TDR Targets

Basic information

Technical information

TDR Targets ID: 799986
Name: 4-(2,4-difluorophenyl)-7-(4-fluorophenyl)-1,3 ,4,6,7,8-hexahydroquinoline-2,5-dione
MW: 371.352 | Formula: C21H16F3NO2
H donors: 1 H acceptors: 2 LogP: 2.91 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc(cc1)C1CC2=C(C(=O)C1)C(CC(=O)N2)c1ccc(cc1F)F
InChi: 1S/C21H16F3NO2/c22-13-3-1-11(2-4-13)12-7-18-21(19(26)8-12)16(10-20(27)25-18)15-6-5-14(23)9-17(15)24/h1-6,9,12,16H,7-8,10H2,(H,25,27)
InChiKey: WKVWTEXFFVVCRM-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

4-(2,4-difluorophenyl)-7-(4-fluorophenyl)-1,3,4,6,7,8-hexahydroquinoline-2,5-quinone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	putative neuropeptide receptor	0.00967454	0.568314	0.338051
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.00967454	0.568314	0.568314
Echinococcus granulosus	g protein coupled receptor	0.00967454	0.568314	0.0886102
Echinococcus multilocularis	rhodopsin orphan GPCR	0.00967454	0.568314	0.0886102
Echinococcus multilocularis	potassium large conductance calcium activated	0.0105485	0.63889	1
Schistosoma mansoni	neuropeptide F-like receptor	0.00967454	0.568314	0.568314
Echinococcus granulosus	neuropeptide FF receptor 2	0.00967454	0.568314	0.0886102
Loa Loa (eye worm)	FAT-3 protein	0.0150042	0.998701	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.00967454	0.568314	0.338051
Schistosoma mansoni	neuropeptide f receptor 76f	0.00967454	0.568314	0.568314
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.00967454	0.568314	0.568314
Loa Loa (eye worm)	hypothetical protein	0.00967454	0.568314	0.569053
Echinococcus granulosus	neuropeptide Y receptor	0.00967454	0.568314	0.0886102
Schistosoma mansoni	hypothetical protein	0.00967454	0.568314	0.568314
Loa Loa (eye worm)	hypothetical protein	0.00967454	0.568314	0.569053
Echinococcus multilocularis	g protein coupled receptor	0.00967454	0.568314	0.0886102
Loa Loa (eye worm)	hypothetical protein	0.00967454	0.568314	0.569053
Loa Loa (eye worm)	hypothetical protein	0.00967454	0.568314	0.569053
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.00967454	0.568314	0.0886102
Loa Loa (eye worm)	hypothetical protein	0.00967454	0.568314	0.569053
Loa Loa (eye worm)	hypothetical protein	0.00967454	0.568314	0.569053
Schistosoma mansoni	myosin xvIII	0.00967454	0.568314	0.568314
Echinococcus multilocularis	serotonin receptor	0.00967454	0.568314	0.0886102
Echinococcus multilocularis	rhodopsin orphan GPCR	0.00967454	0.568314	0.0886102
Loa Loa (eye worm)	hypothetical protein	0.00967454	0.568314	0.569053
Echinococcus granulosus	rhodopsin orphan GPCR	0.00967454	0.568314	0.0886102
Schistosoma mansoni	alpha-1 adrenergic receptor	0.00967454	0.568314	0.568314
Echinococcus granulosus	tachykinin peptides receptor 99D	0.00967454	0.568314	0.0886102
Schistosoma mansoni	amine GPCR	0.00967454	0.568314	0.568314
Loa Loa (eye worm)	hypothetical protein	0.00967454	0.568314	0.569053
Schistosoma mansoni	fatty acid desaturase	0.0150203	1	1
Brugia malayi	follicle stimulating hormone receptor	0.00967454	0.568314	0.338051
Schistosoma mansoni	neuropeptide receptor	0.00967454	0.568314	0.568314
Echinococcus granulosus	peptide allatostatin:somatostatin	0.00967454	0.568314	0.0886102
Brugia malayi	AKH receptor	0.00967454	0.568314	0.338051
Loa Loa (eye worm)	hypothetical protein	0.00967454	0.568314	0.569053
Loa Loa (eye worm)	hypothetical protein	0.0150042	0.998701	1
Echinococcus granulosus	somatostatin receptor	0.00967454	0.568314	0.0886102
