Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0266 | 0.0412 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0125 | 0.1018 | 0.227 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0025 | 0.0141 | 0.0219 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0266 | 0.0412 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0741 | 0.6455 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0057 | 0.0423 | 0.0656 |
Echinococcus granulosus | GPCR family 2 | 0.0039 | 0.0266 | 0.0412 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.009 | 0.0712 | 0.1103 |
Mycobacterium ulcerans | hypothetical protein | 0.1143 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.009 | 0.0712 | 0.1103 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.009 | 0.0712 | 0.1103 |
Schistosoma mansoni | survival motor neuron protein | 0.0077 | 0.0597 | 0.0926 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.001 | 0.001 | 0.0015 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.009 | 0.0712 | 0.1103 |
Loa Loa (eye worm) | hypothetical protein | 0.0518 | 0.4485 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0062 | 0.0464 | 1 |
Onchocerca volvulus | 0.0077 | 0.0597 | 0.3249 | |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0116 | 0.0936 | 0.0495 |
Onchocerca volvulus | 0.0062 | 0.0464 | 0.2526 | |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0062 | 0.0464 | 0.072 |
Schistosoma mansoni | tar DNA-binding protein | 0.0057 | 0.0423 | 0.0656 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0207 | 0.1745 | 0.389 |
Schistosoma mansoni | hypothetical protein | 0.0077 | 0.0597 | 0.0926 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0062 | 0.0464 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0064 | 0.0478 | 0.074 |
Onchocerca volvulus | 0.0137 | 0.1124 | 0.6112 | |
Schistosoma mansoni | amine GPCR | 0.0149 | 0.1228 | 0.1902 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.009 | 0.0712 | 0.1103 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0062 | 0.0464 | 0.5 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0741 | 0.6455 | 1 |
Schistosoma mansoni | lamin | 0.0045 | 0.0314 | 0.0486 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0116 | 0.0936 | 0.0495 |
Brugia malayi | hypothetical protein | 0.0132 | 0.1078 | 0.2404 |
Onchocerca volvulus | 0.0045 | 0.0314 | 0.1705 | |
Echinococcus multilocularis | tar DNA binding protein | 0.0057 | 0.0423 | 0.0656 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0024 | 0.0127 | 0.0197 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0116 | 0.0936 | 0.145 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0173 | 0.1443 | 0.3218 |
Mycobacterium tuberculosis | Probable transcriptional regulatory protein | 0.1143 | 1 | 1 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0031 | 0.019 | 0.0423 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0025 | 0.0141 | 0.0219 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0077 | 0.0597 | 0.1332 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0464 | 0.1036 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0464 | 0.1036 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0025 | 0.0141 | 0.0219 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0085 | 0.067 | 0.1494 |
Brugia malayi | follicle stimulating hormone receptor | 0.0207 | 0.1745 | 0.389 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0025 | 0.0141 | 0.0219 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0062 | 0.0464 | 0.072 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0039 | 0.0266 | 0.0412 |
Schistosoma mansoni | hypothetical protein | 0.0064 | 0.0478 | 0.074 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0025 | 0.0141 | 0.0219 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0396 | 0.3412 | 0.3091 |
Mycobacterium tuberculosis | Possible two component transcriptional regulatory protein (probably LuxR-family) | 0.1143 | 1 | 1 |
Echinococcus granulosus | dnaJ subfamily B | 0.0439 | 0.3792 | 0.5875 |
Echinococcus multilocularis | GPCR, family 2 | 0.0039 | 0.0266 | 0.0412 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0116 | 0.0936 | 1 |
Mycobacterium ulcerans | nitrate/nitrite response regulator protein NarL | 0.1143 | 1 | 1 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0025 | 0.0141 | 0.0219 |
Onchocerca volvulus | Huntingtin homolog | 0.0132 | 0.1078 | 0.5863 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0039 | 0.0266 | 0.0593 |
