Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0175 | 0.1509 | 0.16 |
Onchocerca volvulus | 0.0187 | 0.1658 | 0.1912 | |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0281 | 0.279 | 0.2751 |
Schistosoma mansoni | hypothetical protein | 0.0098 | 0.0587 | 0.0586 |
Brugia malayi | glutathione reductase | 0.0142 | 0.1116 | 0.1067 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0149 | 0.1199 | 0.1199 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0085 | 0.043 | 0.043 |
Echinococcus granulosus | expressed protein | 0.0768 | 0.8646 | 0.8638 |
Echinococcus granulosus | non lysosomal glucosylceramidase | 0.0437 | 0.466 | 0.4631 |
Trichomonas vaginalis | glycogen debranching enzyme, putative | 0.0136 | 0.1041 | 0.1618 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0356 | 0.3683 | 0.6007 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0094 | 0.0541 | 0.0489 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0281 | 0.279 | 0.5842 |
Loa Loa (eye worm) | glutamate receptor | 0.0131 | 0.0979 | 0.0979 |
Loa Loa (eye worm) | glutaminase 2 | 0.0555 | 0.6086 | 0.6086 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0281 | 0.279 | 0.5842 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0542 | 0.5925 | 0.9732 |
Entamoeba histolytica | glycogen debranching enzyme, putative | 0.0136 | 0.1041 | 0.2862 |
Trichomonas vaginalis | chromobox protein, putative | 0.0139 | 0.1073 | 0.1671 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0187 | 0.1658 | 0.1612 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0078 | 0.034 | 0.0453 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0301 | 0.3028 | 0.299 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0278 | 0.2755 | 0.2972 |
Schistosoma mansoni | jumonji domain containing protein | 0.0075 | 0.0308 | 0.0279 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.0751 | 0.8438 | 0.9227 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.006 | 0.0122 | 0.0122 |
Trypanosoma brucei | glucosidase, putative | 0.0149 | 0.1199 | 0.2049 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0356 | 0.3683 | 0.6007 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0409 | 0.4328 | 0.4297 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.0751 | 0.8438 | 0.9227 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0187 | 0.1658 | 0.1658 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0281 | 0.279 | 0.4524 |
Loa Loa (eye worm) | glutamate receptor | 0.0332 | 0.3404 | 0.3404 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0078 | 0.034 | 0.0453 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0281 | 0.279 | 0.3263 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0324 | 0.3306 | 0.8342 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0426 | 0.4534 | 1 |
Trypanosoma brucei | polo-like protein kinase | 0.0281 | 0.279 | 0.5842 |
Echinococcus granulosus | bile acid beta glucosidase | 0.0437 | 0.466 | 0.4631 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0361 | 0.3742 | 1 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0187 | 0.1658 | 0.1612 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0187 | 0.1658 | 0.1612 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0149 | 0.1199 | 0.1881 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0281 | 0.279 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0542 | 0.5925 | 0.9732 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0278 | 0.2755 | 0.2715 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0094 | 0.0541 | 0.0489 |
Leishmania major | trypanothione reductase | 0.0142 | 0.1116 | 0.1849 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.0751 | 0.8438 | 0.8438 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0139 | 0.1081 | 0.1684 |
Trichomonas vaginalis | conserved hypothetical protein | 0.007 | 0.0245 | 0.0295 |
Onchocerca volvulus | Uncharacterized family 31 glucosidase KIAA1161 homolog | 0.0078 | 0.034 | 0.0341 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0375 | 0.3913 | 0.639 |
Loa Loa (eye worm) | hypothetical protein | 0.0295 | 0.2952 | 0.2952 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0078 | 0.034 | 0.0453 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0149 | 0.1199 | 0.1151 |
Trypanosoma brucei | trypanothione reductase | 0.0142 | 0.1116 | 0.1849 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0324 | 0.3306 | 0.8342 |
Schistosoma mansoni | alpha-glucosidase | 0.0809 | 0.9141 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0881 | 1 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0084 | 0.0411 | 0.0571 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0142 | 0.1116 | 0.1849 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.0437 | 0.466 | 0.5068 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0281 | 0.279 | 0.4524 |
Loa Loa (eye worm) | glutathione reductase | 0.0142 | 0.1116 | 0.1116 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0187 | 0.1658 | 0.1658 |