Echinococcus granulosus	orexin receptor type 2	0.00967454	0.568314	0.0886102
Loa Loa (eye worm)	large conductance calcium-activated potassium channel alpha subunit ai	0.00958956	0.561452	0.562183
Schistosoma mansoni	amine GPCR	0.00967454	0.568314	0.568314
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.00967454	0.568314	0.338051
Echinococcus granulosus	g protein coupled receptor	0.00967454	0.568314	0.0886102
Echinococcus granulosus	hypothetical protein	0.00967454	0.568314	0.0886102
Brugia malayi	G-protein coupled receptor	0.00967454	0.568314	0.338051
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.00967454	0.568314	0.568314
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.00967454	0.568314	0.0886102
Plasmodium falciparum	potassium channel	0.00263684	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.00967454	0.568314	0.569053
Echinococcus multilocularis	G-protein coupled receptor, putative	0.00967454	0.568314	0.0886102
Loa Loa (eye worm)	hypothetical protein	0.00967454	0.568314	0.569053
Loa Loa (eye worm)	hypothetical protein	0.00967454	0.568314	0.569053
Brugia malayi	larval opioid receptor	0.00967454	0.568314	0.338051
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.00967454	0.568314	0.0886102
Loa Loa (eye worm)	hypothetical protein	0.00967454	0.568314	0.569053
Schistosoma mansoni	hypothetical protein	0.00967454	0.568314	0.568314
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.00967454	0.568314	0.0886102
Echinococcus multilocularis	g protein coupled receptor	0.00967454	0.568314	0.0886102
Schistosoma mansoni	opsin-like receptor	0.00967454	0.568314	0.568314
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.00967454	0.568314	0.0886102
Echinococcus granulosus	tm gpcr rhodopsin	0.00967454	0.568314	0.0886102
Echinococcus granulosus	g-protein coupled receptor	0.00967454	0.568314	0.0886102
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.00967454	0.568314	0.569053
Echinococcus multilocularis	allatostatin A receptor	0.00967454	0.568314	0.0886102
Echinococcus granulosus	rhodopsin orphan GPCR	0.00967454	0.568314	0.0886102
Schistosoma mansoni	amine GPCR	0.00967454	0.568314	0.568314
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.00967454	0.568314	0.568314
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.00967454	0.568314	0.569053
Schistosoma mansoni	biogenic amine (5HT) receptor	0.00967454	0.568314	0.568314
Loa Loa (eye worm)	MaxiK calcium-activated potassium channel	0.00695272	0.348519	0.348973
Brugia malayi	hypothetical protein	0.00967454	0.568314	0.338051
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.00967454	0.568314	0.568314
Echinococcus multilocularis	g protein coupled receptor	0.00967454	0.568314	0.0886102
Echinococcus multilocularis	rhodopsin orphan GPCR	0.00967454	0.568314	0.0886102
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.00967454	0.568314	0.338051
Schistosoma mansoni	neuropeptide F-like receptor	0.00967454	0.568314	0.568314
Loa Loa (eye worm)	hypothetical protein	0.00967454	0.568314	0.569053
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.00967454	0.568314	0.0886102
Brugia malayi	Dopamine receptor protein 1	0.00967454	0.568314	0.338051
Loa Loa (eye worm)	hypothetical protein	0.00967454	0.568314	0.569053
Echinococcus granulosus	G protein coupled receptor 139	0.00967454	0.568314	0.0886102
Brugia malayi	hypothetical protein	0.00967454	0.568314	0.338051
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.00967454	0.568314	0.0886102
Loa Loa (eye worm)	hypothetical protein	0.00967454	0.568314	0.569053
