Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Adrenergic receptor alpha-1 | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Displacement (binding) | % | Percent displacement of [3H]-clonidine from alpha2-adrenoceptor in rat brain homogenates at 10E-6 M ; Activity of less than 50%. | ChEMBL. | 2888896 |
Displacement (binding) | 0 % | Percent displacement of [3H]-clonidine from alpha2-adrenoceptor in rat brain homogenates at 10E-6 M ; Activity of less than 50%. | ChEMBL. | 2888896 |
Ki (binding) | = 0.27 nM | Binding affinity against alpha1-adrenoceptor in rat brain homogenates [3H]-prazosin displacement. | ChEMBL. | 2888896 |
Ki (binding) | = 0.27 nM | Binding affinity against alpha1-adrenoceptor in rat brain homogenates [3H]-prazosin displacement. | ChEMBL. | 2888896 |
Reduction (functional) | = 12 % | Antihypertensive activity was determined by percent reduction in blood pressure after 4 hr upon per oral administration of 3 mg/kg dose in spontaneously hypertensive rats(SHR). | ChEMBL. | 2888896 |
Reduction (functional) | = 21 % | Antihypertensive activity was determined by percent reduction in blood pressure after 1 hr upon per oral administration of 5 mg/kg dose in spontaneously hypertensive rats(SHR). | ChEMBL. | 2888896 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.