TDR Targets

Basic information

Technical information

TDR Targets ID: 798352
Name: (7-chlorofuro[5,4-b]quinolin-2-yl)-[4-(2-fluo rophenyl)piperazin-1-yl]methanone
MW: 409.841 | Formula: C22H17ClFN3O2
H donors: 0 H acceptors: 2 LogP: 4.81 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc2c(c1)nc1c(c2)cc(o1)C(=O)N1CCN(CC1)c1ccccc1F
InChi: 1S/C22H17ClFN3O2/c23-16-6-5-14-11-15-12-20(29-21(15)25-18(14)13-16)22(28)27-9-7-26(8-10-27)19-4-2-1-3-17(19)24/h1-6,11-13H,7-10H2
InChiKey: PCDSFQHBDSMFIT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(7-chloro-2-furo[5,4-b]quinolinyl)-[4-(2-fluorophenyl)-1-piperazinyl]methanone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0048	0.0672	0.0672
Echinococcus granulosus	nibrin	0.002	0.0097	0.0303
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0672	0.2103
Loa Loa (eye worm)	transcription factor SMAD2	0.0119	0.2154	0.7656
Toxoplasma gondii	poly(ADP-ribose) polymerase catalytic domain-containing protein	0.002	0.0097	0.1637
Trypanosoma cruzi	hypothetical protein, conserved	0.002	0.0097	1
Brugia malayi	hypothetical protein	0.0151	0.2814	0.2814
Echinococcus multilocularis	tar DNA binding protein	0.0064	0.1005	0.3144
Schistosoma mansoni	hypothetical protein	0.0016	0.0003	0.0011
Mycobacterium leprae	PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT)	0.0044	0.0592	1
Echinococcus granulosus	GPCR family 2	0.0016	0.0003	0.0011
Brugia malayi	topoisomerase	0.002	0.0097	0.0097
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.0721	0.2561
Brugia malayi	RNA binding protein	0.0064	0.1005	0.1005
Brugia malayi	MH2 domain containing protein	0.0119	0.2154	0.2154
Brugia malayi	Pax transcription activation domain interacting protein	0.002	0.0097	0.0097
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0672	0.2103
Echinococcus multilocularis	ornithine aminotransferase	0.0044	0.0592	0.1852
Mycobacterium ulcerans	ornithine aminotransferase RocD1 and RocD2	0.0044	0.0592	0.05
Mycobacterium tuberculosis	Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase)	0.0495	1	1
Mycobacterium tuberculosis	Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase)	0.0044	0.0592	0.0592
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0672	0.2103
Echinococcus granulosus	replication factor c subunit 1	0.002	0.0097	0.0303
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0003	0.0012
Plasmodium falciparum	ornithine aminotransferase	0.0044	0.0592	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0097	0.0344
Trypanosoma cruzi	FHA domain containing protein, putative	0.002	0.0097	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0119	0.2154	0.7656
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0003	0.0011
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0003	0.0011
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.1005	0.3144
Loa Loa (eye worm)	hypothetical protein	0.0151	0.2814	1
Schistosoma mansoni	topbp1	0.002	0.0097	0.0303
Entamoeba histolytica	hypothetical protein	0.0038	0.0469	0.288
Mycobacterium leprae	Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM	0.0044	0.0592	1
Echinococcus multilocularis	replication factor c subunit 1	0.002	0.0097	0.0303
Brugia malayi	hypothetical protein	0.002	0.0097	0.0097
Loa Loa (eye worm)	hypothetical protein	0.002	0.0097	0.0344
Echinococcus granulosus	geminin	0.0169	0.3196	1
Mycobacterium tuberculosis	Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at)	0.0044	0.0592	0.0592
Loa Loa (eye worm)	hypothetical protein	0.005	0.0721	0.2561
Brugia malayi	ATP dependent DNA ligase C terminal region family protein	0.002	0.0097	0.0097
Entamoeba histolytica	hypothetical protein	0.0038	0.0469	0.288
Plasmodium vivax	ornithine aminotransferase, putative	0.0044	0.0592	1
Schistosoma mansoni	hypothetical protein	0.0034	0.0389	0.1216
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0003	0.0003
Echinococcus multilocularis	ornithine aminotransferase	0.0044	0.0592	0.1852
Loa Loa (eye worm)	RNA binding protein	0.0064	0.1005	0.357
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.1005	0.3144
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.1005	0.3144
Brugia malayi	TAR-binding protein	0.0064	0.1005	0.1005
Loa Loa (eye worm)	hypothetical protein	0.002	0.0097	0.0344
Schistosoma mansoni	ornithine--oxo-acid transaminase	0.0044	0.0592	0.1852
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0003	0.0011
Entamoeba histolytica	Acid sphingomyelinase-like phosphodiesterase, putative	0.0082	0.1389	1
Schistosoma mansoni	hypothetical protein	0.0016	0.0003	0.0011
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0048	0.0672	0.2388
Mycobacterium tuberculosis	Probable aminotransferase	0.0044	0.0592	0.0592
Wolbachia endosymbiont of Brugia malayi	acetylornithine transaminase protein	0.0044	0.0592	1
