Detailed information for compound 812763

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 453.531 | Formula: C25H31N3O5
  • H donors: 1 H acceptors: 3 LogP: 2.28 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(c(c1)CC(=O)N1CCC2(CC1)CCC(O2)CNC(=O)c1ccccn1)OC
  • InChi: 1S/C25H31N3O5/c1-31-19-6-7-22(32-2)18(15-19)16-23(29)28-13-10-25(11-14-28)9-8-20(33-25)17-27-24(30)21-5-3-4-12-26-21/h3-7,12,15,20H,8-11,13-14,16-17H2,1-2H3,(H,27,30)
  • InChiKey: TXXUEPUXWPQVSK-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Onchocerca volvulus Peroxidasin homolog 0.0039 0.0062 0.0115
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.077 0.3901 1
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0186 0.0835 0.2105
Plasmodium vivax unspecified product 0.0423 0.2078 0.5306
Onchocerca volvulus 0.0241 0.1125 0.2852
Plasmodium falciparum serine repeat antigen 2 0.0186 0.0835 0.2015
Entamoeba histolytica cysteine proteinase 1, putative 0.0423 0.2078 0.5327
Brugia malayi Cathepsin L-like cysteine proteinase 0.0533 0.2658 0.2645
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0206 0.0189
Onchocerca volvulus 0.077 0.3901 1
Onchocerca volvulus 0.077 0.3901 1
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0176 0.0784 0.0767
Brugia malayi cathepsin F-like cysteine proteinase 0.0186 0.0835 0.0819
Brugia malayi cathepsin F-like cysteine proteinase 0.0237 0.1101 0.1085
Giardia lamblia Cathepsin L precursor 0.0186 0.0835 0.2144
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0237 0.1101 0.1101
Onchocerca volvulus 0.0186 0.0835 0.2105
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0345 0.0334
Brugia malayi TAR-binding protein 0.0066 0.0206 0.0189
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0061 0.018 0.0119
Giardia lamblia Cathepsin L precursor 0.0186 0.0835 0.2144
Loa Loa (eye worm) hypothetical protein 0.0039 0.0062 0.0062
Giardia lamblia Hypothetical protein 0.0186 0.0835 0.2144
Onchocerca volvulus Peroxidase homolog 0.0039 0.0062 0.0115
Echinococcus multilocularis cathepsin L 0.0186 0.0835 0.0819
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.077 0.3901 0.3901
Echinococcus multilocularis calpain A 0.0177 0.0786 0.077
Giardia lamblia Cathepsin L precursor 0.0186 0.0835 0.2144
Echinococcus multilocularis pyruvate kinase 0.0039 0.0062 0.0044
Loa Loa (eye worm) matrixin family protein 0.0054 0.014 0.014
Brugia malayi MH2 domain containing protein 0.0237 0.1103 0.1087
Entamoeba histolytica cysteine protease, putative 0.0186 0.0835 0.2141
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0186 0.0835 0.2105
Echinococcus multilocularis calpain 7 (C02 family) 0.0061 0.018 0.0162
Brugia malayi Papain family cysteine protease containing protein 0.0186 0.0835 0.0819
Brugia malayi Peroxidasin 0.0039 0.0062 0.0045
Giardia lamblia Cathepsin B precursor 0.0186 0.0835 0.2144
Echinococcus granulosus cathepsin l1 0.0533 0.2658 0.265
Echinococcus multilocularis calpain 0.0061 0.018 0.0162
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0186 0.0835 0.2015
Echinococcus multilocularis survival motor neuron protein 1 0.0257 0.1206 0.119
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0345 0.0328
Mycobacterium leprae Probable pyruvate kinase PykA 0.0039 0.0062 0.5
Loa Loa (eye worm) hypothetical protein 0.0039 0.0062 0.0062
Trypanosoma brucei calpain-like protein, putative 0.0061 0.018 0.0307
Loa Loa (eye worm) hypothetical protein 0.0144 0.0614 0.0614
Echinococcus granulosus cathepsin L 0.0186 0.0835 0.0824
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0533 0.2658 0.6763
Onchocerca volvulus Cathepsin L homolog 0.077 0.3901 1
Loa Loa (eye worm) hypothetical protein 0.0186 0.0835 0.0835
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1932 1 1
Echinococcus granulosus pyruvate kinase 0.0039 0.0062 0.005
Trypanosoma cruzi major cysteine proteinase, putative 0.0186 0.0835 0.0778
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0186 0.0835 0.2015
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0186 0.0835 0.2144
