TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 490.635 | Formula: C24H30N2O5S2
H donors: 1 H acceptors: 4 LogP: 3.64 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: COC(=O)c1c2CCN(Cc2sc1S(=O)(=O)NC1CCCC1)C(=O)CCCc1ccccc1
InChi: 1S/C24H30N2O5S2/c1-31-23(28)22-19-14-15-26(21(27)13-7-10-17-8-3-2-4-9-17)16-20(19)32-24(22)33(29,30)25-18-11-5-6-12-18/h2-4,8-9,18,25H,5-7,10-16H2,1H3
InChiKey: GTLDVWNOEQTDON-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	celfurPC protein	0.0081	0.0329	0.0512
Trypanosoma cruzi	N-myristoyl transferase, putative	0.0183	0.097	0.2817
Leishmania major	ribonucleoside-diphosphate reductase small chain, putative	0.0134	0.0658	0.1785
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0036	0.0039	0.0049
Schistosoma mansoni	tumor necrosis factor receptor related	0.0044	0.009	0.0053
Leishmania major	ribonucleoside-diphosphate reductase large chain, putative	0.0528	0.3143	1
Plasmodium vivax	subtilisin-like serine protease, putative	0.0081	0.0329	0.0323
Toxoplasma gondii	aspartyl protease ASP3	0.0063	0.0214	0.0136
Plasmodium falciparum	plasmepsin VII	0.0063	0.0214	0.0161
Loa Loa (eye worm)	N-myristoyltransferase 2	0.0183	0.097	0.0956
Mycobacterium tuberculosis	Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase)	0.0173	0.0903	0.289
Mycobacterium ulcerans	membrane-anchored mycosin MycP3	0.0081	0.0329	0.0832
Schistosoma mansoni	integrin alpha-ps	0.047	0.2777	0.3347
Trypanosoma brucei	ribonucleoside-diphosphate reductase small chain, putative	0.0134	0.0658	0.1832
Plasmodium falciparum	plasmepsin IX	0.0063	0.0214	0.0161
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0042	0.0077	0.0127
Plasmodium vivax	hypothetical protein, conserved	0.0048	0.0118	0.0025
Trichomonas vaginalis	ribonucleoside-diphosphate reductase alpha chain, putative	0.048	0.2842	1
Trypanosoma cruzi	N-myristoyl transferase, putative	0.0183	0.097	0.2817
Plasmodium vivax	plasmepsin V, putative	0.0063	0.0214	0.0161
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 6	0.0048	0.0118	0.0211
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0081	0.0329	0.0773
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0081	0.0329	0.0773
Echinococcus multilocularis	Furin 1	0.0081	0.0329	0.0644
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0366	0.2122	0.7354
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0081	0.0329	0.0773
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0081	0.0329	0.0773
Toxoplasma gondii	subtilisin SUB10	0.0081	0.0329	0.0299
Giardia lamblia	CDC72	0.0183	0.097	0.4253
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0033	0.0022	0.0013
Toxoplasma gondii	aspartyl protease	0.0063	0.0214	0.0136
Plasmodium vivax	subtilisin-like protease 2, putative	0.0081	0.0329	0.0323
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0142	0.0127
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0063	0.0214	0.0205
Entamoeba histolytica	NAD-dependent deacetylase 1, putative	0.0048	0.0118	0.1077
Plasmodium falciparum	subtilisin-like protease 1	0.1166	0.7172	1
Echinococcus granulosus	TNFR CD27 30 40 95 cysteine rich region	0.0044	0.009	0.0154
Trypanosoma brucei	N-myristoyl transferase, putative	0.0183	0.097	0.2858
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0081	0.0329	0.0773
Schistosoma mansoni	adam (A disintegrin and metalloprotease	0.0116	0.0547	0.0613
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0042	0.0077	0.0127
Trichomonas vaginalis	N-myristoyl transferase, putative	0.0183	0.097	0.3127
Trichomonas vaginalis	conserved hypothetical protein	0.0081	0.0329	0.0773
Plasmodium vivax	NAD-dependent deacetylase, putative	0.0048	0.0118	0.0025
Plasmodium falciparum	plasmepsin VI	0.01	0.0443	0.0484
Echinococcus granulosus	subfamily M12B unassigned peptidase	0.0089	0.0374	0.0737
Loa Loa (eye worm)	hypothetical protein	0.0245	0.1357	0.1344
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0081	0.0329	0.0773
Echinococcus multilocularis		0.0081	0.0329	0.0644
Echinococcus multilocularis	integrin alpha ps	0.047	0.2777	0.5677
Toxoplasma gondii	subtilisin SUB11	0.0081	0.0329	0.0299
Echinococcus granulosus	epidermal growth factor receptor	0.0161	0.0829	0.1672
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0081	0.0329	0.0773
Loa Loa (eye worm)	aspartic protease BmAsp-1	0.0063	0.0214	0.0199
Brugia malayi	Disintegrin family protein	0.0037	0.0047	0.0073
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0081	0.0329	0.0773
Plasmodium falciparum	plasmepsin III	0.0063	0.0214	0.0161
Brugia malayi	ribonucleotide reductase 2	0.0134	0.0658	0.1025
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0081	0.0329	0.0773
Brugia malayi	Membrane-bound transcription factor site-1 protease precursor	0.0081	0.0329	0.0512
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0047	0.0031