Echinococcus multilocularis | bile acid beta glucosidase | 0.0437 | 0.466 | 0.4631 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0542 | 0.5925 | 0.9732 |
Toxoplasma gondii | thioredoxin reductase | 0.0142 | 0.1116 | 0.4695 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0139 | 0.1081 | 0.1684 |
Onchocerca volvulus | 0.0187 | 0.1658 | 0.1912 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0426 | 0.4534 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0142 | 0.1116 | 0.1116 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0139 | 0.1073 | 0.1073 |
Schistosoma mansoni | alpha glucosidase | 0.0149 | 0.1199 | 0.126 |
Giardia lamblia | Kinase, PLK | 0.0281 | 0.279 | 0.7113 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0078 | 0.034 | 0.0453 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0281 | 0.279 | 0.2751 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0281 | 0.279 | 0.3011 |
Mycobacterium tuberculosis | Probable reductase | 0.0324 | 0.3306 | 0.8342 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0332 | 0.3404 | 0.3368 |
Brugia malayi | chromobox protein homolog 3 | 0.0078 | 0.034 | 0.0287 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0078 | 0.034 | 0.0287 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0542 | 0.5925 | 0.5903 |
Loa Loa (eye worm) | glutaminase | 0.0555 | 0.6086 | 0.6086 |
Schistosoma mansoni | chromobox protein | 0.0139 | 0.1073 | 0.1121 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0078 | 0.034 | 0.0453 |
Brugia malayi | Heterochromatin protein 1 | 0.0139 | 0.1073 | 0.1024 |
Echinococcus multilocularis | non lysosomal glucosylceramidase | 0.0437 | 0.466 | 0.4631 |
Echinococcus multilocularis | chromobox protein 1 | 0.0139 | 0.1073 | 0.1024 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0356 | 0.3683 | 0.4328 |
Brugia malayi | jmjC domain containing protein | 0.0094 | 0.0541 | 0.0489 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0881 | 1 | 1 |
Brugia malayi | Ceramide glucosyltransferase | 0.0751 | 0.8438 | 0.843 |
Brugia malayi | glutaminase DH11.1 | 0.0555 | 0.6086 | 0.6065 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.034 | 0.034 |
Trichomonas vaginalis | glycogen debranching enzyme, putative | 0.0136 | 0.1041 | 0.1618 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0361 | 0.3742 | 1 |
Onchocerca volvulus | 0.0187 | 0.1658 | 0.1912 | |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.043 | 0.043 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 0.1658 | 0.1658 |
Leishmania major | hypothetical protein, conserved | 0.0426 | 0.4534 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0149 | 0.1199 | 0.1881 |
Plasmodium vivax | glutathione reductase, putative | 0.0142 | 0.1116 | 0.5 |
Echinococcus granulosus | glycogen debranching enzyme | 0.0136 | 0.1041 | 0.0992 |
Plasmodium falciparum | glutathione reductase | 0.0142 | 0.1116 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0356 | 0.3683 | 0.6007 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0881 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0542 | 0.5925 | 0.9732 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0078 | 0.034 | 0.0453 |
Echinococcus granulosus | chromobox protein 1 | 0.0139 | 0.1073 | 0.1024 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0281 | 0.279 | 0.2751 |
Brugia malayi | ShTK domain containing protein | 0.0187 | 0.1658 | 0.1612 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0078 | 0.034 | 0.0453 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0281 | 0.279 | 0.4524 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0149 | 0.1199 | 0.1881 |
Schistosoma mansoni | alpha-glucosidase | 0.0809 | 0.9141 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0361 | 0.3742 | 1 |
Onchocerca volvulus | 0.0061 | 0.0138 | 0.01 | |
Schistosoma mansoni | tyrosinase precursor | 0.0187 | 0.1658 | 0.1764 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0881 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0409 | 0.4328 | 0.4328 |
Echinococcus granulosus | chromobox protein 1 | 0.0139 | 0.1073 | 0.1024 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0149 | 0.1199 | 0.1151 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0149 | 0.1199 | 0.2049 |
Giardia lamblia | Ceramide glucosyltransferase | 0.034 | 0.35 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0162 | 0.1354 | 0.1431 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0142 | 0.1116 | 0.1067 |
Echinococcus multilocularis | chromobox protein 1 | 0.0139 | 0.1073 | 0.1024 |
Plasmodium falciparum | thioredoxin reductase | 0.0142 | 0.1116 | 0.5 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0324 | 0.3306 | 0.8342 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0149 | 0.1199 | 0.1881 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0149 | 0.1199 | 0.1881 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0078 | 0.034 | 0.0453 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0149 | 0.1199 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0356 | 0.3683 | 0.6007 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0142 | 0.1116 | 0.5 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0162 | 0.1354 | 0.1307 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0356 | 0.3683 | 0.6007 |
