Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | inositol transporter | 0.0041 | 0.0496 | 0.0497 |
Brugia malayi | bHLH-PAS transcription factor | 0.0036 | 0.035 | 0.035 |
Echinococcus granulosus | geminin | 0.018 | 0.4522 | 0.4522 |
Loa Loa (eye worm) | glyceraldehyde 3-phosphate dehydrogenase | 0.0098 | 0.2159 | 0.216 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.015 | 0.3653 | 1 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.015 | 0.3653 | 1 |
Schistosoma mansoni | lamin | 0.0029 | 0.0147 | 0.0147 |
Brugia malayi | hypothetical protein | 0.013 | 0.3081 | 0.3083 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.015 | 0.3653 | 1 |
Trypanosoma cruzi | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0098 | 0.2156 | 0.4996 |
Trypanosoma brucei | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | 0.015 | 0.3653 | 1 |
Leishmania major | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | 0.015 | 0.3653 | 1 |
Trypanosoma brucei | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | 0.015 | 0.3653 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0029 | 0.0147 | 0.0147 |
Echinococcus multilocularis | sodium coupled monocarboxylate transporter 1 | 0.0041 | 0.0496 | 0.0496 |
Wolbachia endosymbiont of Brugia malayi | glyceraldehyde-3-phosphate dehydrogenase, GapA | 0.015 | 0.3653 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0127 | 0.2985 | 0.2987 |
Brugia malayi | Glyceraldehyde 3-phosphate dehydrogenase | 0.0052 | 0.0814 | 0.0814 |
Schistosoma mansoni | lipoxygenase | 0.0059 | 0.1014 | 0.1015 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0078 | 0.1573 | 0.1573 |
Echinococcus multilocularis | sodium:myo inositol cotransporter | 0.0041 | 0.0496 | 0.0496 |
Echinococcus multilocularis | tumor protein p63 | 0.0359 | 0.9694 | 0.9694 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.015 | 0.3653 | 1 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0048 | 0.0711 | 0.0712 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 0.3989 | 0.3992 |
Echinococcus granulosus | sodium coupled monocarboxylate transporter 1 | 0.0041 | 0.0496 | 0.0496 |
Echinococcus multilocularis | sodium:glucose cotransporter 2 | 0.0041 | 0.0496 | 0.0496 |
Schistosoma mansoni | hypothetical protein | 0.018 | 0.4522 | 0.4526 |
Echinococcus granulosus | lamin dm0 | 0.0029 | 0.0147 | 0.0147 |
Treponema pallidum | glyceraldehyde 3-phosphate dehydrogenase (gap) | 0.015 | 0.3653 | 0.5 |
Trypanosoma cruzi | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0098 | 0.2156 | 0.4996 |
Schistosoma mansoni | lamin | 0.0029 | 0.0147 | 0.0147 |
Brugia malayi | MH2 domain containing protein | 0.0127 | 0.2985 | 0.2987 |
Plasmodium falciparum | glyceraldehyde-3-phosphate dehydrogenase | 0.015 | 0.3653 | 0.5 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.015 | 0.3653 | 1 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.015 | 0.3653 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0029 | 0.0147 | 0.0147 |
Onchocerca volvulus | 0.0029 | 0.0147 | 0.0478 | |
Brugia malayi | PAS domain containing protein | 0.0048 | 0.0711 | 0.0712 |
Brugia malayi | hypoxia-induced factor 1 | 0.0149 | 0.3628 | 0.363 |
Mycobacterium ulcerans | glyceraldehyde 3-phosphate dehydrogenase Gap | 0.015 | 0.3653 | 1 |
Entamoeba histolytica | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.015 | 0.3653 | 1 |
Echinococcus granulosus | single minded 2 | 0.0036 | 0.035 | 0.035 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.015 | 0.3653 | 1 |
Entamoeba histolytica | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.015 | 0.3653 | 1 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0149 | 0.3628 | 0.363 |
Echinococcus multilocularis | high affinity choline transporter 1 | 0.0369 | 0.9992 | 0.9992 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.3081 | 0.3083 |
Loa Loa (eye worm) | glyceraldehyde-3-phosphate dehydrogenase | 0.0103 | 0.2311 | 0.2312 |
Echinococcus multilocularis | solute carrier family 5 | 0.0041 | 0.0496 | 0.0496 |
Giardia lamblia | Glyceraldehyde 3-phosphate dehydrogenase | 0.015 | 0.3653 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.3081 | 0.3083 |
Onchocerca volvulus | 0.0029 | 0.0147 | 0.0478 | |
Schistosoma mansoni | sodium/solute symporter | 0.0041 | 0.0496 | 0.0497 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.015 | 0.3653 | 0.3656 |
Schistosoma mansoni | intermediate filament proteins | 0.0029 | 0.0147 | 0.0147 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0029 | 0.0147 | 0.0147 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0098 | 0.2159 | 0.4737 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.015 | 0.3653 | 1 |
Onchocerca volvulus | 0.0036 | 0.035 | 0.1134 | |
Loa Loa (eye worm) | glyceraldehyde 3-phosphate dehydrogenase | 0.0098 | 0.2159 | 0.216 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0132 | 0.0132 |
Echinococcus multilocularis | geminin | 0.018 | 0.4522 | 0.4522 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0496 | 0.0497 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0059 | 0.1014 | 0.1014 |