Brugia malayi	hypothetical protein	0.00967454	0.568314	0.338051
Brugia malayi	RE15519p	0.00967454	0.568314	0.338051
Schistosoma mansoni	neuropeptide receptor	0.00967454	0.568314	0.568314
Toxoplasma gondii	ion channel protein	0.00263684	0	0.5
Echinococcus multilocularis	fmrfamide receptor	0.00967454	0.568314	0.0886102
Loa Loa (eye worm)	neuropeptide F receptor	0.00967454	0.568314	0.569053
Echinococcus multilocularis	neuropeptide receptor A26	0.00967454	0.568314	0.0886102
Brugia malayi	hypothetical protein	0.00967454	0.568314	0.338051
Loa Loa (eye worm)	hypothetical protein	0.00967454	0.568314	0.569053
Brugia malayi	G protein-coupled receptor	0.00967454	0.568314	0.338051
Brugia malayi	G-protein coupled receptor	0.00967454	0.568314	0.338051
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.00967454	0.568314	0.568314
Schistosoma mansoni	biogenic amine (5HT) receptor	0.00967454	0.568314	0.568314
Loa Loa (eye worm)	hypothetical protein	0.00967454	0.568314	0.569053
Echinococcus granulosus	sex peptide receptor	0.00967454	0.568314	0.0886102
Brugia malayi	hypothetical protein	0.00967454	0.568314	0.338051
Loa Loa (eye worm)	hypothetical protein	0.00967454	0.568314	0.569053
Trypanosoma cruzi	calcium/potassium channel (CAKC), putative	0.00263684	0	0.5
Echinococcus granulosus	fmrfamide receptor	0.00967454	0.568314	0.0886102
Schistosoma mansoni	calcium-activated potassium channel	0.0105485	0.63889	0.63889
Echinococcus multilocularis	rhodopsin orphan GPCR	0.00967454	0.568314	0.0886102
Echinococcus granulosus	biogenic amine 5HT receptor	0.00967454	0.568314	0.0886102
Loa Loa (eye worm)	hypothetical protein	0.00967454	0.568314	0.569053
Echinococcus granulosus	g protein coupled receptor	0.00967454	0.568314	0.0886102
Brugia malayi	Tachykinin-like peptides receptor 99D	0.00967454	0.568314	0.338051
Brugia malayi	hypothetical protein	0.00967454	0.568314	0.338051
Schistosoma mansoni	hypothetical protein	0.00967454	0.568314	0.568314
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.00967454	0.568314	0.0886102
Trypanosoma brucei	calcium/potassium channel (CAKC), putative	0.00263684	0	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.00967454	0.568314	0.0886102
Schistosoma mansoni	amine GPCR	0.00967454	0.568314	0.568314
Loa Loa (eye worm)	hypothetical protein	0.00967454	0.568314	0.569053
Echinococcus granulosus	neuropeptide Y receptor	0.00967454	0.568314	0.0886102
Echinococcus granulosus	neuropeptides capa receptor	0.00967454	0.568314	0.0886102
Loa Loa (eye worm)	hypothetical protein	0.00967454	0.568314	0.569053
Brugia malayi	neuropeptide F receptor	0.00967454	0.568314	0.338051
Loa Loa (eye worm)	hypothetical protein	0.00967454	0.568314	0.569053
Echinococcus granulosus	dro:myosuppressin receptor	0.00967454	0.568314	0.0886102
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.00967454	0.568314	0.568314
Loa Loa (eye worm)	hypothetical protein	0.00695272	0.348519	0.348973
Echinococcus granulosus	rhodopsin orphan GPCR	0.00967454	0.568314	0.0886102
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.00967454	0.568314	0.569053
Echinococcus multilocularis	neuropeptide Y receptor	0.00967454	0.568314	0.0886102
Schistosoma mansoni	growth hormone secretagogue receptor	0.00967454	0.568314	0.568314
Echinococcus granulosus	neuropeptide receptor	0.00967454	0.568314	0.0886102
Loa Loa (eye worm)	hypothetical protein	0.00967454	0.568314	0.569053
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.00967454	0.568314	0.568314
