TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 496.024 | Formula: C25H26ClN5O2S
H donors: 0 H acceptors: 3 LogP: 4.29 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(ccc1OC)CN(Cc1nnc(n1c1cccc(c1)Cl)SCc1ccncc1)C
InChi: 1S/C25H26ClN5O2S/c1-30(15-19-7-8-22(32-2)23(13-19)33-3)16-24-28-29-25(34-17-18-9-11-27-12-10-18)31(24)21-6-4-5-20(26)14-21/h4-14H,15-17H2,1-3H3
InChiKey: POAYCWJBRMCJGL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	beta tubulin	0.009	0.0044	0.0275
Giardia lamblia	Alpha-tubulin	0.0167	0.0125	0.0281
Giardia lamblia	Beta tubulin	0.009	0.0044	0.0092
Trichomonas vaginalis	glucosylceramidase, putative	0.9658	1	1
Schistosoma mansoni	alpha tubulin	0.0167	0.0125	0.0132
Echinococcus granulosus	bile acid beta glucosidase	0.8187	0.8469	0.8985
Leishmania major	beta tubulin	0.009	0.0044	0.0275
Onchocerca volvulus	Glucosylceramidase homolog	0.6337	0.6544	0.6942
Leishmania major	glycosyl hydrolase-like protein	0.0775	0.0757	0.5316
Echinococcus multilocularis	Tubulin beta 2C chain	0.009	0.0044	0.0047
Brugia malayi	MAP kinase sur-1	0.0053	0.0005	0.0002
Brugia malayi	Melibiase family protein	0.0117	0.0072	0.0069
Leishmania major	beta tubulin	0.009	0.0044	0.0275
Trichomonas vaginalis	tubulin alpha chain, putative	0.009	0.0044	0.0044
Echinococcus multilocularis	beta galactosidase	0.0174	0.0131	0.0139
Loa Loa (eye worm)	alpha amylase	0.0144	0.01	0.0095
Schistosoma mansoni	serine/threonine protein kinase	0.0053	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0128	0.0084	0.0079
Trypanosoma brucei	epsilon tubulin	0.009	0.0044	0.0288
Brugia malayi	Glycosyl hydrolases family 31 protein	0.1412	0.1419	0.1416
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0775	0.0757	0.0754
Leishmania major	beta tubulin	0.009	0.0044	0.0275
Giardia lamblia	Beta tubulin	0.009	0.0044	0.0092
Trichomonas vaginalis	alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative	0.0117	0.0072	0.0072
Trichomonas vaginalis	glucosylceramidase, putative	0.6337	0.6544	0.6544
Trichomonas vaginalis	glycoside hydrolase, putative	0.0511	0.0482	0.0482
Trichomonas vaginalis	tubulin beta chain, putative	0.0167	0.0125	0.0125
Trypanosoma brucei	glucosidase, putative	0.1412	0.1419	1
Brugia malayi	Beta-glucuronidase precursor	0.0199	0.0157	0.0154
Echinococcus granulosus	Tubulin alpha 1 chain	0.0167	0.0125	0.0132
Echinococcus granulosus	ceramide glucosyltransferase	0.9106	0.9426	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0051	0.0003	0.0003
Trichomonas vaginalis	tubulin gamma chain, putative	0.009	0.0044	0.0044
Giardia lamblia	Gamma tubulin	0.009	0.0044	0.0092
Trichomonas vaginalis	tubulin alpha chain, putative	0.009	0.0044	0.0044
Brugia malayi	Alpha amylase, catalytic domain containing protein	0.0144	0.01	0.0097
Brugia malayi	Amylo-alpha-1,6-glucosidase family protein	0.0086	0.004	0.0037
Echinococcus granulosus	tubulin alpha chain	0.0167	0.0125	0.0132
Trypanosoma brucei	protein kinase, putative	0.0053	0.0005	0.0013
Loa Loa (eye worm)	beta-tubulin	0.009	0.0044	0.0039
Loa Loa (eye worm)	tubulin beta chain	0.009	0.0044	0.0039
Echinococcus multilocularis	mitogen activated protein kinase	0.0053	0.0005	0.0005
Echinococcus granulosus	Tubulin beta 2C chain	0.009	0.0044	0.0047
Echinococcus granulosus	Alpha N acetylgalactosaminidase	0.0117	0.0072	0.0077
Entamoeba histolytica	beta-galactosidase, putative	0.0249	0.021	0.1479
