Detailed information for compound 799573

Basic information

Technical information
  • TDR Targets ID: 799573
  • Name: ethyl 2-[[2-(cyclopentylamino)-1-(4-methoxyph enyl)-2-oxoethyl]-(phenylmethyl)amino]acetate
  • MW: 424.533 | Formula: C25H32N2O4
  • H donors: 1 H acceptors: 2 LogP: 4.33 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)CN(C(c1ccc(cc1)OC)C(=O)NC1CCCC1)Cc1ccccc1
  • InChi: 1S/C25H32N2O4/c1-3-31-23(28)18-27(17-19-9-5-4-6-10-19)24(20-13-15-22(30-2)16-14-20)25(29)26-21-11-7-8-12-21/h4-6,9-10,13-16,21,24H,3,7-8,11-12,17-18H2,1-2H3,(H,26,29)
  • InChiKey: WWSWDFSQFLTLHE-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • ethyl 2-[[2-(cyclopentylamino)-1-(4-methoxyphenyl)-2-oxo-ethyl]-(phenylmethyl)amino]acetate
  • 2-[[2-(cyclopentylamino)-1-(4-methoxyphenyl)-2-oxoethyl]-(phenylmethyl)amino]acetic acid ethyl ester
  • 2-[benzyl-[2-(cyclopentylamino)-2-keto-1-(4-methoxyphenyl)ethyl]amino]acetic acid ethyl ester
  • ethyl 2-[[2-(cyclopentylamino)-1-(4-methoxyphenyl)-2-oxo-ethyl]-(phenylmethyl)amino]ethanoate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.004 0.0071 0.0054
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0155 0.0618 0.2326
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0029 0.0017 0.0396
Brugia malayi mbt repeat family protein 0.0052 0.0127 0.0317
Schistosoma mansoni apoptosis regulator bax 0.0082 0.0272 0.0256
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0056 0.13
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0177 0.0727 0.0712
Onchocerca volvulus 0.0979 0.4556 1
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0066 0.1535
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.004 0.0071 0.0054
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0066 0.0049
Onchocerca volvulus 0.0052 0.0127 0.0217
Schistosoma mansoni zinc finger protein 0.0063 0.0182 0.0165
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0082 0.0272 0.0256
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0066 0.0022
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0055 0.0143 0.3328
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0055 0.0143 0.3328
Mycobacterium tuberculosis Probable reductase 0.0263 0.1136 0.3561
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0071 0.0221 0.0555
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0316 0.1391 0.2965
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.004 0.0071 0.0231
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0316 0.1391 0.2965
Echinococcus multilocularis muscleblind protein 0.0149 0.0591 0.0575
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.004 0.0071 0.1646
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0056 0.014
Schistosoma mansoni hypothetical protein 0.0029 0.0019 0.0002
Echinococcus granulosus thioredoxin glutathione reductase 0.0117 0.0438 0.0422
Trichomonas vaginalis glutathione reductase, putative 0.004 0.0071 0.0033
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.0127 0.011
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.0071 0.1646
Mycobacterium leprae Probable 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase IspF (MECPS) (MECDP-synthase ) 0.0536 0.2439 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0029 0.002 0.0051
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0056 0.0039
Trypanosoma cruzi trypanothione reductase, putative 0.004 0.0071 0.1646
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.0446 0.1117
Loa Loa (eye worm) hypothetical protein 0.0149 0.0591 0.1481
Loa Loa (eye worm) hypothetical protein 0.0149 0.0591 0.1481
Loa Loa (eye worm) bromodomain containing protein 0.0055 0.0145 0.0362
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0189 0.0782 0.0766
Chlamydia trachomatis 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 0.0668 0.3071 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.0143 0.3328
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0029 0.002 0.0051
Brugia malayi jmjC domain containing protein 0.0291 0.127 0.3184
Giardia lamblia PHD finger protein 15 0.0089 0.0305 0.1862
Schistosoma mansoni cpg binding protein 0.0039 0.0066 0.0049
Echinococcus granulosus polycomb protein SCMH1 0.0052 0.0127 0.011
Brugia malayi jmjC domain containing protein 0.0029 0.0017 0.0043
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0093 0.0076