Echinococcus multilocularis	Aminotransferase class III	0.0044	0.0592	0.1852
Echinococcus multilocularis	nibrin	0.002	0.0097	0.0303
Schistosoma mansoni	topbp1	0.002	0.0097	0.0303
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0003	0.0012
Chlamydia trachomatis	glutamate-1-semialdehyde-2,1-aminomutase	0.0044	0.0592	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0038	0.0469	0.1468
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0003	0.0011
Schistosoma mansoni	hypothetical protein	0.0169	0.3196	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.0721	0.0721
Trypanosoma brucei	BRCA1 C Terminus (BRCT) domain containing protein, putative	0.002	0.0097	1
Echinococcus multilocularis	geminin	0.0169	0.3196	1
Schistosoma mansoni	DNA ligase IV	0.002	0.0097	0.0303
Trichomonas vaginalis	acetylornithine aminotransferase, putative	0.0044	0.0592	1
Brugia malayi	hypothetical protein	0.0038	0.0469	0.0469
Trypanosoma cruzi	hypothetical protein, conserved	0.002	0.0097	1
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.1005	0.3144
Brugia malayi	DKFZp564C0469 protein	0.002	0.0097	0.0097
Mycobacterium ulcerans	4-aminobutyrate aminotransferase	0.0044	0.0592	0.05
Mycobacterium ulcerans	L-lysine aminotransferase	0.0495	1	1
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0003	0.0011
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.1005	0.3144
Onchocerca volvulus		0.0151	0.2814	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0672	0.2103
Loa Loa (eye worm)	hypothetical protein	0.002	0.0097	0.0344
Mycobacterium ulcerans	hypothetical protein	0.0044	0.0592	0.05
Trypanosoma cruzi	BRCA1 C Terminus (BRCT) domain containing protein, putative	0.002	0.0097	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0038	0.0469	0.1468
Treponema pallidum	DNA ligase (lig)	0.002	0.0097	0.5
Entamoeba histolytica	hypothetical protein	0.0038	0.0469	0.288
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0389	0.0389
Echinococcus granulosus	Aminotransferase class III	0.0044	0.0592	0.1852
Schistosoma mansoni	hypothetical protein	0.0016	0.0003	0.0011
Toxoplasma gondii	ornithine aminotransferase, mitochondrial precursor, putative	0.0044	0.0592	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0064	0.1005	0.357
Schistosoma mansoni	hypothetical protein	0.0169	0.3196	1
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0016	0	0.5
Mycobacterium leprae	PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA	0.0044	0.0592	1
Mycobacterium tuberculosis	Probable acetylornithine aminotransferase ArgD	0.0044	0.0592	0.0592
Echinococcus granulosus	tar DNA binding protein	0.0064	0.1005	0.3144
Brugia malayi	RNA recognition motif domain containing protein	0.0064	0.1005	0.1005
Schistosoma mansoni	chromosome transmission fidelity factor	0.002	0.0097	0.0303
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0672	0.2103
Mycobacterium ulcerans	4-aminobutyrate aminotransferase	0.0044	0.0592	0.05
Echinococcus granulosus	ornithine aminotransferase	0.0044	0.0592	0.1852
Brugia malayi	hypothetical protein	0.002	0.0097	0.0097
Loa Loa (eye worm)	TAR-binding protein	0.0064	0.1005	0.357
Toxoplasma gondii	ATPase, AAA family protein	0.002	0.0097	0.1637
Entamoeba histolytica	Acid sphingomyelinase-like phosphodiesterase, putative	0.0082	0.1389	1
Mycobacterium tuberculosis	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA	0.0044	0.0592	0.0592
Giardia lamblia	Replication factor C, subunit 1	0.002	0.0097	0.5
Loa Loa (eye worm)	hypothetical protein	0.002	0.0097	0.0344
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0003	0.0003
Schistosoma mansoni	hypothetical protein	0.0038	0.0469	0.1468
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.0721	0.0721
Plasmodium falciparum	replication factor C subunit 1, putative	0.002	0.0097	0.1637
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0389	0.1381
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0672	0.2103
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0672	0.2103
Mycobacterium ulcerans	acetylornithine aminotransferase	0.0044	0.0592	0.05
Plasmodium vivax	replication factor C subunit 1, putative	0.002	0.0097	0.1637
Schistosoma mansoni	hypothetical protein	0.0016	0.0003	0.0011
Mycobacterium leprae	Probable Acetylornithine aminotransferase ArgD	0.0044	0.0592	1
Schistosoma mansoni	transcription factor LCR-F1	0.0038	0.0469	0.1468
Mycobacterium ulcerans	glutamate-1-semialdehyde aminotransferase	0.0044	0.0592	0.05
Loa Loa (eye worm)	hypothetical protein	0.0082	0.1389	0.4936
Entamoeba histolytica	hypothetical protein	0.0038	0.0469	0.288
Loa Loa (eye worm)	hypothetical protein	0.002	0.0097	0.0344
Mycobacterium ulcerans	adenosylmethionine-8-amino-7-oxononanoate aminotransferase	0.0044	0.0592	0.05

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 798352