBKinase1_015166

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis serine:threonine protein kinase N2 0.0075 0.0452 0.0452
Echinococcus granulosus tyrosine protein kinase shark 0.028 0.5461 0.5461
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0075 0.0452 0.0452
Brugia malayi phosphoinositide-dependent protein kinase I 0.0057 0.0016 0.0016
Schistosoma mansoni serine/threonine protein kinase 0.0075 0.0452 0.0452
Echinococcus granulosus tyrosine protein kinase Src42A 0.0144 0.215 0.215
Echinococcus granulosus insulin receptor 0.011 0.1302 0.1302
Schistosoma mansoni serine/threonine protein kinase 0.0075 0.0452 0.0452
Brugia malayi Variant SH3 domain containing protein 0.0099 0.1043 0.1043
Loa Loa (eye worm) TK/EGFR protein kinase 0.0312 0.6223 0.6223
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0057 0.0016 0.0016
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0144 0.215 0.215
Brugia malayi Protein kinase domain containing protein 0.0181 0.3052 0.3052
Echinococcus granulosus nervana 2 0.0102 0.1117 0.1117
Brugia malayi Variant SH3 domain containing protein 0.0099 0.1043 0.1043
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0144 0.215 0.215
Echinococcus granulosus NCK adaptor protein 0.0099 0.1043 0.1043
Schistosoma mansoni serine/threonine-protein kinase 0.0116 0.1447 0.1447
Entamoeba histolytica protein kinase, putative 0.0177 0.2936 0.962
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0075 0.0452 0.0452
Loa Loa (eye worm) TK/FER protein kinase 0.0069 0.0313 0.0313
Brugia malayi 5'-AMP-activated protein kinase, beta subunit, complex-interacting region containing protein 0.0113 0.1374 0.1374
Brugia malayi Protein kinase domain containing protein 0.0069 0.0313 0.0313
Brugia malayi protein kinase C II. 0.0075 0.0452 0.0452
Schistosoma mansoni serine/threonine protein kinase 0.0467 1 1
Brugia malayi Tyrosine-protein kinase abl-1 0.0115 0.1443 0.1443
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0016 0.0016
Schistosoma mansoni adapter molecule crk 0.0099 0.1043 0.1043
Schistosoma mansoni serine/threonine protein kinase 0.0188 0.3201 0.3201
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0467 1 1
Echinococcus granulosus mitogen activated protein kinase 11 0.0383 0.7972 0.7972
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0144 0.215 0.215
Echinococcus multilocularis mitogen activated protein kinase 14 0.0383 0.7972 0.7972
Echinococcus multilocularis 5' AMP activated protein kinase subunit gamma 0.0211 0.3769 0.3769
Echinococcus multilocularis epidermal growth factor receptor 0.0312 0.6223 0.6223
Brugia malayi P38 map kinase family protein 2 0.0383 0.7972 0.7972
Onchocerca volvulus 0.0069 0.0313 0.1322
Loa Loa (eye worm) TK/ABL protein kinase 0.0069 0.0313 0.0313
Echinococcus granulosus Protein kinase C brain isozyme 0.0075 0.0452 0.0452
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0144 0.215 0.215
Loa Loa (eye worm) TK/FER protein kinase 0.0069 0.0313 0.0313
Echinococcus multilocularis NCK adaptor protein 0.0099 0.1043 0.1043
Trypanosoma brucei 5'-AMP-activated protein kinase subunit beta 0.0113 0.1374 0.1723
Trichomonas vaginalis AGC family protein kinase 0.0181 0.3052 1
Onchocerca volvulus Alicorn homolog 0.0098 0.1027 0.4335
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0086 0.073 0.2393
Echinococcus granulosus 5' AMP activated protein kinase subunit gamma 0.0232 0.4278 0.4278
Brugia malayi 5'-AMP-activated protein kinase, beta subunit, complex-interacting region containing protein 0.0113 0.1374 0.1374
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0102 0.1117 0.1117
Echinococcus multilocularis mitogen activated protein kinase 14 0.0383 0.7972 0.7972
Loa Loa (eye worm) TK/FER protein kinase 0.0069 0.0313 0.0313
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0144 0.215 0.215
Trypanosoma brucei Casein kinase II 0.0142 0.2084 0.2615
Echinococcus multilocularis 5' AMP activated protein kinase subunit gamma 0.0232 0.4278 0.4278
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0244 0.4583 0.4583
Echinococcus granulosus tyrosine protein kinase Src42A 0.0082 0.0619 0.0619
Echinococcus multilocularis tyrosine protein kinase Srms 0.0098 0.102 0.102
