Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | HMG-CoA reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | ceramide glucosyltransferase | 0.0248 | 0.4118 | 0.4394 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0165 | 0.2322 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0358 | 0.652 | 0.652 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0081 | 0.0478 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.034 | 0.6122 | 0.6122 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.0248 | 0.4118 | 0.4642 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.034 | 0.6122 | 0.6122 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0085 | 0.0573 | 0.0414 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0081 | 0.0478 | 0.0478 |
Trypanosoma brucei | lysosomal alpha-mannosidase precursor, putative | 0.0082 | 0.0502 | 0.2161 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0081 | 0.0478 | 0.2056 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0081 | 0.0478 | 0.0478 |
Plasmodium falciparum | plasmepsin I | 0.0077 | 0.0405 | 1 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0077 | 0.0405 | 0.0405 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0165 | 0.2322 | 1 |
Plasmodium falciparum | plasmepsin II | 0.0077 | 0.0405 | 1 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.0165 | 0.2322 | 0.2378 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0518 | 1 | 1 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0081 | 0.0478 | 0.0478 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0078 | 0.0411 | 0.0411 |
Echinococcus multilocularis | beta galactosidase | 0.0159 | 0.2176 | 0.2214 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0405 | 0.0405 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0081 | 0.0478 | 0.0478 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0477 | 0.9112 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.034 | 0.6122 | 0.6122 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0477 | 0.9112 | 0.9112 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0081 | 0.0478 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0477 | 0.9112 | 1 |
Echinococcus granulosus | ceramide glucosyltransferase | 0.0248 | 0.4118 | 0.4394 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.0248 | 0.4118 | 0.4118 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0077 | 0.0405 | 0.0225 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0518 | 1 | 1 |
Brugia malayi | Hydroxymethylglutaryl-coenzyme A reductase family protein | 0.0165 | 0.2322 | 0.2322 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0085 | 0.0573 | 0.0573 |
Trypanosoma cruzi | lysosomal alpha-mannosidase precursor, putative | 0.0082 | 0.0502 | 0.2161 |
Echinococcus multilocularis | non lysosomal glucosylceramidase | 0.0216 | 0.343 | 0.3622 |
Plasmodium vivax | plasmepsin IV, putative | 0.0077 | 0.0405 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0477 | 0.9112 | 0.9112 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.0216 | 0.343 | 0.3827 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0068 | 0.0204 | 0.0204 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.0216 | 0.343 | 0.3827 |
Echinococcus multilocularis | lysosomal alpha mannosidase | 0.0082 | 0.0502 | 0.0334 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.034 | 0.6122 | 0.6122 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0477 | 0.9112 | 1 |
Plasmodium falciparum | plasmepsin VI | 0.0077 | 0.0405 | 1 |
Echinococcus granulosus | bile acid beta glucosidase | 0.0216 | 0.343 | 0.3622 |
Echinococcus multilocularis | bile acid beta glucosidase | 0.0216 | 0.343 | 0.3622 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0081 | 0.0478 | 0.0478 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0081 | 0.0478 | 0.2056 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.0248 | 0.4118 | 0.4642 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0078 | 0.0411 | 0.0411 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0077 | 0.0405 | 0.0238 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0204 | 0.0204 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0165 | 0.2322 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.0573 | 0.0573 |
Trypanosoma brucei | glucosidase, putative | 0.0081 | 0.0478 | 0.2056 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0077 | 0.0405 | 1 |
Onchocerca volvulus | 0.041 | 0.7666 | 1 | |
Trypanosoma cruzi | lysosomal alpha-mannosidase precursor, putative | 0.0082 | 0.0502 | 0.2161 |
Schistosoma mansoni | alpha glucosidase | 0.0081 | 0.0478 | 0.0324 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0085 | 0.0573 | 0.0438 |
Trypanosoma brucei | lysosomal alpha-mannosidase precursor, putative | 0.0068 | 0.0208 | 0.0894 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.19 | 0.19 |
Brugia malayi | CHE-14 protein | 0.0068 | 0.0204 | 0.0204 |
Loa Loa (eye worm) | hypothetical protein | 0.0272 | 0.4645 | 0.4645 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.034 | 0.6122 | 0.7986 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0081 | 0.0478 | 0.0478 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.0165 | 0.2322 | 0.5 |
Echinococcus granulosus | lysosomal alpha mannosidase | 0.0082 | 0.0502 | 0.0334 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0358 | 0.652 | 0.652 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0518 | 1 | 1 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.0165 | 0.2322 | 0.2513 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0081 | 0.0478 | 0.0478 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0081 | 0.0478 | 0.0307 |
Schistosoma mansoni | alpha-glucosidase | 0.0455 | 0.8634 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.034 | 0.6122 | 0.6122 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0081 | 0.0478 | 0.0478 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0077 | 0.0405 | 0.0225 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0165 | 0.2322 | 1 |
Giardia lamblia | Ceramide glucosyltransferase | 0.0112 | 0.1168 | 1 |
Echinococcus granulosus | non lysosomal glucosylceramidase | 0.0216 | 0.343 | 0.3622 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0081 | 0.0478 | 0.0478 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.034 | 0.6122 | 0.6122 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0077 | 0.0405 | 0.0238 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0081 | 0.0478 | 0.0478 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.2322 | 0.2322 |
Plasmodium falciparum | plasmepsin IV | 0.0077 | 0.0405 | 1 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0077 | 0.0405 | 0.0405 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0518 | 1 | 1 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.0248 | 0.4118 | 0.5372 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0081 | 0.0478 | 0.2056 |
Schistosoma mansoni | beta-galactosidase | 0.0159 | 0.2176 | 0.2339 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0518 | 1 | 1 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0068 | 0.0204 | 0.0204 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0081 | 0.0478 | 0.0307 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0077 | 0.0405 | 0.0238 |
Brugia malayi | Ceramide glucosyltransferase | 0.0248 | 0.4118 | 0.4118 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.2176 | 0.2176 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0518 | 1 | 1 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0081 | 0.0478 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.034 | 0.6122 | 0.6122 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0518 | 1 | 1 |
Onchocerca volvulus | 0.0085 | 0.0573 | 0.0748 | |
Echinococcus granulosus | beta galactosidase | 0.0159 | 0.2176 | 0.2214 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.0165 | 0.2322 | 0.2378 |
Schistosoma mansoni | alpha-glucosidase | 0.0455 | 0.8634 | 1 |
Schistosoma mansoni | lysosomal alpha-mannosidase (mannosidase alpha class 2b member 1) | 0.0082 | 0.0502 | 0.0353 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0148 | 0.0148 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0081 | 0.0478 | 0.0478 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0078 | 0.0411 | 0.0411 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0085 | 0.0573 | 0.0414 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.