TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 248.304 | Formula: C11H12N4OS
H donors: 1 H acceptors: 3 LogP: 2.12 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: CCc1nnc(n1N=Cc1ccc(cc1)O)S
InChi: 1S/C11H12N4OS/c1-2-10-13-14-11(17)15(10)12-7-8-3-5-9(16)6-4-8/h3-7,16H,2H2,1H3,(H,14,17)/b12-7+
InChiKey: VALMTGAZUIMOKI-KPKJPENVSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.013	0.0558	0.0558
Plasmodium vivax	acyl-CoA synthetase, putative	0.0035	0.0074	0.6769
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0061	0.0207	0.0207
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0026	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0095	0.038	0.038
Brugia malayi	glutamate-cysteine ligase modifier subunit	0.0038	0.0086	0.0086
Schistosoma mansoni	tyrosine kinase	0.0118	0.0498	0.0498
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0135	0.0135
Trypanosoma brucei	aldo/keto reductase, putative	0.0038	0.0086	0.0637
Echinococcus granulosus	expressed conserved protein	0.009	0.0351	0.0351
Brugia malayi	SWIRM domain containing protein	0.0042	0.0109	0.0109
Echinococcus granulosus	sodium coupled monocarboxylate transporter 1	0.0042	0.0106	0.0106
Schistosoma mansoni	tyrosine kinase	0.0121	0.0509	0.0509
Onchocerca volvulus		0.0042	0.0106	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0377	0.1818	0.1818
Echinococcus granulosus	aldo keto reductase family 1, member B4	0.0038	0.0086	0.0086
Trypanosoma brucei	CMGC/DYRK protein kinase, putative	0.0287	0.1355	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.013	0.0558	0.0558
Echinococcus multilocularis	sodium:myo inositol cotransporter	0.0042	0.0106	0.0106
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.0042	0.0109	0.0109
Loa Loa (eye worm)	TAR-binding protein	0.0061	0.0207	0.0207
Brugia malayi	Protein kinase domain containing protein	0.0147	0.0642	0.0642
Echinococcus multilocularis	peroxidasin	0.0076	0.0283	0.0283
Onchocerca volvulus	Dual oxidase homolog	0.0076	0.0283	0.0283
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0047	0.0135	0.0439
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.013	0.0558	0.0558
Trichomonas vaginalis	aldo-keto reductase, putative	0.013	0.0558	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.013	0.0558	0.0558
Entamoeba histolytica	protein kinase, putative	0.0287	0.1355	1
Brugia malayi	Niemann-Pick C1 protein precursor	0.0095	0.038	0.038
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0408	0.0408
Wolbachia endosymbiont of Brugia malayi	NAD-dependent DNA ligase, Lig	0.0021	0	0.5
Brugia malayi	hypothetical protein	0.0035	0.0072	0.0072
Plasmodium falciparum	lysine-specific histone demethylase 1, putative	0.0042	0.0109	1
Schistosoma mansoni	hypothetical protein	0.0251	0.1176	0.1176
Trichomonas vaginalis	aldo/keto reductase, putative	0.013	0.0558	1
Trypanosoma brucei	prostaglandin f synthase	0.013	0.0558	0.4117
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0072	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0631	0.0631
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.013	0.0558	0.0558
Onchocerca volvulus		0.0094	0.0374	0.0374
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0283	0.0283
Onchocerca volvulus		0.013	0.0558	0.0558
Plasmodium vivax	lysine-specific histone demethylase 1, putative	0.0042	0.0109	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.013	0.0558	0.0558
Onchocerca volvulus		0.013	0.0558	0.0558
Echinococcus multilocularis	aldo keto reductase	0.013	0.0558	0.0558
Brugia malayi	GH02984p	0.0377	0.1818	0.1818
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0599	0.2951	0.9607
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0035	0.0074	0.0033
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.013	0.0558	0.0558
Plasmodium vivax	aldehyde reductase, putative	0.0038	0.0086	0.7896
Mycobacterium leprae	PROBABLE OXIDOREDUCTASE	0.013	0.0558	1
