TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 457.564 | Formula: C28H31N3O3
H donors: 2 H acceptors: 3 LogP: 5.1 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CNC(=O)c1cn(cc(c1=O)C(=O)NC(c1ccccc1)Cc1ccccc1)C1CCCCC1
InChi: 1S/C28H31N3O3/c1-29-27(33)23-18-31(22-15-9-4-10-16-22)19-24(26(23)32)28(34)30-25(21-13-7-3-8-14-21)17-20-11-5-2-6-12-20/h2-3,5-8,11-14,18-19,22,25H,4,9-10,15-17H2,1H3,(H,29,33)(H,30,34)
InChiKey: UWZDHBIEBNUVFM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	glucosylceramidase, putative	0.1856	0.7504	1
Schistosoma mansoni	ceramide glucosyltransferase	0.1956	0.7912	1
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0063	0.0187	0.0237
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0066	0.02	0.0252
Trichomonas vaginalis	alpha-glucosidase, putative	0.0347	0.1346	0.1794
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0151	0.0545	0.0726
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0064	0.019	0.024
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0033	0.0248
Echinococcus granulosus	neuropeptide s receptor	0.0463	0.1819	0.2299
Leishmania major	alpha glucosidase II subunit, putative	0.0347	0.1346	1
Echinococcus multilocularis	lysosomal alpha glucosidase	0.1765	0.7134	0.7134
Echinococcus granulosus	non lysosomal glucosylceramidase	0.1496	0.6035	0.7627
Onchocerca volvulus		0.0049	0.0128	0.0162
Trichomonas vaginalis	alpha-glucosidase, putative	0.0151	0.0545	0.0726
Schistosoma mansoni	hypothetical protein	0.0169	0.0619	0.0782
Echinococcus granulosus	neutral alpha glucosidase AB	0.0347	0.1346	0.1701
Schistosoma mansoni	hypothetical protein	0.0064	0.019	0.024
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0092	0.0306	0.0387
Onchocerca volvulus		0.0151	0.0547	0.0691
Brugia malayi	Bromodomain containing protein	0.0038	0.0086	0.0109
Trichomonas vaginalis	glucosylceramidase, putative	0.1218	0.49	0.6529
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0033	1
Schistosoma mansoni	hypothetical protein	0.0049	0.0128	0.0162
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0064	0.019	0.019
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0078	0.0078
Onchocerca volvulus		0.1054	0.4232	0.5349
Schistosoma mansoni	hypothetical protein	0.0064	0.019	0.024
Trichomonas vaginalis	glucosylceramidase, putative	0.1218	0.49	0.6529
Echinococcus multilocularis	ceramide glucosyltransferase	0.1956	0.7912	0.7912
Echinococcus granulosus	tar DNA binding protein	0.0063	0.0189	0.0238
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0066	0.02	0.1482
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0078	0.0098
Brugia malayi	F/Y-rich N-terminus family protein	0.002	0.001	0.0012
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0018	0.0003	0.0003
Trichomonas vaginalis	conserved hypothetical protein	0.0067	0.0205	0.0273
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0058	0.0166	0.021
Echinococcus multilocularis	sterol regulatory element binding protein	0.0043	0.0107	0.0107
Echinococcus multilocularis	neuropeptide receptor A26	0.0463	0.1819	0.1819
Schistosoma mansoni	hypothetical protein	0.0064	0.019	0.024
Schistosoma mansoni	cpg binding protein	0.0063	0.0187	0.0237
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0066	0.02	0.1482
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0066	0.02	0.1482
Trichomonas vaginalis	alpha-glucosidase, putative	0.0347	0.1346	0.1794
Brugia malayi	Ceramide glucosyltransferase	0.1956	0.7912	1
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0018	0.0003	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0004	0.0005
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0078	0.0098
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0029	0.0037
Trichomonas vaginalis	alpha-glucosidase, putative	0.0347	0.1346	0.1794
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0036	0.0077	0.0077
Schistosoma mansoni	cpg binding protein	0.0058	0.0166	0.021
Echinococcus granulosus	survival motor neuron protein 1	0.0238	0.0901	0.1139
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0347	0.1346	0.1794
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0004	0.0005
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.0029	0.5
Entamoeba histolytica	hypothetical protein	0.0036	0.0078	0.0577
Trichomonas vaginalis	glucosylceramidase, putative	0.1856	0.7504	1
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0024	0.0029	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0151	0.0545	0.0726
Brugia malayi	hypothetical protein	0.0238	0.0901	0.1139
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0024	0.0029	1
Loa Loa (eye worm)	hypothetical protein	0.0238	0.0901	0.1139
Trichomonas vaginalis	glucosylceramidase, putative	0.1284	0.5167	0.6886
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0029	0.0037
Onchocerca volvulus	Uncharacterized family 31 glucosidase KIAA1161 homolog	0.0151	0.0545	0.0688
Trichomonas vaginalis	glucosylceramidase, putative	0.1218	0.49	0.6529
