Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Glutamate receptor ionotropic, AMPA | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | Hyaluronidase | 0.0582 | 0.9367 | 0.9365 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0036 | 0.0124 | 0.0104 |
Chlamydia trachomatis | glutamine binding protein | 0.0029 | 0 | 0.5 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0036 | 0.0124 | 0.0104 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0029 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0247 | 0.37 | 0.3932 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0029 | 0 | 0.5 |
Echinococcus granulosus | glutamate receptor 2 | 0.0036 | 0.0124 | 0.0104 |
Brugia malayi | Hyaluronidase family protein | 0.0582 | 0.9367 | 1 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0036 | 0.0124 | 0.0098 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0036 | 0.0124 | 0.0104 |
Echinococcus multilocularis | bifunctional protein NCOAT | 0.0582 | 0.9367 | 1 |
Loa Loa (eye worm) | hyaluronidase | 0.0582 | 0.9367 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0036 | 0.0124 | 0.0104 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0036 | 0.0124 | 0.0104 |
Schistosoma mansoni | aminopeptidase P homologue (M24 family) | 0.0582 | 0.9367 | 0.9365 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0036 | 0.0124 | 0.0104 |
Echinococcus granulosus | nmda type glutamate receptor | 0.004 | 0.019 | 0.0175 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.004 | 0.019 | 0.0175 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.004 | 0.019 | 0.0175 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0029 | 0 | 0.5 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0036 | 0.0124 | 0.0104 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0029 | 0 | 0.5 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0029 | 0 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0036 | 0.0124 | 0.0104 |
Echinococcus granulosus | bifunctional protein NCOAT | 0.0582 | 0.9367 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0036 | 0.0124 | 0.0104 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 433 nM | Ability to block kainate-induced 45 [Ca2+] influx through functional assay of Ionotropic glutamate receptor AMPA activity in rat cerebellar granule cells | ChEMBL. | 11206453 |
IC50 (functional) | = 433 nM | Ability to block kainate-induced 45 [Ca2+] influx through functional assay of Ionotropic glutamate receptor AMPA activity in rat cerebellar granule cells | ChEMBL. | 11206453 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.