Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | sterol 24-c-methyltransferase, putative | 0.0377 | 0.2984 | 0.2708 |
Echinococcus multilocularis | geminin | 0.0166 | 0.1042 | 0.1537 |
Leishmania major | sterol 24-c-methyltransferase, putative | 0.0377 | 0.2984 | 0.2943 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0183 | 0.1198 | 0.2667 |
Leishmania major | C-14 sterol reductase, putative | 0.0094 | 0.0378 | 0.0322 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0059 | 0.0058 | 0.5 |
Trypanosoma brucei | Emopamil binding protein, putative | 0.0283 | 0.2125 | 0.1815 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.054 | 0.4494 | 1 |
Trypanosoma brucei | sterol 24-c-methyltransferase, putative | 0.0377 | 0.2984 | 0.2708 |
Leishmania major | lanosterol synthase, putative | 0.0323 | 0.2489 | 0.2445 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.0058 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0582 | 0.4873 | 0.4873 |
Mycobacterium tuberculosis | Halimadienyl diphosphate synthase | 0.0212 | 0.1463 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0184 | 0.1205 | 0.1205 |
Trypanosoma cruzi | Emopamil binding protein, putative | 0.0283 | 0.2125 | 0.1815 |
Leishmania major | C-8 sterol isomerase-like protein | 0.1138 | 1 | 1 |
Echinococcus granulosus | lamin b receptor | 0.0094 | 0.0378 | 0.0841 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.1138 | 1 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.0058 | 0.0272 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.1138 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.1042 | 0.4933 |
Leishmania major | hypothetical protein, conserved | 0.0283 | 0.2125 | 0.2079 |
Brugia malayi | S-adenosyl-methionine cycloartenol-C24-methyltransferase | 0.0184 | 0.1205 | 0.1205 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.054 | 0.4494 | 0.6625 |
Schistosoma mansoni | Lamin B receptor (ERG24) | 0.0094 | 0.0378 | 0.1789 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0059 | 0.0058 | 0.0085 |
Trypanosoma cruzi | Emopamil binding protein, putative | 0.0283 | 0.2125 | 0.1815 |
Leishmania major | 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative | 0.0283 | 0.2125 | 0.2079 |
Echinococcus multilocularis | lamin b receptor | 0.0094 | 0.0378 | 0.0557 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0059 | 0.0058 | 0.0128 |
Trypanosoma cruzi | sterol 24-c-methyltransferase, putative | 0.0377 | 0.2984 | 0.2708 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0789 | 0.6784 | 1 |
Leishmania major | sterol 24-c-methyltransferase, putative | 0.0377 | 0.2984 | 0.2943 |
Trypanosoma cruzi | 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative | 0.0283 | 0.2125 | 0.1815 |
Loa Loa (eye worm) | hypothetical protein | 0.1138 | 1 | 1 |
Trypanosoma cruzi | sterol 24-c-methyltransferase, putative | 0.0377 | 0.2984 | 0.2708 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.1042 | 0.4933 |
Trypanosoma cruzi | lanosterol synthase, putative | 0.0344 | 0.268 | 0.2392 |
Trypanosoma cruzi | sterol 24-c-methyltransferase, putative | 0.0377 | 0.2984 | 0.2708 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.0058 | 0.0272 |
Echinococcus granulosus | geminin | 0.0166 | 0.1042 | 0.2319 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0183 | 0.1198 | 0.1767 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.0058 | 0.5 |
Trypanosoma brucei | sterol 24-c-methyltransferase, putative | 0.0196 | 0.1323 | 0.0982 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.0058 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0282 | 0.2113 | 1 |
Trypanosoma brucei | Sterol methyltransferase, putative | 0.0377 | 0.2984 | 0.2708 |
Onchocerca volvulus | 0.0283 | 0.2125 | 0.5 | |
Trypanosoma cruzi | lanosterol synthase, putative | 0.0344 | 0.268 | 0.2392 |
Trypanosoma brucei | lanosterol synthase | 0.0344 | 0.268 | 0.2392 |
Trypanosoma cruzi | 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative | 0.0283 | 0.2125 | 0.1815 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.