Echinococcus granulosus	hypothetical protein	0.013	0.0558	0.0558
Echinococcus granulosus	sodium:glucose cotransporter	0.0042	0.0106	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0026	0.0026
Schistosoma mansoni	inositol transporter	0.0042	0.0106	0.0106
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.013	0.0558	0.0558
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	0.0287	0.1355	0.1355
Schistosoma mansoni	tyrosine kinase	0.0265	0.1246	0.1246
Echinococcus granulosus	muscleblind protein	0.0145	0.0632	0.0632
Treponema pallidum	DNA ligase (lig)	0.0021	0	0.5
Loa Loa (eye worm)	ShTK domain-containing protein	0.0094	0.0374	0.0374
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0109	0.0109
Brugia malayi	AMP-binding enzyme family protein	0.0047	0.0135	0.0135
Trichomonas vaginalis	aldo-keto reductase, putative	0.013	0.0558	1
Trichomonas vaginalis	aldo/keto reductase, putative	0.013	0.0558	1
Mycobacterium ulcerans	protoporphyrinogen oxidase	0.0042	0.0109	0.0356
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0047	0.0135	0.0439
Mycobacterium ulcerans	oxidoreductase	0.013	0.0558	0.1816
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	0.0287	0.1355	1
Echinococcus multilocularis	epidermal growth factor receptor	0.0121	0.0509	0.0509
Entamoeba histolytica	hypothetical protein	0.0035	0.0072	0.0529
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0207	0.0207
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0072	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0283	0.0283
Loa Loa (eye worm)	oxidoreductase	0.013	0.0558	0.0558
Leishmania major	aldo/keto reductase, putative,aldo/keto reductase family-like protein	0.0038	0.0086	0.0456
Onchocerca volvulus		0.013	0.0558	0.0558
Leishmania major	4-coumarate:coa ligase-like protein	0.0047	0.0135	0.0822
Echinococcus granulosus	epidermal growth factor receptor	0.0121	0.0509	0.0509
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0287	0.1355	1
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.013	0.0558	0.0558
Schistosoma mansoni	hypothetical protein	0.0063	0.0214	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0283	0.0283
Brugia malayi	Protein kinase domain containing protein	0.0287	0.1355	0.1355
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0374	0.0374
Brugia malayi	Peroxidasin	0.0076	0.0283	0.0283
Mycobacterium leprae	Possible oxidoreductase	0.0038	0.0086	0.1548
Schistosoma mansoni	lipoxygenase	0.0114	0.0476	0.0476
Entamoeba histolytica	acyl-coA synthetase, putative	0.0047	0.0135	0.0996
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0042	0.0109	0.0807
Echinococcus granulosus	peroxidasin	0.0076	0.0283	0.0283
Loa Loa (eye worm)	ShTK domain-containing protein	0.0094	0.0374	0.0374
Echinococcus multilocularis	protoporphyrinogen oxidase	0.0042	0.0109	0.0109
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.013	0.0558	0.0558
Mycobacterium tuberculosis	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)	0.0557	0.2736	0.8883
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0094	0.0374	0.0374
Schistosoma mansoni	high-affinity choline transporter	0.0377	0.1818	0.1818
Trichomonas vaginalis	aldo-keto reductase, putative	0.0038	0.0086	0.1548
Brugia malayi	RNA binding protein	0.0061	0.0207	0.0207
Mycobacterium ulcerans	hypothetical protein	0.0038	0.0086	0.0281
Echinococcus granulosus	aldo keto reductase	0.013	0.0558	0.0558
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.013	0.0558	0.0558
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0207	0.0207
Brugia malayi	hypothetical protein	0.0076	0.0283	0.0283
Echinococcus granulosus	epidermal growth factor receptor	0.0121	0.0509	0.0509
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0114	0.0476	0.0476
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.013	0.0558	0.0558
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.0042	0.0109	0.0109
Schistosoma mansoni	tyrosine kinase	0.0118	0.0498	0.0498
