Detailed information for compound 77694

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 582.587 | Formula: C26H22F4N2O5S2
  • H donors: 2 H acceptors: 4 LogP: 5.7 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: C[C@@H]1Oc2ccc(cc2[C@H]([C@H]1Cc1cccc(c1)NS(=O)(=O)C(F)(F)F)O)OCc1nc2c(s1)ccc(c2)F
  • InChi: 1S/C26H22F4N2O5S2/c1-14-19(10-15-3-2-4-17(9-15)32-39(34,35)26(28,29)30)25(33)20-12-18(6-7-22(20)37-14)36-13-24-31-21-11-16(27)5-8-23(21)38-24/h2-9,11-12,14,19,25,32-33H,10,13H2,1H3/t14-,19-,25-/m0/s1
  • InChiKey: OQMSTTQHFRKDFE-AOXIIXCZSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cysteinyl leukotriene receptor 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0162 0.0952 0.1471
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0252 0.0345
Trypanosoma cruzi eukaryotic translation initiation factor 4E (eIF4E) interacting protein, putative 0.0103 0.0545 0.0752
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.006 0.0252 0.0345
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0252 0.0345
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0191 0.0203
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.0864 0.5779 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0156 0.091 0.9557
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0153 0.0888 0.1534
Leishmania major hypothetical protein, conserved 0.0089 0.0453 0.078
Leishmania major hypothetical protein, conserved 0.006 0.0252 0.0433
Onchocerca volvulus 0.0025 0.0006 0.0029
Schistosoma mansoni cercarial elastase (S01 family) 0.0025 0.0006 0.0006
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.006 0.0252 0.0252
Trichomonas vaginalis conserved hypothetical protein 0.0103 0.0545 0.0858
Onchocerca volvulus 0.0025 0.0006 0.0029
Trypanosoma cruzi Adenine phosphoribosyltransferase, putative 0.0047 0.0158 0.0066
Mycobacterium ulcerans two component sensory transduction transcriptional regulatory protein MtrA 0.0032 0.0054 0.0438
Mycobacterium ulcerans two component sensory transduction protein RegX3 0.0032 0.0054 0.0438
Schistosoma mansoni cercarial elastase (S01 family) 0.0025 0.0006 0.0006
Trichomonas vaginalis Ribose-phosphate pyrophosphokinase, putative 0.0047 0.0158 0.018
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0252 0.0433
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative 0.0199 0.1206 0.192
Plasmodium falciparum orotidine 5'-phosphate decarboxylase 0.0113 0.0617 0.5104
Mycobacterium ulcerans two component regulator receiver domain-containing protein 0.0032 0.0054 0.0438
Trypanosoma cruzi hypothetical protein, conserved 0.006 0.0252 0.0233
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.006 0.0252 0.0345
Toxoplasma gondii hypoxanthine-xanthine-guanine phosphoribosyl transferase HXGPRT 0.0199 0.1206 0.2085
Brugia malayi translation initiation factor 4E 0.0864 0.5779 0.6141
Entamoeba histolytica hypothetical protein 0.0103 0.0545 0.0941
Loa Loa (eye worm) TK/ROR protein kinase 0.0089 0.0453 0.0481
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.006 0.0252 0.2077
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.006 0.0252 0.0345
Giardia lamblia hypothetical protein 0.006 0.0252 0.0899
Toxoplasma gondii RNA-directed DNA polymerase 0.0087 0.0438 0.0756
Treponema pallidum protein-glutamate methylesterase (cheB) 0.0032 0.0054 0.3385
Entamoeba histolytica eukaryotic initiation factor 4E, putative 0.0103 0.0545 0.0941
Plasmodium vivax orotate phosphoribosyltransferase, putative 0.0097 0.0501 0.4146
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0282 0.2328
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.006 0.0252 0.0233
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0153 0.0888 0.0943
Onchocerca volvulus 0.0025 0.0006 0.0029
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0252 0.0433
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.006 0.0252 0.0899
Plasmodium vivax phosphodiesterase gamma, putative 0.006 0.0252 0.2077
Schistosoma mansoni hypothetical protein 0.0089 0.0453 0.0453
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0103 0.0545 0.0941
Entamoeba histolytica translation initiation factor 4e, putative 0.0103 0.0545 0.0941
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0162 0.0952 1
Echinococcus granulosus hypoxanthine guanine phosphoribosyltransferase 0.0199 0.1206 0.2079
Mycobacterium tuberculosis Conserved hypothetical protein 0.0047 0.0158 0.1641
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0252 0.0345
Trypanosoma cruzi orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative 0.016 0.0937 0.1444
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.006 0.0252 0.0345
Onchocerca volvulus 0.0025 0.0006 0.0029
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0032 0.0054 0.0555
