Detailed information for compound 799825

Basic information

Technical information
  • TDR Targets ID: 799825
  • Name: 5,7-dimethoxy-4-[2-(2-methylpropoxy)phenyl]-3 ,4-dihydro-1H-quinolin-2-one
  • MW: 355.428 | Formula: C21H25NO4
  • H donors: 1 H acceptors: 1 LogP: 3.76 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(OC)c2c(c1)NC(=O)CC2c1ccccc1OCC(C)C
  • InChi: 1S/C21H25NO4/c1-13(2)12-26-18-8-6-5-7-15(18)16-11-20(23)22-17-9-14(24-3)10-19(25-4)21(16)17/h5-10,13,16H,11-12H2,1-4H3,(H,22,23)
  • InChiKey: BDDYAARPWHYPIX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(2-isobutoxyphenyl)-5,7-dimethoxy-3,4-dihydro-1H-quinolin-2-one
  • 4-(2-isobutoxyphenyl)-5,7-dimethoxy-3,4-dihydrocarbostyril

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi RNA-editing complex protein MP100, putative 0.0016 0.0677 0.1561
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0007 0.0122 0.0122
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0016 0.0677 0.1561
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0007 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.0007 0.0122 0.013
Loa Loa (eye worm) hypothetical protein 0.0007 0.0122 0.013
Echinococcus granulosus muscleblind protein 0.0171 0.9348 0.9348
Giardia lamblia Leucyl-tRNA synthetase 0.0024 0.1112 0.2562
Echinococcus granulosus cpg binding protein 0.0032 0.1553 0.1553
Echinococcus multilocularis inositol monophosphatase 1 0.0042 0.2124 0.2124
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0137 0.0317
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0016 0.0677 0.1561
Treponema pallidum methionyl-tRNA synthetase 0.0024 0.1112 0.1186
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0016 0.0677 0.1561
Echinococcus granulosus traf and tnf receptor associated protein 0.0016 0.0677 0.0677
Chlamydia trachomatis leucine--tRNA ligase 0.0024 0.1112 1
Echinococcus multilocularis methionine tRNA synthetase 0.0063 0.3315 0.3315
Leishmania major hypothetical protein, conserved 0.0016 0.0677 0.1561
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0007 0.0122 0.028
Toxoplasma gondii tRNA ligases class I (M) protein 0.0024 0.1112 0.2562
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0016 0.0677 0.0677
Brugia malayi hypothetical protein 0.0007 0.0122 0.013
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0016 0.0677 0.1119
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0016 0.0677 0.0677
Loa Loa (eye worm) hypothetical protein 0.0007 0.0122 0.013
Trichomonas vaginalis inositol monophosphatase, putative 0.0042 0.2124 0.4896
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0007 0.0122 0.0122
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0153 0.837 0.837
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0042 0.2124 0.4896
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0007 0.0122 0.0122
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0677 0.1119
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0153 0.837 0.837
Brugia malayi methionyl-tRNA synthetase 0.0063 0.3315 0.3546
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0677 0.1561
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0082 0.4339 1
Schistosoma mansoni cpg binding protein 0.003 0.1455 0.1455
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0112 0.6053 0.6053
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0112 0.6053 0.6053
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0007 0.0122 0.0122
Trypanosoma brucei methionyl-tRNA synthetase, putative 0.0063 0.3315 0.764
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.3585 0.8263
Mycobacterium ulcerans leucyl-tRNA synthetase 0.0024 0.1112 0.2562
Onchocerca volvulus 0.016 0.8718 1
Echinococcus granulosus methionyl tRNA synthetase cytoplasmic 0.0024 0.1112 0.1112
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0677 0.1561
Loa Loa (eye worm) hypothetical protein 0.0171 0.9348 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.3366 0.3366
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0677 0.1561
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0279 0.0279
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.1455 0.1557
Loa Loa (eye worm) hypothetical protein 0.0007 0.0122 0.013
Echinococcus granulosus methionine tRNA synthetase 0.0063 0.3315 0.3315
Plasmodium vivax hypothetical protein, conserved 0.0024 0.1112 0.1186
Schistosoma mansoni hypothetical protein 0.0112 0.6053 0.6053
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0137 0.0317
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0016 0.0677 0.1119
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0007 0.0122 0.0122
Schistosoma mansoni GTP-binding protein alpha subunit 0.0007 0.0122 0.0122
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0082 0.4339 1
Leishmania major leucyl-tRNA synthetase, putative 0.0024 0.1112 0.2562
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0007 0.0122 0.028
Brugia malayi Muscleblind-like protein 0.0171 0.9348 1
Trypanosoma cruzi mitochondrial protein 99, putative 0.0016 0.0677 0.1561
Loa Loa (eye worm) hypothetical protein 0.0016 0.0677 0.0725
Trichomonas vaginalis methionine-tRNA synthetase, putative 0.0063 0.3315 0.764
Echinococcus multilocularis leucyl tRNA synthetase 0.0024 0.1112 0.1112
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.2124 0.4896
Echinococcus multilocularis cpg binding protein 0.0032 0.1553 0.1553
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0016 0.0677 0.1561
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0175 0.0175
Echinococcus multilocularis muscleblind protein 1 0.0171 0.9348 0.9348