Schistosoma mansoni	tyrosine kinase	0.0265	0.1246	0.1246
Plasmodium vivax	hypothetical protein, conserved	0.0042	0.0109	1
Echinococcus granulosus	insulin receptor	0.0265	0.1246	0.1246
Plasmodium vivax	ataxin-2 like protein, putative	0.0026	0.0026	0.2348
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0599	0.2951	0.9607
Brugia malayi	DnaJ domain containing protein	0.0063	0.0214	0.0214
Onchocerca volvulus	Peroxidasin homolog	0.0076	0.0283	0.0283
Echinococcus granulosus	tar DNA binding protein	0.0061	0.0207	0.0207
Entamoeba histolytica	aldose reductase, putative	0.013	0.0558	0.4117
Mycobacterium leprae	PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO)	0.0042	0.0109	0.1961
Schistosoma mansoni	hypothetical protein	0.0039	0.0095	0.0095
Mycobacterium ulcerans	arylamine N-acetyltransferase Nat	0.0623	0.3072	1
Schistosoma mansoni	tyrosinase precursor	0.0094	0.0374	0.0374
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0283	0.0283
Onchocerca volvulus		0.013	0.0558	0.0558
Loa Loa (eye worm)	oxidoreductase	0.013	0.0558	0.0558
Echinococcus granulosus	dnaJ subfamily C 6	0.0063	0.0214	0.0214
Brugia malayi	Uncharacterized hematopoietic stem/progenitor cells protein MDS029	0.0101	0.0408	0.0408
Leishmania major	4-coumarate:coa ligase-like protein	0.0047	0.0135	0.0822
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0287	0.1355	1
Echinococcus multilocularis	proto oncogene serine:threonine protein kinase	0.1982	1	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0109	0.0109
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0035	0.0074	0.0241
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0086	0.1548
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0109	0.0109
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0207	0.0207
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0026	0.2348
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0041	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.005	0.015	0.015
Brugia malayi	Blistered cuticle protein 3	0.0076	0.0283	0.0283
Mycobacterium ulcerans	hypothetical protein	0.0047	0.0135	0.0439
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0047	0.0135	0.0235
Chlamydia trachomatis	protoporphyrinogen oxidase	0.0042	0.0109	1
Entamoeba histolytica	alcohol dehydrogenase, putative	0.0038	0.0086	0.0637
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.0042	0.0109	0.0109
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.013	0.0558	0.0558
Mycobacterium ulcerans	oxidoreductase	0.0042	0.0109	0.0356
Toxoplasma gondii	transporter, solute:sodium symporter (SSS) family protein	0.0042	0.0106	0.1906
Brugia malayi	Animal haem peroxidase family protein	0.0076	0.0283	0.0283
Echinococcus multilocularis	Niemann Pick C1 protein	0.0095	0.038	0.038
Toxoplasma gondii	aldo-keto reductase	0.0038	0.0086	0.1548
Mycobacterium ulcerans	acyl-CoA synthetase	0.0047	0.0135	0.0439
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0047	0.0135	0.0235
Schistosoma mansoni	inositol transporter	0.0042	0.0106	0.0106
Echinococcus multilocularis	aldo keto reductase	0.013	0.0558	0.0558
Echinococcus multilocularis	cdgsh iron sulfur domain containing protein	0.0237	0.1103	0.1103
Plasmodium vivax	oxidoreductase, aldo/keto reductase domain containing protein	0.0038	0.0086	0.7896
Schistosoma mansoni	tyrosinase precursor	0.0094	0.0374	0.0374
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0103	0.1841
Trypanosoma brucei	aldo-keto reductase, putative	0.013	0.0558	0.4117
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0095	0.038	0.2806
Echinococcus granulosus	proto oncogene serine:threonine protein kinase	0.1982	1	1
Loa Loa (eye worm)	blistered cuticle protein 3	0.0076	0.0283	0.0283
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0047	0.0135	0.0996
Entamoeba histolytica	alcohol dehydrogenase, putative	0.0038	0.0086	0.0637