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0252 0.0345
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0153 0.0888 0.1527
Giardia lamblia hypothetical protein 0.0103 0.0545 0.3698
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.185 0.3056
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.0282 0.2951
Brugia malayi Eukaryotic translation initiation factor 4E type 3, putative 0.0103 0.0545 0.058
Plasmodium falciparum orotate phosphoribosyltransferase 0.0097 0.0501 0.4146
Brugia malayi hypothetical protein 0.0252 0.157 0.1669
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0252 0.0433
Mycobacterium leprae TWO COMPONENT RESPONSE TRANSCRIPTIONAL REGULATORY PROTEIN PRRA 0.0032 0.0054 0.0555
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0138 0.079 0.1364
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.006 0.0252 0.0426
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative 0.0199 0.1206 0.192
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.0282 0.0485
Leishmania major guanosine monophosphate reductase 0.0162 0.0952 0.1645
Loa Loa (eye worm) GMP reductase 0.0067 0.03 0.0319
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0252 0.0433
Leishmania major eukaryotic translation initiation factor, putative 0.0103 0.0545 0.0941
Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferase 0.0047 0.0158 0.0158
Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferase 0.0199 0.1206 0.1206
Plasmodium falciparum cGMP-specific phosphodiesterase 0.006 0.0252 0.2077
Loa Loa (eye worm) hypothetical protein 0.0029 0.0038 0.004
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0864 0.5779 1
Schistosoma mansoni hypothetical protein 0.0025 0.0006 0.0006
Brugia malayi Adenine phosphoribosyltransferase 0.0047 0.0158 0.0167
Mycobacterium tuberculosis Conserved hypothetical protein 0.0154 0.0897 0.9421
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0252 0.0433
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.006 0.0252 0.0345
Trypanosoma cruzi Adenine phosphoribosyltransferase, putative 0.0047 0.0158 0.0066
Plasmodium falciparum telomerase reverse transcriptase 0.0087 0.0438 0.3626
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0152 0.0886 0.7341
Echinococcus multilocularis expressed protein 0.0398 0.2573 0.4447
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0153 0.0888 0.1527
Treponema pallidum chemotaxis response regulator (cheY) 0.0032 0.0054 0.3385
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.006 0.0252 0.0268
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0252 0.0345
Brugia malayi GTP-binding protein, identical 0.0149 0.0859 0.0913
Loa Loa (eye worm) eukaryotic translation initiation factor 4E type 3 0.0103 0.0545 0.058
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0864 0.5779 1
Schistosoma mansoni sensor histidine kinase/response regulator 0.0032 0.0054 0.0054
Trypanosoma cruzi hypothetical protein, conserved 0.006 0.0252 0.0233
Loa Loa (eye worm) hypothetical protein 0.0252 0.157 0.1669
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0252 0.0345
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.185 0.3056
Onchocerca volvulus Putative eukaryotic translation initiation factor 4e 0.0103 0.0545 0.2601
Mycobacterium ulcerans two component response transcriptional regulatory protein PrrA 0.0032 0.0054 0.0438
Brugia malayi GTP-binding protein 0.0149 0.0859 0.0913
Giardia lamblia Hypothetical protein 0.0103 0.0545 0.3698
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.006 0.0252 0.0426
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0162 0.0952 0.1645
Mycobacterium tuberculosis Two component sensory transduction protein RegX3 (transcriptional regulatory protein) (probably LuxR-family) 0.0032 0.0054 0.0555
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.0282 0.0478
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0162 0.0952 0.1639
Mycobacterium leprae TWO COMPONENT SENSORY TRANSDUCTION PROTEIN REGX3 (TRANSCRIPTIONAL REGULATORY PROTEIN) (PROBABLY LUXR-FAMILY) 0.0032 0.0054 0.0555
Schistosoma mansoni cercarial elastase (S01 family) 0.0025 0.0006 0.0006
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.006 0.0252 0.0345
Treponema pallidum adenine phosphoribosyltransferase 0.0047 0.0158 1
Mycobacterium tuberculosis Probable transcriptional regulatory protein KdpE 0.0032 0.0054 0.0555
Leishmania major xanthine phosphoribosyltransferase 0.0199 0.1206 0.2085
Schistosoma mansoni cercarial elastase (S01 family) 0.0025 0.0006 0.0006
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.006 0.0252 0.0426
Trypanosoma brucei hypothetical protein, conserved 0.006 0.0252 0.0433
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0029 0.0037 0.0037