Echinococcus multilocularis	rhodopsin orphan GPCR	0.00967454	0.568314	0.0886102
Brugia malayi	Serotonin receptor	0.00967454	0.568314	0.338051
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.00967454	0.568314	0.568314
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.00967454	0.568314	0.568314
Trypanosoma cruzi	calcium/potassium channel (CAKC), putative	0.00263684	0	0.5
Loa Loa (eye worm)	melatonin receptor type 1A	0.00967454	0.568314	0.569053
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.00967454	0.568314	0.568314
Schistosoma mansoni	amine GPCR	0.00967454	0.568314	0.568314
Echinococcus multilocularis	dro:myosuppressin receptor	0.00967454	0.568314	0.0886102
Echinococcus granulosus	neuropeptides capa receptor	0.00967454	0.568314	0.0886102
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.00967454	0.568314	0.0886102
Leishmania major	delta-5 fatty acid desaturase	0.0150042	0.998701	1
Echinococcus multilocularis	g-protein coupled receptor	0.00967454	0.568314	0.0886102
Echinococcus granulosus	neuropeptide receptor A26	0.00967454	0.568314	0.0886102
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.00967454	0.568314	0.338051
Brugia malayi	putative neuropeptide receptor NPR1	0.00967454	0.568314	0.338051
Onchocerca volvulus		0.0150203	1	1
Loa Loa (eye worm)	hypothetical protein	0.00967454	0.568314	0.569053
Loa Loa (eye worm)	hypothetical protein	0.00967454	0.568314	0.569053
Echinococcus multilocularis	neuropeptide FF receptor 2	0.00967454	0.568314	0.0886102
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.00967454	0.568314	0.568314
Echinococcus granulosus	tm gpcr rhodopsin	0.00967454	0.568314	0.0886102
Echinococcus granulosus	alpha 1A adrenergic receptor	0.00967454	0.568314	0.0886102
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.00967454	0.568314	0.568314
Echinococcus multilocularis	neuropeptide receptor	0.00967454	0.568314	0.0886102
Echinococcus granulosus	rhodopsin orphan GPCR	0.00967454	0.568314	0.0886102
Loa Loa (eye worm)	hypothetical protein	0.00967454	0.568314	0.569053
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.00967454	0.568314	0.338051
Loa Loa (eye worm)	hypothetical protein	0.00967454	0.568314	0.569053
Echinococcus granulosus	biogenic amine 5HT receptor	0.00967454	0.568314	0.0886102
Schistosoma mansoni	biogenic amine receptor	0.00967454	0.568314	0.568314
Brugia malayi	Dopamine receptor protein 2	0.00967454	0.568314	0.338051
Echinococcus granulosus	rhodopsin orphan GPCR	0.00967454	0.568314	0.0886102
Echinococcus granulosus	rhodopsin orphan GPCR	0.00967454	0.568314	0.0886102
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.00967454	0.568314	0.568314
Echinococcus multilocularis	neuropeptides capa receptor	0.00967454	0.568314	0.0886102
Schistosoma mansoni	histamine h1 receptor	0.00967454	0.568314	0.568314
Echinococcus granulosus	neuropeptide s receptor	0.00967454	0.568314	0.0886102
Brugia malayi	Serotonin receptor	0.00967454	0.568314	0.338051
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.00967454	0.568314	0.0886102
Loa Loa (eye worm)	neuropeptide F receptor	0.00967454	0.568314	0.569053
Loa Loa (eye worm)	hypothetical protein	0.00967454	0.568314	0.569053
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.00967454	0.568314	0.0886102
Echinococcus granulosus	allatostatin A receptor	0.00967454	0.568314	0.0886102
Schistosoma mansoni	neuropeptide receptor	0.00967454	0.568314	0.568314
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.00967454	0.568314	0.568314