Brugia malayi | RNA binding protein | 0.0057 | 0.0423 | 0.0943 |
Onchocerca volvulus | 0.0031 | 0.019 | 0.1031 | |
Onchocerca volvulus | 0.0062 | 0.0464 | 0.2526 | |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0125 | 0.1018 | 0.227 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0025 | 0.0141 | 0.0219 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0062 | 0.0464 | 0.072 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0101 | 0.0226 |
Entamoeba histolytica | hypothetical protein | 0.0064 | 0.0478 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0064 | 0.0478 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.009 | 0.0712 | 0.1103 |
Brugia malayi | MH2 domain containing protein | 0.0108 | 0.087 | 0.1941 |
Onchocerca volvulus | 0.0218 | 0.1839 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0439 | 0.3792 | 0.5875 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0314 | 0.0699 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0039 | 0.0266 | 0.0593 |
Brugia malayi | hypothetical protein | 0.0064 | 0.0478 | 0.1065 |
Schistosoma mansoni | intermediate filament proteins | 0.0045 | 0.0314 | 0.0486 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0039 | 0.0266 | 0.0412 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0039 | 0.0266 | 0.0593 |
Trichomonas vaginalis | set domain proteins, putative | 0.0197 | 0.1653 | 1 |
Onchocerca volvulus | 0.0045 | 0.0314 | 0.1705 | |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.1078 | 0.2404 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0039 | 0.0266 | 0.0412 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0062 | 0.0464 | 0.1036 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.1124 | 0.2506 |
Mycobacterium ulcerans | two component transcriptional regulatory protein DevR | 0.1143 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0109 | 0.0242 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0266 | 0.0593 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0464 | 0.1036 |
Onchocerca volvulus | 0.0197 | 0.1653 | 0.8991 | |
Brugia malayi | Pax transcription factor protein 2 | 0.0218 | 0.1839 | 0.41 |
Entamoeba histolytica | hypothetical protein | 0.0064 | 0.0478 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.0045 | 0.0314 | 0.0486 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.001 | 0.001 | 0.0015 |
Brugia malayi | hypothetical protein | 0.0137 | 0.1124 | 0.2506 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0116 | 0.0936 | 0.0495 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0464 | 0.1036 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0378 | 0.3251 | 0.5036 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0064 | 0.0478 | 0.074 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0066 | 0.0503 | 0.0779 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0125 | 0.1018 | 0.227 |
Entamoeba histolytica | hypothetical protein | 0.0064 | 0.0478 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0266 | 0.0412 |
Brugia malayi | hypothetical protein | 0.0518 | 0.4485 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.0132 | 0.1078 | 0.5863 |
Schistosoma mansoni | tar DNA-binding protein | 0.0057 | 0.0423 | 0.0656 |
Mycobacterium ulcerans | hydrolase/amidase | 0.0271 | 0.231 | 0.1935 |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.0218 | 0.1839 | 0.41 |
Brugia malayi | beta-lactamase | 0.0062 | 0.0464 | 0.1036 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0116 | 0.0936 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0062 | 0.0464 | 0.1036 |
Echinococcus multilocularis | musashi | 0.0045 | 0.0314 | 0.0486 |
Loa Loa (eye worm) | TAR-binding protein | 0.0057 | 0.0423 | 0.0943 |
Echinococcus multilocularis | lamin dm0 | 0.0045 | 0.0314 | 0.0486 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0116 | 0.0936 | 0.0495 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0039 | 0.0266 | 0.0412 |
Echinococcus multilocularis | lamin | 0.0045 | 0.0314 | 0.0486 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0108 | 0.087 | 0.1941 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0059 | 0.0441 | 0.3769 |
Echinococcus multilocularis | cpg binding protein | 0.0033 | 0.0205 | 0.0318 |
Schistosoma mansoni | tar DNA-binding protein | 0.0057 | 0.0423 | 0.0656 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.009 | 0.0712 | 0.1587 |
Schistosoma mansoni | tar DNA-binding protein | 0.0057 | 0.0423 | 0.0656 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0057 | 0.0423 | 0.0943 |