Chlamydia trachomatis two component regulatory system response regulator/ATPase 0.0032 0.0054 1
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0067 0.03 0.0319
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0864 0.5779 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0252 0.0345
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.006 0.0252 0.0252
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0864 0.5779 1
Schistosoma mansoni hypothetical protein 0.0025 0.0006 0.0006
Mycobacterium tuberculosis Probable orotate phosphoribosyltransferase PyrE (OPRT) (oprtase) 0.0097 0.0501 0.5255
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.006 0.0252 0.0426
Trypanosoma cruzi Eukaryotic translation initiation factor 4E type 5, putative 0.0103 0.0545 0.0752
Mycobacterium ulcerans two-component system transcriptional regulator 0.0032 0.0054 0.0438
Loa Loa (eye worm) hypothetical protein 0.1392 0.9411 1
Mycobacterium tuberculosis Probable two component transcriptional regulatory protein TcrX 0.0032 0.0054 0.0555
Trichomonas vaginalis conserved hypothetical protein 0.0103 0.0545 0.0858
Mycobacterium ulcerans two component transcriptional regulatory protein DevR 0.0032 0.0054 0.0438
Trypanosoma brucei RNA helicase, putative 0.0376 0.2422 0.419
Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase, putative 0.0199 0.1206 0.2085
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0103 0.0545 0.0858
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.079 0.1364
Schistosoma mansoni cercarial elastase (S01 family) 0.0025 0.0006 0.0006
Trypanosoma brucei Eukaryotic translation initiation factor 4E-2 0.0103 0.0545 0.0941
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0153 0.0888 0.1534
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.006 0.0252 0.0426
Mycobacterium tuberculosis Conserved hypothetical protein 0.0156 0.091 0.9557
Leishmania major inosine-5-monophosphate dehydrogenase 0.0162 0.0952 0.1645
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0252 0.0345
Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase 0.0199 0.1206 0.2085
Onchocerca volvulus 0.0025 0.0006 0.0029
Onchocerca volvulus 0.0051 0.0191 0.0909
Brugia malayi Trypsin family protein 0.0025 0.0006 0.0007
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0025 0.0006 0.0006
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0252 0.0345
Mycobacterium ulcerans orotidine 5'-phosphate decarboxylase 0.0113 0.0617 0.5104
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.006 0.0252 0.0345
Mycobacterium ulcerans two component system response phosphate regulon transcriptional regulator, PhoP 0.0032 0.0054 0.0438
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0162 0.0952 0.1471
Brugia malayi Kringle domain containing protein 0.0089 0.0453 0.0481
Trypanosoma brucei Eukaryotic translation initiation factor 4E-3 0.0103 0.0545 0.0941
Echinococcus multilocularis survival motor neuron protein 1 0.0252 0.157 0.271
Loa Loa (eye worm) PDE1B protein 0.0153 0.0888 0.0943
Echinococcus multilocularis L aminoadipate semialdehyde 0.0085 0.0422 0.0721
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0293 0.185 0.3199
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0252 0.0433
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0103 0.0545 0.0858
Treponema pallidum hypothetical protein 0.0047 0.0158 1
Schistosoma mansoni Adenine phosphoribosyltransferase 0.0047 0.0158 0.0158
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0162 0.0952 0.1471
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0252 0.0345
Mycobacterium ulcerans two component transcriptional regulatory protein TcrX 0.0032 0.0054 0.0438
Giardia lamblia Telomerase catalytic subunit 0.0087 0.0438 0.2678
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0252 0.0345
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0252 0.0345
Loa Loa (eye worm) orotate phosphoribosyltransferase 0.016 0.0937 0.0996
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-3 0.0103 0.0545 0.0752
Trypanosoma brucei unspecified product 0.0031 0.0052 0.0087
Leishmania major hypothetical protein, conserved 0.0103 0.0545 0.0941
Onchocerca volvulus 0.0199 0.1206 0.5751
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0252 0.0345
Leishmania major adenine phosphoribosyltransferase 0.0047 0.0158 0.027
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0153 0.0888 0.1357
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0085 0.0422 0.0422
Plasmodium falciparum eukaryotic translation initiation factor 4E, putative 0.0103 0.0545 0.4514
Trypanosoma brucei ingi protein (ORF1) 0.0031 0.0052 0.0087
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0252 0.0345
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.079 0.1183