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.013	0.0558	0.0558
Echinococcus multilocularis	muscleblind protein	0.0145	0.0632	0.0632
Schistosoma mansoni	potassium channel beta	0.0038	0.0086	0.0086
Brugia malayi	Animal haem peroxidase family protein	0.0076	0.0283	0.0283
Trichomonas vaginalis	aldo-keto reductase, putative	0.013	0.0558	1
Onchocerca volvulus	Peroxidasin homolog	0.0076	0.0283	0.0283
Brugia malayi	Protein kinase domain containing protein	0.0265	0.1246	0.1246
Brugia malayi	Common central domain of tyrosinase family protein	0.0094	0.0374	0.0374
Toxoplasma gondii	aldose reductase, putative	0.013	0.0558	1
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0283	0.0283
Loa Loa (eye worm)	animal heme peroxidase	0.0076	0.0283	0.0283
Echinococcus multilocularis	voltage gated potassium channel subunit	0.0038	0.0086	0.0086
Onchocerca volvulus	Serine\/threonine protein kinase homolog	0.1982	1	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.013	0.0558	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0109	0.0109
Echinococcus multilocularis	sodium:glucose cotransporter 2	0.0042	0.0106	0.0106
Trichomonas vaginalis	aldo/keto reductase, putative	0.013	0.0558	1
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.013	0.0558	0.0558
Leishmania major	prostaglandin f2-alpha synthase/D-arabinose dehydrogenase	0.013	0.0558	0.4003
Onchocerca volvulus		0.0094	0.0374	0.0374
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0114	0.0476	0.0476
Trichomonas vaginalis	alcohol dehydrogenase, putative	0.0038	0.0086	0.1548
Toxoplasma gondii	LsmAD domain-containing protein	0.0026	0.0026	0.046
Onchocerca volvulus		0.0101	0.0408	0.0408
Onchocerca volvulus	Chorion peroxidase homolog	0.0076	0.0283	0.0283
Echinococcus granulosus	solute carrier family 5	0.0042	0.0106	0.0106
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0026	0.0189
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0047	0.0135	0.0439
Echinococcus granulosus	aldo keto reductase	0.013	0.0558	0.0558
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0109	0.0109
Brugia malayi	NADH-dependent xylose reductase	0.0038	0.0086	0.0086
Mycobacterium ulcerans	monoamine oxidase	0.0042	0.0109	0.0356
Schistosoma mansoni	tyrosine kinase	0.0121	0.0509	0.0509
Onchocerca volvulus		0.0047	0.0135	0.0135
Schistosoma mansoni	aldo-keto reductase	0.013	0.0558	0.0558
Onchocerca volvulus	Peroxidase homolog	0.0076	0.0283	0.0283
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0035	0.0074	0.6769
Loa Loa (eye worm)	animal heme peroxidase	0.0076	0.0283	0.0283
Leishmania major	aldehyde reductase, putative,oxidoreductase, putative	0.013	0.0558	0.4003
Trypanosoma brucei	PAB1-binding protein , putative	0.0026	0.0026	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0273	0.1287	0.1287
Echinococcus multilocularis	Niemann Pick C1 protein	0.0136	0.0589	0.0589
Mycobacterium leprae	Conserved hypothetical protein	0.0092	0.0366	0.6554
Schistosoma mansoni	tyrosine kinase	0.0121	0.0509	0.0509
Giardia lamblia	Aldose reductase	0.013	0.0558	1
Brugia malayi	TAR-binding protein	0.0061	0.0207	0.0207
Echinococcus multilocularis	sterol regulatory element binding protein	0.0041	0.0103	0.0103
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0047	0.0135	0.2419
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0042	0.0109	0.0807
Brugia malayi	Serine/threonine-protein kinase Pim-3	0.1982	1	1
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0094	0.0374	0.0374
Entamoeba histolytica	aldose reductase, putative	0.013	0.0558	0.4117
Brugia malayi	AMP-binding enzyme family protein	0.0047	0.0135	0.0135
Echinococcus granulosus	sodium:glucose cotransporter 2	0.0042	0.0106	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0283	0.0283
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0283	0.0283
Brugia malayi	Furin-like cysteine rich region family protein	0.0121	0.0509	0.0509