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0099 0.1043 0.1043
Trichomonas vaginalis AGC family protein kinase 0.0181 0.3052 1
Trichomonas vaginalis AGC family protein kinase 0.0057 0.0016 0.0052
Entamoeba histolytica protein kinase, putative 0.0181 0.3052 1
Schistosoma mansoni serine/threonine protein kinase 0.0244 0.4583 0.4583
Echinococcus granulosus tyrosine protein kinase ABL1 0.0069 0.0313 0.0313
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0188 0.3201 0.3201
Schistosoma mansoni tyrosine kinase 0.0174 0.2877 0.2877
Schistosoma mansoni serine/threonine kinase 0.0075 0.0452 0.0452
Loa Loa (eye worm) TK/FER protein kinase 0.0069 0.0313 0.0313
Loa Loa (eye worm) TK/FER protein kinase 0.0069 0.0313 0.0313
Onchocerca volvulus 0.0069 0.0313 0.1322
Schistosoma mansoni serine/threonine protein kinase 0.0075 0.0452 0.0452
Brugia malayi Protein kinase domain containing protein 0.0069 0.0313 0.0313
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0467 1 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0144 0.215 0.215
Entamoeba histolytica protein kinase, putative 0.0061 0.0127 0.0415
Trichomonas vaginalis CMGC family protein kinase 0.0142 0.2084 0.6828
Trypanosoma cruzi casein kinase II, putative 0.0142 0.2084 0.2615
Echinococcus granulosus tyrosine protein kinase Srms 0.0069 0.0313 0.0313
Loa Loa (eye worm) TK/FER protein kinase 0.0069 0.0313 0.0313
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0098 0.102 0.102
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0075 0.0452 0.0452
Echinococcus granulosus nervana 2 0.0102 0.1117 0.1117
Echinococcus granulosus serine/threonine protein kinase 0.0116 0.1447 0.1447
Brugia malayi Hr1 repeat family protein 0.0075 0.0452 0.0452
Trypanosoma brucei rac serine-threonine kinase, putative 0.0181 0.3052 0.3829
Schistosoma mansoni growth factor receptor-bound protein 0.0099 0.1043 0.1043
Loa Loa (eye worm) SRC-1 0.0144 0.215 0.215
Trichomonas vaginalis AGC family protein kinase 0.0181 0.3052 1
Echinococcus granulosus serine:threonine protein kinase N2 0.0075 0.0452 0.0452
Trichomonas vaginalis CMGC family protein kinase 0.0142 0.2084 0.6828
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0144 0.215 0.215
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0098 0.102 0.102
Schistosoma mansoni tyrosine kinase 0.0174 0.2877 0.2877
Brugia malayi SH2 domain containing protein 0.0069 0.0313 0.0313
Loa Loa (eye worm) TK/INSR protein kinase 0.011 0.1302 0.1302
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0075 0.0452 0.0452
Onchocerca volvulus 0.0153 0.2368 1
Echinococcus multilocularis epidermal growth factor receptor 0.0174 0.2877 0.2877
Trichomonas vaginalis AGC family protein kinase 0.0181 0.3052 1
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.011 0.1302 0.1302
Brugia malayi Sex muscle abnormal protein 5 0.0099 0.1043 0.1043
Brugia malayi Casein kinase II, alpha chain 0.0142 0.2084 0.2084
Echinococcus multilocularis tyrosine kinase 0.0069 0.0313 0.0313
Schistosoma mansoni tyrosine kinase 0.028 0.5461 0.5461
Loa Loa (eye worm) TK/FER protein kinase 0.0069 0.0313 0.0313
Echinococcus multilocularis AMPK beta subunit 0.0113 0.1374 0.1374
Echinococcus granulosus insulin growth factor 1 receptor beta 0.011 0.1302 0.1302
Schistosoma mansoni serine/threonine-protein kinase 0.0116 0.1447 0.1447
Brugia malayi Variant SH3 domain containing protein 0.0057 0.0029 0.0029
Schistosoma mansoni tyrosine kinase 0.0158 0.2476 0.2476
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0075 0.0452 0.0452
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0188 0.3201 0.3201
Trichomonas vaginalis AGC family protein kinase 0.0181 0.3052 1
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0075 0.0452 0.0452
Trichomonas vaginalis AGC family protein kinase 0.0095 0.0945 0.3095
Echinococcus granulosus tyrosine protein kinase Lyn 0.0153 0.2364 0.2364
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0144 0.215 0.215
Echinococcus granulosus protein kinase C gamma type 0.0075 0.0452 0.0452
Leishmania major casein kinase II, putative 0.0142 0.2084 0.2615
Echinococcus granulosus c src tyrosine kinase 0.0115 0.1443 0.1443