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0252 0.0345
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0252 0.0433
Toxoplasma gondii eukaryotic initiation factor-4E, putative 0.0103 0.0545 0.0941
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0291 0.1836 0.3032
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0282 0.0282
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-4 0.0103 0.0545 0.0752
Schistosoma mansoni cercarial elastase (S01 family) 0.0025 0.0006 0.0006
Mycobacterium tuberculosis Two component sensory transduction transcriptional regulatory protein MtrA 0.0032 0.0054 0.0555
Leishmania major telomerase reverse transcriptase, putative 0.0087 0.0438 0.0756
Leishmania major hypothetical protein, conserved 0.006 0.0252 0.0433
Treponema pallidum phosphoribosylpyrophosphate synthetase 0.0047 0.0158 1
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0103 0.0545 0.0941
Mycobacterium ulcerans hypothetical protein 0.0025 0.0006 0.0037
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.006 0.0252 0.0345
Wolbachia endosymbiont of Brugia malayi amidophosphoribosyltransferase 0.0047 0.0158 0.1641
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0103 0.0545 0.0941
Mycobacterium leprae conserved hypothetical protein 0.0156 0.091 0.9557
Mycobacterium ulcerans bifunctional pyrimidine regulatory protein PyrR/uracil phosphoribosyltransferase 0.0047 0.0158 0.1295
Schistosoma mansoni survival motor neuron protein 0.0051 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0025 0.0006 0.0007
Schistosoma mansoni cercarial elastase (S01 family) 0.0025 0.0006 0.0006
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.006 0.0252 0.0426
Echinococcus granulosus uridine 5' monophosphate synthase 0.016 0.0937 0.1613
Brugia malayi hypothetical protein 0.0025 0.0006 0.0007
Plasmodium vivax orotidine 5'-phosphate decarboxylase, putative 0.0113 0.0617 0.5104
Schistosoma mansoni hypothetical protein 0.0376 0.2422 0.2422
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.012 0.0663 0.0663
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0103 0.0545 0.0858
Mycobacterium leprae Probable orotidine 5'-phosphate decarboxylase PyrF (OMP decarboxylase) (OMPDCase) (OMPdecase) 0.0113 0.0617 0.6469
Loa Loa (eye worm) hypothetical protein 0.0089 0.0453 0.0481
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.012 0.0205
Brugia malayi eukaryotic translation initiation factor 4E-1 0.0103 0.0545 0.058
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0025 0.0006 0.0006
Leishmania major eukaryotic translation initiation factor 4e, putative 0.0103 0.0545 0.0941
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0252 0.0345
Loa Loa (eye worm) hypothetical protein 0.006 0.0252 0.0268
Wolbachia endosymbiont of Brugia malayi orotate phosphoribosyltransferase 0.0097 0.0501 0.5255
Leishmania major hypothetical protein, conserved 0.0103 0.0545 0.0941
Mycobacterium ulcerans adenine phosphoribosyltransferase 0.0047 0.0158 0.1295
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0864 0.5779 1
Trypanosoma cruzi eukaryotic translation initiation factor 4E (eIF4E) interacting protein, putative 0.0103 0.0545 0.0752
Trypanosoma brucei telomerase reverse transcriptase 0.0087 0.0438 0.0756
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.006 0.0252 0.0426
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0291 0.1836 0.3175
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.006 0.0252 0.0252
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0252 0.0433
Loa Loa (eye worm) hypothetical protein 0.012 0.0663 0.0705
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.006 0.0252 0.0268
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.006 0.0252 0.0345
Trichomonas vaginalis hypothetical protein 0.0103 0.0545 0.0858
Trypanosoma brucei Adenine phosphoribosyltransferase, putative 0.0047 0.0158 0.027
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0864 0.5779 1
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0087 0.0438 0.0563
Trypanosoma cruzi hypothetical protein, conserved 0.006 0.0252 0.0233
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.006 0.0252 0.0345
Trypanosoma brucei ingi protein (ORF1) 0.0031 0.0052 0.0087
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0031 0.0052 0.0087
Giardia lamblia Hypothetical protein 0.0103 0.0545 0.3698
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.006 0.0252 0.0426
Mycobacterium ulcerans hypothetical protein 0.0154 0.0897 0.7433
Loa Loa (eye worm) hypothetical protein 0.0025 0.0006 0.0007
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0153 0.0888 0.1527
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0103 0.0545 0.0858
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0103 0.0545 0.0858
