TDR Targets

Basic information

Technical information

TDR Targets ID: 801524
Name: 3-[(4-acetylphenyl)amino]-2-(4-ethoxyphenyl)- 3H-isoindol-1-one
MW: 386.443 | Formula: C24H22N2O3
H donors: 1 H acceptors: 2 LogP: 4.35 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1ccc(cc1)N1C(Nc2ccc(cc2)C(=O)C)c2c(C1=O)cccc2
InChi: 1S/C24H22N2O3/c1-3-29-20-14-12-19(13-15-20)26-23(21-6-4-5-7-22(21)24(26)28)25-18-10-8-17(9-11-18)16(2)27/h4-15,23,25H,3H2,1-2H3
InChiKey: WAMSUBPVOFRCKZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

3-[(4-acetylphenyl)amino]-2-(4-ethoxyphenyl)isoindolin-1-one
3-[(4-acetylphenyl)amino]-2-(4-ethoxyphenyl)-1-isoindolinone
3-[(4-ethanoylphenyl)amino]-2-(4-ethoxyphenyl)-3H-isoindol-1-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	estradiol 17 beta-dehydrogenase, putative	0.0016	0.0037	0.1111
Echinococcus multilocularis	Dehydrogenase:reductase SDR family	0.0016	0.0037	0.0038
Leishmania major	short chain dehydrogenase/reductase, putative	0.0016	0.0037	0.0491
Echinococcus granulosus	PHD finger protein rhinoceros	0.0029	0.0159	0.0168
Entamoeba histolytica	Ulp1 protease family, C-terminal catalytic domain containing protein	0.0013	0.0001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0283	0.0717
Echinococcus multilocularis	steroid dehydrogenase	0.0016	0.0037	0.0038
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0016	0.0037	0.0491
Schistosoma mansoni	carbonyl reductase	0.0016	0.0037	0.0036
Trichomonas vaginalis	steroid dehydrogenase, putative	0.0016	0.0037	0.1111
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0016	0.0037	0.0796
Schistosoma mansoni	serine/threonine protein kinase	0.0087	0.0745	0.0744
Toxoplasma gondii	sterol carrier protein-2 HAD-2SCP-2	0.0016	0.0037	0.0796
Trypanosoma cruzi	NAD(P)-dependent oxidoreductase, putative	0.0016	0.0037	0.0491
Plasmodium vivax	hypothetical protein, conserved	0.0041	0.0283	0.6274
Entamoeba histolytica	protein kinase domain containing protein	0.0087	0.0745	1
Leishmania major	quinonoid dihydropteridine reductase	0.0016	0.0037	0.0491
Trichomonas vaginalis	Clan CE, family C48, Ulp1-like cysteine peptidase	0.0013	0.0001	0.0023
Plasmodium vivax	protoporphyrinogen oxidase, putative	0.0041	0.0283	0.6274
Echinococcus multilocularis	geminin	0.0166	0.1526	0.1619
Leishmania major	dehydrogenase-like protein	0.0016	0.0037	0.0491
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0029	0.0159	0.0158
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.0041	0.0283	0.03
Trichomonas vaginalis	Sentrin-specific protease, putative	0.0013	0.0001	0.0023
Brugia malayi	Ets-domain containing protein	0.0071	0.0581	0.1474
Onchocerca volvulus		0.0016	0.0037	0.0091
Onchocerca volvulus		0.0016	0.0037	0.0091
Mycobacterium ulcerans	oxidoreductase	0.0041	0.0283	0.0414
Loa Loa (eye worm)	oxidoreductase	0.0016	0.0037	0.0091
Entamoeba histolytica	short chain dehydrogenase family protein	0.0016	0.0037	0.0491
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0016	0.0037	0.0091
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 1 homolog	0.0016	0.0037	0.0091
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0015	0.0029	0.0071
Echinococcus granulosus	carbonyl reductase 1	0.0016	0.0037	0.0038
Toxoplasma gondii	PHD-finger domain-containing protein	0.0029	0.0159	0.352
Schistosoma mansoni	steroid dehydrogenase	0.0016	0.0037	0.0036
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0016	0.0037	0.0091
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0016	0.0037	0.0091
Trypanosoma cruzi	short chain dehydrogenase/reductase, putative	0.0016	0.0037	0.0491
Onchocerca volvulus		0.0016	0.0037	0.0091
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0121	0.203
Schistosoma mansoni	short chain dehydrogenase	0.0016	0.0037	0.0036
Brugia malayi	amine oxidase, flavin-containing family protein	0.0041	0.0283	0.0717
Entamoeba histolytica	short chain dehydrogenase family protein	0.0016	0.0037	0.0491