Schistosoma mansoni serine/threonine protein kinase 0.0075 0.0452 0.0452
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0379 0.7875 0.7875
Brugia malayi loechrig isoform VII 0.0232 0.4278 0.4278
Brugia malayi p70 ribosomal S6 kinase beta 0.0177 0.2936 0.2936
Toxoplasma gondii CMGC kinase, CK2 family 0.0142 0.2084 0.7098
Echinococcus granulosus tyrosine kinase 0.0098 0.102 0.102
Echinococcus granulosus epidermal growth factor receptor 0.0312 0.6223 0.6223
Trichomonas vaginalis CMGC family protein kinase 0.0142 0.2084 0.6828
Brugia malayi Protein kinase domain containing protein 0.0057 0.0016 0.0016
Entamoeba histolytica protein kinase, putative 0.0057 0.0016 0.0052
Echinococcus multilocularis serine threonine protein kinase 0.0075 0.0452 0.0452
Brugia malayi hypothetical protein 0.0069 0.0313 0.0313
Schistosoma mansoni tyrosine kinase 0.0144 0.215 0.215
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0144 0.215 0.215
Trypanosoma cruzi SNF1-related protein kinase regulatory subunit beta, putative 0.0113 0.1374 0.1723
Echinococcus multilocularis Glutaredoxin protein 5 0.0102 0.1117 0.1117
Schistosoma mansoni protein kinase 0.0142 0.2084 0.2084
Echinococcus granulosus epidermal growth factor receptor 0.0174 0.2877 0.2877
Loa Loa (eye worm) AGC/NDR protein kinase 0.0075 0.0452 0.0452
Echinococcus multilocularis rac serine:threonine kinase 0.0116 0.1447 0.1447
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0099 0.1043 0.1043
Echinococcus granulosus serine threonine protein kinase nrc 0.0111 0.1331 0.1331
Brugia malayi SRC-1 0.0144 0.215 0.215
Echinococcus multilocularis rho associated protein kinase 0.0153 0.2368 0.2368
Schistosoma mansoni tyrosine kinase 0.0158 0.2476 0.2476
Brugia malayi Protein kinase domain containing protein 0.0069 0.0313 0.0313
Echinococcus multilocularis 5' AMP activated protein kinase subunit beta 1 0.006 0.0103 0.0103
Trichomonas vaginalis AGC family protein kinase 0.0181 0.3052 1
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0244 0.4583 0.4583
Entamoeba histolytica PH domain containing protein kinase, putative 0.0116 0.1447 0.474
Schistosoma mansoni tyrosine kinase 0.0312 0.6223 0.6223
Loa Loa (eye worm) TK/FER protein kinase 0.0069 0.0313 0.0313
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0102 0.1117 0.1117
Plasmodium falciparum casein kinase 2, alpha subunit 0.0142 0.2084 1
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0069 0.0313 0.1025
Schistosoma mansoni protein kinase subunit beta 0.0113 0.1374 0.1374
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0379 0.7875 0.7875
Loa Loa (eye worm) AGC/PKN protein kinase 0.0075 0.0452 0.0452
Loa Loa (eye worm) 5'-AMP-activated protein kinase 0.0113 0.1374 0.1374
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0244 0.4583 0.4583
Brugia malayi Protein kinase domain containing protein 0.0175 0.2892 0.2892
Onchocerca volvulus 0.0069 0.0313 0.1322
Echinococcus granulosus tyrosine protein kinase Fyn 0.0144 0.215 0.215
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0082 0.0619 0.0619
Giardia lamblia Kinase, AGC PKA 0.0111 0.1331 0.3111
Echinococcus multilocularis serine:threonine protein kinase N2 0.0075 0.0452 0.0452
Loa Loa (eye worm) hypothetical protein 0.0069 0.0313 0.0313
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0075 0.0452 0.0452
Trichomonas vaginalis CMGC family protein kinase 0.0142 0.2084 0.6828
Echinococcus granulosus growth factor receptor bound protein 2 0.0099 0.1043 0.1043
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0383 0.7972 0.7972
Loa Loa (eye worm) hypothetical protein 0.0099 0.1043 0.1043
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0111 0.1331 0.1331
Giardia lamblia 5-AMP-activated protein kinase, beta-1 subunit 0.0113 0.1374 0.3211
Schistosoma mansoni serine/threonine protein kinase 0.0075 0.0452 0.0452
Schistosoma mansoni protein kinase subunit beta 0.006 0.0103 0.0103
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0142 0.2084 0.2084
Plasmodium vivax unspecified product 0.0142 0.2084 1
Trichomonas vaginalis AGC family protein kinase 0.0057 0.0016 0.0052
Echinococcus multilocularis growth factor receptor bound protein 2 0.0099 0.1043 0.1043
Schistosoma mansoni atypical protein kinase C 0.0075 0.0452 0.0452