Echinococcus granulosus | lamin | 0.0045 | 0.0314 | 0.0486 |
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.0205 | 0.0318 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0045 | 0.0314 | 0.0699 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0306 | 0.0683 |
Mycobacterium tuberculosis | Possible nitrate/nitrite response transcriptional regulatory protein NarL | 0.1143 | 1 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0116 | 0.0936 | 0.145 |
Loa Loa (eye worm) | hypothetical protein | 0.0378 | 0.3251 | 0.7249 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.001 | 0.0009 | 0.0019 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0464 | 0.1036 |
Echinococcus granulosus | cpg binding protein | 0.0033 | 0.0205 | 0.0318 |
Onchocerca volvulus | 0.0025 | 0.0141 | 0.0769 | |
Brugia malayi | TAR-binding protein | 0.0057 | 0.0423 | 0.0943 |
Mycobacterium tuberculosis | Probable transcriptional regulatory protein (LuxR-family) | 0.1143 | 1 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0116 | 0.0936 | 0.145 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0062 | 0.0464 | 0.072 |
Mycobacterium tuberculosis | Possible transcriptional regulatory protein | 0.1143 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.1078 | 0.2404 |
Toxoplasma gondii | ABC1 family protein | 0.0062 | 0.0464 | 0.4066 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0064 | 0.0478 | 0.074 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0022 | 0.0109 | 0.0168 |
Brugia malayi | intermediate filament protein | 0.0045 | 0.0314 | 0.0699 |
Schistosoma mansoni | lamin | 0.0045 | 0.0314 | 0.0486 |
Mycobacterium tuberculosis | Probable transcriptional regulatory protein (probably LuxR/UhpA-family) | 0.1143 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0085 | 0.067 | 0.1038 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0062 | 0.0464 | 0.1036 |
Loa Loa (eye worm) | beta-lactamase | 0.0062 | 0.0464 | 0.1036 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0057 | 0.0423 | 0.0943 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0062 | 0.0464 | 0.5 |
Brugia malayi | CXXC zinc finger family protein | 0.0031 | 0.019 | 0.0423 |
Brugia malayi | Pre-SET motif family protein | 0.0025 | 0.0141 | 0.0315 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0024 | 0.013 | 0.0289 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0045 | 0.0314 | 0.0699 |
Brugia malayi | beta-lactamase family protein | 0.0062 | 0.0464 | 0.1036 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.019 | 0.0294 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.067 | 0.1494 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0141 | 0.0315 |
Loa Loa (eye worm) | intermediate filament protein | 0.0045 | 0.0314 | 0.0699 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0439 | 0.3792 | 0.5875 |
Brugia malayi | hypothetical protein | 0.0378 | 0.3251 | 0.7249 |
Echinococcus granulosus | lamin dm0 | 0.0045 | 0.0314 | 0.0486 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0116 | 0.0936 | 0.145 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0464 | 0.1036 |
Mycobacterium ulcerans | putative regulatory protein | 0.1143 | 1 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0378 | 0.3251 | 0.5036 |
Schistosoma mansoni | tar DNA-binding protein | 0.0057 | 0.0423 | 0.0656 |
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.0205 | 0.0318 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.009 | 0.0712 | 0.1103 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0024 | 0.013 | 0.0289 |
Loa Loa (eye worm) | histone methyltransferase | 0.001 | 0.001 | 0.0022 |
Onchocerca volvulus | 0.0062 | 0.0464 | 0.2526 | |
Brugia malayi | Pre-SET motif family protein | 0.0173 | 0.1443 | 0.3218 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0741 | 0.6455 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.009 | 0.0712 | 0.1587 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0108 | 0.087 | 0.1941 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0266 | 0.0412 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.1018 | 0.227 |
Loa Loa (eye worm) | RNA binding protein | 0.0057 | 0.0423 | 0.0943 |
Mycobacterium ulcerans | two component transcriptional regulator | 0.1143 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0101 | 0.0226 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0022 | 0.0109 | 0.0168 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.