Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | sodium/solute symporter | 0.0038 | 0.085 | 0.0908 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.085 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.029 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0433 | 0.5091 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.029 | 1 | 0.5 |
Echinococcus multilocularis | sodium coupled monocarboxylate transporter 1 | 0.0038 | 0.085 | 0.0908 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.029 | 1 | 0.5 |
Schistosoma mansoni | inositol transporter | 0.0148 | 0.485 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.029 | 1 | 0.5 |
Schistosoma mansoni | high-affinity choline transporter | 0.0038 | 0.085 | 0.0908 |
Echinococcus granulosus | high affinity choline transporter 1 | 0.0038 | 0.085 | 0.0908 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.029 | 1 | 0.5 |
Echinococcus granulosus | solute carrier family 5 | 0.0148 | 0.485 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.029 | 1 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.0451 | 0.53 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0451 | 0.53 |
Mycobacterium leprae | conserved hypothetical protein | 0.0169 | 0.5589 | 1 |
Brugia malayi | Sodium:solute symporter family protein | 0.0038 | 0.085 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0169 | 0.5589 | 1 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.029 | 1 | 0.5 |
Echinococcus granulosus | sodium:myo inositol cotransporter | 0.0148 | 0.485 | 1 |
Echinococcus multilocularis | high affinity choline transporter 1 | 0.0038 | 0.085 | 0.0908 |
Echinococcus granulosus | sodium coupled monocarboxylate transporter 1 | 0.0038 | 0.085 | 0.0908 |
Toxoplasma gondii | transporter, solute:sodium symporter (SSS) family protein | 0.0038 | 0.085 | 0.5 |
Brugia malayi | GH02984p | 0.0038 | 0.085 | 1 |
Echinococcus multilocularis | sodium:glucose cotransporter 2 | 0.0148 | 0.485 | 1 |
Onchocerca volvulus | 0.0038 | 0.085 | 1 | |
Mycobacterium tuberculosis | Conserved protein | 0.0169 | 0.5589 | 1 |
Echinococcus multilocularis | sodium:myo inositol cotransporter | 0.0148 | 0.485 | 1 |
Echinococcus granulosus | sodium:glucose cotransporter 2 | 0.0148 | 0.485 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.0451 | 0.53 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.029 | 1 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0169 | 0.5589 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.085 | 1 |
Echinococcus granulosus | sodium:glucose cotransporter | 0.0148 | 0.485 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.0451 | 0.53 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.0451 | 0.53 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.029 | 1 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.029 | 1 | 0.5 |
Echinococcus multilocularis | solute carrier family 5 | 0.0148 | 0.485 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.029 | 1 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0169 | 0.5589 | 1 |
Schistosoma mansoni | inositol transporter | 0.0148 | 0.485 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 11 uM | The compound was tested for potency by measuring the concentration (micromolar) that gives 1% clonogenic cell survival in hypoxia | ChEMBL. | 7752202 |
Selectivity (ADMET) | = 50 | Hypoxia cytotoxicity ratio (dose in air / hypoxia giving 99% of cell killing) | ChEMBL. | 7752202 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.