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.0071 0.1646
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0155 0.0618 0.1836
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.0071 0.1646
Schistosoma mansoni hypothetical protein 0.0065 0.0189 0.0172
Loa Loa (eye worm) hypothetical protein 0.0135 0.0527 0.1321
Schistosoma mansoni mixed-lineage leukemia protein mll 0.007 0.0217 0.02
Schistosoma mansoni hypothetical protein 0.0082 0.0272 0.0256
Echinococcus multilocularis thioredoxin glutathione reductase 0.0117 0.0438 0.0422
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.004 0.0071 0.1646
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0017 0.0043
Leishmania major dihydrolipoamide dehydrogenase, putative 0.004 0.0071 0.1646
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.014
Loa Loa (eye worm) PHD-finger family protein 0.0065 0.0189 0.0474
Plasmodium vivax thioredoxin reductase, putative 0.0115 0.0431 0.1403
Echinococcus multilocularis muscleblind protein 1 0.0149 0.0591 0.0575
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0036 0.0054 0.0037
Trypanosoma cruzi ISWI complex protein 0.0048 0.0109 0.2532
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0316 0.1391 0.2965
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0249 0.1069 0.3337
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0071 0.0221 0.0204
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0059 0.0161 0.0403
Loa Loa (eye worm) PHD-finger family protein 0.0089 0.0305 0.0763
Leishmania major trypanothione reductase 0.0115 0.0431 1
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0031 0.0028 0.0091
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0119 0.0447 0.0431
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0071 0.0221 0.5135
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0041 0.0077 0.006
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0263 0.1136 0.3561
Brugia malayi PHD-finger family protein 0.0037 0.0056 0.014
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1686 0.793 0.7926
Echinococcus multilocularis zinc finger protein 0.0063 0.0182 0.0165
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0082 0.0272 0.0256
Brugia malayi follicle stimulating hormone receptor 0.0253 0.1089 0.273
Mycobacterium ulcerans 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 0.0668 0.3071 1
Brugia malayi mbt repeat family protein 0.0052 0.0127 0.0317
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0316 0.1391 0.2965
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0029 0.0017 0.0396
Echinococcus granulosus transcription factor Dp 1 0.0041 0.0078 0.0061
Echinococcus multilocularis mitogen activated protein kinase 0.0055 0.0143 0.0127
Brugia malayi PHD-finger family protein 0.008 0.0261 0.0655
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0072 0.0226 0.0209
Echinococcus granulosus jumonji domain containing protein 0.0124 0.0471 0.0454
Onchocerca volvulus Alhambra homolog 0.0089 0.0305 0.061
Brugia malayi jmjC domain containing protein 0.0029 0.0017 0.0043
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0189 0.0782 0.0766
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0055 0.0143 0.0467
Echinococcus granulosus neuropeptide s receptor 0.0492 0.2229 0.2216
Giardia lamblia Fructose-bisphosphate aldolase 0.0316 0.1391 1
Loa Loa (eye worm) hypothetical protein 0.0128 0.049 0.1228
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0177 0.0727 0.0712
Loa Loa (eye worm) hypothetical protein 0.0133 0.0513 0.1287
Plasmodium vivax JmjC domain containing protein 0.0029 0.0017 0.0056
Echinococcus granulosus fetal alzheimer antigen falz 0.0072 0.0226 0.0209
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0052 0.0127 0.0217
Mycobacterium tuberculosis Probable oxidoreductase 0.0292 0.1277 0.4028
Brugia malayi AF-10 protein 0.0029 0.0019 0.0047
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0066 0.0022
Loa Loa (eye worm) hypothetical protein 0.0089 0.0305 0.0763
Brugia malayi F/Y-rich N-terminus family protein 0.0049 0.0114 0.0287
Brugia malayi hypothetical protein 0.0036 0.0051 0.0128
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.004 0.0071 0.0231
Echinococcus granulosus histone acetyltransferase MYST2 0.0059 0.0161 0.0144