Leishmania major	pteridine reductase 1	0.0016	0.0037	0.0491
Schistosoma mansoni	short chain dehydrogenase	0.0016	0.0037	0.0036
Brugia malayi	Hypothetical oxidoreductase F56D1.5	0.0016	0.0037	0.0091
Onchocerca volvulus	Sepiapterin reductase homolog	0.0016	0.0037	0.0091
Echinococcus granulosus	Dehydrogenase:reductase SDR family	0.0016	0.0037	0.0038
Brugia malayi	Dehydrogenases, short chain protein 2	0.0016	0.0037	0.0091
Onchocerca volvulus		0.0058	0.0451	0.1144
Schistosoma mansoni	short chain dehydrogenase	0.0016	0.0037	0.0036
Onchocerca volvulus		0.0016	0.0037	0.0091
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0016	0.0037	0.0091
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0001	0.0023
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0016	0.0037	0.0796
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0582	0.5668	0.9464
Onchocerca volvulus		0.0016	0.0037	0.0091
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0016	0.0037	0.0491
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0283	0.0717
Trypanosoma cruzi	beta-ketoacyl-ACP reductase 2, putative	0.0016	0.0037	0.0491
Brugia malayi	Ulp1 protease family, C-terminal catalytic domain containing protein	0.0046	0.0329	0.0834
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0016	0.0037	0.1111
Echinococcus multilocularis	dual specificity	0.0087	0.0745	0.0789
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0016	0.0037	0.0091
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0094	0.0805	0.0854
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0016	0.0037	0.0491
Schistosoma mansoni	steroid dehydrogenase	0.0016	0.0037	0.0036
Trypanosoma brucei	beta-D-hydroxybutyrate dehydrogenase	0.0016	0.0037	0.0491
Loa Loa (eye worm)	fli-1 protein	0.0215	0.2017	0.5125
Echinococcus granulosus	carbonyl reductase 1	0.0016	0.0037	0.0038
Schistosoma mansoni	short chain dehydrogenase	0.0016	0.0037	0.0036
Schistosoma mansoni	steroid dehydrogenase	0.0016	0.0037	0.0036
Echinococcus granulosus	lysine specific demethylase 5A	0.0035	0.0219	0.0231
Leishmania major	quinonoid dihydropteridine reductase	0.0016	0.0037	0.0491
Onchocerca volvulus		0.0016	0.0037	0.0091
Schistosoma mansoni	hypothetical protein	0.0015	0.0029	0.0028
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0016	0.0037	0.0491
Trypanosoma brucei	3-keto-dihydrosphingosine reductase	0.0016	0.0037	0.0491
Trypanosoma cruzi	short chain dehydrogenase/reductase, putative	0.0016	0.0037	0.0491
Plasmodium vivax	hypothetical protein, conserved	0.0058	0.0451	1
Echinococcus multilocularis	lysine specific demethylase 5A	0.0035	0.0219	0.0231
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.0041	0.0283	0.0282
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0451	0.1144
Mycobacterium tuberculosis	Possible oxidoreductase	0.0041	0.0283	0.0414
Echinococcus multilocularis	sentrin specific protease 1	0.0046	0.0329	0.0348
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	0.0087	0.0745	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0037	0.0091
Trichomonas vaginalis	sentrin/sumo-specific protease, senp8, putative	0.0013	0.0001	0.0023
Plasmodium falciparum	protoporphyrinogen oxidase	0.0041	0.0283	0.5951
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0016	0.0037	0.0038
Trichomonas vaginalis	DNA helicase recq, putative	0.0024	0.0109	0.3311
Mycobacterium tuberculosis	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)	0.0541	0.526	0.8778
Echinococcus granulosus	conserved hypothetical protein	0.0058	0.0451	0.0477
Schistosoma mansoni	steroid dehydrogenase	0.0016	0.0037	0.0036
Echinococcus granulosus	carbonyl reductase 1	0.0016	0.0037	0.0038
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0016	0.0037	0.1111
Echinococcus granulosus	steroid dehydrogenase	0.0016	0.0037	0.0038
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0016	0.0037	0.0796
Echinococcus multilocularis		0.0041	0.0283	0.03