Wolbachia endosymbiont of Brugia malayi response regulator 0.0032 0.0054 0.0555
Brugia malayi Trypsin family protein 0.0025 0.0006 0.0007
Trypanosoma cruzi Eukaryotic translation initiation factor 4E type 5, putative 0.0103 0.0545 0.0752
Plasmodium falciparum hypoxanthine-guanine phosphoribosyltransferase 0.0199 0.1206 1
Trichomonas vaginalis ribose-phosphate pyrophosphokinase, putative 0.0047 0.0158 0.018
Wolbachia endosymbiont of Brugia malayi response regulator PleD 0.0032 0.0054 0.0555
Trypanosoma brucei Eukaryotic translation initiation factor 4E-4 0.0103 0.0545 0.0941
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0103 0.0545 0.0858
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0103 0.0545 0.0858
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.1392 0.9411 1
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.006 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.012 0.0663 0.0705
Brugia malayi Muscle positioning protein 4 0.0029 0.0038 0.004
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.006 0.0252 0.0345
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.006 0.0252 0.0345
Trypanosoma brucei hypothetical protein, conserved 0.0031 0.0052 0.0087
Plasmodium vivax telomerase reverse transcriptase, putative 0.0087 0.0438 0.3626
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0153 0.0888 0.0888
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0252 0.0345
Onchocerca volvulus 0.0029 0.0038 0.0181
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0085 0.0423 0.4428
Echinococcus multilocularis ras gtpase 0.0149 0.0859 0.1477
Trichomonas vaginalis hypoxanthine-guanine phosphoribosyltransferase, putative 0.0199 0.1206 0.2012
Brugia malayi Trypsin family protein 0.0025 0.0006 0.0007
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0252 0.0433
Leishmania major eukaryotic translation initiation factor-like 0.0864 0.5779 1
Echinococcus multilocularis eukaryotic translation initiation factor 4E 0.0864 0.5779 1
Echinococcus multilocularis adenine phosphoribosyltransferase 0.0047 0.0158 0.0262
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.0864 0.5779 1
Mycobacterium tuberculosis Hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (imp pyrophosphor 0.0152 0.0886 0.9301
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.006 0.0252 0.0433
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.006 0.0252 0.0345
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.006 0.0252 0.0252
Mycobacterium tuberculosis Adenine phosphoribosyltransferase Apt (APRT) (AMP diphosphorylase) (AMP pyrophosphorylase) (transphosphoribosidase) 0.0047 0.0158 0.1641
Mycobacterium tuberculosis Two component transcriptional regulator TrcR 0.0032 0.0054 0.0555
Echinococcus granulosus survival motor neuron protein 1 0.0252 0.157 0.271
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0025 0.0006 0.0007
Mycobacterium ulcerans nitrate/nitrite response regulator protein NarL 0.0032 0.0054 0.0438
Mycobacterium tuberculosis Probable two-component system transcriptional regulator 0.0032 0.0054 0.0555
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0085 0.0423 0.4428
Mycobacterium ulcerans hypothetical protein 0.0047 0.0158 0.1295
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative 0.0199 0.1206 0.192
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0252 0.0345
Mycobacterium ulcerans two component transcriptional regulator 0.0032 0.0054 0.0438
Loa Loa (eye worm) trypsin family protein 0.0025 0.0006 0.0007
Mycobacterium ulcerans two component transcriptional regulator TrcR 0.0032 0.0054 0.0438
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0162 0.0952 0.7891
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0153 0.0888 0.7357
Trypanosoma cruzi Adenine phosphoribosyltransferase, putative 0.0047 0.0158 0.0066
Brugia malayi Protein kinase domain containing protein 0.0089 0.0453 0.0481
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0182 0.0109
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0252 0.0433
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0252 0.0345
Mycobacterium tuberculosis Two component DNA binding transcriptional regulatory protein TcrA 0.0032 0.0054 0.0555
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0152 0.0886 0.7341
Echinococcus granulosus ras gtpase 0.0149 0.0859 0.1477
Schistosoma mansoni orotidine 5'-phosphate decarboxylase 0.016 0.0937 0.0937
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0092 0.0469 0.0725
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.006 0.0252 0.0433
Onchocerca volvulus Putative GMP reductase 0.0067 0.03 0.1433
Toxoplasma gondii hypothetical protein 0.0047 0.0162 0.0277
Onchocerca volvulus Adenine phosphoribosyltransferase homolog 0.0047 0.0158 0.0751
Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferase 0.0047 0.0158 0.0158
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.006 0.0252 0.0426
Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase, putative 0.0199 0.1206 1
Trypanosoma cruzi GMP reductase 0.0162 0.0952 0.1471
Trypanosoma brucei cAMP-specific phosphodiesterase 0.006 0.0252 0.0433
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0103 0.0545 0.0858
Brugia malayi Trypsin family protein 0.012 0.0663 0.0705
Mycobacterium leprae PROBABLE OROTATE PHOSPHORIBOSYLTRANSFERASE PYRE (OPRT) (OPRTASE) 0.0097 0.0501 0.5255
Mycobacterium tuberculosis Amidophosphoribosyltransferase PurF (glutamine phosphoribosylpyrophosphate amidotransferase) (ATASE) (gpatase) 0.0047 0.0158 0.1641
Mycobacterium ulcerans two component response transcriptional regulatory protein MprA 0.0032 0.0054 0.0438
Toxoplasma gondii IMP dehydrogenas 0.0162 0.0952 0.1645
Toxoplasma gondii orotate phosphoribosyltransferase 0.0097 0.0501 0.0865
Leishmania major eukaryotic translation initiation factor-like protein 0.0864 0.5779 1
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0329 0.2098 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0252 0.0433
Mycobacterium tuberculosis Possible two component system response transcriptional positive regulator PhoP 0.0032 0.0054 0.0555
Mycobacterium ulcerans hypothetical protein 0.0032 0.0054 0.0438
Trypanosoma cruzi orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative 0.0113 0.0617 0.0877
Trypanosoma cruzi orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative 0.016 0.0937 0.1444
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0087 0.0438 0.0563
Echinococcus multilocularis uridine 5' monophosphate synthase 0.016 0.0937 0.1613
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0103 0.0545 0.0858
Schistosoma mansoni cell polarity protein 0.0149 0.0859 0.0859
Brugia malayi orotate phosphoribosyltransferase family protein 0.016 0.0937 0.0996
Schistosoma mansoni cercarial elastase (S01 family) 0.0025 0.0006 0.0006
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.006 0.0252 0.2077
Schistosoma mansoni hypothetical protein 0.0051 0.0191 0.0191
Toxoplasma gondii eukaryotic initiation factor-4E, putative 0.0864 0.5779 1
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0089 0.0453 0.3743
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0252 0.0345
Echinococcus multilocularis hypoxanthine guanine phosphoribosyltransferase 0.0199 0.1206 0.2079
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0252 0.0433
Mycobacterium ulcerans adenylylate/guanylate cyclase 0.0032 0.0054 0.0438
Schistosoma mansoni uracil phosphoribosyltransferase 0.0047 0.0158 0.0158
Mycobacterium tuberculosis Possible nitrate/nitrite response transcriptional regulatory protein NarL 0.0032 0.0054 0.0555
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-4 0.0103 0.0545 0.0752
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0077 0.0367 0.303
Echinococcus granulosus adenine phosphoribosyltransferase 0.0047 0.0158 0.0262
Trypanosoma cruzi hypothetical protein, conserved 0.006 0.0252 0.0233
Schistosoma mansoni cercarial elastase (S01 family) 0.0025 0.0006 0.0006
Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase 0.0199 0.1206 0.2085
Loa Loa (eye worm) hypothetical protein 0.0085 0.0422 0.0449
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0162 0.0952 0.1639
Trypanosoma brucei cAMP-specific phosphodiesterase 0.006 0.0252 0.0433
Schistosoma mansoni cercarial elastase (S01 family) 0.0025 0.0006 0.0006
Mycobacterium leprae AMIDOPHOSPHORIBOSYLTRANSFERASE PURF (GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE) (ATASE) (GPATASE) 0.0047 0.0158 0.1641
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0282 0.2328
Plasmodium falciparum cysteine repeat modular protein 1 0.0089 0.0453 0.3743
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.006 0.0252 0.0252
Trypanosoma cruzi hypothetical protein, conserved 0.006 0.0252 0.0233
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.006 0.0252 0.0426
Onchocerca volvulus 0.0085 0.0422 0.2014
Leishmania major cAMP-specific phosphodiesterase, putative 0.0291 0.1836 0.3175
Brugia malayi Phosphoribosyl transferase domain containing protein 0.0199 0.1206 0.1282
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0153 0.0888 0.1534
Mycobacterium tuberculosis Probable orotidine 5'-phosphate decarboxylase PyrF (OMP decarboxylase) (ompdecase) 0.005 0.0181 0.1882
Schistosoma mansoni cercarial elastase (S01 family) 0.0025 0.0006 0.0006
Echinococcus granulosus L aminoadipate semialdehyde 0.0085 0.0422 0.0721
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.006 0.0252 0.0233