Trichomonas vaginalis	glucosylceramidase, putative	0.6337	0.6544	0.6544
Schistosoma mansoni	hypothetical protein	0.0062	0.0015	0.0016
Schistosoma mansoni	beta-galactosidase	0.0174	0.0131	0.0139
Trypanosoma brucei	tubulin gamma chain	0.009	0.0044	0.0288
Trichomonas vaginalis	glucosylceramidase, putative	0.6678	0.6899	0.6899
Plasmodium vivax	tubulin alpha chain, putative	0.0167	0.0125	1
Trichomonas vaginalis	tubulin gamma chain, putative	0.009	0.0044	0.0044
Echinococcus multilocularis	Alpha N acetylgalactosaminidase	0.0117	0.0072	0.0077
Plasmodium falciparum	tubulin gamma chain	0.009	0.0044	0.3232
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0167	0.0125	0.0132
Toxoplasma gondii	alpha tubulin TUBA1	0.0167	0.0125	0.0844
Schistosoma mansoni	alpha-amylase	0.0144	0.01	0.0106
Trypanosoma brucei	epsilon tubulin	0.009	0.0044	0.0288
Schistosoma mansoni	alpha-amylase	0.0144	0.01	0.0106
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0117	0.0072	0.0077
Brugia malayi	Tubulin alpha-2 chain	0.0167	0.0125	0.0121
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0117	0.0072	0.0077
Schistosoma mansoni	tubulin subunit beta	0.009	0.0044	0.0047
Toxoplasma gondii	beta-tubulin, putative	0.009	0.0044	0.0275
Trypanosoma brucei	beta tubulin	0.009	0.0044	0.0288
Loa Loa (eye worm)	tubulin alpha 2	0.0077	0.0031	0.0026
Echinococcus granulosus	non lysosomal glucosylceramidase	0.8187	0.8469	0.8985
Leishmania major	alpha tubulin	0.0167	0.0125	0.0844
Brugia malayi	Alpha amylase, catalytic domain containing protein	0.0144	0.01	0.0097
Leishmania major	alpha tubulin	0.0167	0.0125	0.0844
Giardia lamblia	Ceramide glucosyltransferase	0.4128	0.4246	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0167	0.0125	0.0125
Echinococcus granulosus	tubulin alpha 3 chain	0.0167	0.0125	0.0132
Leishmania major	beta tubulin	0.009	0.0044	0.0275
Trichomonas vaginalis	tubulin beta chain, putative	0.0167	0.0125	0.0125
Trypanosoma brucei	beta tubulin	0.009	0.0044	0.0288
Brugia malayi	Tubulin beta-1 chain	0.009	0.0044	0.0041
Mycobacterium ulcerans	trehalose synthase TreS	0.0144	0.01	1
Leishmania major	gamma-tubulin	0.009	0.0044	0.0275
Trichomonas vaginalis	beta-glucosidase, putative	0.0218	0.0177	0.0177
Echinococcus granulosus	peroxisome assembly protein 26	0.0167	0.0125	0.0132
Plasmodium falciparum	alpha tubulin 1	0.0167	0.0125	1
Trichomonas vaginalis	glucosylceramidase, putative	0.9658	1	1
Trypanosoma cruzi	epsilon tubulin, putative	0.009	0.0044	0.0275
Trichomonas vaginalis	tubulin gamma chain, putative	0.009	0.0044	0.0044
Toxoplasma gondii	alpha-tubulin I, putative	0.0167	0.0125	0.0844
Entamoeba histolytica	tubulin alpha chain, putative	0.0167	0.0125	0.0877
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.009	0.0044	0.0047
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0775	0.0757	0.0757
Entamoeba histolytica	tubulin alpha-1 chain	0.0167	0.0125	0.0877
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0116	0.0071	0.0071
Trypanosoma brucei	alpha tubulin	0.0167	0.0125	0.0856
Brugia malayi	tubulin alpha-2 chain	0.0167	0.0125	0.0121
Echinococcus granulosus	mitogen activated protein kinase	0.0053	0.0005	0.0005
Echinococcus granulosus	tubulin subunit beta	0.009	0.0044	0.0047
Loa Loa (eye worm)	tubulin beta-4 chain	0.009	0.0044	0.0039
Echinococcus granulosus	Tubulin beta 2C chain	0.009	0.0044	0.0047
Loa Loa (eye worm)	BEN-1 protein	0.009	0.0044	0.0039