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.0029	0.5
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0347	0.1346	0.1701
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0029	0.0037
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0033	1
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0043	0.0107	0.0135
Trichomonas vaginalis	glucosylceramidase, putative	0.1856	0.7504	1
Giardia lamblia	Ceramide glucosyltransferase	0.0887	0.3548	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0092	0.0306	0.0387
Entamoeba histolytica	hypothetical protein	0.0036	0.0078	0.0577
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0036	0.0077	0.0097
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0347	0.1346	1
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0063	0.0187	0.0187
Echinococcus multilocularis	GPCR, family 2	0.0064	0.019	0.019
Trichomonas vaginalis	glucosylceramidase, putative	0.1218	0.49	0.6529
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0092	0.0306	0.0387
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0123	0.0431	0.0545
Echinococcus multilocularis	tar DNA binding protein	0.0063	0.0189	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0131	0.0466	0.0588
Echinococcus multilocularis	survival motor neuron protein 1	0.0238	0.0901	0.0901
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0189	0.0238
Schistosoma mansoni	hypothetical protein	0.0021	0.0014	0.0018
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0064	0.019	0.024
Echinococcus multilocularis	Niemann Pick C1 protein	0.0145	0.052	0.052
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0024	0.0029	1
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0189	0.0238
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0202	0.0753	0.0951
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0029	0.0218
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0092	0.0306	0.0387
Loa Loa (eye worm)	amylo-alpha-1,6-glucosidase	0.0064	0.0191	0.0241
Leishmania major	glycosyl hydrolase-like protein	0.0151	0.0545	0.4046
Brugia malayi	latrophilin 2 splice variant baaae	0.0138	0.0492	0.0622
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0033	0.0248
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0189	0.0238
Loa Loa (eye worm)	histone methyltransferase	0.0018	0.0003	0.0004
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0029	0.0218
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0029	1
Echinococcus granulosus	GPCR family 2	0.0064	0.019	0.024
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0189	0.0238
Echinococcus granulosus	lysosomal alpha glucosidase	0.1765	0.7134	0.9016
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0107	0.0135
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0029	0.0037
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0092	0.0306	0.0387
Loa Loa (eye worm)	bromodomain containing protein	0.0018	0.0002	0.0003
Echinococcus granulosus	zinc finger protein	0.0023	0.0023	0.0029
Leishmania major	hypothetical protein, conserved	0.0025	0.0033	0.0248
Trichomonas vaginalis	alpha-glucosidase, putative	0.0151	0.0545	0.0726
Schistosoma mansoni	alpha-glucosidase	0.1569	0.6332	0.8003
Trichomonas vaginalis	glucosylceramidase, putative	0.1218	0.49	0.6529
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0029	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0096	0.0122
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0018	0.0004	0.5
Onchocerca volvulus		0.0058	0.0166	0.021
Trichomonas vaginalis	glucosylceramidase, putative	0.1856	0.7504	1
Loa Loa (eye worm)	hypothetical protein	0.0064	0.019	0.024
Echinococcus granulosus	microtubule associated protein 2	0.0691	0.2749	0.3474
Loa Loa (eye worm)	TAR-binding protein	0.0063	0.0189	0.0238
Echinococcus granulosus	cpg binding protein	0.0063	0.0187	0.0237
Schistosoma mansoni	hypothetical protein	0.0042	0.0101	0.0127
Trichomonas vaginalis	alpha-glucosidase, putative	0.0347	0.1346	0.1794
Echinococcus multilocularis	transcription factor Dp 1	0.0038	0.0086	0.0086
Brugia malayi	hypothetical protein	0.0029	0.005	0.0063
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.0107	0.0143
Onchocerca volvulus	Glucosylceramidase homolog	0.1218	0.49	0.6193
Schistosoma mansoni	zinc finger protein	0.0023	0.0023	0.0029
Echinococcus multilocularis	cpg binding protein	0.0063	0.0187	0.0187
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0026	0.0035	0.0045
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0024	0.0029	1
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0753	0.0951
Schistosoma mansoni	microtubule-associated protein tau	0.0691	0.2749	0.3474
Giardia lamblia	4-alpha-glucanotransferase, amylo-alpha-1,6-glucosidase	0.0131	0.0466	0.1312
Echinococcus multilocularis	zinc finger protein	0.0023	0.0023	0.0023
Trichomonas vaginalis	glycogen debranching enzyme, putative	0.0131	0.0466	0.062
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0029	0.0218