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0361	0.0915
Plasmodium vivax	hypothetical protein, conserved	0.0058	0.0451	1
Schistosoma mansoni	carbonyl reductase	0.0016	0.0037	0.0036
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0041	0.0283	0.5951
Loa Loa (eye worm)	hypothetical protein	0.0408	0.3935	1
Brugia malayi	jmjC domain containing protein	0.0035	0.0219	0.0554
Trypanosoma cruzi	3-ketoacyl-CoA reductase, putative	0.0016	0.0037	0.0491
Brugia malayi	Uncharacterized hematopoietic stem/progenitor cells protein MDS029	0.0408	0.3935	1
Entamoeba histolytica	oxidoreductase, short chain dehydrogenase/reductase family	0.0016	0.0037	0.0491
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0021	0.0081	0.1062
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0329	0.0834
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0041	0.0283	0.3801
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0015	0.0029	0.003
Schistosoma mansoni	amine oxidase	0.0041	0.0283	0.0282
Brugia malayi	hypothetical protein	0.0041	0.0283	0.0717
Plasmodium vivax	hypothetical protein, conserved	0.0016	0.0037	0.0796
Trichomonas vaginalis	Clan CE, family C48, Ulp1-like cysteine peptidase	0.0013	0.0001	0.0023
Schistosoma mansoni	hypothetical protein	0.0029	0.0159	0.0158
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0016	0.0037	0.0091
Loa Loa (eye worm)	short chain dehydrogenase/reductase family oxidoreductase	0.0016	0.0037	0.0091
Leishmania major	short chain dehydrogenase, putative	0.0016	0.0037	0.0491
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0361	0.0915
Loa Loa (eye worm)	jmjC domain-containing protein	0.0035	0.0219	0.0554
Loa Loa (eye worm)	hypothetical protein	0.0087	0.074	0.1879
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0037	0.0091
Trypanosoma brucei	beta-ketoacyl-ACP reductase 2	0.0016	0.0037	0.0491
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0016	0.0037	0.0091
Brugia malayi	hypothetical protein	0.0016	0.0037	0.0091
Toxoplasma gondii	zinc finger cdgsh type protein	0.0058	0.0451	1
Echinococcus multilocularis	carbonyl reductase 1	0.0016	0.0037	0.0038
Leishmania major	UDP-galactopyranose mutase	0.0041	0.0283	0.3801
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0159	0.0402
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0016	0.0037	0.1111
Echinococcus multilocularis	jumonji domain containing protein	0.004	0.027	0.0286
Brugia malayi	RE40412p	0.0058	0.0451	0.1144
Onchocerca volvulus		0.0016	0.0037	0.0091
Schistosoma mansoni	retinal dehydrogenase	0.0016	0.0037	0.0036
Trichomonas vaginalis	short-chain dehydrogenases/reductase, putative	0.0016	0.0037	0.1111
Schistosoma mansoni	blooms syndrome DNA helicase	0.0019	0.006	0.0059
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0016	0.0037	0.0091
Trypanosoma cruzi	beta-ketoacyl-ACP reductase 2, putative	0.0016	0.0037	0.0491
Plasmodium vivax	steroid dehydrogenase, putative	0.0016	0.0037	0.0796
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0016	0.0037	0.0038
Trichomonas vaginalis	Clan CE, family C48, Ulp1-like cysteine peptidase	0.0013	0.0001	0.0023
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0041	0.0283	0.0414
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0582	0.5668	0.9464
Plasmodium vivax	lysine-specific histone demethylase 1, putative	0.0041	0.0283	0.6274
Plasmodium vivax	hypothetical protein, conserved	0.0041	0.0283	0.6274
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0016	0.0037	0.0091
Trypanosoma cruzi	hypothetical protein	0.0013	0.0001	0.001
Schistosoma mansoni	steroid dehydrogenase	0.0016	0.0037	0.0036
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0041	0.0283	0.03
Trypanosoma cruzi	quinonoid dihydropteridine reductase, putative	0.0016	0.0037	0.0491
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0016	0.0037	0.0091
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0015	0.0029	0.003
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0041	0.0283	0.03