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0677 0.0725
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0137 0.0317
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.2124 0.4896
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0007 0.0122 0.0122
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0677 0.1119
Loa Loa (eye worm) methionyl-tRNA synthetase 0.0063 0.3315 0.3546
Entamoeba histolytica hypothetical protein 0.0112 0.6053 1
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0007 0.0122 0.0122
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0153 0.837 0.837
Loa Loa (eye worm) hypothetical protein 0.0016 0.0677 0.0725
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.2124 0.4896
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0007 0.0122 0.013
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0007 0.0122 0.0122
Schistosoma mansoni neutral sphingomyelinase 0.0016 0.0677 0.0677
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0082 0.4339 1
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0007 0.0122 0.0122
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0677 0.1561
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0137 0.0317
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0137 0.0317
Plasmodium falciparum methionine--tRNA ligase 0.0063 0.3315 0.7203
Brugia malayi methionyl-tRNA synthetase 0.0024 0.1112 0.1189
Loa Loa (eye worm) inositol-1 0.0042 0.2124 0.2272
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0082 0.4339 0.4339
Brugia malayi CXXC zinc finger family protein 0.003 0.1455 0.1557
Wolbachia endosymbiont of Brugia malayi methionyl-tRNA synthetase 0.0063 0.3315 0.6827
Trichomonas vaginalis ap endonuclease, putative 0.0082 0.4339 1
Schistosoma mansoni synaptojanin 0.0016 0.0677 0.0677
Brugia malayi G-protein alpha subunit 0.0007 0.0122 0.013
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0137 0.0317
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0153 0.837 0.8953
Brugia malayi protein ZK524.3 0.0024 0.1112 0.1189
Schistosoma mansoni cript-related 0.0016 0.0677 0.0677
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0137 0.0317
Onchocerca volvulus 0.0016 0.0677 0.0777
Loa Loa (eye worm) G protein alpha subunit 3 0.0007 0.0122 0.013
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0677 0.1561
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0279 0.0298
Entamoeba histolytica hypothetical protein 0.0112 0.6053 1
Trichomonas vaginalis helicase, putative 0.0007 0.0137 0.0317
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.2124 0.4896
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0082 0.4339 1
Schistosoma mansoni inositol monophosphatase 0.0042 0.2124 0.2124
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0175 0.0175
Onchocerca volvulus Putative neutral sphingomyelinase 0.0016 0.0677 0.0777
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0137 0.0317
Leishmania major pantothenate kinase subunit, putative 0.0016 0.0677 0.1561
Loa Loa (eye worm) tyrosyl-tRNA synthetase 0.0039 0.1955 0.2091
Mycobacterium tuberculosis Probable exported protein 0.0016 0.0677 0.1561
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0016 0.0677 0.0677
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0137 0.0317
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0016 0.0677 0.1561
Leishmania major inositol phosphosphingolipid phospholipase C-Like 0.0016 0.0677 0.1561
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0007 0.0122 0.0122
Entamoeba histolytica G protein alpha subunit, putative 0.0007 0.0122 0.0201
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0137 0.0317
Schistosoma mansoni hypothetical protein 0.0016 0.0677 0.0677
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0677 0.0725
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0153 0.837 0.837
Loa Loa (eye worm) hypothetical protein 0.0024 0.1112 0.1189
Giardia lamblia Inositol 5-phosphatase 4 0.0016 0.0677 0.1561
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0082 0.4339 0.7168
Trypanosoma cruzi inositol 5-phosphatase 1, putative 0.0016 0.0677 0.1561
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0677 0.1561
Schistosoma mansoni cpg binding protein 0.0032 0.1553 0.1553
Schistosoma mansoni transcription factor LCR-F1 0.0112 0.6053 0.6053
Leishmania major inositol/phosphatidylinositol phosphatase, putative 0.0016 0.0677 0.1561
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0042 0.2124 0.3138
Echinococcus multilocularis neutral sphingomyelinase 0.0016 0.0677 0.0677
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0007 0.0122 0.0122
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0068 0.3585 0.8263
Schistosoma mansoni hypothetical protein 0.0183 1 1
Brugia malayi CCR4 0.0016 0.0677 0.0725
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0007 0.0122 0.013
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.2124 0.4896
Echinococcus multilocularis muscleblind protein 0.0171 0.9348 0.9348
Schistosoma mansoni ap endonuclease 0.0082 0.4339 0.4339
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0082 0.4339 0.4339
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0677 0.1561
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0007 0.0122 0.013
Leishmania major RNA-editing complex protein MP100, putative 0.0016 0.0677 0.1561
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0007 0.0122 0.0122
Toxoplasma gondii aldehyde dehydrogenase 0.0068 0.3585 0.8263
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0137 0.0317
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0016 0.0677 0.0677