Trichomonas vaginalis	alpha-glucosidase, putative	0.0347	0.1346	0.1794
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0092	0.0306	0.0387
Brugia malayi	Niemann-Pick C1 protein precursor	0.0101	0.0343	0.0433
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0347	0.1346	0.1346
Brugia malayi	PHD-finger family protein	0.0028	0.0045	0.0057
Echinococcus multilocularis	protein patched	0.0043	0.0107	0.0107
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0024	0.0029	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0347	0.1346	1
Schistosoma mansoni	hypothetical protein	0.0064	0.019	0.024
Echinococcus multilocularis	Niemann Pick C1 protein	0.0101	0.0343	0.0343
Entamoeba histolytica	hypothetical protein	0.0036	0.0078	0.0577
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0112	0.0387	0.2694
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0219	0.0277
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0066	0.02	0.0252
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0064	0.019	0.024
Echinococcus multilocularis	non lysosomal glucosylceramidase	0.1496	0.6035	0.6035
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0151	0.0545	0.0726
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0064	0.019	0.019
Echinococcus granulosus	histone lysine methyltransferase setb	0.0018	0.0005	0.0006
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0066	0.02	0.02
Schistosoma mansoni	alpha glucosidase	0.0347	0.1346	0.1701
Schistosoma mansoni	ceramide glucosyltransferase	0.1956	0.7912	1
Schistosoma mansoni	hypothetical protein	0.0036	0.0078	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0004	0.0005
Loa Loa (eye worm)	ceramide glucosyltransferase	0.1956	0.7912	1
Trypanosoma cruzi	glycosyl hydrolase-like protein, putative	0.0151	0.0545	0.4046
Echinococcus multilocularis	microtubule associated protein 2	0.0691	0.2749	0.2749
Echinococcus multilocularis	dnaJ subfamily B	0.0409	0.1601	0.1601
Echinococcus granulosus	sterol regulatory element binding protein	0.0043	0.0107	0.0135
Echinococcus multilocularis	protein dispatched 1	0.005	0.0132	0.0132
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.1765	0.7134	0.9016
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0066	0.02	0.0252
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0101	0.0343	0.2548
Loa Loa (eye worm)	hypothetical protein	0.101	0.4051	0.512
Schistosoma mansoni	cpg binding protein	0.0063	0.0187	0.0237
Schistosoma mansoni	survival motor neuron protein	0.0049	0.0128	0.0162
Schistosoma mansoni	hypothetical protein	0.0138	0.0492	0.0622
Schistosoma mansoni	hypothetical protein	0.0042	0.0101	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0118	0.0149
Brugia malayi	RNA binding protein	0.0063	0.0189	0.0238
Schistosoma mansoni	bromodomain containing protein	0.0067	0.0202	0.0255
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0004	0.0005
Loa Loa (eye worm)	PHD-finger family protein	0.0021	0.0014	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0087	0.0109
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0064	0.019	0.024
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0029	0.0218
Schistosoma mansoni	hypothetical protein	0.0042	0.0101	0.0127
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0066	0.02	0.0252
Trypanosoma cruzi	glycosyl hydrolase-like protein, putative	0.0151	0.0545	0.4046
Echinococcus granulosus	transcription factor Dp 1	0.0038	0.0086	0.0109
Brugia malayi	hypothetical protein	0.0025	0.0033	0.0042
Entamoeba histolytica	acyl-coA synthetase, putative	0.0024	0.0029	0.0218
Schistosoma mansoni	bile acid beta-glucosidase-related	0.1496	0.6035	0.7627
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0018	0.0004	0.139
Brugia malayi	hypothetical protein	0.0151	0.0547	0.0691
Trichomonas vaginalis	glucosylceramidase, putative	0.1218	0.49	0.6529
Trichomonas vaginalis	alpha-glucosidase, putative	0.0151	0.0545	0.0726
Trichomonas vaginalis	glucosylceramidase, putative	0.1856	0.7504	1
Echinococcus multilocularis	expressed conserved protein	0.0095	0.0318	0.0318
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0049	0.0128	0.0162
Trypanosoma cruzi	hypothetical protein, conserved	0.0347	0.1346	1
Plasmodium falciparum	acyl-CoA synthetase	0.0018	0.0004	0.1264
Echinococcus granulosus	expressed conserved protein	0.0095	0.0318	0.0402
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0151	0.0545	0.0688
Echinococcus granulosus	dnaJ subfamily B	0.0409	0.1601	0.2023
Brugia malayi	Amylo-alpha-1,6-glucosidase family protein	0.0131	0.0466	0.0588
Trichomonas vaginalis	glucosylceramidase, putative	0.1218	0.49	0.6529
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0202	0.0753	0.0951
Schistosoma mansoni	patched 1	0.0043	0.0107	0.0135
Trypanosoma brucei	glycosyl hydrolase-like protein	0.0151	0.0545	0.4046
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0147	0.0186
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0018	0.0005	0.0006