Entamoeba histolytica	tubulin family protein	0.009	0.0044	0.031
Brugia malayi	beta-tubulin, identical	0.009	0.0044	0.0041
Schistosoma mansoni	hypothetical protein	0.0272	0.0233	0.0247
Echinococcus multilocularis	lysosomal alpha glucosidase	0.8012	0.8287	0.8792
Leishmania major	beta tubulin	0.009	0.0044	0.0275
Echinococcus granulosus	beta tubulin	0.009	0.0044	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0174	0.0131	0.0126
Echinococcus granulosus	lysosomal alpha glucosidase	0.8012	0.8287	0.8792
Schistosoma mansoni	alpha-glucosidase	0.7375	0.7625	0.8089
Leishmania major	beta tubulin	0.009	0.0044	0.0275
Echinococcus multilocularis	tubulin alpha 1C chain	0.0167	0.0125	0.0132
Trichomonas vaginalis	sucrase-isomaltase, putative	0.1412	0.1419	0.1419
Loa Loa (eye worm)	tubulin alpha 2	0.0128	0.0084	0.0079
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0775	0.0757	0.0757
Schistosoma mansoni	bile acid beta-glucosidase-related	0.8187	0.8469	0.8985
Brugia malayi	Tubulin alpha chain	0.0167	0.0125	0.0121
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.1412	0.1419	0.1415
Trichomonas vaginalis	alpha-glucosidase, putative	0.0775	0.0757	0.0757
Echinococcus multilocularis	ceramide glucosyltransferase	0.9106	0.9426	1
Echinococcus granulosus	Tubulin alpha 1 chain	0.0167	0.0125	0.0132
Loa Loa (eye worm)	BEN-1 protein	0.009	0.0044	0.0039
Schistosoma mansoni	tubulin subunit alpha	0.0167	0.0125	0.0132
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0775	0.0757	0.5333
Trichomonas vaginalis	CMGC family protein kinase	0.0053	0.0005	0.0005
Loa Loa (eye worm)	ceramide glucosyltransferase	0.9106	0.9426	0.9425
Trichomonas vaginalis	tubulin alpha chain, putative	0.0051	0.0003	0.0003
Schistosoma mansoni	alpha tubulin	0.0167	0.0125	0.0132
Echinococcus granulosus	tubulin alpha 1C chain	0.0167	0.0125	0.0132
Leishmania major	alpha tubulin	0.0167	0.0125	0.0844
Echinococcus multilocularis	beta tubulin	0.009	0.0044	0.0047
Leishmania major	beta tubulin	0.009	0.0044	0.0275
Echinococcus multilocularis	lysosomal alpha glucosidase	0.8012	0.8287	0.8792
Plasmodium falciparum	alpha tubulin 2	0.0167	0.0125	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0775	0.0757	0.0757
Echinococcus granulosus	tubulin gamma 1 chain	0.009	0.0044	0.0047
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.1412	0.1419	1
Leishmania major	beta tubulin	0.009	0.0044	0.0275
Schistosoma mansoni	tubulin subunit beta	0.009	0.0044	0.0047
Trypanosoma brucei	alpha tubulin	0.0167	0.0125	0.0856
Echinococcus granulosus	beta galactosidase	0.0174	0.0131	0.0139
Trypanosoma cruzi	glycosyl hydrolase-like protein, putative	0.0775	0.0757	0.5316
Echinococcus multilocularis	tubulin alpha chain	0.0167	0.0125	0.0132
Entamoeba histolytica	oligo-1,6-glucosidase, putative	0.0144	0.01	0.0704
Schistosoma mansoni	ceramide glucosyltransferase	0.9106	0.9426	1
Echinococcus granulosus	alpha tubulin	0.0167	0.0125	0.0132
Echinococcus granulosus	Tubulin beta 2C chain	0.009	0.0044	0.0047
Echinococcus multilocularis	beta tubulin	0.009	0.0044	0.0047
Echinococcus granulosus	tubulin alpha 3 chain	0.0167	0.0125	0.0132
Schistosoma mansoni	alpha tubulin	0.0167	0.0125	0.0132
Trypanosoma cruzi	glycosyl hydrolase-like protein, putative	0.0775	0.0757	0.5316
Echinococcus multilocularis	tubulin alpha chain	0.0167	0.0125	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0086	0.004	0.0035