Entamoeba histolytica PH domain containing protein kinase, putative 0.0116 0.1447 0.474
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0075 0.0452 0.0452
Schistosoma mansoni tyrosine kinase 0.0144 0.215 0.215
Echinococcus granulosus protein kinase c epsilon type 0.0075 0.0452 0.0452
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0383 0.7972 1
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0383 0.7972 1
Trichomonas vaginalis AGC family protein kinase 0.01 0.1061 0.3475
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0099 0.1043 0.1043
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0111 0.1331 0.1669
Onchocerca volvulus 0.0069 0.0313 0.1322
Leishmania major hypothetical protein, conserved 0.0113 0.1374 0.1723
Trichomonas vaginalis AGC family protein kinase 0.0075 0.0452 0.148
Schistosoma mansoni serine/threonine protein kinase 0.0175 0.2892 0.2892
Echinococcus multilocularis insulin receptor 0.011 0.1302 0.1302
Echinococcus multilocularis protein kinase c iota type 0.0075 0.0452 0.0452
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0188 0.3201 0.3201
Echinococcus multilocularis serine:threonine protein kinase 38 0.0075 0.0452 0.0452
Toxoplasma gondii AGC kinase 0.0177 0.2936 1
Onchocerca volvulus 0.0145 0.2154 0.9095
Echinococcus granulosus tyrosine protein kinase Fyn 0.0144 0.215 0.215
Echinococcus multilocularis protein kinase c epsilon type 0.0075 0.0452 0.0452
Onchocerca volvulus 0.0069 0.0313 0.1322
Echinococcus multilocularis tyrosine protein kinase shark 0.028 0.5461 0.5461
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0383 0.7972 1
Schistosoma mansoni vav2 0.0057 0.0029 0.0029
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0115 0.1443 0.1443
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0174 0.2877 0.2877
Trichomonas vaginalis CMGC family protein kinase 0.0142 0.2084 0.6828
Schistosoma mansoni tyrosine kinase 0.0228 0.418 0.418
Trichomonas vaginalis CMGC family protein kinase 0.0142 0.2084 0.6828
Brugia malayi protein-tyrosine kinase 0.0098 0.102 0.102
Echinococcus granulosus Glutaredoxin protein 5 0.0102 0.1117 0.1117
Loa Loa (eye worm) AGC/AKT protein kinase 0.0181 0.3052 0.3052
Echinococcus granulosus tyrosine protein kinase Src64B 0.0144 0.215 0.215
Schistosoma mansoni tyrosine kinase 0.0333 0.6745 0.6745
Entamoeba histolytica protein kinase 2, putative 0.0111 0.1331 0.436
Schistosoma mansoni tyrosine kinase 0.011 0.1302 0.1302
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0175 0.2892 0.2892
Echinococcus multilocularis casein kinase ii subunit alpha 0.0142 0.2084 0.2084
Schistosoma mansoni tyrosine kinase 0.0115 0.1443 0.1443
Echinococcus granulosus 5' AMP activated protein kinase subunit beta 1 0.006 0.0103 0.0103
Echinococcus granulosus casein kinase ii subunit alpha 0.0142 0.2084 0.2084
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0383 0.7972 1
Entamoeba histolytica protein kinase domain containing protein 0.0142 0.2084 0.6828
Schistosoma mansoni tyrosine kinase 0.0115 0.1443 0.1443
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0057 0.0016 0.0016
Echinococcus granulosus mitogen activated protein kinase 14 0.0383 0.7972 0.7972
Brugia malayi map kinase activated protein kinase protein 2 0.0188 0.3201 0.3201
Echinococcus multilocularis nervana 2 0.0102 0.1117 0.1117
Schistosoma mansoni tyrosine kinase 0.011 0.1302 0.1302
Echinococcus multilocularis c src tyrosine kinase 0.0115 0.1443 0.1443
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0069 0.0313 0.0313
Schistosoma mansoni serine/threonine protein kinase 0.0063 0.0163 0.0163
Onchocerca volvulus 0.0069 0.0313 0.1322
Trichomonas vaginalis AGC family protein kinase 0.0181 0.3052 1
Echinococcus multilocularis tyrosine protein kinase Abl 0.0115 0.1443 0.1443
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0069 0.0313 0.0313
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0142 0.2084 1
Brugia malayi Protein kinase domain containing protein 0.0095 0.0945 0.0945
Schistosoma mansoni nck2/grb4 0.0099 0.1043 0.1043
Giardia lamblia 5-AMP-activated protein kinase, gamma-1 subunit 0.0232 0.4278 1
Schistosoma mansoni tyrosine kinase 0.0158 0.2476 0.2476