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.00967454	0.568314	0.0886102
Brugia malayi	G protein-coupled receptor F59B2.13	0.00967454	0.568314	0.338051
Loa Loa (eye worm)	hypothetical protein	0.00967454	0.568314	0.569053
Echinococcus granulosus	tm gpcr rhodopsin	0.00967454	0.568314	0.0886102
Loa Loa (eye worm)	hypothetical protein	0.00967454	0.568314	0.569053
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.00967454	0.568314	0.0886102
Echinococcus multilocularis	rhodopsin orphan GPCR	0.00967454	0.568314	0.0886102
Loa Loa (eye worm)	hypothetical protein	0.00967454	0.568314	0.569053
Echinococcus multilocularis	G protein coupled receptor 139	0.00967454	0.568314	0.0886102
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.00967454	0.568314	0.568314
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.00967454	0.568314	0.569053
Echinococcus granulosus	neuropeptide receptor	0.00967454	0.568314	0.0886102
Echinococcus granulosus	7TM GPCR rhodopsin	0.00967454	0.568314	0.0886102
Echinococcus multilocularis	neuropeptide Y receptor	0.00967454	0.568314	0.0886102
Brugia malayi	sulfakinin receptor protein	0.00967454	0.568314	0.338051
Schistosoma mansoni	hypothetical protein	0.00967454	0.568314	0.568314
Echinococcus multilocularis	neuropeptide receptor	0.00967454	0.568314	0.0886102
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.00967454	0.568314	0.568314
Loa Loa (eye worm)	hypothetical protein	0.00967454	0.568314	0.569053
Loa Loa (eye worm)	hypothetical protein	0.00967454	0.568314	0.569053
Loa Loa (eye worm)	hypothetical protein	0.0134462	0.872888	0.874024
Brugia malayi	ORL1-like opioid receptor	0.00967454	0.568314	0.338051
Echinococcus multilocularis	sex peptide receptor	0.00967454	0.568314	0.0886102
Schistosoma mansoni	opsin-like receptor	0.00967454	0.568314	0.568314
Echinococcus multilocularis	fmrfamide receptor	0.00967454	0.568314	0.0886102
Schistosoma mansoni	adenoreceptor	0.00967454	0.568314	0.568314
Brugia malayi	GnHR receptor homolog	0.00967454	0.568314	0.338051
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.00967454	0.568314	0.0886102
Echinococcus multilocularis	calcium activated potassium channel	0.0105485	0.63889	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.00967454	0.568314	0.0886102
Loa Loa (eye worm)	G-protein coupled receptor	0.00967454	0.568314	0.569053
Echinococcus multilocularis	orexin receptor type 2	0.00967454	0.568314	0.0886102
Brugia malayi	neuropeptide F receptor	0.00967454	0.568314	0.338051
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.00967454	0.568314	0.0886102
Loa Loa (eye worm)	TYRA-2 protein	0.00967454	0.568314	0.569053
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.00967454	0.568314	0.0886102
Schistosoma mansoni	opsin-like receptor	0.00967454	0.568314	0.568314
Loa Loa (eye worm)	G-protein coupled receptor	0.00967454	0.568314	0.569053
Loa Loa (eye worm)	hypothetical protein	0.00967454	0.568314	0.569053
Echinococcus granulosus	calcium activated potassium channel	0.0105485	0.63889	1
Echinococcus multilocularis	neuropeptides capa receptor	0.00967454	0.568314	0.0886102
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.00967454	0.568314	0.568314
Loa Loa (eye worm)	hypothetical protein	0.00967454	0.568314	0.569053
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.00967454	0.568314	0.568314
Brugia malayi	hypothetical protein	0.00967454	0.568314	0.338051
Loa Loa (eye worm)	hypothetical protein	0.00967454	0.568314	0.569053
Echinococcus granulosus	potassium large conductance calcium activated	0.0105485	0.63889	1