Brugia malayi	jmjC domain containing protein	0.0094	0.0805	0.2045
Echinococcus multilocularis	steroid dehydrogenase	0.0016	0.0037	0.0038
Echinococcus granulosus	peregrin	0.0029	0.0159	0.0168
Schistosoma mansoni	hypothetical protein	0.0166	0.1526	0.1525
Schistosoma mansoni	family C48 unassigned peptidase (C48 family)	0.0046	0.0329	0.0328
Onchocerca volvulus		0.0016	0.0037	0.0091
Loa Loa (eye worm)	jmjC domain-containing protein	0.0059	0.0462	0.1171
Mycobacterium ulcerans	monoamine oxidase	0.0041	0.0283	0.0414
Echinococcus granulosus	dual specificity	0.0087	0.0745	0.0789
Brugia malayi	Protein kinase domain containing protein	0.0087	0.0745	0.1891
Brugia malayi	hypothetical protein	0.0016	0.0034	0.0084
Toxoplasma gondii	carbonyl reductase 1, putative	0.0016	0.0037	0.0796
Trypanosoma brucei	beta-ketoacyl-ACP reductase 3, putative	0.0016	0.0037	0.0491
Leishmania major	hypothetical protein, conserved	0.0016	0.0037	0.0491
Plasmodium falciparum	phd finger protein, putative	0.0029	0.0159	0.2959
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0037	0.0091
Schistosoma mansoni	hypothetical protein	0.0033	0.0207	0.0206
Echinococcus granulosus	oxidoreductase	0.0016	0.0037	0.0038
Leishmania major	short chain dehydrogenase-like protein	0.0016	0.0037	0.0491
Toxoplasma gondii	3-ketoacyl-CoA reductase, putative	0.0016	0.0037	0.0796
Echinococcus multilocularis	epidermal retinal dehydrogenase 2	0.0016	0.0037	0.0038
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0016	0.0037	0.1111
Leishmania major	quinonoid dihydropteridine reductase	0.0016	0.0037	0.0491
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0015	0.0029	0.003
Schistosoma mansoni	oxidoreductase short chain dehydrogenase/reductase family	0.0016	0.0037	0.0036
Entamoeba histolytica	Ulp1 protease family, C-terminal catalytic domain containing protein	0.0013	0.0001	0.001
Schistosoma mansoni	hypothetical protein	0.0015	0.0029	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0037	0.0091
Echinococcus granulosus	3 ketodihydrosphingosine reductase	0.0016	0.0037	0.0038
Schistosoma mansoni	gabp alpha	0.0071	0.0581	0.058
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0121	0.162
Schistosoma mansoni	short chain dehydrogenase	0.0016	0.0037	0.0036
Entamoeba histolytica	hypothetical protein	0.0087	0.0745	1
Echinococcus granulosus	cdgsh iron sulfur domain containing protein	0.096	0.9424	1
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0016	0.0037	0.1111
Brugia malayi	Bromodomain containing protein	0.0029	0.0159	0.0402
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0037	0.0091
Leishmania major	quinonoid dihydropteridine reductase	0.0016	0.0037	0.0491
Trypanosoma cruzi	short chain dehydrogenase, putative	0.0016	0.0037	0.0491
Schistosoma mansoni	short chain dehydrogenase	0.0016	0.0037	0.0036
Brugia malayi	hypothetical protein	0.0016	0.0037	0.0091
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C48, putative	0.0013	0.0001	0.001
Toxoplasma gondii	2,4-dienoyl CoA reductase 2, peroxisomal family protein	0.0016	0.0037	0.0796
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0029	0.0159	0.0168
Onchocerca volvulus		0.0408	0.3935	1
Echinococcus multilocularis	cdgsh iron sulfur domain containing protein	0.096	0.9424	1
Giardia lamblia	Reductase, putative	0.0016	0.0037	0.2262
Leishmania major	hypothetical protein, conserved	0.0025	0.0121	0.162
Toxoplasma gondii	PfMNL-2 CISD1 family iron-sulfur protein, putative	0.0058	0.0451	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0016	0.0037	0.0491
Trypanosoma cruzi	short chain dehydrogenase, putative	0.0016	0.0037	0.0491
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0283	0.0717
Echinococcus multilocularis	bloom syndrome protein	0.0024	0.0109	0.0115
Plasmodium vivax	hypothetical protein, conserved	0.0058	0.0451	1
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0016	0.0037	0.1111
Leishmania major	hypothetical protein, unknown function	0.0058	0.0451	0.6053