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.077 0.3901 1
Loa Loa (eye worm) hypothetical protein 0.0257 0.1206 0.1206
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0186 0.0835 0.2015
Trypanosoma brucei calpain-like protein, putative 0.0061 0.018 0.0307
Echinococcus granulosus calpain A 0.0061 0.018 0.0168
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.077 0.3901 1
Trypanosoma cruzi cysteine proteinase, putative 0.0423 0.2078 0.2029
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0186 0.0835 0.0819
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0186 0.0835 0.0819
Schistosoma mansoni cathepsin S (C01 family) 0.0186 0.0835 0.0819
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0186 0.0835 0.2105
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.077 0.3901 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.0345 0.0328
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0812 0.4119 0.4108
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0186 0.0835 0.2015
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0186 0.0835 0.2105
Loa Loa (eye worm) hypothetical protein 0.0101 0.0389 0.0389
Brugia malayi Cathepsin L-like precursor 0.077 0.3901 0.389
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.077 0.3901 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0186 0.0835 0.0819
Loa Loa (eye worm) hypothetical protein 0.0186 0.0835 0.0835
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1932 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0345 0.0328
Echinococcus granulosus peptidyl glycine alpha amidating monooxygenase 0.0231 0.1073 0.1063
Loa Loa (eye worm) hypothetical protein 0.0039 0.0062 0.0062
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0186 0.0835 0.0835
Brugia malayi calpain 7 0.0061 0.018 0.0162
Echinococcus granulosus cathepsin b 0.1932 1 1
Giardia lamblia Encystation-specific protease 0.0186 0.0835 0.2144
Brugia malayi Cathepsin L-like precursor 0.077 0.3901 0.389
Loa Loa (eye worm) calpain family protein 1 0.012 0.0486 0.0486
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0081 0.0282 0.027
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0186 0.0835 0.2141
Giardia lamblia Cysteine protease 0.0186 0.0835 0.2144
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0186 0.0835 0.2015
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0186 0.0835 0.0819
Toxoplasma gondii cathepsin CPL 0.077 0.3901 1
Entamoeba histolytica cysteine proteinase, putative 0.0423 0.2078 0.5327
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0186 0.0835 0.2141
Brugia malayi Papain family cysteine protease containing protein 0.077 0.3901 0.389
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.077 0.3901 1
Loa Loa (eye worm) animal heme peroxidase 0.0039 0.0062 0.0062
Plasmodium falciparum serine repeat antigen 9 0.0186 0.0835 0.2015
Echinococcus multilocularis cathepsin l cysteine peptidase 0.077 0.3901 0.389
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1932 1 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0062 0.0062
Loa Loa (eye worm) ctsf protein 0.077 0.3901 0.3901
Plasmodium falciparum serine repeat antigen 7 0.0186 0.0835 0.2015
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.077 0.3901 1
Onchocerca volvulus 0.0101 0.0389 0.0957
Plasmodium falciparum serine repeat antigen 6 0.0186 0.0835 0.2015
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.0133 0.0115
Onchocerca volvulus Peroxidase homolog 0.0039 0.0062 0.0115
Plasmodium vivax vivapain-2 0.077 0.3901 1
Loa Loa (eye worm) pyruvate kinase 0.0039 0.0062 0.0062
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0061 0.018 0.0119
Leishmania major cathepsin L-like protease 0.077 0.3901 1
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0186 0.0835 0.2105
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0186 0.0835 0.2015
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.018 0.0307
Onchocerca volvulus 0.0031 0.0023 0.0014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.077 0.3901 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0186 0.0835 0.2015