Loa Loa (eye worm)	hypothetical protein	0.00967454	0.568314	0.569053
Loa Loa (eye worm)	hypothetical protein	0.00967454	0.568314	0.569053
Echinococcus multilocularis	neuropeptide s receptor	0.00967454	0.568314	0.0886102
Echinococcus granulosus	7tm_1 domain containing protein	0.00967454	0.568314	0.0886102
Echinococcus granulosus	rhodopsin orphan GPCR	0.00967454	0.568314	0.0886102
Brugia malayi	hypothetical protein	0.00967454	0.568314	0.338051
Loa Loa (eye worm)	hypothetical protein	0.00967454	0.568314	0.569053
Loa Loa (eye worm)	hypothetical protein	0.00967454	0.568314	0.569053
Loa Loa (eye worm)	hypothetical protein	0.00967454	0.568314	0.569053
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.00967454	0.568314	0.569053
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.00967454	0.568314	0.0886102
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.00967454	0.568314	0.568314
Loa Loa (eye worm)	hypothetical protein	0.00967454	0.568314	0.569053
Echinococcus multilocularis	rhodopsin orphan GPCR	0.00967454	0.568314	0.0886102
Schistosoma mansoni	biogenic amine receptor	0.00967454	0.568314	0.568314
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.00967454	0.568314	0.568314
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.00967454	0.568314	0.0886102
Echinococcus granulosus	serotonin receptor	0.00967454	0.568314	0.0886102
Brugia malayi	Melatonin receptor type 1A	0.00967454	0.568314	0.338051
Loa Loa (eye worm)	hypothetical protein	0.00967454	0.568314	0.569053
Echinococcus multilocularis	somatostatin receptor	0.00967454	0.568314	0.0886102
Schistosoma mansoni	biogenic amine receptor	0.00967454	0.568314	0.568314
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.00967454	0.568314	0.568314
Loa Loa (eye worm)	hypothetical protein	0.00967454	0.568314	0.569053
Schistosoma mansoni	neuropeptide receptor	0.00967454	0.568314	0.568314
Brugia malayi	Delta5 fatty acid desaturase	0.0150042	0.998701	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.00967454	0.568314	0.0886102
Toxoplasma gondii	ion channel protein	0.00263684	0	0.5
Brugia malayi	Dopamine receptor	0.00967454	0.568314	0.338051
Echinococcus multilocularis	serotonin receptor	0.00967454	0.568314	0.0886102
Brugia malayi	hypothetical protein	0.00967454	0.568314	0.338051
Plasmodium vivax	potassium channel, putative	0.00263684	0	0.5
Schistosoma mansoni	calcium-activated potassium channel	0.00958956	0.561452	0.561452
Brugia malayi	hypothetical protein	0.00967454	0.568314	0.338051

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 0.73 uM	Plasmodium falciparum K1 EC50 (uM) as measured by SYBR green dye	Saint Jude.	20485428
EC50 (functional)	0.73 uM	ST_JUDE: Plasmodium falciparum K1 EC50 (uM) as measured by SYBR green dye	ChEMBL.	20485428
EC50 (functional)	= 4.71 uM	Plasmodium falciparum 3D7 EC50 (uM) as measured by SYBR green dye	Saint Jude.	20485428
EC50 (functional)	4.7138 uM	ST_JUDE: Plasmodium falciparum 3D7 EC50 (uM) as measured by SYBR green dye	ChEMBL.	20485428
Percent growth inhibition (functional)	= 93.4 %	Plasmodium falciparum 3D7 % growth inhibition at 7uM as measured by YOYO-3 red dye	Saint Jude.	20485428
Percent growth inhibition (functional)	= 114.6 %	Plasmodium falciparum 3D7 % growth inhibition at 7uM as measured by SYBR green dye	Saint Jude.	20485428

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23	20485428

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL589201
Search by Saint Jude

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 799986