Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Ceramide glucosyltransferase | 0.0109 | 0.1837 | 0.5 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.031 | 1 | 1 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.0209 | 0.5925 | 0.5646 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.031 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.2996 | 0.2996 |
Onchocerca volvulus | 0.031 | 1 | 1 | |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.031 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.2996 | 0.2996 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.316 | 0.316 |
Schistosoma mansoni | alpha-glucosidase | 0.031 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.018 | 0.4716 | 0.1027 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.026 | 0.7974 | 1 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.024 | 0.7168 | 0.6974 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.0209 | 0.5925 | 0.5646 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.026 | 0.7974 | 1 |
Trypanosoma brucei | lysosomal alpha-mannosidase precursor, putative | 0.0079 | 0.0641 | 1 |
Echinococcus granulosus | beta galactosidase | 0.0137 | 0.2996 | 0.2517 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.026 | 0.7974 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.026 | 0.7974 | 1 |
Echinococcus granulosus | ceramide glucosyltransferase | 0.024 | 0.7168 | 0.6974 |
Echinococcus granulosus | bile acid beta glucosidase | 0.0209 | 0.5925 | 0.5646 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.026 | 0.7974 | 0.2846 |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.024 | 0.7168 | 0.6974 |
Echinococcus multilocularis | bile acid beta glucosidase | 0.0209 | 0.5925 | 0.5646 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.018 | 0.4716 | 0.1027 |
Trypanosoma cruzi | lysosomal alpha-mannosidase precursor, putative | 0.0079 | 0.0641 | 0.5 |
Echinococcus multilocularis | beta galactosidase | 0.0137 | 0.2996 | 0.2517 |
Schistosoma mansoni | beta-galactosidase | 0.0137 | 0.2996 | 0.2517 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.026 | 0.7974 | 1 |
Trypanosoma cruzi | lysosomal alpha-mannosidase precursor, putative | 0.0079 | 0.0641 | 0.5 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.024 | 0.7168 | 0.7168 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.026 | 0.7974 | 1 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.024 | 0.7168 | 0.6974 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.026 | 0.7974 | 0.7974 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.031 | 1 | 1 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.024 | 0.7168 | 0.4993 |
Schistosoma mansoni | alpha-glucosidase | 0.031 | 1 | 1 |
Echinococcus granulosus | non lysosomal glucosylceramidase | 0.0209 | 0.5925 | 0.5646 |
Echinococcus multilocularis | non lysosomal glucosylceramidase | 0.0209 | 0.5925 | 0.5646 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
C10 (functional) | = 58.7 uM | Concentration required to reduce plating efficiency to 10 percent of controls, under aerobic conditions in mouse SCCVII tumor cells. | ChEMBL. | 12502371 |
C10 (functional) | = 67.7 uM | Concentration required to reduce plating efficiency to 10 percent of controls, under hypoxic conditions in mouse SCCVII tumor cells. | ChEMBL. | 12502371 |
HCR (functional) | = 0.87 | Intraexperimental difference between the hypoxic and aerobic cytotoxicity | ChEMBL. | 12502371 |
RHT (functional) | = 0.15 | Intraexperimental ratio of hypoxic TPZ C10 to hypoxic BTO C10 in mouse SCCVII tumor cells. | ChEMBL. | 12502371 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.