Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0127 | 0.0841 | 1 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0198 | 0.1713 | 0.1865 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.0814 | 0.9183 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0127 | 0.0841 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.0108 | 0.0616 | 0.5 |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.0814 | 0.9183 | 1 |
Brugia malayi | Ceramide glucosyltransferase | 0.0814 | 0.9183 | 0.9183 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0609 | 0.67 | 0.6483 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0108 | 0.0616 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0881 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0108 | 0.0616 | 0.067 |
Schistosoma mansoni | hypothetical protein | 0.0306 | 0.302 | 0.3289 |
Loa Loa (eye worm) | hypothetical protein | 0.0479 | 0.5123 | 0.5123 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0881 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0578 | 0.6322 | 0.6081 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0108 | 0.0616 | 0.067 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.0814 | 0.9183 | 1 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.071 | 0.7925 | 0.8629 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0881 | 1 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0108 | 0.0616 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.1226 | 0.1226 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0578 | 0.6322 | 0.6081 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0881 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0108 | 0.0616 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0108 | 0.0616 | 0.0616 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0198 | 0.1713 | 0.1865 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0108 | 0.0616 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0881 | 1 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0127 | 0.0841 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0108 | 0.0616 | 0.067 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0881 | 1 | 1 |
Echinococcus granulosus | bile acid beta glucosidase | 0.071 | 0.7925 | 0.8629 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0127 | 0.0841 | 1 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0108 | 0.0616 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0578 | 0.6322 | 0.6081 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0578 | 0.6322 | 0.6081 |
Echinococcus granulosus | ceramide glucosyltransferase | 0.0814 | 0.9183 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0158 | 0.1226 | 0.1226 |
Echinococcus multilocularis | bile acid beta glucosidase | 0.071 | 0.7925 | 0.8629 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0108 | 0.0616 | 0.5 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.0814 | 0.9183 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0108 | 0.0618 | 0.0673 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0108 | 0.0618 | 0.0618 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.0814 | 0.9183 | 0.9183 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0609 | 0.67 | 0.6483 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0881 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0108 | 0.0616 | 0.067 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0578 | 0.6322 | 0.6081 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0158 | 0.1226 | 0.1226 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0108 | 0.0616 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0158 | 0.1226 | 0.1226 |
Giardia lamblia | Ceramide glucosyltransferase | 0.0369 | 0.3783 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0108 | 0.0616 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0108 | 0.0616 | 0.067 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.0618 | 0.0618 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0578 | 0.6322 | 0.6081 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.071 | 0.7925 | 0.8629 |
Echinococcus granulosus | non lysosomal glucosylceramidase | 0.071 | 0.7925 | 0.8629 |
Brugia malayi | MAP kinase sur-1 | 0.0108 | 0.0616 | 0.0616 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0578 | 0.6322 | 0.6081 |
Echinococcus multilocularis | non lysosomal glucosylceramidase | 0.071 | 0.7925 | 0.8629 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.