Schistosoma mansoni	steroid dehydrogenase	0.0016	0.0037	0.0036
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	0.0087	0.0745	0.1891
Entamoeba histolytica	hypothetical protein	0.0016	0.0037	0.0491
Loa Loa (eye worm)	hypothetical protein	0.0118	0.1052	0.2673
Schistosoma mansoni	amine oxidase	0.0041	0.0283	0.0282
Schistosoma mansoni	short chain dehydrogenase	0.0016	0.0037	0.0036
Entamoeba histolytica	Ulp1 protease family, C-terminal catalytic domain containing protein	0.0046	0.0329	0.4418
Plasmodium falciparum	CDGSH iron-sulfur domain-containing protein, putative	0.0058	0.0451	1
Brugia malayi	hypothetical protein	0.0025	0.0121	0.0305
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.0041	0.0283	0.0282
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0035	0.0219	0.0218
Schistosoma mansoni	hypothetical protein	0.0015	0.0029	0.0028
Schistosoma mansoni	hypothetical protein	0.0015	0.0029	0.0028
Entamoeba histolytica	protein kinase, putative	0.0087	0.0745	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0037	0.0091
Echinococcus granulosus	carbonyl reductase 1	0.0016	0.0037	0.0038
Echinococcus multilocularis	carbonyl reductase 1	0.0016	0.0037	0.0038
Echinococcus granulosus	WW domain containing oxidoreductase	0.0016	0.0037	0.0038
Entamoeba histolytica	estradiol 17-beta-dehydrogenase, putative	0.0016	0.0037	0.0491
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0121	0.162
Brugia malayi	Latrophilin receptor protein 2	0.0015	0.0029	0.0071
Echinococcus multilocularis	retinol dehydrogenase 11	0.0016	0.0037	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0362	0.0918
Echinococcus multilocularis	3 ketodihydrosphingosine reductase	0.0016	0.0037	0.0038
Echinococcus granulosus	retinol dehydrogenase 11	0.0016	0.0037	0.0038
Trichomonas vaginalis	hydroxyacyl dehydrogenase, putative	0.0016	0.0037	0.1111
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0037	0.0091
Schistosoma mansoni	short chain dehydrogenase	0.0016	0.0037	0.0036
Schistosoma mansoni	ets-related	0.0215	0.2017	0.2017
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0016	0.0031	0.068
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0071	0.0581	0.1474
Brugia malayi	D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor	0.0016	0.0037	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0207	0.0524
Loa Loa (eye worm)	oxidoreductase	0.0016	0.0037	0.0091
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0016	0.0037	0.0796
Trichomonas vaginalis	Clan CE, family C48, Ulp1-like cysteine peptidase	0.0013	0.0001	0.0023
Trichomonas vaginalis	Clan CE, family C48, Ulp1-like cysteine peptidase	0.0013	0.0001	0.0023
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.0016	0.0033	0.0721
Loa Loa (eye worm)	oxidoreductase	0.0016	0.0037	0.0091
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 13 homolog	0.0016	0.0037	0.0091
Loa Loa (eye worm)	RecQ helicase	0.0024	0.0109	0.0275
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0087	0.0745	1
Plasmodium falciparum	CDGSH iron-sulfur domain-containing protein, putative	0.0058	0.0451	1
Toxoplasma gondii	PHD-finger domain-containing protein	0.0029	0.0159	0.352
Onchocerca volvulus		0.0041	0.0283	0.0717
Trypanosoma cruzi	short-chain dehydrogenase, putative	0.0016	0.0037	0.0491
Giardia lamblia	Short-chain dehydrogenase, putative	0.0016	0.0037	0.2262
Mycobacterium ulcerans	dehydrogenase	0.0041	0.0283	0.0414
Leishmania major	short chain dehydrogenase/reductase, putative	0.0016	0.0037	0.0491
Toxoplasma gondii	Ulp1 protease family, C-terminal catalytic domain-containing protein	0.0046	0.0329	0.7295
Giardia lamblia	Oxidoreductase, short chain dehydrogenase/reductase family	0.0016	0.0037	0.2262
Toxoplasma gondii	histone lysine-specific demethylase LSD1/BHC110/KDMA1A	0.0041	0.0283	0.6274
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0121	0.2665
Trypanosoma cruzi	hypothetical protein, conserved	0.0016	0.0037	0.0491