Schistosoma mansoni	tubulin subunit alpha	0.0167	0.0125	0.0132
Echinococcus granulosus	Tubulin beta 2C chain	0.009	0.0044	0.0047
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0167	0.0125	0.0119
Leishmania major	alpha tubulin	0.0167	0.0125	0.0844
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0125	0.0119
Trichomonas vaginalis	alpha-glucosidase, putative	0.1412	0.1419	0.1419
Trichomonas vaginalis	glucosylceramidase, putative	0.6337	0.6544	0.6544
Trichomonas vaginalis	tubulin beta chain, putative	0.0167	0.0125	0.0125
Echinococcus multilocularis	tubulin beta 1 chain	0.009	0.0044	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0525	0.0497	0.0492
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0167	0.0125	0.0125
Trypanosoma cruzi	tubulin gamma chain	0.009	0.0044	0.0275
Trichomonas vaginalis	tubulin alpha chain, putative	0.0051	0.0003	0.0003
Plasmodium vivax	tubulin gamma chain, putative	0.009	0.0044	0.3232
Echinococcus granulosus	tubulin alpha chain	0.0167	0.0125	0.0132
Brugia malayi	alpha-tubulin	0.0167	0.0125	0.0121
Leishmania major	alpha tubulin	0.0167	0.0125	0.0844
Echinococcus multilocularis	Tubulin beta 2C chain	0.009	0.0044	0.0047
Trichomonas vaginalis	tubulin, putative	0.0051	0.0003	0.0003
Schistosoma mansoni	tubulin subunit gamma	0.009	0.0044	0.0047
Onchocerca volvulus	Uncharacterized family 31 glucosidase KIAA1161 homolog	0.0775	0.0757	0.08
Brugia malayi	Tubulin gamma chain	0.009	0.0044	0.0041
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0117	0.0072	0.0077
Echinococcus multilocularis	tubulin subunit TubB	0.0167	0.0125	0.0132
Plasmodium falciparum	tubulin beta chain	0.009	0.0044	0.3232
Trichomonas vaginalis	alpha-glucosidase, putative	0.1412	0.1419	0.1419
Brugia malayi	Ceramide glucosyltransferase	0.9106	0.9426	0.9425
Trichomonas vaginalis	beta-mannosidase, putative	0.012	0.0075	0.0075
Trichomonas vaginalis	tubulin epsilon chain, putative	0.009	0.0044	0.0044
Loa Loa (eye worm)	tubulin alpha chain	0.0167	0.0125	0.0119
Trichomonas vaginalis	alpha-glucosidase, putative	0.0775	0.0757	0.0757
Trichomonas vaginalis	glycogen debranching enzyme, putative	0.0086	0.004	0.004
Schistosoma mansoni	bile acid beta-glucosidase-related	0.8187	0.8469	0.8985
Toxoplasma gondii	beta-1 tubulin, putative	0.009	0.0044	0.0275
Loa Loa (eye worm)	tubulin alpha-3 chain	0.0116	0.0071	0.0066
Leishmania major	beta tubulin	0.009	0.0044	0.0275
Schistosoma mansoni	alpha glucosidase	0.1412	0.1419	0.1505
Trypanosoma brucei	glycosyl hydrolase-like protein	0.0775	0.0757	0.5322
Schistosoma mansoni	alpha-amylase	0.0144	0.01	0.0106
Trichomonas vaginalis	glucosylceramidase, putative	0.6337	0.6544	0.6544
Echinococcus granulosus	tubulin alpha chain	0.0167	0.0125	0.0132
Schistosoma mansoni	tubulin subunit beta	0.009	0.0044	0.0047
Trichomonas vaginalis	CMGC family protein kinase	0.0053	0.0005	0.0005
Giardia lamblia	Beta tubulin	0.009	0.0044	0.0092
Trichomonas vaginalis	glucosylceramidase, putative	0.6678	0.6899	0.6899
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0775	0.0757	0.0757
Schistosoma mansoni	tubulin subunit beta	0.009	0.0044	0.0047
Leishmania major	beta tubulin	0.009	0.0044	0.0275
Trypanosoma cruzi	alpha tubulin, putative	0.0167	0.0125	0.0844
Echinococcus multilocularis	tubulin alpha chain	0.0167	0.0125	0.0132
Echinococcus multilocularis	peroxisome assembly protein 26	0.0167	0.0125	0.0132