Echinococcus granulosus | high affinity choline transporter 1 | 0.0369 | 0.9992 | 0.9992 |
Leishmania major | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | 0.015 | 0.3653 | 1 |
Brugia malayi | glyceraldehyde 3-phosphate dehydrogenase | 0.0046 | 0.0662 | 0.0662 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.015 | 0.3653 | 1 |
Brugia malayi | hypothetical protein | 0.0078 | 0.1573 | 0.1574 |
Brugia malayi | Glyceraldehyde 3-phosphate dehydrogenase | 0.015 | 0.3653 | 0.3656 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.015 | 0.3653 | 0.3656 |
Brugia malayi | Sodium:solute symporter family protein | 0.0041 | 0.0496 | 0.0497 |
Echinococcus granulosus | sodium:glucose cotransporter | 0.0041 | 0.0496 | 0.0496 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0059 | 0.1014 | 0.1014 |
Echinococcus multilocularis | glyceraldehyde 3 phosphate dehydrogenase | 0.015 | 0.3653 | 0.3653 |
Chlamydia trachomatis | glyceraldehyde-3-phosphate dehydrogenase | 0.015 | 0.3653 | 0.5 |
Echinococcus multilocularis | musashi | 0.0029 | 0.0147 | 0.0147 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.015 | 0.3653 | 1 |
Mycobacterium tuberculosis | Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) | 0.0052 | 0.0816 | 0.5 |
Echinococcus granulosus | solute carrier family 5 | 0.0041 | 0.0496 | 0.0496 |
Onchocerca volvulus | Huntingtin homolog | 0.013 | 0.3081 | 1 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.015 | 0.3653 | 1 |
Echinococcus granulosus | sodium:myo inositol cotransporter | 0.0041 | 0.0496 | 0.0496 |
Echinococcus granulosus | glyceraldehyde 3 phosphate dehydrogenase | 0.0098 | 0.2159 | 0.2159 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.015 | 0.3653 | 0.3656 |
Schistosoma mansoni | single-minded | 0.0048 | 0.0711 | 0.0712 |
Trypanosoma brucei | glyceraldehyde 3-phosphate dehydrogenase, cytosolic | 0.015 | 0.3653 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.2159 | 0.216 |
Plasmodium vivax | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.015 | 0.3653 | 0.5 |
Onchocerca volvulus | 0.0053 | 0.0838 | 0.2719 | |
Echinococcus multilocularis | lamin | 0.0029 | 0.0147 | 0.0147 |
Loa Loa (eye worm) | glyceraldehyde-3-phosphate dehydrogenase | 0.0103 | 0.2311 | 0.2312 |
Schistosoma mansoni | high-affinity choline transporter | 0.0369 | 0.9992 | 1 |
Mycobacterium leprae | Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) | 0.0052 | 0.0816 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.0029 | 0.0147 | 0.0147 |
Toxoplasma gondii | glyceraldehyde-3-phosphate dehydrogenase GAPDH2 | 0.015 | 0.3653 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0029 | 0.0147 | 0.0147 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0078 | 0.1573 | 0.1574 |
Echinococcus granulosus | lamin | 0.0029 | 0.0147 | 0.0147 |
Loa Loa (eye worm) | hypothetical protein | 0.0369 | 0.9992 | 1 |
Brugia malayi | intermediate filament protein | 0.0029 | 0.0147 | 0.0147 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0053 | 0.0838 | 0.0839 |
Echinococcus multilocularis | glyceraldehyde 3 phosphate dehydrogenase | 0.0098 | 0.2159 | 0.2159 |
Toxoplasma gondii | glyceraldehyde-3-phosphate dehydrogenase GAPDH1 | 0.015 | 0.3653 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0078 | 0.1573 | 0.1574 |
Echinococcus multilocularis | expressed protein | 0.0369 | 1 | 1 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.015 | 0.3653 | 0.3656 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0127 | 0.2985 | 0.2987 |
Brugia malayi | hypothetical protein | 0.0162 | 0.3989 | 0.3992 |
Brugia malayi | GH02984p | 0.0369 | 0.9992 | 1 |
Entamoeba histolytica | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.015 | 0.3653 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0838 | 0.0839 |
Echinococcus granulosus | tumor protein p63 | 0.0359 | 0.9694 | 0.9694 |
Echinococcus granulosus | sodium:glucose cotransporter 2 | 0.0041 | 0.0496 | 0.0496 |
Echinococcus multilocularis | transfer RNA-Lys | 0.0036 | 0.035 | 0.035 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0147 | 0.0147 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0078 | 0.1573 | 0.1573 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.015 | 0.3653 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.013 | 0.3081 | 1 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0098 | 0.2159 | 0.4737 |
Schistosoma mansoni | inositol transporter | 0.0041 | 0.0496 | 0.0497 |
Echinococcus multilocularis | glyceraldehyde 3 phosphate dehydrogenase | 0.015 | 0.3653 | 0.3653 |
Onchocerca volvulus | 0.0041 | 0.0496 | 0.1611 | |
Echinococcus granulosus | glyceraldehyde 3 phosphate dehydrogenase | 0.015 | 0.3653 | 0.3653 |
Schistosoma mansoni | hypothetical protein | 0.018 | 0.4522 | 0.4526 |
Echinococcus granulosus | glyceraldehyde 3 phosphate dehydrogenase | 0.015 | 0.3653 | 0.3653 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.