Echinococcus multilocularis	estradiol 17 beta dehydrogenase 12	0.0016	0.0037	0.0038
Schistosoma mansoni	short chain dehydrogenase	0.0016	0.0037	0.0036
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 13 homolog	0.0016	0.0037	0.0091
Trichomonas vaginalis	Clan CE, family C48, Ulp1-like cysteine peptidase	0.0046	0.0329	1
Entamoeba histolytica	estradiol 17-beta-dehydrogenase, putative	0.0016	0.0037	0.0491
Onchocerca volvulus		0.0016	0.0037	0.0091
Echinococcus granulosus	hypothetical protein	0.0016	0.0037	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0478	0.1214
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0121	0.0305
Trypanosoma brucei	SUMO1/Ulp2, putative	0.0013	0.0001	0.001
Giardia lamblia	PHD finger protein 15	0.0029	0.0159	1
Echinococcus granulosus	retinol dehydrogenase 11	0.0016	0.0037	0.0038
Brugia malayi	Retinol dehydrogenase 12	0.0016	0.0037	0.0091
Leishmania major	SUMO1/Ulp2, putative,cysteine peptidase, Clan CA, family C48, putative	0.0013	0.0001	0.001
Brugia malayi	PHD-finger family protein	0.0029	0.0159	0.0402
Mycobacterium tuberculosis	Arylamine N-acetyltransferase Nat (arylamine acetylase)	0.0614	0.5987	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0361	0.0915
Trypanosoma cruzi	short-chain dehydrogenase, putative	0.0016	0.0037	0.0491
Leishmania major	quinonoid dihydropteridine reductase	0.0016	0.0037	0.0491
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0016	0.0037	0.0091
Loa Loa (eye worm)	oxidoreductase	0.0016	0.0037	0.0091
Brugia malayi	oxidoreductase	0.0016	0.0037	0.0091
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0016	0.0037	0.0796
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0016	0.0037	0.1111
Entamoeba histolytica	Ulp1 protease family, C-terminal catalytic domain containing protein	0.0013	0.0001	0.001
Schistosoma mansoni	short chain dehydrogenase	0.0016	0.0037	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0361	0.0915
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0037	0.0091
Echinococcus granulosus	sentrin specific protease 1	0.0046	0.0329	0.0348
Echinococcus granulosus	epidermal retinal dehydrogenase 2	0.0016	0.0037	0.0038
Entamoeba histolytica	hypothetical protein, conserved	0.0016	0.0037	0.0491
Schistosoma mansoni	short chain dehydrogenase	0.0016	0.0037	0.0036
Plasmodium falciparum	CDGSH iron-sulfur domain-containing protein, putative	0.0058	0.0451	1
Trypanosoma cruzi	3-keto-dihydrosphingosine reductase	0.0016	0.0037	0.0491
Loa Loa (eye worm)	oxidoreductase	0.0016	0.0037	0.0091
Loa Loa (eye worm)	oxidoreductase	0.0016	0.0037	0.0091
Schistosoma mansoni	3-keto-dihydrosphingosine reductase	0.0016	0.0037	0.0036
Schistosoma mansoni	hypothetical protein	0.0166	0.1526	0.1525
Trypanosoma cruzi	NAD(P)-dependent oxidoreductase, putative	0.0016	0.0037	0.0491
Echinococcus multilocularis	oxidoreductase	0.0016	0.0037	0.0038
Plasmodium falciparum	sentrin-specific protease 1	0.0046	0.0329	0.7061
Mycobacterium leprae	PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO)	0.0041	0.0283	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0016	0.0037	0.0091
Plasmodium vivax	sentrin-specific protease 1, putative	0.0046	0.0329	0.7295
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0087	0.0745	1
Leishmania major	quinonoid dihydropteridine reductase	0.0016	0.0037	0.0491
Schistosoma mansoni	short-chain dehydrogenase/reductase	0.0016	0.0037	0.0036
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0016	0.0037	0.0091
Entamoeba histolytica	Ulp1 protease family, C-terminal catalytic domain containing protein	0.0013	0.0001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0283	0.0717
Trypanosoma brucei	CMGC/DYRK protein kinase, putative	0.0087	0.0745	1
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0016	0.0037	0.0491
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0016	0.0037	0.1111
Toxoplasma gondii	histone lysine-specific demethylase	0.0041	0.0283	0.6274