Schistosoma mansoni cathepsin F (C01 family) 0.077 0.3901 0.389
Loa Loa (eye worm) hypothetical protein 0.0039 0.0062 0.0062
Entamoeba histolytica cysteine protease, putative 0.0423 0.2078 0.5327
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0061 0.018 0.0119
Loa Loa (eye worm) papain family cysteine protease containing protein 0.077 0.3901 0.3901
Trypanosoma cruzi cysteine proteinase, putative 0.0423 0.2078 0.2029
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.077 0.3901 1
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0186 0.0835 0.0819
Schistosoma mansoni survival motor neuron protein 0.0052 0.0133 0.0115
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.077 0.3901 1
Echinococcus multilocularis cathepsin L 0.0423 0.2078 0.2064
Trypanosoma cruzi kinesin, putative 0.0043 0.0083 0.0021
Loa Loa (eye worm) hypothetical protein 0.0186 0.0835 0.0835
Brugia malayi Animal haem peroxidase family protein 0.0039 0.0062 0.0045
Entamoeba histolytica cysteine protease, putative 0.0186 0.0835 0.2141
Leishmania major cathepsin L-like protease 0.077 0.3901 1
Onchocerca volvulus Chorion peroxidase homolog 0.0039 0.0062 0.0115
Onchocerca volvulus 0.0039 0.0062 0.0115
Echinococcus multilocularis cathepsin b 0.1932 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0186 0.0835 0.0819
Loa Loa (eye worm) animal heme peroxidase 0.0039 0.0062 0.0062
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0186 0.0835 0.2144
Echinococcus granulosus microtubule associated protein 2 0.0803 0.4072 0.4065
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.077 0.3901 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.077 0.3901 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0533 0.2658 0.6763
Schistosoma mansoni cathepsin B (C01 family) 0.0186 0.0835 0.0819
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.077 0.3901 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0212 0.0972 0.0972
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.077 0.3901 1
Trypanosoma cruzi cruzipain precursor, putative 0.0237 0.1101 0.1046
Toxoplasma gondii cathepsin CPC2 0.0186 0.0835 0.2105
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.077 0.3901 1
Entamoeba histolytica cysteine proteinase, putative 0.0423 0.2078 0.5327
Entamoeba histolytica cysteine protease, putative 0.0423 0.2078 0.5327
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0186 0.0835 0.2015
Echinococcus multilocularis cathepsin b 0.1932 1 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.0423 0.2078 0.5252
Echinococcus multilocularis microtubule associated protein 2 0.0803 0.4072 0.4061
Giardia lamblia Hypothetical protein 0.0186 0.0835 0.2144
Entamoeba histolytica cysteine protease, putative 0.0423 0.2078 0.5327
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0176 0.0784 0.0767
Entamoeba histolytica cysteine proteinase, putative 0.0533 0.2658 0.6814
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0186 0.0835 0.2015
Loa Loa (eye worm) cysteine protease 0.077 0.3901 0.3901
Trypanosoma cruzi cysteine peptidase, putative 0.077 0.3901 0.3863
Giardia lamblia Cathepsin L-like protease 0.0186 0.0835 0.2144
Onchocerca volvulus Cathepsin L homolog 0.0186 0.0835 0.2105
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0206 0.0189
Trypanosoma brucei kinesin, putative 0.0043 0.0083 0.0056
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0206 0.0189
Brugia malayi hypothetical protein 0.0039 0.0062 0.0045
Loa Loa (eye worm) hypothetical protein 0.0039 0.0062 0.0062
Onchocerca volvulus Cathepsin F homolog 0.077 0.3901 1
Leishmania major cathepsin L-like protease 0.077 0.3901 1
Brugia malayi Cathepsin L-like precursor 0.077 0.3901 0.389
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0423 0.2078 0.2029
Schistosoma mansoni hypothetical protein 0.0052 0.0133 0.0115
Entamoeba histolytica protein kinase, putative 0.0043 0.0083 0.0213
Brugia malayi Hemopexin family protein 0.0031 0.0023 0.0006