Loa Loa (eye worm) hypothetical protein 0.0024 0.1112 0.1189
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0677 0.1561
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0007 0.0122 0.013
Entamoeba histolytica methionyl-tRNA synthetase, putative 0.0024 0.1112 0.1837
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0016 0.0677 0.1561
Echinococcus multilocularis synaptojanin 1 0.0016 0.0677 0.0677
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0677 0.0725
Echinococcus granulosus expressed protein 0.0007 0.0122 0.0122
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0068 0.3585 0.8263
Echinococcus multilocularis methionyl tRNA synthetase, cytoplasmic 0.0024 0.1112 0.1112
Onchocerca volvulus 0.0007 0.0122 0.0139
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0016 0.0677 0.1561
Loa Loa (eye worm) hypothetical protein 0.0024 0.1112 0.1189
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.3585 0.3585
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0677 0.1119
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0016 0.0677 0.0677
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0068 0.3585 0.3585
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0677 0.1119
Schistosoma mansoni carbon catabolite repressor protein 0.0016 0.0677 0.0677
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0677 0.1561
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0007 0.0122 0.013
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0082 0.4339 1
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0016 0.0677 0.0677
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0677 0.0725
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0007 0.0122 0.013
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.298 0.6868
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0082 0.4339 1
Treponema pallidum leucyl-tRNA synthetase 0.0024 0.1112 0.1186
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0137 0.0317
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0016 0.0677 0.1561
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0137 0.0317
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0082 0.4339 1
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0677 0.1561
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0677 0.0725
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0007 0.0122 0.028
Trypanosoma brucei RNA editing exonuclease 2 0.0016 0.0677 0.1561
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0007 0.0122 0.013
Entamoeba histolytica inositol polyphosphate 5-phosphatase, putative 0.0016 0.0677 0.1119
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0042 0.2124 0.3509
Brugia malayi hypothetical protein 0.0112 0.6053 0.6475
Toxoplasma gondii exonuclease III APE 0.0082 0.4339 1
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0007 0.0122 0.013
Schistosoma mansoni nocturnin 0.0016 0.0677 0.0677
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0007 0.0122 0.0122
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0677 0.1561
Brugia malayi hypothetical protein 0.016 0.8718 0.9326
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0137 0.0317
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0279 0.0279
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0016 0.0677 0.0725
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0677 0.0725
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0007 0.0122 0.028
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0153 0.837 0.837
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0677 0.1561
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0175 0.0175
Schistosoma mansoni leucyl-tRNA synthetase 0.0024 0.1112 0.1112
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0007 0.0122 0.013
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0007 0.0122 0.028
Plasmodium vivax methionine--tRNA ligase, putative 0.0024 0.1112 0.1186
Echinococcus multilocularis expressed protein 0.0007 0.0122 0.0122
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0042 0.2124 0.4896
Loa Loa (eye worm) hypothetical protein 0.0016 0.0677 0.0725
Schistosoma mansoni cpg binding protein 0.0032 0.1553 0.1553
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0016 0.0677 0.0677
Trichomonas vaginalis Phospholipase C precursor, putative 0.0016 0.0677 0.1561
Schistosoma mansoni GTP-binding protein alpha subunit 0.0007 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.0007 0.0122 0.013
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0007 0.0122 0.028
Entamoeba histolytica inositol polyphosphate-5-phosphatase, putative 0.0016 0.0677 0.1119
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0082 0.4339 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.3585 0.8263
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0016 0.0677 0.1561
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0677 0.0725
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0016 0.0677 0.1561
Chlamydia trachomatis methionine--tRNA ligase 0.0024 0.1112 1
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0007 0.0122 0.028
Loa Loa (eye worm) hypothetical protein 0.0016 0.0677 0.0725
Onchocerca volvulus 0.003 0.1455 0.167
Leishmania major methionyl-tRNA synthetase, putative 0.0063 0.3315 0.764
Trypanosoma cruzi mitochondrial protein 99, putative 0.0016 0.0677 0.1561
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0677 0.0725
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0007 0.0122 0.013
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0038 0.1876 0.4323
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0007 0.0122 0.0122