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0094	0.0805	0.0854
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0016	0.0037	0.0036
Wolbachia endosymbiont of Brugia malayi	Short-chain alcohol dehydrogenase family enzyme	0.0016	0.0037	0.5
Entamoeba histolytica	protein kinase, putative	0.0087	0.0745	1
Loa Loa (eye worm)	oxidoreductase	0.0016	0.0037	0.0091
Brugia malayi	dehydrogenases, short chain protein 9	0.0016	0.0037	0.0091
Onchocerca volvulus		0.0016	0.0037	0.0091
Leishmania major	short chain dehydrogenase, putative	0.0016	0.0037	0.0491
Brugia malayi	Fli-1 protein	0.0215	0.2017	0.5125
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0016	0.0037	0.0491
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0121	0.2665
Trichomonas vaginalis	Clan CE, family C48, Ulp1-like cysteine peptidase	0.0013	0.0001	0.0023
Leishmania major	hypothetical protein, conserved	0.0016	0.0037	0.0491
Echinococcus multilocularis	GA binding protein alpha chain	0.0071	0.0581	0.0615
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0015	0.0029	0.003
Schistosoma mansoni	short chain dehydrogenase	0.0016	0.0037	0.0036
Giardia lamblia	Hypothetical protein	0.0016	0.0037	0.2262
Onchocerca volvulus		0.0016	0.0037	0.0091
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0016	0.0037	0.0491
Echinococcus multilocularis	retinol dehydrogenase 11	0.0016	0.0037	0.0038
Toxoplasma gondii	oxidoreductase, putative	0.0016	0.0037	0.0796
Trypanosoma cruzi	hypothetical protein, conserved	0.0016	0.0037	0.0491
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0035	0.0219	0.0218
Trichomonas vaginalis	DNA helicase recq1, putative	0.0024	0.0109	0.3311
Leishmania major	quinonoid dihydropteridine reductase	0.0016	0.0037	0.0491
Chlamydia trachomatis	protoporphyrinogen oxidase	0.0041	0.0283	1
Schistosoma mansoni	steroid dehydrogenase	0.0016	0.0037	0.0036
Trichomonas vaginalis	Clan CE, family C48, Ulp1-like cysteine peptidase	0.0013	0.0001	0.0023
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0041	0.0283	0.3801
Echinococcus multilocularis	transient receptor potential cation channel	0.0016	0.0037	0.0038
Brugia malayi	Dehydrogenases, short chain protein 30	0.0016	0.0037	0.0091
Leishmania major	hypothetical protein, conserved	0.0016	0.0037	0.0491
Trypanosoma cruzi	SUMO1/Ulp2, putative	0.0013	0.0001	0.001
Echinococcus granulosus	hypothetical protein	0.0016	0.0037	0.0038
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0016	0.0037	0.0091
Brugia malayi	dehydrogenases, short chain protein 2	0.0016	0.0037	0.0091
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0016	0.0037	0.0091
Echinococcus multilocularis	carbonyl reductase 1	0.0016	0.0037	0.0038
Schistosoma mansoni	steroid dehydrogenase	0.0016	0.0037	0.0036
Echinococcus multilocularis	GPCR, family 2	0.0015	0.0029	0.003
Echinococcus granulosus	bloom syndrome protein	0.0024	0.0109	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0029	0.0071
Onchocerca volvulus		0.0016	0.0037	0.0091
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0016	0.0037	0.0491
Schistosoma mansoni	steroid dehydrogenase	0.0016	0.0037	0.0036
Onchocerca volvulus		0.0016	0.0037	0.0091
Echinococcus granulosus	geminin	0.0166	0.1526	0.1619
Loa Loa (eye worm)	dehydrogenase	0.0016	0.0037	0.0091
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0207	0.0524
Trypanosoma cruzi	hypothetical protein, conserved	0.0016	0.0037	0.0491
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0016	0.0037	0.0091
Trichomonas vaginalis	Clan CE, family C48, Ulp1-like cysteine peptidase	0.0013	0.0001	0.0023
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0016	0.0037	0.0091
Schistosoma mansoni	hypothetical protein	0.0058	0.0451	0.045
Trypanosoma brucei	3-ketoacyl-CoA reductase, putative	0.0016	0.0037	0.0491
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0121	0.203
Loa Loa (eye worm)	dehydrogenase	0.0016	0.0037	0.0091