Schistosoma mansoni microtubule-associated protein tau 0.2119 1 1
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0082 0.0272 0.0683
Schistosoma mansoni hypothetical protein 0.0314 0.1379 0.1364
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0056 0.0036
Loa Loa (eye worm) glutathione reductase 0.0115 0.0431 0.108
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0291 0.127 0.1255
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0056 0.13
Schistosoma mansoni zinc finger protein 0.0048 0.0109 0.0092
Loa Loa (eye worm) hypothetical protein 0.0133 0.0513 0.1287
Leishmania major acetoin dehydrogenase e3 component-like protein 0.004 0.0071 0.1646
Plasmodium falciparum JmjC domain-containing protein, putative 0.0029 0.0017 0.0056
Schistosoma mansoni jumonji domain containing protein 0.0231 0.0985 0.0969
Trypanosoma brucei ISWI complex protein 0.0048 0.0109 0.2532
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0029 0.0019 0.0436
Echinococcus multilocularis polycomb protein SCMH1 0.0052 0.0127 0.011
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0055 0.0143 0.3328
Echinococcus granulosus mitogen activated protein kinase 0.0055 0.0143 0.0127
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0292 0.1277 0.4028
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.004 0.0071 0.1646
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0051 0.0034
Loa Loa (eye worm) hypothetical protein 0.0222 0.0939 0.2353
Trypanosoma cruzi ISWI complex protein 0.0048 0.0109 0.2532
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0143 0.0127
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0029 0.0017 0.0396
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.004 0.0071 0.1646
Brugia malayi Bromodomain containing protein 0.0237 0.1011 0.2535
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.0071 0.1646
Schistosoma mansoni jumonji/arid domain-containing protein 0.0115 0.0431 0.0415
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0113 0.0418 0.0402
Echinococcus granulosus PHD finger protein rhinoceros 0.0089 0.0305 0.0288
Toxoplasma gondii PHD-finger domain-containing protein 0.0089 0.0305 0.0992
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0082 0.0272 0.0256
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.0221 0.5135
Onchocerca volvulus 0.0039 0.0066 0.0083
Trypanosoma cruzi trypanothione reductase, putative 0.0115 0.0431 1
Toxoplasma gondii ABC1 family protein 0.0039 0.0066 0.0215
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0071 0.0221 0.0555
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0113 0.0418 0.0402
Schistosoma mansoni hypothetical protein 0.0048 0.0109 0.0092
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0051 0.0034
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.004 0.0071 0.0231
Schistosoma mansoni bromodomain containing protein 0.02 0.0836 0.082
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0055 0.0143 0.0359
Brugia malayi beta-lactamase 0.0039 0.0066 0.0166
Trichomonas vaginalis set domain proteins, putative 0.0979 0.4556 1
Brugia malayi MH2 domain containing protein 0.0118 0.0446 0.1117
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0291 0.127 0.1255
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0263 0.1136 0.4511
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.0143 0.3328
Loa Loa (eye worm) hypothetical protein 0.0052 0.0127 0.0317
Giardia lamblia NADH oxidase lateral transfer candidate 0.004 0.0071 0.0112
Echinococcus granulosus dnaJ subfamily B 0.0443 0.1994 0.198
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0124 0.0472 0.0456
Toxoplasma gondii histone lysine methyltransferase SET1 0.0071 0.0218 0.0711
Loa Loa (eye worm) hypothetical protein 0.0039 0.0066 0.0166
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0082 0.0272 0.0256
Echinococcus multilocularis microtubule associated protein 2 0.2119 1 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0203 0.0851 0.0836
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0066 0.0166
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.004 0.0071 0.0054
Loa Loa (eye worm) beta-lactamase 0.0039 0.0066 0.0166
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0093 0.0076
Schistosoma mansoni hypothetical protein 0.0036 0.0051 0.0034
Echinococcus multilocularis histone acetyltransferase MYST2 0.0059 0.0161 0.0144
