Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0069 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable DNA polymerase I PolA | 0.006 | 0.8079 | 1 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0069 | 1 | 0.5 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.005 | 0.6065 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.5291 | 0.4103 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0069 | 1 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.005 | 0.6065 | 0.5 |
Brugia malayi | Probable DNA topoisomerase II | 0.0069 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable 5'-3' exonuclease | 0.0043 | 0.4491 | 0.533 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0069 | 1 | 1 |
Mycobacterium leprae | PROBABLE DNA POLYMERASE I POLA | 0.006 | 0.8079 | 0.5 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0069 | 1 | 0.5 |
Plasmodium vivax | 5'-3' exonuclease, N-terminal resolvase-like domain, putative | 0.0043 | 0.4491 | 0.4264 |
Giardia lamblia | DNA topoisomerase II | 0.0066 | 0.9368 | 0.5 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0062 | 0.8559 | 1 |
Plasmodium falciparum | 5'-3' exonuclease, N-terminal resolvase-like domain, putative | 0.0043 | 0.4491 | 0.4264 |
Treponema pallidum | DNA polymerase I (polA) | 0.006 | 0.8079 | 1 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0069 | 1 | 0.5 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0038 | 0.3455 | 0.398 |
Mycobacterium ulcerans | 5'-3' exonuclease | 0.0043 | 0.4491 | 0.533 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.5291 | 0.4103 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.005 | 0.6065 | 0.5 |
Leishmania major | DNA topoisomerase ii | 0.0062 | 0.8559 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0055 | 0.6942 | 0.6025 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0062 | 0.8559 | 1 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0055 | 0.6942 | 0.6025 |
Wolbachia endosymbiont of Brugia malayi | DNA polymerase I | 0.006 | 0.8079 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0055 | 0.6942 | 0.6025 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0055 | 0.6942 | 0.6025 |
Schistosoma mansoni | DNA topoisomerase II | 0.0069 | 1 | 0.5 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0062 | 0.8559 | 1 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0062 | 0.8559 | 1 |
Chlamydia trachomatis | DNA polymerase I | 0.006 | 0.8079 | 1 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0069 | 1 | 1 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0069 | 1 | 0.5 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0023 | 0.0397 | 0.0397 |
Mycobacterium ulcerans | DNA polymerase I | 0.006 | 0.8079 | 1 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0069 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.