Trypanosoma cruzi Inositol phosphosphingolipids phospholipase C 0.0016 0.0677 0.1561
Mycobacterium ulcerans methionyl-tRNA synthetase 0.0063 0.3315 0.764
Onchocerca volvulus 0.0007 0.0122 0.0139
Toxoplasma gondii methionyl-tRNA synthetase 0.0063 0.3315 0.764
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0175 0.0175
Entamoeba histolytica sphingomyelinase C precursor, putative 0.0016 0.0677 0.1119
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0677 0.1561
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0153 0.837 0.837
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0137 0.0317
Plasmodium falciparum methionine--tRNA ligase, putative 0.0024 0.1112 0.1186
Treponema pallidum exodeoxyribonuclease (exoA) 0.0082 0.4339 1
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.0016 0.0677 0.1561
Schistosoma mansoni methionine-tRNA synthetase 0.0063 0.3315 0.3315
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0677 0.0725
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.3585 0.3585
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0007 0.0122 0.013
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.0016 0.0677 0.1561
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0007 0.0122 0.0122
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0153 0.837 0.8953
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0175 0.0175
Trypanosoma cruzi methionyl-tRNA synthetase, putative 0.0063 0.3315 0.764
Onchocerca volvulus 0.0039 0.1955 0.2242
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0007 0.0122 0.0122
Entamoeba histolytica hypothetical protein 0.0112 0.6053 1
Plasmodium vivax methionine--tRNA ligase, putative 0.0063 0.3315 0.7203
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0137 0.0317
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0007 0.0122 0.0122
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0038 0.1876 0.5658
Trichomonas vaginalis ap endonuclease, putative 0.0082 0.4339 1
Trypanosoma cruzi endonuclease/exonuclease/phosphatase, putative 0.0016 0.0677 0.1561
Echinococcus granulosus synaptojanin 1 0.0016 0.0677 0.0677
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0082 0.4339 1
Leishmania major endonuclease/exonuclease protein-like protein 0.0016 0.0677 0.1561
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0677 0.1561
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0677 0.0725
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0007 0.0122 0.0122
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0677 0.0725
Loa Loa (eye worm) hypothetical protein 0.0171 0.9348 1
Mycobacterium tuberculosis Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) 0.0063 0.3315 0.764
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0007 0.0122 0.013
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.0016 0.0677 0.1561
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0137 0.0317
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0007 0.0122 0.0122
Onchocerca volvulus 0.0007 0.0122 0.0139
Giardia lamblia Methionyl-tRNA synthetase 0.0063 0.3315 0.764
Onchocerca volvulus 0.0016 0.0677 0.0777
Schistosoma mansoni ap endonuclease 0.0082 0.4339 0.4339
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0016 0.0677 0.1561
Schistosoma mansoni hypothetical protein 0.0183 1 1
Giardia lamblia hypothetical protein 0.0016 0.0677 0.1561
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0677 0.1119
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0007 0.0122 0.013
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0007 0.0122 0.0122
Echinococcus multilocularis traf and tnf receptor associated protein 0.0016 0.0677 0.0677
Echinococcus granulosus neutral sphingomyelinase 0.0016 0.0677 0.0677
Brugia malayi exodeoxyribonuclease III family protein 0.0082 0.4339 0.4641
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0677 0.0725
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.3585 0.8263
Entamoeba histolytica hypothetical protein 0.0112 0.6053 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0153 0.837 0.837
Echinococcus multilocularis deoxyribonuclease 1 2 0.0016 0.0677 0.0677
Schistosoma mansoni inositol monophosphatase 0.0042 0.2124 0.2124
Echinococcus granulosus inositol monophosphatase 1 0.0042 0.2124 0.2124
Mycobacterium leprae Probable methionyl-tRNA synthase MetS 0.0063 0.3315 1
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0016 0.0677 0.1561
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.2124 0.4896
Schistosoma mansoni methionine-tRNA synthetase 0.0024 0.1112 0.1112
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0082 0.4339 0.4641
Schistosoma mansoni synaptojanin 0.0016 0.0677 0.0677
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0272 0.0291
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0677 0.1561
Leishmania major hypothetical protein, conserved 0.0016 0.0677 0.1561
Loa Loa (eye worm) hypothetical protein 0.016 0.8718 0.9326
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0677 0.0725
Echinococcus multilocularis geminin 0.0183 1 1
Leishmania major hypothetical protein, conserved 0.0016 0.0677 0.1561
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0068 0.3585 0.3585
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0007 0.0122 0.028
Brugia malayi Inositol-1 0.0042 0.2124 0.2272
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0677 0.0725
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0082 0.4339 1
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0677 0.1119

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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