Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | methionine tRNA synthetase | 0.006 | 1 | 1 |
Plasmodium falciparum | methionine--tRNA ligase | 0.006 | 1 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.005 | 0.5598 | 0.5598 |
Echinococcus multilocularis | methionine tRNA synthetase | 0.006 | 1 | 1 |
Trypanosoma brucei | methionyl-tRNA synthetase, putative | 0.006 | 1 | 0.5 |
Loa Loa (eye worm) | methionyl-tRNA synthetase | 0.006 | 1 | 1 |
Giardia lamblia | Methionyl-tRNA synthetase | 0.006 | 1 | 0.5 |
Mycobacterium leprae | Probable methionyl-tRNA synthase MetS | 0.006 | 1 | 0.5 |
Plasmodium vivax | methionine--tRNA ligase, putative | 0.006 | 1 | 0.5 |
Onchocerca volvulus | 0.0037 | 0 | 0.5 | |
Schistosoma mansoni | methionine-tRNA synthetase | 0.006 | 1 | 1 |
Toxoplasma gondii | methionyl-tRNA synthetase | 0.006 | 1 | 0.5 |
Mycobacterium ulcerans | methionyl-tRNA synthetase | 0.006 | 1 | 0.5 |
Trypanosoma cruzi | methionyl-tRNA synthetase, putative | 0.006 | 1 | 0.5 |
Mycobacterium tuberculosis | Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) | 0.006 | 1 | 0.5 |
Trichomonas vaginalis | methionine-tRNA synthetase, putative | 0.006 | 1 | 0.5 |
Leishmania major | methionyl-tRNA synthetase, putative | 0.006 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | methionyl-tRNA synthetase | 0.006 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.