Brugia malayi Animal haem peroxidase family protein 0.0039 0.0062 0.0045
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0345 0.0328
Entamoeba histolytica cysteine proteinase, putative 0.0423 0.2078 0.5327
Trypanosoma cruzi cruzipain precursor, putative 0.077 0.3901 0.3863
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0061 0.018 0.0307
Brugia malayi Blistered cuticle protein 3 0.0039 0.0062 0.0045
Toxoplasma gondii preprocathepsin c precursor, putative 0.0186 0.0835 0.2105
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.077 0.3901 1
Trichomonas vaginalis set domain proteins, putative 0.0241 0.1125 0.277
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0061 0.018 0.0307
Loa Loa (eye worm) pyruvate kinase 0.0039 0.0062 0.0062
Leishmania major kinesin, putative 0.0043 0.0083 0.0056
Onchocerca volvulus 0.077 0.3901 1
Giardia lamblia Cysteine protease 0.0186 0.0835 0.2144
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0186 0.0835 0.2144
Entamoeba histolytica cysteine proteinase 2 0.0423 0.2078 0.5327
Echinococcus granulosus cathepsin L cysteine proteinase 0.077 0.3901 0.3894
Onchocerca volvulus 0.0039 0.0062 0.0115
Giardia lamblia Cathepsin L precursor 0.0186 0.0835 0.2144
Loa Loa (eye worm) hypothetical protein 0.0186 0.0835 0.0835
Brugia malayi Pre-SET motif family protein 0.0212 0.0972 0.0956
Trypanosoma cruzi cysteine peptidase, putative 0.077 0.3901 0.3863
Echinococcus granulosus tar DNA binding protein 0.0066 0.0206 0.0195
Entamoeba histolytica cysteine protease, putative 0.0186 0.0835 0.2141
Loa Loa (eye worm) hypothetical protein 0.0123 0.0503 0.0503
Loa Loa (eye worm) hypothetical protein 0.0039 0.0062 0.0062
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.077 0.3901 1
Loa Loa (eye worm) hypothetical protein 0.0533 0.2658 0.2658
Entamoeba histolytica cysteine protease, putative 0.0423 0.2078 0.5327
Loa Loa (eye worm) hypothetical protein 0.0186 0.0835 0.0835
Schistosoma mansoni hypothetical protein 0.0031 0.0023 0.0006
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0081 0.0282 0.0265
Schistosoma mansoni Mername-AA248 (C02 family) 0.0061 0.018 0.0162
Schistosoma mansoni calpain-7 (C02 family) 0.0061 0.018 0.0162
Echinococcus granulosus cathepsin b 0.1932 1 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0186 0.0835 0.0778
Echinococcus multilocularis pyruvate kinase 0.0039 0.0062 0.0044
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0186 0.0835 0.2015
Toxoplasma gondii cathepsin B 0.0726 0.367 0.9404
Brugia malayi hypothetical protein 0.0257 0.1206 0.119
Plasmodium vivax unspecified product 0.0237 0.1101 0.2789
Echinococcus granulosus cysteine protease 0.0423 0.2078 0.2069
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0061 0.018 0.0119
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0186 0.0835 0.0819
Echinococcus granulosus calpain 5 0.0061 0.018 0.0168
Leishmania major cathepsin L-like protease 0.077 0.3901 1
Onchocerca volvulus Peroxidasin homolog 0.0039 0.0062 0.0115
Onchocerca volvulus 0.0052 0.0133 0.0297
Trypanosoma brucei cysteine peptidase C (CPC) 0.0726 0.367 0.9397
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0186 0.0835 0.2015
Loa Loa (eye worm) hypothetical protein 0.0039 0.0062 0.0062
Plasmodium vivax unspecified product 0.0186 0.0835 0.2105
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0186 0.0835 0.2015
Brugia malayi Papain family cysteine protease containing protein 0.0186 0.0835 0.0819
Entamoeba histolytica cysteine protease, putative 0.0423 0.2078 0.5327
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0423 0.2078 0.5252
Giardia lamblia Cathepsin B precursor 0.0726 0.367 1
Onchocerca volvulus Dual oxidase homolog 0.0039 0.0062 0.0115
Loa Loa (eye worm) hypothetical protein 0.0533 0.2658 0.2658
Plasmodium falciparum serine repeat antigen 1 0.0186 0.0835 0.2015
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0186 0.0835 0.2015
Trypanosoma brucei antigen, putative 0.0061 0.018 0.0307
Trypanosoma cruzi kinesin, putative 0.0043 0.0083 0.0021