Trypanosoma cruzi	hypothetical protein, conserved	0.1412	0.1419	1
Mycobacterium tuberculosis	Trehalose synthase TreS	0.0144	0.01	0.5
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0128	0.0084	0.0079
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0117	0.0072	0.0077
Trichomonas vaginalis	alpha-glucosidase, putative	0.0775	0.0757	0.0757
Trypanosoma cruzi	epsilon tubulin, putative	0.009	0.0044	0.0275
Leishmania major	beta tubulin	0.009	0.0044	0.0275
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0117	0.0072	0.0077
Trypanosoma brucei	beta tubulin	0.009	0.0044	0.0288
Entamoeba histolytica	tubulin gamma chain	0.009	0.0044	0.031
Trichomonas vaginalis	glucosylceramidase, putative	0.9658	1	1
Echinococcus granulosus	tubulin beta 1 chain	0.009	0.0044	0.0047
Trichomonas vaginalis	alpha-glucosidase, putative	0.0775	0.0757	0.0757
Brugia malayi	tubulin alpha chain - mouse	0.0167	0.0125	0.0121
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0167	0.0125	0.0125
Trichomonas vaginalis	glucosylceramidase, putative	0.9658	1	1
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0167	0.0125	0.0132
Trichomonas vaginalis	glucosylceramidase, putative	0.6337	0.6544	0.6544
Leishmania major	alpha tubulin	0.0167	0.0125	0.0844
Trypanosoma brucei	beta tubulin	0.009	0.0044	0.0288
Leishmania major	epsilon tubulin, putative	0.009	0.0044	0.0275
Echinococcus multilocularis	glycogen debranching enzyme	0.0086	0.004	0.0043
Echinococcus multilocularis	tubulin epsilon chain	0.009	0.0044	0.0047
Plasmodium vivax	tubulin alpha chain, putative	0.0167	0.0125	1
Trichomonas vaginalis	CMGC family protein kinase	0.0053	0.0005	0.0005
Onchocerca volvulus		0.5208	0.5369	0.5695
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0071	0.0066
Echinococcus granulosus	tubulin alpha chain	0.0167	0.0125	0.0132
Brugia malayi	Glycosyl hydrolases family 2, sugar binding domain containing protein	0.0209	0.0167	0.0164
Brugia malayi	Tubulin alpha-2 chain	0.0167	0.0125	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0775	0.0757	0.0752
Trichomonas vaginalis	conserved hypothetical protein	0.0369	0.0334	0.0334
Trichomonas vaginalis	glycoside hydrolases, putative	0.0218	0.0177	0.0177
Echinococcus multilocularis	non lysosomal glucosylceramidase	0.8187	0.8469	0.8985
Mycobacterium tuberculosis	Probable alpha-glucosidase AglA (maltase) (glucoinvertase) (glucosidosucrase) (maltase-glucoamylase) (lysosomal alpha-glucosidas	0.0144	0.01	0.5
Schistosoma mansoni	alpha-glucosidase	0.7375	0.7625	0.8089
Trichomonas vaginalis	tubulin alpha chain, putative	0.0051	0.0003	0.0003
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.1412	0.1419	0.1419
Echinococcus multilocularis	tubulin alpha 1C chain	0.0167	0.0125	0.0132
Echinococcus granulosus	alpha glucosidase	0.0144	0.01	0.0106
Trichomonas vaginalis	CMGC family protein kinase	0.0053	0.0005	0.0005
Echinococcus multilocularis	Tubulin beta 2C chain	0.009	0.0044	0.0047
Echinococcus multilocularis	Glycoside hydrolase, family 27	0.0117	0.0072	0.0077
Trichomonas vaginalis	glucosylceramidase, putative	0.6337	0.6544	0.6544
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.1412	0.1419	1
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0167	0.0125	0.0132
Echinococcus multilocularis	tubulin alpha 3 chain	0.0167	0.0125	0.0132
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.9658	1	1
