Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0025 | 0.0289 | 0.0523 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.0044 | 0.0631 | 0.1141 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.0044 | 0.0631 | 0.1741 |
Plasmodium vivax | polyprenol reductase, putative | 0.0044 | 0.0631 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.021 | 0.3625 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0098 | 0.1608 | 0.4438 |
Giardia lamblia | Synaptic glycoprotein SC2 | 0.0044 | 0.0631 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0064 | 0.0984 | 0.2716 |
Echinococcus granulosus | tar DNA binding protein | 0.0064 | 0.0984 | 0.2716 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.0044 | 0.0631 | 0.1141 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0631 | 0.1141 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.0984 | 0.2716 |
Loa Loa (eye worm) | hypothetical protein | 0.021 | 0.3625 | 0.6558 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0192 | 0.3295 | 1 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0315 | 0.5527 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.021 | 0.3625 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0011 | 0.0036 | 0.0098 |
Echinococcus multilocularis | 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal | 0.0044 | 0.0631 | 0.1741 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0011 | 0.0036 | 0.0098 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.0984 | 0.2716 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0098 | 0.1608 | 0.4438 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0098 | 0.1608 | 0.4438 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0098 | 0.1608 | 0.4438 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0315 | 0.5527 | 1 |
Brugia malayi | TAR-binding protein | 0.0064 | 0.0984 | 0.1781 |
Brugia malayi | Synaptic glycoprotein SC2 | 0.0044 | 0.0631 | 0.1141 |
Plasmodium falciparum | polyprenol reductase, putative | 0.0044 | 0.0631 | 1 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0563 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0315 | 0.5527 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0064 | 0.0984 | 0.1781 |
Trypanosoma brucei | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0044 | 0.0631 | 0.0653 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0315 | 0.5527 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0098 | 0.1608 | 0.291 |
Loa Loa (eye worm) | hypothetical protein | 0.0192 | 0.3295 | 0.5961 |
Echinococcus granulosus | synaptic glycoprotein sc2 | 0.0044 | 0.0631 | 0.1741 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0011 | 0.0036 | 0.0098 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.021 | 0.3625 | 1 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0044 | 0.0631 | 0.0653 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.0984 | 0.2716 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0289 | 0.0523 |
Echinococcus granulosus | 3 oxo 5 alpha steroid 4 dehydrogenase C terminal | 0.0044 | 0.0631 | 0.1741 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0098 | 0.1608 | 0.4438 |
Brugia malayi | N-terminal motif family protein | 0.0192 | 0.3295 | 0.5961 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.0289 | 0.0523 |
Echinococcus multilocularis | hormone sensitive lipase | 0.021 | 0.3625 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0098 | 0.1608 | 0.4438 |
Loa Loa (eye worm) | TAR-binding protein | 0.0064 | 0.0984 | 0.1781 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0631 | 0.1141 |
Echinococcus granulosus | hormone sensitive lipase | 0.021 | 0.3625 | 1 |
Leishmania major | 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein | 0.0315 | 0.5527 | 1 |
Entamoeba histolytica | steroid 5-alpha reductase, putative | 0.0315 | 0.5527 | 1 |
Brugia malayi | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | 0.0315 | 0.5527 | 1 |
Plasmodium falciparum | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0044 | 0.0631 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.0984 | 0.2716 |
Onchocerca volvulus | 0.0044 | 0.0631 | 0.1915 | |
Brugia malayi | hypothetical protein | 0.0016 | 0.0126 | 0.0228 |
Plasmodium vivax | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0044 | 0.0631 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0064 | 0.0984 | 0.1781 |
Echinococcus multilocularis | synaptic glycoprotein sc2 | 0.0044 | 0.0631 | 0.1741 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.0315 | 0.5527 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0098 | 0.1608 | 0.291 |
Brugia malayi | RNA binding protein | 0.0064 | 0.0984 | 0.1781 |
Trypanosoma brucei | 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative | 0.0315 | 0.5527 | 1 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0315 | 0.5527 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0098 | 0.1608 | 0.4438 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.0044 | 0.0631 | 0.1741 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0064 | 0.0984 | 0.1781 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.0984 | 0.2716 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0315 | 0.5527 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.