Loa Loa (eye worm) hypothetical protein 0.0075 0.0452 0.0452
Brugia malayi Protein kinase domain containing protein 0.011 0.1302 0.1302
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0116 0.1447 0.1815
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0095 0.0945 0.0945
Brugia malayi Protein kinase domain containing protein 0.0459 0.9804 0.9804
Trypanosoma cruzi Protein kinase B 0.0116 0.1447 0.1815
Echinococcus granulosus rho-associated protein kinase 1 0.0153 0.2368 0.2368
Entamoeba histolytica casein kinase, putative 0.0142 0.2084 0.6828
Loa Loa (eye worm) hypothetical protein 0.0057 0.0029 0.0029
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0111 0.1331 0.6385
Echinococcus multilocularis nervana 2 0.0102 0.1117 0.1117
Echinococcus multilocularis 0.0092 0.087 0.087
Schistosoma mansoni serine/threonine protein kinase 0.0075 0.0452 0.0452
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0459 0.9804 0.9804
Schistosoma mansoni serine/threonine protein kinase 0.0153 0.2368 0.2368
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0177 0.2936 0.2936
Echinococcus granulosus tyrosine protein kinase Blk 0.0098 0.102 0.102
Brugia malayi SH2 domain containing protein 0.0069 0.0313 0.0313
Echinococcus granulosus AMPK beta subunit 0.0113 0.1374 0.1374
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0061 0.0127 0.0415
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0244 0.4583 0.4583
Trichomonas vaginalis CMGC family protein kinase 0.0142 0.2084 0.6828
Trichomonas vaginalis AGC family protein kinase 0.0095 0.0945 0.3095
Loa Loa (eye worm) TK protein kinase 0.0098 0.102 0.102
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0111 0.1331 0.6385
Loa Loa (eye worm) TK/FER protein kinase 0.0069 0.0313 0.0313
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0144 0.215 0.215
Echinococcus granulosus tyrosine kinase 0.0069 0.0313 0.0313
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0075 0.0452 0.0452
Echinococcus multilocularis mitogen activated protein kinase 11 0.0383 0.7972 0.7972
Loa Loa (eye worm) loechrig isoform VII 0.0232 0.4278 0.4278
Trypanosoma cruzi 5'-AMP-activated protein kinase subunit beta, putative 0.0113 0.1374 0.1723
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0057 0.0029 0.0029
Schistosoma mansoni protein kinase subunit gamma 0.0232 0.4278 0.4278
Entamoeba histolytica protein kinase, putative 0.0075 0.0452 0.148
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0144 0.215 0.215
Giardia lamblia Kinase, CMGC CK2 0.0142 0.2084 0.4873
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0111 0.1331 0.1331
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0057 0.0016 0.0016
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0144 0.215 0.215
Echinococcus granulosus protein kinase c iota type 0.0075 0.0452 0.0452
Echinococcus multilocularis tyrosine protein kinase Blk 0.0098 0.102 0.102
Schistosoma mansoni growth factor receptor-bound protein 0.0099 0.1043 0.1043
Echinococcus multilocularis mitogen activated protein kinase 11 0.0383 0.7972 0.7972
Schistosoma mansoni serine/threonine protein kinase 0.0075 0.0452 0.0452
Echinococcus granulosus NDR protein kinase 0.0075 0.0452 0.0452
Brugia malayi Furin-like cysteine rich region family protein 0.0312 0.6223 0.6223
Loa Loa (eye worm) TK/FER protein kinase 0.0069 0.0313 0.0313
Echinococcus granulosus c-Jun N-terminal kinases 0.0467 1 1
Toxoplasma gondii 5'-AMP-activated protein kinase subunit beta-1 family protein, putative 0.0066 0.025 0.085
Entamoeba histolytica protein kinase, putative 0.0181 0.3052 1
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0057 0.0016 0.0016
Brugia malayi Protein kinase domain containing protein 0.0075 0.0452 0.0452
Trichomonas vaginalis AGC family protein kinase 0.0057 0.0016 0.0052
Brugia malayi Protein kinase domain containing protein 0.0069 0.0313 0.0313
Brugia malayi Protein kinase domain containing protein 0.0069 0.0313 0.0313
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0075 0.0452 0.0452
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0069 0.0313 0.0313

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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