Schistosoma mansoni	hypothetical protein	0.0042	0.0101	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0005	0.0006
Schistosoma mansoni	hypothetical protein	0.0409	0.1601	0.2023
Brugia malayi	CHE-14 protein	0.0043	0.0107	0.0135
Brugia malayi	RNA recognition motif domain containing protein	0.0063	0.0189	0.0238
Echinococcus granulosus	ceramide glucosyltransferase	0.1956	0.7912	1
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0151	0.0545	0.4046
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0018	0.0005	0.0005
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0026	0.0035	0.0035
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0347	0.1346	0.1794
Trichomonas vaginalis	glucosylceramidase, putative	0.1284	0.5167	0.6886
Echinococcus multilocularis	lysosomal alpha glucosidase	0.1765	0.7134	0.7134
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0092	0.0306	0.0306
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.1856	0.7504	0.9485
Brugia malayi	TAR-binding protein	0.0063	0.0189	0.0238
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0063	0.0189	0.0238
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0347	0.1346	0.1794
Entamoeba histolytica	glycogen debranching enzyme, putative	0.0131	0.0466	0.3459
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0545	0.0688
Loa Loa (eye worm)	hypothetical protein	0.0138	0.0492	0.0622
Brugia malayi	Bromodomain containing protein	0.0078	0.025	0.0316
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0029	1
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0347	0.1346	0.1701
Schistosoma mansoni	hypothetical protein	0.0095	0.0317	0.04
Echinococcus multilocularis	bile acid beta glucosidase	0.1496	0.6035	0.6035
Entamoeba histolytica	hypothetical protein	0.0036	0.0078	0.0577
Onchocerca volvulus		0.0024	0.0029	0.0037
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0018	0.0005	0.0006
Echinococcus multilocularis	neuropeptide s receptor	0.0463	0.1819	0.1819
Echinococcus granulosus	Niemann Pick C1 protein	0.0101	0.0343	0.0433
Brugia malayi	Latrophilin receptor protein 2	0.0064	0.019	0.024
Trichomonas vaginalis	glucosylceramidase, putative	0.1856	0.7504	1
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0347	0.1346	1
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0029	0.0037
Loa Loa (eye worm)	RNA binding protein	0.0063	0.0189	0.0238
Echinococcus multilocularis	glycogen debranching enzyme	0.0131	0.0466	0.0466
Trypanosoma brucei	glucosidase, putative	0.0347	0.1346	1
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0347	0.1346	0.1794
Trichomonas vaginalis	glycogen debranching enzyme, putative	0.0131	0.0466	0.062
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.1856	0.7504	0.9485
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0151	0.0545	0.0726
Schistosoma mansoni	alpha-glucosidase	0.1569	0.6332	0.8003
Trichomonas vaginalis	alpha-glucosidase, putative	0.0151	0.0545	0.0726
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0029	0.0037
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0066	0.02	0.1482
Brugia malayi	Glycosyl hydrolases family 31 protein	0.1765	0.7134	0.9016
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0202	0.0753	0.0951
Echinococcus granulosus	neuropeptide receptor A26	0.0463	0.1819	0.2299
Echinococcus granulosus	Protein patched homolog 1	0.0043	0.0107	0.0135
Echinococcus granulosus	glycogen debranching enzyme	0.0131	0.0466	0.0588
Schistosoma mansoni	bile acid beta-glucosidase-related	0.1496	0.6035	0.7627
Echinococcus granulosus	bile acid beta glucosidase	0.1496	0.6035	0.7627
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0066	0.02	0.1482
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0092	0.0306	0.0387
Brugia malayi	hypothetical protein	0.0036	0.0078	0.0098
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0033	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0033	0.0042
Echinococcus granulosus	fetal alzheimer antigen falz	0.0026	0.0035	0.0045
Toxoplasma gondii	Amylo-alpha-1,6-glucosidase	0.0131	0.0466	0.3293
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0092	0.0306	0.0306
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0033	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0343	0.0433
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0347	0.1346	1
Brugia malayi	CXXC zinc finger family protein	0.0058	0.0166	0.021
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0024	0.0029	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0004	0.0005
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0189	0.0238
Mycobacterium ulcerans	hypothetical protein	0.0024	0.0029	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0029	0.0218
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0103	0.0349	0.0441
Onchocerca volvulus	Ceramide glucosyltransferase homolog	0.1956	0.7912	1
Echinococcus granulosus	Niemann Pick C1 protein	0.0145	0.052	0.0657
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0547	0.0691

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 806643