Echinococcus multilocularis jumonji domain containing protein 0.0124 0.0471 0.0454
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0071 0.0221 0.0204
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0056 0.0039
Loa Loa (eye worm) hypothetical protein 0.0029 0.0017 0.0043
Echinococcus granulosus lysine specific demethylase 5A 0.0115 0.0431 0.0415
Leishmania major dihydrolipoamide dehydrogenase, putative 0.004 0.0071 0.1646
Plasmodium falciparum phd finger protein, putative 0.0089 0.0305 0.0992
Plasmodium falciparum glutathione reductase 0.004 0.0071 0.0231
Echinococcus granulosus cpg binding protein 0.0039 0.0066 0.0049
Plasmodium vivax hypothetical protein, conserved 0.0089 0.0305 0.0992
Brugia malayi jmjC domain containing protein 0.0029 0.0017 0.0043
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.014
Echinococcus multilocularis neuropeptide receptor A26 0.0492 0.2229 0.2216
Trypanosoma brucei protein kinase, putative 0.0055 0.0143 0.3328
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.004 0.0071 0.0016
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.004 0.0071 0.0231
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0029 0.0017 0.0056
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0071 0.0221 0.1269
Loa Loa (eye worm) hypothetical protein 0.0059 0.0161 0.0403
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0036 0.0054 0.0037
Wolbachia endosymbiont of Brugia malayi 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 0.0668 0.3071 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0056 0.13
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0316 0.1391 0.2965
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.004 0.0071 0.0178
Loa Loa (eye worm) mbt repeat family protein 0.0052 0.0127 0.0317
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0066 0.0049
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0143 0.0194
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.004 0.0071 0.1646
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0093 0.0234
Brugia malayi Bromodomain containing protein 0.012 0.0453 0.1137
Echinococcus multilocularis dnaJ subfamily B 0.0443 0.1994 0.198
Loa Loa (eye worm) MBCTL1 0.0059 0.0161 0.0403
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0056 0.0039
Echinococcus multilocularis mitogen activated protein kinase 3 0.0055 0.0143 0.0127
Echinococcus granulosus SAM and MBT domain containing protein 0.0052 0.0127 0.011
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0017 0.0043
Loa Loa (eye worm) hypothetical protein 0.0039 0.0066 0.0166
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0263 0.1136 0.3561
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0072 0.0226 0.0209
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0051 0.0034
Giardia lamblia Kinase, CMGC MAPK 0.0055 0.0143 0.0655
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0056 0.0039
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0029 0.0019 0.0436
Echinococcus multilocularis peregrin 0.0096 0.034 0.0323
Plasmodium vivax 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, putative 0.0668 0.3071 1
Leishmania major hypothetical protein, conserved 0.0029 0.0017 0.0396
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0056 0.13
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0066 0.0215
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0292 0.1277 0.4028
Brugia malayi hypothetical protein 0.0133 0.0513 0.1287
Schistosoma mansoni methyl-cpg binding protein mbd 0.0053 0.0135 0.0118
Brugia malayi Bromodomain containing protein 0.0096 0.034 0.0852
Brugia malayi Pre-SET motif family protein 0.0124 0.0472 0.1184
Mycobacterium tuberculosis Probable dehydrogenase 0.0263 0.1136 0.3561
Plasmodium vivax glutathione reductase, putative 0.0115 0.0431 0.1403
Leishmania major hypothetical protein, conserved 0.0039 0.0066 0.1535
Echinococcus granulosus histone lysine methyltransferase setb 0.0177 0.0727 0.0712
Trichomonas vaginalis mercuric reductase, putative 0.004 0.0071 0.0033
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0055 0.0143 0.3328
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0028 0.0091
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0253 0.1089 0.273
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0066 0.1535