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0265	0.1246	0.1246
Echinococcus granulosus	Niemann Pick C1 protein	0.0136	0.0589	0.0589
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0283	0.0283
Echinococcus granulosus	aldehyde reductase	0.0092	0.0366	0.0366
Onchocerca volvulus		0.0076	0.0283	0.0283
Echinococcus multilocularis	sodium coupled monocarboxylate transporter 1	0.0042	0.0106	0.0106
Echinococcus multilocularis	insulin receptor	0.0265	0.1246	0.1246
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.013	0.0558	0.0558
Schistosoma mansoni	hypothetical protein	0.0039	0.0095	0.0095
Loa Loa (eye worm)	TK/INSR protein kinase	0.0265	0.1246	0.1246
Schistosoma mansoni	pol-related	0.013	0.0558	0.0558
Brugia malayi	Animal haem peroxidase family protein	0.0076	0.0283	0.0283
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0074	0.0074
Mycobacterium ulcerans	hypothetical protein	0.0229	0.1062	0.3458
Plasmodium falciparum	aldehyde reductase, putative	0.0038	0.0086	0.7896
Schistosoma mansoni	peroxidasin	0.0076	0.0283	0.0283
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0047	0.0135	0.0439
Mycobacterium ulcerans	dehydrogenase	0.0042	0.0109	0.0356
Leishmania major	4-coumarate:coa ligase-like protein	0.0047	0.0135	0.0822
Loa Loa (eye worm)	hypothetical protein	0.0273	0.1287	0.1287
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0135	0.0135
Loa Loa (eye worm)	oxidoreductase	0.013	0.0558	0.0558
Schistosoma mansoni	hypothetical protein	0.0039	0.0095	0.0095
Onchocerca volvulus		0.0038	0.0086	0.0086
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.013	0.0558	1
Echinococcus multilocularis		0.0035	0.0071	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0283	0.0283
Echinococcus multilocularis		0.0042	0.0109	0.0109
Toxoplasma gondii	histone lysine-specific demethylase LSD1/BHC110/KDMA1A	0.0042	0.0109	0.1961
Entamoeba histolytica	hypothetical protein	0.0287	0.1355	1
Loa Loa (eye worm)	animal heme peroxidase	0.0076	0.0283	0.0283
Brugia malayi	Animal haem peroxidase family protein	0.0076	0.0283	0.0283
Mycobacterium tuberculosis	Possible oxidoreductase	0.0042	0.0109	0.015
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0097	0.0388	0.0388
Echinococcus granulosus	dual specificity	0.0287	0.1355	0.1355
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0283	0.0283
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0283	0.0283
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0026	0.2348
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0374	0.0374
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0042	0.0109	1
Toxoplasma gondii	oxidoreductase, aldo/keto reductase family protein	0.0038	0.0086	0.1548
Loa Loa (eye worm)	RNA binding protein	0.0061	0.0207	0.0207
Trypanosoma cruzi	aldo/keto reductase, putative	0.013	0.0558	0.4117
Trichomonas vaginalis	aldo-keto reductase, putative	0.013	0.0558	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.013	0.0558	0.0558
Loa Loa (eye worm)	oxidoreductase	0.013	0.0558	0.0558
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.013	0.0558	0.0558
Loa Loa (eye worm)	animal heme peroxidase	0.0076	0.0283	0.0283
Brugia malayi	Hypothetical tyrosinase-like protein F21C3.2 in chromosome I	0.0094	0.0374	0.0374
Schistosoma mansoni	amine oxidase	0.0042	0.0109	0.0109
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.013	0.0558	0.0558
Echinococcus multilocularis	solute carrier family 5	0.0042	0.0106	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0103	0.0103
Schistosoma mansoni	hypothetical protein	0.0035	0.0072	0.0072
Echinococcus granulosus	cdgsh iron sulfur domain containing protein	0.0237	0.1103	0.1103
Schistosoma mansoni	lipoxygenase	0.008	0.0301	0.0301
Schistosoma mansoni	amine oxidase	0.0042	0.0109	0.0109
Entamoeba histolytica	hypothetical protein	0.0035	0.0072	0.0529
Echinococcus granulosus	sodium:myo inositol cotransporter	0.0042	0.0106	0.0106