Schistosoma mansoni peroxidasin 0.0039 0.0062 0.0045
Brugia malayi Animal haem peroxidase family protein 0.0039 0.0062 0.0045
Leishmania major cathepsin L-like protease 0.077 0.3901 1
Echinococcus granulosus calpain 0.0061 0.018 0.0168
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0061 0.018 0.0119
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0726 0.367 0.3658
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0186 0.0835 0.0819
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0423 0.2078 0.5252
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0018 0.0006
Loa Loa (eye worm) hypothetical protein 0.0533 0.2658 0.2658
Plasmodium vivax calpain, putative 0.0061 0.018 0.0417
Plasmodium falciparum cysteine proteinase falcipain 2b 0.077 0.3901 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.077 0.3901 1
Schistosoma mansoni microtubule-associated protein tau 0.0803 0.4072 0.4061
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.077 0.3901 1
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0186 0.0835 0.2015
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.018 0.0307
Schistosoma mansoni hypothetical protein 0.0197 0.0893 0.0877
Echinococcus granulosus geminin 0.0197 0.0893 0.0882
Echinococcus multilocularis cathepsin L cysteine protease 0.077 0.3901 0.389
Loa Loa (eye worm) hypothetical protein 0.003 0.0018 0.0018
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0123 0.0503 0.0487
Loa Loa (eye worm) hypothetical protein 0.0039 0.0062 0.0062
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.077 0.3901 1
Plasmodium vivax vivapain-1 0.0423 0.2078 0.5306
Trypanosoma brucei calpain-like protein, putative 0.0061 0.018 0.0307
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0176 0.0784 0.0773
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0231 0.1073 0.1057
Schistosoma mansoni hypothetical protein 0.0197 0.0893 0.0877
Echinococcus multilocularis geminin 0.0197 0.0893 0.0877
Loa Loa (eye worm) hypothetical protein 0.0039 0.0062 0.0062
Entamoeba histolytica cysteine protease, putative 0.0423 0.2078 0.5327
Giardia lamblia Cathepsin B precursor 0.0186 0.0835 0.2144
Loa Loa (eye worm) fibroinase 0.077 0.3901 0.3901
Schistosoma mansoni calpain C (C02 family) 0.0061 0.018 0.0162
Onchocerca volvulus Cathepsin L homolog 0.077 0.3901 1
Loa Loa (eye worm) transcription factor SMAD2 0.0237 0.1103 0.1103
Loa Loa (eye worm) blistered cuticle protein 3 0.0039 0.0062 0.0062
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0162 0.0711 0.0694
Entamoeba histolytica cysteine protease, putative 0.0423 0.2078 0.5327
Plasmodium vivax serine-repeat antigen (SERA) 0.0186 0.0835 0.2105
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0061 0.0176 0.0158
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0186 0.0835 0.0819
Brugia malayi Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein 0.0062 0.0185 0.0168
Loa Loa (eye worm) hypothetical protein 0.0162 0.0711 0.0711
Giardia lamblia Cathepsin B precursor 0.0726 0.367 1
Echinococcus granulosus calpain 7 C02 family 0.0061 0.018 0.0168
Onchocerca volvulus 0.077 0.3901 1
Brugia malayi Cathepsin L-like precursor 0.077 0.3901 0.389
Leishmania major cathepsin L-like protease 0.077 0.3901 1
Loa Loa (eye worm) calpain 0.0061 0.018 0.018
Loa Loa (eye worm) hypothetical protein 0.077 0.3901 0.3901
Schistosoma mansoni peptidylglycine monooxygenase 0.0123 0.0503 0.0487
Onchocerca volvulus Matrilysin homolog 0.0049 0.0117 0.0255
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0186 0.0835 0.2015
Entamoeba histolytica cysteine proteinase, putative 0.077 0.3901 1
Brugia malayi cathepsin L-like precursor 0.0533 0.2658 0.2645
Chlamydia trachomatis pyruvate kinase 0.0039 0.0062 0.5
Loa Loa (eye worm) hypothetical protein 0.0039 0.0062 0.0062
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0237 0.1101 0.1085
Brugia malayi Papain family cysteine protease containing protein 0.0423 0.2078 0.2064
Loa Loa (eye worm) hypothetical protein 0.012 0.0486 0.0486