Schistosoma mansoni	ceramide glucosyltransferase	0.9106	0.9426	1
Loa Loa (eye worm)	tubulin beta-1 chain	0.009	0.0044	0.0039
Trypanosoma cruzi	hypothetical protein, conserved	0.1412	0.1419	1
Echinococcus multilocularis	tubulin alpha chain	0.0167	0.0125	0.0132
Giardia lamblia	Alpha-tubulin	0.0167	0.0125	0.0281
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0053	0.0005	0.0013
Trichomonas vaginalis	tubulin, putative	0.009	0.0044	0.0044
Leishmania major	beta tubulin	0.009	0.0044	0.0275
Schistosoma mansoni	hypothetical protein	0.0111	0.0066	0.007
Trichomonas vaginalis	glucosylceramidase, putative	0.9658	1	1
Echinococcus multilocularis	neutral alpha glucosidase AB	0.1412	0.1419	0.1505
Leishmania major	beta tubulin	0.009	0.0044	0.0275
Echinococcus multilocularis	tubulin alpha 3 chain	0.0167	0.0125	0.0132
Trichomonas vaginalis	tubulin beta chain, putative	0.0167	0.0125	0.0125
Loa Loa (eye worm)	beta-glucuronidase	0.0199	0.0157	0.0152
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.8012	0.8287	0.8286
Echinococcus granulosus	Tubulin beta 2C chain	0.009	0.0044	0.0047
Loa Loa (eye worm)	alpha amylase	0.0144	0.01	0.0095
Schistosoma mansoni	beta-mannosidase	0.012	0.0075	0.0079
Trichomonas vaginalis	alpha-glucosidase, putative	0.1412	0.1419	0.1419
Trichomonas vaginalis	maltase-glucoamylase, putative	0.1412	0.1419	0.1419
Echinococcus granulosus	tubulin alpha chain	0.0167	0.0125	0.0132
Trichomonas vaginalis	glucosylceramidase, putative	0.9658	1	1
Entamoeba histolytica	glycogen debranching enzyme, putative	0.0086	0.004	0.0282
Echinococcus granulosus	tubulin alpha 1C chain	0.0167	0.0125	0.0132
Echinococcus multilocularis	Tubulin beta 2C chain	0.009	0.0044	0.0047
Leishmania major	alpha tubulin	0.0167	0.0125	0.0844
Echinococcus granulosus	tubulin alpha	0.009	0.0044	0.0047
Trichomonas vaginalis	alpha-glucosidase, putative	0.1412	0.1419	0.1419
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.009	0.0044	0.0275
Leishmania major	alpha tubulin	0.0167	0.0125	0.0844
Leishmania major	alpha tubulin	0.0167	0.0125	0.0844
Echinococcus multilocularis	tubulin alpha chain	0.0167	0.0125	0.0132
Trypanosoma brucei	alpha tubulin	0.0167	0.0125	0.0856
Entamoeba histolytica	tubulin family protein	0.009	0.0044	0.031
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0128	0.0084	0.0084
Echinococcus multilocularis	Tubulin beta 2C chain	0.009	0.0044	0.0047
Trichomonas vaginalis	alpha-glucosidase, putative	0.1412	0.1419	0.1419
Leishmania major	alpha tubulin	0.0167	0.0125	0.0844
Loa Loa (eye worm)	alpha-tubulin	0.0167	0.0125	0.0119
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.1412	0.1419	0.1419
Trypanosoma cruzi	beta tubulin, putative	0.009	0.0044	0.0275
Echinococcus granulosus	tubulin subunit TubB	0.0167	0.0125	0.0132
Schistosoma mansoni	tubulin subunit epsilon	0.009	0.0044	0.0047
Toxoplasma gondii	Amylo-alpha-1,6-glucosidase	0.0086	0.004	0.0247
Schistosoma mansoni	alpha-amylase	0.0144	0.01	0.0106
Loa Loa (eye worm)	hypothetical protein	0.5526	0.57	0.5698
Plasmodium vivax	tubulin beta chain, putative	0.009	0.0044	0.3232
Brugia malayi	manba-prov protein	0.012	0.0075	0.0072
Echinococcus multilocularis	tubulin gamma 1 chain	0.009	0.0044	0.0047
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0117	0.0072	0.0077
Leishmania major	alpha glucosidase II subunit, putative	0.1412	0.1419	1
Echinococcus granulosus	tubulin beta 4A class IVa	0.009	0.0044	0.0047