Schistosoma mansoni | kinase | 0.0143 | 0.1126 | 0.1179 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0149 | 0.1199 | 0.1881 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0281 | 0.279 | 0.279 |
Trichomonas vaginalis | glutaminase, putative | 0.0555 | 0.6086 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0054 | 0.0054 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0078 | 0.034 | 0.0453 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0426 | 0.4534 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0356 | 0.3683 | 0.6007 |
Brugia malayi | Common central domain of tyrosinase family protein | 0.0187 | 0.1658 | 0.1612 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0149 | 0.1199 | 0.1881 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0409 | 0.4328 | 0.4297 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0542 | 0.5925 | 0.5925 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0542 | 0.5925 | 0.9732 |
Loa Loa (eye worm) | tyrosinase 1 | 0.0187 | 0.1658 | 0.1658 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0281 | 0.279 | 0.4524 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0281 | 0.279 | 0.4524 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0375 | 0.3913 | 0.639 |
Loa Loa (eye worm) | amylo-alpha-1,6-glucosidase | 0.0066 | 0.0202 | 0.0202 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0142 | 0.1116 | 0.1067 |
Mycobacterium ulcerans | glutaminase | 0.0555 | 0.6086 | 0.5 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0378 | 0.3952 | 0.429 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0324 | 0.3306 | 0.8342 |
Trichomonas vaginalis | chromobox protein, putative | 0.0139 | 0.1073 | 0.1671 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0356 | 0.3683 | 0.6007 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.0751 | 0.8438 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.034 | 0.034 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0078 | 0.034 | 0.0453 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0149 | 0.1199 | 0.1881 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0324 | 0.3306 | 0.8342 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0084 | 0.0411 | 0.0426 |
Schistosoma mansoni | tyrosinase precursor | 0.0187 | 0.1658 | 0.1764 |
Echinococcus multilocularis | expressed protein | 0.0768 | 0.8646 | 0.8638 |
Onchocerca volvulus | 0.0544 | 0.5947 | 0.7029 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0149 | 0.1199 | 0.2049 |
Schistosoma mansoni | chromobox protein | 0.0139 | 0.1073 | 0.1121 |
Echinococcus granulosus | ceramide glucosyltransferase | 0.0751 | 0.8438 | 0.843 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0078 | 0.034 | 0.0341 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 0.1658 | 0.1658 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.0437 | 0.466 | 0.5068 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0138 | 0.0138 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0542 | 0.5925 | 0.9732 |
Schistosoma mansoni | glutaminase | 0.0555 | 0.6086 | 0.6638 |
Echinococcus multilocularis | glycogen debranching enzyme | 0.0136 | 0.1041 | 0.0992 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0281 | 0.279 | 0.5842 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0085 | 0.043 | 0.0378 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0149 | 0.1199 | 0.3507 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0361 | 0.3742 | 1 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0149 | 0.1199 | 0.2049 |
Onchocerca volvulus | 0.0187 | 0.1658 | 0.1912 | |
Trichomonas vaginalis | CAMK family protein kinase | 0.0281 | 0.279 | 0.4524 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0278 | 0.2755 | 0.2715 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0149 | 0.1199 | 0.1881 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.1041 | 0.1041 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0281 | 0.279 | 0.4524 |
Brugia malayi | Amylo-alpha-1,6-glucosidase family protein | 0.0136 | 0.1041 | 0.0992 |
Trichomonas vaginalis | chromobox protein, putative | 0.0084 | 0.0411 | 0.0571 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0149 | 0.1199 | 0.3507 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0149 | 0.1199 | 0.1151 |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.0751 | 0.8438 | 0.843 |
Brugia malayi | Thioredoxin reductase | 0.0142 | 0.1116 | 0.1067 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0085 | 0.043 | 0.043 |
Brugia malayi | Hypothetical tyrosinase-like protein F21C3.2 in chromosome I | 0.0187 | 0.1658 | 0.1612 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.