Loa Loa (eye worm)	DnaJ domain-containing protein	0.0063	0.0214	0.0214
Echinococcus multilocularis	epidermal growth factor receptor	0.0121	0.0509	0.0509
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.1982	1	1
Echinococcus multilocularis	protein dispatched 1	0.0047	0.0132	0.0132
Brugia malayi	CHE-14 protein	0.0041	0.0103	0.0103
Loa Loa (eye worm)	glutamate-cysteine ligase modifier subunit	0.0038	0.0086	0.0086
Schistosoma mansoni	CDGSH-type Zn finger-containing protein-like protein	0.0251	0.1176	0.1176
Entamoeba histolytica	hypothetical protein	0.0035	0.0072	0.0529
Brugia malayi	AMP-binding enzyme family protein	0.0047	0.0135	0.0135
Mycobacterium ulcerans	acyl-CoA synthetase	0.0047	0.0135	0.0439
Plasmodium falciparum	acyl-CoA synthetase	0.0035	0.0074	0.6769
Schistosoma mansoni	serine/threonine protein kinase	0.0287	0.1355	0.1355
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0072	0.0072
Echinococcus multilocularis	high affinity choline transporter 1	0.0377	0.1818	0.1818
Echinococcus granulosus	high affinity choline transporter 1	0.0377	0.1818	0.1818
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.1982	1	1
Trypanosoma cruzi	aldo/keto reductase, putative	0.0038	0.0086	0.0637
Mycobacterium tuberculosis	Arylamine N-acetyltransferase Nat (arylamine acetylase)	0.0623	0.3072	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.013	0.0558	1
Plasmodium falciparum	protoporphyrinogen oxidase	0.0042	0.0109	1
Brugia malayi	hypothetical protein	0.0042	0.0109	0.0109
Trypanosoma cruzi	aldo-keto reductase	0.013	0.0558	0.4117
Onchocerca volvulus		0.0094	0.0374	0.0374
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0121	0.0509	0.0509
Brugia malayi	Sodium:solute symporter family protein	0.0042	0.0106	0.0106
Echinococcus multilocularis	dual specificity	0.0287	0.1355	0.1355
Toxoplasma gondii	histone lysine-specific demethylase	0.0042	0.0109	0.1961
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.013	0.0558	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0074	0.0074
Echinococcus multilocularis	aldehyde reductase	0.0092	0.0366	0.0366
Echinococcus granulosus	Niemann Pick C1 protein	0.0095	0.038	0.038
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0074	0.0074
Onchocerca volvulus		0.013	0.0558	0.0558
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.013	0.0558	0.0558
Trichomonas vaginalis	aldo-keto reductase, putative	0.013	0.0558	1
Onchocerca volvulus		0.0042	0.0109	0.0109
Echinococcus multilocularis	aldo keto reductase	0.013	0.0558	0.0558
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0207	0.0207
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0042	0.0109	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0283	0.0283
Echinococcus multilocularis	muscleblind protein 1	0.0145	0.0632	0.0632
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0632	0.0632
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0283	0.0283
Onchocerca volvulus		0.0076	0.0283	0.0283
Brugia malayi	amine oxidase, flavin-containing family protein	0.0042	0.0109	0.0109
Plasmodium vivax	protoporphyrinogen oxidase, putative	0.0042	0.0109	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.013	0.0558	0.0558
Toxoplasma gondii	aldo/keto reductase family oxidoreductase	0.0038	0.0086	0.1548
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0265	0.1246	0.1246
Schistosoma mansoni	aldo-keto reductase	0.013	0.0558	0.0558
Entamoeba histolytica	protein kinase, putative	0.0287	0.1355	1
Brugia malayi	Animal haem peroxidase family protein	0.0076	0.0283	0.0283
Leishmania major	prostaglandin f synthase, putative	0.013	0.0558	0.4003
Entamoeba histolytica	protein kinase domain containing protein	0.0287	0.1355	1
Onchocerca volvulus	Peroxidase homolog	0.0076	0.0283	0.0283
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.013	0.0558	0.0558
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0042	0.0109	0.015
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0074	0.0074