Giardia lamblia Cathepsin B precursor 0.0186 0.0835 0.2144
Brugia malayi Cathepsin L-like precursor 0.077 0.3901 0.389
Loa Loa (eye worm) hypothetical protein 0.1932 1 1
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0206 0.0189
Mycobacterium ulcerans pyruvate kinase 0.0039 0.0062 0.5
Brugia malayi Matrixin family protein 0.0054 0.014 0.0122
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0423 0.2078 0.2064
Onchocerca volvulus 0.0533 0.2658 0.6799
Loa Loa (eye worm) animal heme peroxidase 0.0039 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0237 0.1101 0.1101
Brugia malayi calpain 5 0.0043 0.0083 0.0065
Trypanosoma cruzi cysteine protease, putative 0.0423 0.2078 0.2029
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.077 0.3901 1
Entamoeba histolytica cysteine proteinase, putative 0.0423 0.2078 0.5327
Brugia malayi calpain family protein 1 0.0162 0.0711 0.0694
Schistosoma mansoni peptidyl-glycine monooxygenase 0.0231 0.1073 0.1057
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.077 0.3901 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0186 0.0835 0.0835
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.077 0.3901 1
Brugia malayi Cathepsin L-like precursor 0.0533 0.2658 0.2645
Loa Loa (eye worm) pyruvate kinase 0.0039 0.0062 0.0062
Loa Loa (eye worm) calpain family protein 1 0.0162 0.0711 0.0711
Echinococcus granulosus cathepsin l cysteine peptidase 0.077 0.3901 0.3894
Onchocerca volvulus 0.077 0.3901 1
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0186 0.0835 0.2105
Brugia malayi calpain family protein 1 0.0162 0.0711 0.0694
Brugia malayi Animal haem peroxidase family protein 0.0039 0.0062 0.0045
Toxoplasma gondii pyruvate kinase PyK1 0.0039 0.0062 0.0113
Schistosoma mansoni cathepsin C 0.0186 0.0835 0.0819
Echinococcus multilocularis hypothetical protein 0.0061 0.018 0.0162
Plasmodium falciparum serine repeat antigen 3 0.0186 0.0835 0.2015
Loa Loa (eye worm) animal heme peroxidase 0.0039 0.0062 0.0062
Onchocerca volvulus 0.077 0.3901 1
Plasmodium vivax serine-repeat antigen (SERA) 0.0186 0.0835 0.2105
Echinococcus granulosus calpain A 0.0177 0.0786 0.0775
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0186 0.0835 0.2105
Echinococcus granulosus cathepsin L cysteine protease 0.0423 0.2078 0.2069
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.018 0.0307
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0206 0.0189
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0206 0.0206
Schistosoma mansoni calpain (C02 family) 0.0061 0.018 0.0162
Entamoeba histolytica calpain large subunit domain III containing protein 0.0043 0.0083 0.0213
Loa Loa (eye worm) hypothetical protein 0.0231 0.1073 0.1073
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.077 0.3901 1
Entamoeba histolytica cysteine protease, putative 0.0423 0.2078 0.5327
Schistosoma mansoni pyruvate kinase 0.0039 0.0062 0.0044
Brugia malayi cathepsin L precursor 0.0186 0.0835 0.0819
Giardia lamblia Cathepsin B precursor 0.0186 0.0835 0.2144
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.077 0.3901 1
Trypanosoma cruzi cysteine peptidase, putative 0.077 0.3901 0.3863
Schistosoma mansoni cathepsin s 0.0237 0.1101 0.1085
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0206 0.0189
Schistosoma mansoni pyruvate kinase 0.0039 0.0062 0.0044
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0423 0.2078 0.2064
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.077 0.3901 1
Loa Loa (eye worm) hypothetical protein 0.0186 0.0835 0.0835
Loa Loa (eye worm) hypothetical protein 0.0237 0.1101 0.1101
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.077 0.3901 1
Echinococcus granulosus cathepsin L 0.0423 0.2078 0.2069
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0423 0.2078 0.2064
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0061 0.018 0.0119
Plasmodium vivax vivapain-2 0.077 0.3901 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0186 0.0835 0.0819
Echinococcus granulosus pyruvate kinase 0.0039 0.0062 0.005