Brugia malayi	SWIRM domain containing protein	0.0041	0.0283	0.0717
Leishmania major	oxidoreductase-like protein	0.0016	0.0037	0.0491
Entamoeba histolytica	Ulp1 protease family, C-terminal catalytic domain containing protein	0.0013	0.0001	0.001
Leishmania major	hypothetical protein, conserved	0.0016	0.0037	0.0491
Plasmodium falciparum	lysine-specific histone demethylase 1, putative	0.0041	0.0283	0.5951
Onchocerca volvulus	Alhambra homolog	0.0029	0.0159	0.0402
Echinococcus multilocularis	peregrin	0.0029	0.0159	0.0168
Brugia malayi	Bloom's syndrome protein homolog	0.0024	0.0109	0.0275
Loa Loa (eye worm)	hypothetical protein	0.0087	0.074	0.1879
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0283	0.0717
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0121	0.162
Plasmodium vivax	hypothetical protein, conserved	0.0029	0.0159	0.352
Toxoplasma gondii	oxidoreductase, putative	0.0016	0.0037	0.0796
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0016	0.0037	0.0091
Brugia malayi	RE40412p	0.0058	0.0451	0.1144
Schistosoma mansoni	hypothetical protein	0.1018	1	1
Loa Loa (eye worm)	oxidoreductase	0.0016	0.0037	0.0091
Trypanosoma cruzi	3-ketoacyl-CoA reductase, putative	0.0016	0.0037	0.0491
Echinococcus granulosus	GPCR family 2	0.0015	0.0029	0.003
Mycobacterium ulcerans	arylamine N-acetyltransferase Nat	0.0614	0.5987	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0283	0.0717
Echinococcus granulosus	GA binding protein alpha chain	0.0071	0.0581	0.0615
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0451	0.1144
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0037	0.0091
Leishmania major	3-keto-dihydrosphingosine reductase	0.0016	0.0037	0.0491
Entamoeba histolytica	hypothetical protein, conserved	0.0016	0.0037	0.0491
Onchocerca volvulus		0.0058	0.0451	0.1144
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0037	0.0091
Loa Loa (eye worm)	oxidoreductase	0.0016	0.0037	0.0091
Schistosoma mansoni	short chain dehydrogenase	0.0016	0.0037	0.0036
Echinococcus multilocularis	retinol dehydrogenase 13	0.0016	0.0037	0.0038
Leishmania major	hypothetical protein, conserved	0.0016	0.0037	0.0491
Schistosoma mansoni	steroid dehydrogenase	0.0016	0.0037	0.0036
Entamoeba histolytica	estradiol 17-beta-dehydrogenase, putative	0.0016	0.0037	0.0491
Schistosoma mansoni	jumonji domain containing protein	0.0074	0.0614	0.0613
Trypanosoma cruzi	3-keto-dihydrosphingosine reductase	0.0016	0.0037	0.0491
Schistosoma mansoni	short chain dehydrogenase	0.0016	0.0037	0.0036
Echinococcus multilocularis	conserved hypothetical protein	0.0016	0.0037	0.0038
Schistosoma mansoni	short chain dehydrogenase	0.0016	0.0037	0.0036
Schistosoma mansoni	family C48 unassigned peptidase (C48 family)	0.0046	0.0329	0.0328
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0016	0.0037	0.0091
Echinococcus multilocularis	protoporphyrinogen oxidase	0.0041	0.0283	0.03
Brugia malayi	Ets-domain containing protein	0.0071	0.0581	0.1474
Trypanosoma cruzi	hypothetical protein, conserved	0.0016	0.0037	0.0491
Trypanosoma brucei	oxidoreductase-like protein	0.0016	0.0037	0.0491
Trypanosoma cruzi	hypothetical protein, conserved	0.0016	0.0037	0.0491
Echinococcus multilocularis	carbonyl reductase 1	0.0016	0.0037	0.0038
Mycobacterium ulcerans	protoporphyrinogen oxidase	0.0041	0.0283	0.0414
Toxoplasma gondii	zinc finger CDGSH-type domain-containing protein	0.0058	0.0451	1
Echinococcus granulosus	jumonji domain containing protein	0.004	0.027	0.0286
Loa Loa (eye worm)	PHD-finger family protein	0.0029	0.0159	0.0402
Echinococcus multilocularis	conserved hypothetical protein	0.0058	0.0451	0.0477
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0015	0.0029	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0037	0.0091
Entamoeba histolytica	3-ketodihydrosphingosine reductase protein, putative	0.0016	0.0037	0.0491
Schistosoma mansoni	carbonyl reductase	0.0016	0.0037	0.0036

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 801524