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.006 0.0252 0.0268
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0162 0.0952 0.1012
Plasmodium falciparum phosphodiesterase gamma, putative 0.006 0.0252 0.2077
Loa Loa (eye worm) IMP dehydrogenase 1 0.0162 0.0952 0.1012
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0252 0.0345
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0067 0.03 0.0319
Loa Loa (eye worm) GTP-binding protein 0.0149 0.0859 0.0913
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0162 0.0952 0.0952
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0103 0.0545 0.0858
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.0282 0.0478
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.006 0.0252 0.0252
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0252 0.0345
Loa Loa (eye worm) adenine phosphoribosyltransferase 0.0047 0.0158 0.0167
Echinococcus granulosus tissue type plasminogen activator 0.0089 0.0453 0.0773
Trichomonas vaginalis conserved hypothetical protein 0.0103 0.0545 0.0858
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0025 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.006 0.0252 0.0268
Giardia lamblia Guanine phosphoribosyltransferase 0.0199 0.1206 1
Trypanosoma brucei orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative 0.016 0.0937 0.1619
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.006 0.0252 0.0426
Echinococcus multilocularis hypoxanthine guanine phosphoribosyltransferase 0.0199 0.1206 0.2079
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0252 0.0433
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0252 0.0345
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.006 0.0252 0.0268
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0252 0.0345
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0129 0.0723 0.0723
Schistosoma mansoni cell polarity protein 0.0149 0.0859 0.0859
Loa Loa (eye worm) translation initiation factor 4E 0.0864 0.5779 0.6141
Treponema pallidum response regulatory protein (atoC) 0.0032 0.0054 0.3385
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0252 0.0433
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.006 0.0252 0.0233
Mycobacterium tuberculosis Probable pyrimidine operon regulatory protein PyrR 0.0047 0.0158 0.1641
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0252 0.0345
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0103 0.0545 0.0858
Toxoplasma gondii hypothetical protein 0.0103 0.0545 0.0941
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.006 0.0252 0.0345
Echinococcus granulosus eukaryotic translation initiation factor 4E type 0.0103 0.0545 0.0934
Mycobacterium leprae Probable hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (IMP pho 0.0152 0.0886 0.9301
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0252 0.0345
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.006 0.0252 0.0345
Mycobacterium tuberculosis Two component response transcriptional regulatory protein PrrA 0.0032 0.0054 0.0555
Leishmania major mitochondrial DNA polymerase beta 0.0293 0.185 0.3199
Wolbachia endosymbiont of Brugia malayi orotidine-5'-phosphate decarboxylase 0.0063 0.0273 0.2855
Echinococcus multilocularis tissue type plasminogen activator 0.0089 0.0453 0.0773
Loa Loa (eye worm) hypothetical protein 0.006 0.0252 0.0268
Giardia lamblia Translation elongation factor 0.0103 0.0545 0.3698
Loa Loa (eye worm) hypothetical protein 0.0025 0.0006 0.0007
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.006 0.0252 0.0345
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0162 0.0952 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0252 0.0433
Toxoplasma gondii kringle domain-containing protein 0.0089 0.0453 0.078
Onchocerca volvulus 0.0096 0.0494 0.2356
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.006 0.0252 0.0252
Mycobacterium leprae conserved hypothetical protein 0.0156 0.091 0.9557
Trypanosoma cruzi hypothetical protein, conserved 0.006 0.0252 0.0233
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0282 0.2328
Loa Loa (eye worm) eukaryotic translation initiation factor 4E-1 0.0103 0.0545 0.058
Onchocerca volvulus 0.012 0.0663 0.3163
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative 0.0199 0.1206 0.192
Loa Loa (eye worm) hypothetical protein 0.1331 0.8996 0.9559
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.0282 0.0485
Leishmania major orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative,OMPDCase-OPRTase, putative 0.016 0.0937 0.1619
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0153 0.0888 0.1357
Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferase 0.0199 0.1206 0.1206
Mycobacterium tuberculosis Conserved protein 0.0047 0.0158 0.1641