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0345 0.0334
Echinococcus multilocularis calpain family protein 1, d 0.012 0.0486 0.0469
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.077 0.3901 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.077 0.3901 1
Echinococcus multilocularis cathepsin L cysteine protease 0.077 0.3901 0.389
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0039 0.0062 0.5
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0061 0.018 0.0119
Schistosoma mansoni peroxidasin 0.0039 0.0062 0.0045
Loa Loa (eye worm) MH2 domain-containing protein 0.0237 0.1103 0.1103
Onchocerca volvulus Pyruvate kinase homolog 0.0039 0.0062 0.0113
Trypanosoma cruzi cysteine peptidase, putative 0.077 0.3901 0.3863
Loa Loa (eye worm) hypothetical protein 0.0237 0.1101 0.1101
Giardia lamblia Cathepsin L precursor 0.0186 0.0835 0.2144
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0186 0.0835 0.2015
Loa Loa (eye worm) matrixin family protein 0.0049 0.0117 0.0117
Entamoeba histolytica cysteine proteinase, putative 0.077 0.3901 1
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0186 0.0835 0.0819
Giardia lamblia Cathepsin L-like protease 0.0186 0.0835 0.2144
Plasmodium vivax pyruvate kinase, putative 0.0039 0.0062 0.0113
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1932 1 1
Loa Loa (eye worm) calpain 5 0.0043 0.0083 0.0083
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0186 0.0835 0.2015
Trypanosoma cruzi cysteine peptidase, putative 0.0423 0.2078 0.2029
Schistosoma mansoni cathepsin F (C01 family) 0.077 0.3901 0.389
Trypanosoma cruzi cysteine peptidase, putative 0.0237 0.1101 0.1046
Brugia malayi cathepsin Z-like cysteine proteinase 0.0186 0.0835 0.0819
Entamoeba histolytica hypothetical protein 0.0186 0.0835 0.2141
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0061 0.018 0.0119
Loa Loa (eye worm) hypothetical protein 0.0039 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0039 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0039 0.0062 0.0062
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1932 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0186 0.0835 0.2015
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0061 0.018 0.0119
Plasmodium vivax vivapain-3 0.0423 0.2078 0.5306
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0186 0.0835 0.2015
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0176 0.0784 0.0767
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0186 0.0835 0.0835
Trichomonas vaginalis conserved hypothetical protein 0.0186 0.0835 0.2015
Entamoeba histolytica cysteine protease, putative 0.0423 0.2078 0.5327
Entamoeba histolytica cysteine protease, putative 0.0186 0.0835 0.2141
Entamoeba histolytica cysteine protease, putative 0.0186 0.0835 0.2141
Loa Loa (eye worm) RNA binding protein 0.0066 0.0206 0.0206
Loa Loa (eye worm) hypothetical protein 0.0039 0.0062 0.0062
Brugia malayi Animal haem peroxidase family protein 0.0039 0.0062 0.0045
Leishmania major cathepsin L-like protease 0.077 0.3901 1
Onchocerca volvulus Matrix metalloproteinase homolog 0.0049 0.0117 0.0255
Trypanosoma brucei calpain-like protein, putative 0.0061 0.018 0.0307
Brugia malayi RNA binding protein 0.0066 0.0206 0.0189
Giardia lamblia Cathepsin L precursor 0.0186 0.0835 0.2144
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0345 0.0328
Brugia malayi Cathepsin L-like precursor 0.0533 0.2658 0.2645
Echinococcus multilocularis cysteine protease 0.077 0.3901 0.389
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0186 0.0835 0.2105
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0186 0.0835 0.2105
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0186 0.0835 0.2015
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.077 0.3901 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0186 0.0835 0.2144
Brugia malayi cathepsin L-like cysteine proteinase 0.0186 0.0835 0.0819
Brugia malayi Papain family cysteine protease containing protein 0.0186 0.0835 0.0819