Onchocerca volvulus 0.0039 0.0066 0.0083
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0053 0.0135 0.0118
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0029 0.0019 0.0061
Brugia malayi jmjC domain containing protein 0.0029 0.0017 0.0043
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0124 0.0472 0.0456
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0143 0.0194
Loa Loa (eye worm) hypothetical protein 0.0039 0.0066 0.0166
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0066 0.1535
Echinococcus granulosus neuropeptide receptor A26 0.0492 0.2229 0.2216
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0093 0.0076
Loa Loa (eye worm) hypothetical protein 0.0152 0.0608 0.1524
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0316 0.1391 0.2965
Loa Loa (eye worm) hypothetical protein 0.012 0.0454 0.1139
Onchocerca volvulus 0.0039 0.0066 0.0083
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.086 0.3989 1
Echinococcus granulosus zinc finger protein 0.0063 0.0182 0.0165
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0066 0.0049
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0059 0.0161 0.0144
Echinococcus granulosus mitogen activated protein kinase 3 0.0055 0.0143 0.0127
Plasmodium falciparum thioredoxin reductase 0.0115 0.0431 0.1403
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0082 0.0272 0.0256
Brugia malayi jmjC domain containing protein 0.0115 0.0431 0.108
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0292 0.1277 0.5102
Echinococcus multilocularis neuropeptide s receptor 0.0492 0.2229 0.2216
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0028 0.0071
Schistosoma mansoni hypothetical protein 0.0082 0.0272 0.0256
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0066 0.0022
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.004 0.0071 0.1646
Schistosoma mansoni cpg binding protein 0.0039 0.0066 0.0049
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0052 0.0127 0.011
Loa Loa (eye worm) hypothetical protein 0.0029 0.0017 0.0043
Toxoplasma gondii PHD-finger domain-containing protein 0.0089 0.0305 0.0992
Schistosoma mansoni methyl-cpg binding protein mbd 0.0053 0.0135 0.0118
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0143 0.0194
Loa Loa (eye worm) hypothetical protein 0.0039 0.0066 0.0166
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0143 0.0194
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.0446 0.1117
Loa Loa (eye worm) hypothetical protein 0.0039 0.0066 0.0166
Schistosoma mansoni hypothetical protein 0.0082 0.0272 0.0256
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.004 0.0071 0.0231
Echinococcus granulosus methyl CpG binding domain protein 2 0.0053 0.0135 0.0118
Onchocerca volvulus Huntingtin homolog 0.0133 0.0513 0.1071
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0316 0.1391 0.2965
Plasmodium falciparum thioredoxin reductase 0.004 0.0071 0.0231
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0124 0.0472 0.1537
Schistosoma mansoni cpg binding protein 0.0031 0.0028 0.0011
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0316 0.1391 0.2965
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0029 0.0017 0.0056
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0093 0.0076
Echinococcus multilocularis transcription factor Dp 1 0.0041 0.0078 0.0061
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.0127 0.011
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0056 0.0039
Loa Loa (eye worm) thioredoxin reductase 0.0115 0.0431 0.108
Treponema pallidum fructose-bisphosphate aldolase 0.0316 0.1391 0.4398
Brugia malayi beta-lactamase family protein 0.0039 0.0066 0.0166
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0316 0.1391 1
Loa Loa (eye worm) hypothetical protein 0.0082 0.0272 0.0683
Mycobacterium tuberculosis Probable 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase IspF (MECPS) 0.0536 0.2439 0.7895
Echinococcus granulosus muscleblind protein 0.0149 0.0591 0.0575
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0055 0.0143 0.3328
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0263 0.1136 0.3561
Onchocerca volvulus Huntingtin homolog 0.0133 0.0513 0.1071
Schistosoma mansoni hypothetical protein 0.0443 0.1994 0.198
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.0071 0.1646
