Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | protein kinase | 0.1046 | 0.7032 | 0.7031 |
Echinococcus granulosus | insulin receptor | 0.0047 | 0.0248 | 0.0244 |
Schistosoma mansoni | mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 | 0.0437 | 0.2896 | 0.2892 |
Loa Loa (eye worm) | hypothetical protein | 0.0437 | 0.2896 | 0.2906 |
Schistosoma mansoni | tyrosine kinase | 0.0047 | 0.0248 | 0.0243 |
Schistosoma mansoni | protein kinase | 0.1483 | 1 | 1 |
Echinococcus granulosus | GTPase activating Rap:RanGAP domain 3 | 0.0437 | 0.2896 | 0.2903 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0138 | 0.0867 | 0.0131 |
Echinococcus granulosus | protein kinase | 0.1046 | 0.7032 | 0.7056 |
Loa Loa (eye worm) | hypothetical protein | 0.0437 | 0.2896 | 0.2906 |
Schistosoma mansoni | tyrosine kinase | 0.0077 | 0.0452 | 0.0447 |
Loa Loa (eye worm) | STE/STE20/MSN protein kinase | 0.1046 | 0.7032 | 0.7058 |
Echinococcus multilocularis | 0.0045 | 0.0233 | 0.0324 | |
Schistosoma mansoni | tyrosine kinase | 0.0077 | 0.0452 | 0.0447 |
Schistosoma mansoni | tyrosine kinase | 0.0146 | 0.0919 | 0.0915 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.0442 | 0.2932 | 0.2939 |
Echinococcus granulosus | roundabout 2 | 0.0014 | 0.0025 | 0.002 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0047 | 0.0248 | 0.0244 |
Echinococcus multilocularis | serine:threonine protein kinase MRCK beta | 0.0442 | 0.2932 | 0.4165 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0025 | 0.0025 |
Echinococcus multilocularis | roundabout 2 | 0.0014 | 0.0025 | 0.0029 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0047 | 0.0248 | 0.0249 |
Trypanosoma brucei | Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative | 0.0437 | 0.2896 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0148 | 0.0933 | 0.0702 |
Schistosoma mansoni | mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 | 0.0437 | 0.2896 | 0.2892 |
Schistosoma mansoni | tyrosine kinase | 0.0077 | 0.0452 | 0.0447 |
Trypanosoma cruzi | Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative | 0.0437 | 0.2896 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.0442 | 0.2932 | 0.2939 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0079 | 0.0463 | 0.0652 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0047 | 0.0248 | 0.0346 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0146 | 0.0919 | 0.0688 |
Brugia malayi | hypothetical protein | 0.0437 | 0.2896 | 0.2715 |
Onchocerca volvulus | 0.0437 | 0.2896 | 1 | |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0146 | 0.0919 | 0.0923 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0442 | 0.2932 | 0.2929 |
Echinococcus multilocularis | 0.1046 | 0.7032 | 1 | |
Schistosoma mansoni | cell adhesion molecule | 0.0012 | 0.0009 | 0.0004 |
Schistosoma mansoni | tyrosine kinase | 0.0079 | 0.0463 | 0.0458 |
Loa Loa (eye worm) | hypothetical protein | 0.1477 | 0.9964 | 1 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0079 | 0.0463 | 0.046 |
Schistosoma mansoni | tyrosine kinase | 0.0047 | 0.0248 | 0.0243 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0012 | 0.0009 | 0.0004 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0148 | 0.0933 | 0.0936 |
Schistosoma mansoni | protein kinase | 0.0442 | 0.2932 | 0.2929 |
Schistosoma mansoni | hypothetical protein | 0.0437 | 0.2896 | 0.2892 |
Echinococcus multilocularis | GTPase activating Rap:RanGAP domain 3 | 0.0437 | 0.2896 | 0.4114 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0025 | 0.0025 |
Brugia malayi | Temporarily assigned gene name protein 59 | 0.0437 | 0.2896 | 0.2715 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.0442 | 0.2932 | 0.4165 |
Echinococcus granulosus | Serine/threonine-protein kinase Genghis Khan | 0.0442 | 0.2932 | 0.2939 |
Schistosoma mansoni | vam6/vps39 related | 0.0437 | 0.2896 | 0.2892 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0146 | 0.0919 | 0.1301 |
Trypanosoma cruzi | Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative | 0.0437 | 0.2896 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.0442 | 0.2932 | 0.4165 |
Echinococcus granulosus | Vam6:Vps39 protein | 0.0437 | 0.2896 | 0.2903 |
Schistosoma mansoni | rap gtpase-activating protein | 0.0437 | 0.2896 | 0.2892 |
Echinococcus granulosus | twitchin | 0.0017 | 0.0041 | 0.0037 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0009 | 0.0009 |
Loa Loa (eye worm) | hypothetical protein | 0.0437 | 0.2896 | 0.2906 |
Schistosoma mansoni | tyrosine kinase | 0.0079 | 0.0463 | 0.0458 |
Echinococcus granulosus | serine:threonine protein kinase mig 15 | 0.1477 | 0.9964 | 1 |
Echinococcus multilocularis | insulin receptor | 0.0047 | 0.0248 | 0.0346 |
Loa Loa (eye worm) | STE/STE20/KHS protein kinase | 0.0442 | 0.2932 | 0.2943 |
Brugia malayi | Protein kinase domain containing protein | 0.0442 | 0.2932 | 0.2752 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0442 | 0.2932 | 0.2929 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0079 | 0.0463 | 0.046 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0146 | 0.0919 | 0.0918 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.