Echinococcus multilocularis cysteine protease 0.077 0.3901 0.389
Echinococcus multilocularis peroxidasin 0.0039 0.0062 0.0045
Entamoeba histolytica cysteine protease, putative 0.0423 0.2078 0.5327
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.0345 0.0345
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0206 0.0189
Entamoeba histolytica cysteine protease, putative 0.077 0.3901 1
Entamoeba histolytica cysteine protease, putative 0.0186 0.0835 0.2141
Giardia lamblia Cathepsin B precursor 0.0186 0.0835 0.2144
Entamoeba histolytica cysteine protease, putative 0.0423 0.2078 0.5327
Giardia lamblia Cathepsin B precursor 0.0726 0.367 1
Plasmodium falciparum serine repeat antigen 5 0.0186 0.0835 0.2015
Plasmodium falciparum cysteine proteinase falcipain 3 0.077 0.3901 1
Leishmania major cathepsin L-like protease 0.077 0.3901 1
Brugia malayi Pyruvate kinase, M2 isozyme 0.0039 0.0062 0.0044
Leishmania major cysteine peptidase A (CPA) 0.077 0.3901 1
Echinococcus granulosus peroxidasin 0.0039 0.0062 0.0051
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.077 0.3901 1
Echinococcus granulosus survival motor neuron protein 1 0.0257 0.1206 0.1195
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0206 0.0206
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0726 0.367 0.9397
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0423 0.2078 0.5252
Schistosoma mansoni calpain-7 (C02 family) 0.0061 0.018 0.0162
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0726 0.367 0.363
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0186 0.0835 0.2105
Onchocerca volvulus Pyruvate kinase homolog 0.0039 0.0062 0.0113
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.077 0.3901 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.077 0.3901 1
Brugia malayi Cathepsin L-like precursor 0.077 0.3901 0.389
Entamoeba histolytica cysteine protease, putative 0.0423 0.2078 0.5327
Echinococcus multilocularis calpain 5 0.0061 0.018 0.0162
Brugia malayi Cathepsin L-like precursor 0.0237 0.1101 0.1085
Schistosoma mansoni cathepsin F (C01 family) 0.0533 0.2658 0.2645
Echinococcus granulosus cathepsin l1 0.077 0.3901 0.3894
Echinococcus multilocularis cathepsin l cysteine peptidase 0.077 0.3901 0.389
Toxoplasma gondii cathepsin CPC1 0.0186 0.0835 0.2105
Schistosoma mansoni dopamine-beta-monooxygenase 0.0123 0.0503 0.0487
Plasmodium falciparum serine repeat antigen 8 0.0186 0.0835 0.2015
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.077 0.3901 1
Loa Loa (eye worm) cathepsin B 0.0726 0.367 0.367
Giardia lamblia Cysteine protease 0.0186 0.0835 0.2144
Onchocerca volvulus 0.0039 0.0062 0.0115
Onchocerca volvulus 0.077 0.3901 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0423 0.2078 0.5252
Trichomonas vaginalis conserved hypothetical protein 0.0186 0.0835 0.2015
Onchocerca volvulus Pyruvate kinase homolog 0.0039 0.0062 0.0113
Brugia malayi Pyruvate kinase, muscle isozyme 0.0039 0.0062 0.0044
Brugia malayi fibroinase precursor 0.0186 0.0835 0.0819
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0533 0.2658 0.2613
Plasmodium falciparum serine repeat antigen 4 0.0186 0.0835 0.2015
Echinococcus multilocularis pyruvate kinase 0.0031 0.0019 0.0001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.077 0.3901 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.077 0.3901 1
Echinococcus multilocularis peptidyl glycine alpha amidating monooxygenase 0.0231 0.1073 0.1057
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0726 0.367 0.9397
Brugia malayi Papain family cysteine protease containing protein 0.0423 0.2078 0.2064
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.077 0.3901 1
Giardia lamblia Cysteine protease 0.0186 0.0835 0.2144
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0061 0.018 0.0119
Entamoeba histolytica cysteine protease, putative 0.0423 0.2078 0.5327
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0345 0.0328

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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