Trypanosoma brucei	alpha tubulin	0.0167	0.0125	0.0856
Giardia lamblia	4-alpha-glucanotransferase, amylo-alpha-1,6-glucosidase	0.0086	0.004	0.0082
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.1412	0.1419	1
Trichomonas vaginalis	beta-galactosidase, putative	0.0369	0.0334	0.0334
Schistosoma mansoni	tubulin subunit beta	0.009	0.0044	0.0047
Echinococcus multilocularis	tubulin alpha	0.009	0.0044	0.0047
Echinococcus granulosus	neutral alpha glucosidase AB	0.1412	0.1419	0.1505
Echinococcus granulosus	tubulin epsilon chain	0.009	0.0044	0.0047
Echinococcus multilocularis	hypothetical protein	0.0167	0.0125	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0072	0.0067
Mycobacterium leprae	Putative uncharacterized protein ML2045	0.0144	0.01	0.5
Echinococcus multilocularis	alpha glucosidase	0.0144	0.01	0.0106
Echinococcus granulosus	beta tubulin	0.009	0.0044	0.0047
Trichomonas vaginalis	tubulin beta chain, putative	0.0051	0.0003	0.0003
Brugia malayi	Glycosyl hydrolases family 31 protein	0.8012	0.8287	0.8286
Trichomonas vaginalis	tubulin beta chain, putative	0.0167	0.0125	0.0125
Trypanosoma brucei	beta tubulin	0.009	0.0044	0.0288
Plasmodium vivax	tubulin epsilon chain, putative	0.009	0.0044	0.3232
Trichomonas vaginalis	tubulin beta chain, putative	0.009	0.0044	0.0044
Onchocerca volvulus	Ceramide glucosyltransferase homolog	0.9106	0.9426	1
Echinococcus granulosus	glycogen debranching enzyme	0.0086	0.004	0.0043
Plasmodium falciparum	tubulin epsilon chain, putative	0.009	0.0044	0.3232
Schistosoma mansoni	alpha-amylase	0.0144	0.01	0.0106
Toxoplasma gondii	melibiase subfamily protein	0.0117	0.0072	0.0476
Toxoplasma gondii	beta tubulin	0.009	0.0044	0.0275
Trichomonas vaginalis	glucosylceramidase, putative	0.6337	0.6544	0.6544
Loa Loa (eye worm)	tubulin beta-2A chain	0.009	0.0044	0.0039
Loa Loa (eye worm)	tubulin alpha 2	0.0128	0.0084	0.0079
Echinococcus multilocularis	bile acid beta glucosidase	0.8187	0.8469	0.8985
Trichomonas vaginalis	tubulin epsilon chain, putative	0.009	0.0044	0.0044
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0053	0.0005	0.0005
Loa Loa (eye worm)	tubulin alpha chain	0.0167	0.0125	0.0119
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0167	0.0125	0.0125
Echinococcus granulosus	mitogen activated protein kinase 3	0.0053	0.0005	0.0005
Echinococcus multilocularis	tubulin subunit beta	0.009	0.0044	0.0047
Leishmania major	beta tubulin	0.009	0.0044	0.0275
Leishmania major	beta tubulin	0.009	0.0044	0.0275
Leishmania major	alpha tubulin	0.0167	0.0125	0.0844
Schistosoma mansoni	tubulin subunit alpha	0.0167	0.0125	0.0132
Trichomonas vaginalis	tubulin, putative	0.0051	0.0003	0.0003
Loa Loa (eye worm)	glycosyl hydrolase family 2	0.0209	0.0167	0.0162
Loa Loa (eye worm)	alpha-tubulin	0.0167	0.0125	0.0119
Trichomonas vaginalis	glycogen debranching enzyme, putative	0.0086	0.004	0.004
Leishmania major	beta tubulin	0.009	0.0044	0.0275
Echinococcus granulosus	Tubulin alpha 1 chain	0.0167	0.0125	0.0132
Schistosoma mansoni	tubulin subunit beta	0.009	0.0044	0.0047
Leishmania major	beta tubulin	0.009	0.0044	0.0275
Trypanosoma brucei	epsilon tubulin	0.009	0.0044	0.0288
Leishmania major	alpha tubulin	0.0167	0.0125	0.0844
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0032	0.0027
Loa Loa (eye worm)	tubulin gamma chain	0.009	0.0044	0.0039

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 806622