Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0039 | 0.1028 | 0.0912 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1028 | 0.0591 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0039 | 0.1028 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0094 | 0.3043 | 0.5179 |
Brugia malayi | Doublecortin family protein | 0.0039 | 0.1028 | 0.0912 |
Trichomonas vaginalis | glutaminase, putative | 0.0272 | 0.951 | 0.9283 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0285 | 1 | 1 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0039 | 0.1028 | 0.1749 |
Schistosoma mansoni | polycystin 1-related | 0.0039 | 0.1028 | 0.108 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0285 | 1 | 1 |
Echinococcus multilocularis | UDP glucose 4 epimerase | 0.0098 | 0.3177 | 0.5406 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0172 | 0.5876 | 1 |
Trypanosoma brucei | UDP-galactose 4-epimerase | 0.0102 | 0.3323 | 1 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0039 | 0.1028 | 0.1749 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0495 | 0.0341 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0285 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0094 | 0.3043 | 0.3071 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0285 | 1 | 1 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0175 | 0.5977 | 1 |
Trypanosoma cruzi | UDP-galactose 4-epimerase | 0.0098 | 0.3177 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0094 | 0.3043 | 0.5179 |
Echinococcus granulosus | RUN | 0.0039 | 0.1028 | 0.1749 |
Schistosoma mansoni | lipoxygenase | 0.0172 | 0.5876 | 0.6179 |
Mycobacterium ulcerans | glutaminase | 0.0272 | 0.951 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0094 | 0.3043 | 0.32 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1028 | 0.0591 |
Loa Loa (eye worm) | glutaminase | 0.0272 | 0.951 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0285 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.5586 | 0.5874 |
Echinococcus granulosus | geminin | 0.0164 | 0.5586 | 0.9506 |
Brugia malayi | hypothetical protein | 0.0039 | 0.1028 | 0.0912 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0094 | 0.3043 | 0.5179 |
Schistosoma mansoni | rab6-interacting | 0.0039 | 0.1028 | 0.108 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0039 | 0.1028 | 0.1749 |
Schistosoma mansoni | rab6-interacting | 0.0039 | 0.1028 | 0.108 |
Loa Loa (eye worm) | glutaminase 2 | 0.0272 | 0.951 | 1 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0039 | 0.1028 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0094 | 0.3043 | 0.5179 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0139 | 0.4679 | 0.5 |
Loa Loa (eye worm) | UDP galactose 4'-epimerase | 0.0098 | 0.3177 | 0.2975 |
Schistosoma mansoni | UDP-glucose 4-epimerase | 0.0098 | 0.3177 | 0.334 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0285 | 1 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0172 | 0.5876 | 1 |
Schistosoma mansoni | loxhd1 | 0.0039 | 0.1028 | 0.108 |
Toxoplasma gondii | UDP-glucose 4-epimerase | 0.0098 | 0.3177 | 1 |
Echinococcus granulosus | UDP glucose 4 epimerase | 0.0098 | 0.3177 | 0.5406 |
Schistosoma mansoni | glutaminase | 0.0272 | 0.951 | 1 |
Trypanosoma cruzi | UDP-galactose 4-epimerase, putative | 0.0098 | 0.3177 | 1 |
Echinococcus multilocularis | RUN | 0.0039 | 0.1028 | 0.1749 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0039 | 0.1028 | 0.1749 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0285 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0094 | 0.3043 | 0.2827 |
Schistosoma mansoni | lipoxygenase | 0.0102 | 0.3302 | 0.3472 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0139 | 0.4679 | 0.5 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0285 | 1 | 0.5 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0285 | 1 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0285 | 1 | 1 |
Brugia malayi | N-terminal motif family protein | 0.0175 | 0.5977 | 0.6215 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0039 | 0.1028 | 0.1749 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0285 | 1 | 1 |
Brugia malayi | UDP galactose 4'-epimerase | 0.0098 | 0.3177 | 0.3214 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0094 | 0.3043 | 0.32 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.1028 | 0.108 |
Loa Loa (eye worm) | doublecortin family protein | 0.0039 | 0.1028 | 0.0591 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.5977 | 0.6081 |
Echinococcus multilocularis | geminin | 0.0164 | 0.5586 | 0.9506 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0039 | 0.1028 | 0.1749 |
Brugia malayi | glutaminase DH11.1 | 0.0272 | 0.951 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.5586 | 0.5874 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0094 | 0.3043 | 0.32 |
Leishmania major | udp-glc 4-epimerase, putative | 0.0102 | 0.3323 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.