Leishmania major	UDP-galactopyranose mutase	0.0042	0.0109	0.063
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0207	0.0207
Mycobacterium tuberculosis	Probable oxidoreductase	0.013	0.0558	0.1641
Leishmania major	aldo-keto reductase-like protein	0.013	0.0558	0.4003
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.013	0.0558	0.0558
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0094	0.0374	0.0374
Entamoeba histolytica	aldose reductase, putative	0.013	0.0558	0.4117
Schistosoma mansoni	tyrosine kinase	0.0118	0.0498	0.0498
Trichomonas vaginalis	aldo-keto reductase, putative	0.0038	0.0086	0.1548
Echinococcus multilocularis	expressed conserved protein	0.009	0.0351	0.0351
Echinococcus granulosus	aldo keto reductase	0.013	0.0558	0.0558
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0047	0.0135	0.0996
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0074	0.0074
Schistosoma mansoni	peroxidasin	0.0076	0.0283	0.0283
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0121	0.0509	0.0509
Loa Loa (eye worm)	hypothetical protein	0.013	0.0558	0.0558
Schistosoma mansoni	patched 1	0.0041	0.0103	0.0103
Onchocerca volvulus		0.0076	0.0283	0.0283
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0106	0.0106
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0047	0.0135	0.2419
Giardia lamblia	Aldose reductase	0.013	0.0558	1
Loa Loa (eye worm)	oxidoreductase	0.013	0.0558	0.0558
Plasmodium vivax	hypothetical protein, conserved	0.0042	0.0109	1
Onchocerca volvulus		0.0094	0.0374	0.0374
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0042	0.0109	0.0109
Echinococcus multilocularis	tar DNA binding protein	0.0061	0.0207	0.0207
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.013	0.0558	0.0558
Schistosoma mansoni	sodium/solute symporter	0.0042	0.0106	0.0106
Echinococcus granulosus	Protein patched homolog 1	0.0041	0.0103	0.0103
Schistosoma mansoni	serine/threonine protein kinase	0.1982	1	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0047	0.0135	0.0439
Brugia malayi	ShTK domain containing protein	0.0094	0.0374	0.0374
Brugia malayi	hypothetical protein	0.0026	0.0026	0.0026
Schistosoma mansoni	hypothetical protein	0.0039	0.0095	0.0095
Echinococcus multilocularis	protein patched	0.0041	0.0103	0.0103
Brugia malayi	Muscleblind-like protein	0.0145	0.0632	0.0632
Trichomonas vaginalis	aldo-keto reductase, putative	0.013	0.0558	1
Plasmodium falciparum	aldo-keto reductase, putative	0.0038	0.0086	0.7896
Trichomonas vaginalis	aldo-keto reductase, putative	0.0038	0.0086	0.1548
Echinococcus multilocularis	dnaJ subfamily C 6	0.0063	0.0214	0.0214
Trichomonas vaginalis	aldo-keto reductase, putative	0.013	0.0558	1
Mycobacterium tuberculosis	Conserved protein	0.0038	0.0086	0.0074
Trichomonas vaginalis	aldo-keto reductase, putative	0.013	0.0558	1
Echinococcus granulosus	sterol regulatory element binding protein	0.0041	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0135	0.0135
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.013	0.0558	1
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0283	0.0283
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0109	0.0109
Echinococcus multilocularis	aldo keto reductase	0.013	0.0558	0.0558
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0632	0.0632
Trichomonas vaginalis	protein kinase inhibitor, putative	0.0063	0.0214	0.3833
Onchocerca volvulus		0.013	0.0558	0.0558
Trichomonas vaginalis	aldo-keto reductase, putative	0.013	0.0558	1
Entamoeba histolytica	hypothetical protein	0.0035	0.0072	0.0529
Trichomonas vaginalis	aldo-keto reductase, putative	0.013	0.0558	1
Echinococcus granulosus	voltage gated potassium channel subunit	0.0038	0.0086	0.0086
Brugia malayi	RNA recognition motif domain containing protein	0.0061	0.0207	0.0207
Loa Loa (eye worm)	tyrosinase 1	0.0094	0.0374	0.0374

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 801040