Mycobacterium ulcerans hypoxanthine-guanine phosphoribosyltransferase Hpt 0.0199 0.1206 1
Leishmania major hypoxanthine-guanine phosphoribosyltransferase 0.0199 0.1206 0.2085
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0103 0.0545 0.0858
Plasmodium vivax hypothetical protein, conserved 0.0103 0.0545 0.4514
Loa Loa (eye worm) hypothetical protein 0.0025 0.0006 0.0007
Echinococcus granulosus hypoxanthine guanine phosphoribosyltransferase 0.0199 0.1206 0.2079
Trypanosoma cruzi hypothetical protein, conserved 0.0089 0.0453 0.0588
Loa Loa (eye worm) hypothetical protein 0.0025 0.0006 0.0007
Brugia malayi GMP reductase 0.0067 0.03 0.0319
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0252 0.0433
Brugia malayi Telomerase reverse transcriptase 0.0233 0.1438 0.1527
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.006 0.0252 0.0233
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0153 0.0888 0.1527
Mycobacterium tuberculosis Mycobacterial persistence regulator MRPA (two component response transcriptional regulatory protein) 0.0032 0.0054 0.0555
Plasmodium falciparum phosphodiesterase delta, putative 0.006 0.0252 0.2077
Trypanosoma cruzi Adenine phosphoribosyltransferase, putative 0.0047 0.0158 0.0066
Trypanosoma cruzi GMP reductase 0.0162 0.0952 0.1471
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.006 0.0252 0.0252
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0153 0.0888 0.1534
Toxoplasma gondii orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase 0.0113 0.0617 0.1064
Plasmodium falciparum eukaryotic translation initiation factor 4E 0.0103 0.0545 0.4514
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.006 0.0252 0.2077
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0252 0.0345
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0103 0.0545 0.0858
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.006 0.0252 0.0426
Trypanosoma brucei Adenine phosphoribosyltransferase, putative 0.0047 0.0158 0.027
Trypanosoma brucei Eukaryotic translation initiation factor 4E type 5 0.0103 0.0545 0.0941
Leishmania major eukaryotic translation initiation factor eIF-4E, putative 0.0864 0.5779 1
Entamoeba histolytica eukaryotic initiation factor 4E, putative 0.0103 0.0545 0.0941
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.006 0.0252 0.2077
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0025 0.0006 0.0006
Plasmodium vivax translation initiation factor 4E, putative 0.0103 0.0545 0.4514
Schistosoma mansoni Adenine phosphoribosyltransferase 0.0047 0.0158 0.0158
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0085 0.0422 0.0449
Onchocerca volvulus 0.0089 0.0453 0.2158
Schistosoma mansoni eukaryotic translation initiation factor 4e 0.0864 0.5779 0.5779
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.006 0.0252 0.0345
Mycobacterium ulcerans two component transcriptional regulator 0.0032 0.0054 0.0438
Trypanosoma brucei Eukaryotic translation initiation factor 4E-1 0.0864 0.5779 1
Mycobacterium ulcerans orotate phosphoribosyltransferase 0.0097 0.0501 0.4146
Giardia lamblia Hypothetical protein 0.006 0.0252 0.0899
Echinococcus granulosus expressed protein 0.0398 0.2573 0.4447
Entamoeba histolytica hypothetical protein 0.0103 0.0545 0.0941
Mycobacterium tuberculosis Conserved protein 0.0047 0.0158 0.1641
Plasmodium falciparum cGMP-specific phosphodiesterase 0.006 0.0252 0.2077
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0077 0.0367 0.384
Echinococcus granulosus eukaryotic translation initiation factor 4E 0.0864 0.5779 1
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0152 0.0886 0.7341
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0162 0.0952 1
Brugia malayi Trypsin-like protease protein 5 0.0025 0.0006 0.0007
Mycobacterium ulcerans amidophosphoribosyltransferase 0.0047 0.0158 0.1295
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0025 0.0006 0.0006
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.006 0.0252 0.0233
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.006 0.0252 0.0252
Mycobacterium leprae Probable two-component system transcriptional regulator 0.0032 0.0054 0.0555
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0282 0.0282
Trypanosoma brucei GMP reductase 0.0162 0.0952 0.1645
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.006 0.0252 0.0268
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0252 0.0345

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.019 uM Ability to antagonize LTD4 receptors isolated from guinea pig lung membranes ChEMBL. 9873435
Ki (binding) = 0.019 uM Ability to antagonize LTD4 receptors isolated from guinea pig lung membranes ChEMBL. 9873435

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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