Onchocerca volvulus 0.0124 0.0472 0.098
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0066 0.0022
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0056 0.0039
Trichomonas vaginalis esterase, putative 0.0039 0.0066 0.0022
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0093 0.0076
Brugia malayi beta-lactamase family protein 0.0039 0.0066 0.0166
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0093 0.0234
Loa Loa (eye worm) apoptosis regulator protein 0.0082 0.0272 0.0683
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0056 0.0039
Brugia malayi CXXC zinc finger family protein 0.0031 0.0028 0.0071
Echinococcus multilocularis SAM and MBT domain containing protein 0.0052 0.0127 0.011
Schistosoma mansoni hypothetical protein 0.0089 0.0305 0.0288
Echinococcus multilocularis lysine specific demethylase 5A 0.0108 0.0394 0.0377
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0177 0.0727 0.0712
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0093 0.0076
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0093 0.0076
Loa Loa (eye worm) jmjC domain-containing protein 0.0115 0.0431 0.108
Echinococcus multilocularis PHD finger protein rhinoceros 0.0089 0.0305 0.0288
Trypanosoma brucei trypanothione reductase 0.0115 0.0431 1
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0066 0.0022
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0124 0.0472 0.0456
Mycobacterium ulcerans flavoprotein disulfide reductase 0.004 0.0071 0.0016
Brugia malayi Pre-SET motif family protein 0.086 0.3989 1
Brugia malayi Thioredoxin reductase 0.0115 0.0431 0.108
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.0071 0.1646
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.0221 0.5135
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0066 0.0166
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.004 0.0071 0.0016
Brugia malayi MAP kinase sur-1 0.0055 0.0143 0.0359
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.004 0.0071 0.0016
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0115 0.0431 0.1214
Brugia malayi PHD-finger family protein 0.0089 0.0305 0.0763
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.0221 0.5135
Brugia malayi Muscleblind-like protein 0.0149 0.0591 0.1481
Plasmodium vivax SET domain protein, putative 0.0124 0.0472 0.1537
Toxoplasma gondii thioredoxin reductase 0.0115 0.0431 0.1403
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0056 0.0039
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0089 0.0305 0.0288
Toxoplasma gondii 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase domain-containing protein 0.0668 0.3071 1
Schistosoma mansoni myelin transcription factor 1 myt1 0.0059 0.0161 0.0144
Echinococcus multilocularis cpg binding protein 0.0039 0.0066 0.0049
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0263 0.1136 0.3561
Toxoplasma gondii NADPH-glutathione reductase 0.004 0.0071 0.0231
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0316 0.1391 1
Leishmania major hypothetical protein, conserved 0.0048 0.0109 0.2532
Loa Loa (eye worm) hypothetical protein 0.0039 0.0066 0.0166
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0066 0.0049
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0155 0.0618 0.1836
Echinococcus granulosus peregrin 0.0096 0.034 0.0323
Plasmodium falciparum glutathione reductase 0.0115 0.0431 0.1403
Loa Loa (eye worm) jmjC domain-containing protein 0.0184 0.0757 0.1896
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0019 0.0061
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.004 0.0071 0.1646
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0059 0.0161 0.0144
Schistosoma mansoni jumonji/arid domain-containing protein 0.0115 0.0431 0.0415
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0017 0.0043
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0071 0.0221 0.0204
Treponema pallidum hypothetical protein 0.0668 0.3071 1
Plasmodium falciparum 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 0.0668 0.3071 1
Brugia malayi glutathione reductase 0.0115 0.0431 0.108
Loa Loa (eye worm) hypothetical protein 0.0177 0.0727 0.1824
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0203 0.0851 0.0836

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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