Loa Loa (eye worm)	aspartyl protease 6	0.0063	0.0214	0.0199
Schistosoma mansoni	N-myristoyltransferase	0.0183	0.097	0.1132
Brugia malayi	hypothetical protein	0.0063	0.0214	0.0334
Schistosoma mansoni	site-1 peptidase (S08 family)	0.0081	0.0329	0.0346
Schistosoma mansoni	chromatin regulatory protein sir2	0.0366	0.2122	0.2544
Plasmodium falciparum	transcriptional regulatory protein sir2b	0.0048	0.0118	0.0025
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0096	0.042	0.0833
Schistosoma mansoni	ribonucleoside-diphosphate reductase alpha subunit	0.0528	0.3143	0.3795
Brugia malayi	Hypothetical subtilase-type proteinase F21H12.6 in chromosome II	0.0081	0.0329	0.0512
Echinococcus granulosus	tyrosine protein kinase Blk	0.0036	0.0039	0.0049
Toxoplasma gondii	ribonucleoside-diphosphate reductase small subunit	0.0134	0.0658	0.0765
Echinococcus multilocularis	insulin receptor	0.0096	0.042	0.0833
Echinococcus multilocularis	Peptidase S8 S53, subtilisin kexin sedolisin	0.0081	0.0329	0.0644
Trypanosoma brucei	N-myristoyltransferase	0.0183	0.097	0.2858
Schistosoma mansoni	tyrosine kinase	0.0161	0.0829	0.0958
Schistosoma mansoni	tyrosine kinase	0.0158	0.0811	0.0937
Chlamydia trachomatis	ribonucleoside-diphosphate reductase subunit alpha	0.0528	0.3143	1
Wolbachia endosymbiont of Brugia malayi	ribonucleotide-diphosphate reductase subunit alpha	0.048	0.2842	1
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0329	0.0314
Echinococcus granulosus	adam 17 protease	0.0037	0.0047	0.0064
Schistosoma mansoni	cathepsin D (A01 family)	0.0192	0.1026	0.1201
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0081	0.0329	0.0773
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0081	0.0329	0.0773
Echinococcus granulosus	Blood coagulation inhibitor Disintegrin	0.0037	0.0047	0.0064
Mycobacterium leprae	PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3)	0.0081	0.0329	0.0832
Mycobacterium ulcerans	ribonucleotide-diphosphate reductase subunit alpha	0.048	0.2842	1
Trypanosoma cruzi	subtilisin peptidase	0.0081	0.0329	0.0696
Schistosoma mansoni	integrin alpha-ps	0.0245	0.1357	0.1606
Mycobacterium ulcerans	membrane-anchored serine protease (mycosin), MycP4	0.0081	0.0329	0.0832
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0081	0.0329	0.0773
Toxoplasma gondii	subtilisin SUB1	0.1166	0.7172	1
Echinococcus multilocularis	integrin alpha 3	0.0803	0.488	1
Brugia malayi	proprotein convertase 2	0.0081	0.0329	0.0512
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0298	0.1696	0.1683
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0081	0.0329	0.0773
Leishmania major	ribonucleoside-diphosphate reductase small chain, putative	0.0134	0.0658	0.1785
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0042	0.0077	0.0127
Loa Loa (eye worm)	transcriptional regulator	0.0048	0.0118	0.0103
Onchocerca volvulus		0.0081	0.0329	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0081	0.0329	0.0773
Schistosoma mansoni	memapsin-2 (A01 family)	0.1309	0.8068	0.9834
Brugia malayi	NAD-dependent deacetylase SIRT1	0.0366	0.2122	0.3304
Schistosoma mansoni	subfamily M12B unassigned peptidase (M12 family)	0.0089	0.0374	0.0401
Plasmodium vivax	aspartyl proteinase, putative	0.0063	0.0214	0.0161
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0042	0.0077	0.0127
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0063	0.0214	0.0205
Toxoplasma gondii	subtilisin SUB2	0.0081	0.0329	0.0299
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0036	0.0039	0.0049
Mycobacterium leprae	Possible secreted protease	0.0081	0.0329	0.0832
Brugia malayi	SRC-1	0.0042	0.0077	0.012
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0366	0.2122	0.7354
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.0081	0.0329	0.0346
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0033	0.0022	0.0013
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0081	0.0329	0.0773
Schistosoma mansoni	furin-1 (S08 family)	0.0081	0.0329	0.0346
Loa Loa (eye worm)	hypothetical protein	0.0225	0.1235	0.1221
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0374	0.0359
Plasmodium falciparum	plasmepsin IV	0.01	0.0443	0.0484
Plasmodium vivax	plasmepsin IV, putative	0.01	0.0443	0.0484
Schistosoma mansoni	family A2 unassigned peptidase (A02 family)	0.0242	0.134	0.1586
Brugia malayi	Pepsin A precursor	0.0063	0.0214	0.0334
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0063	0.0214	0.0205
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0081	0.0329	0.0773
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0042	0.0077	0.0127
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0063	0.0214	0.0205
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0366	0.2122	0.7354
Brugia malayi	endoprotease bli-4 precursor	0.0081	0.0329	0.0512
Echinococcus granulosus	tyrosine kinase	0.0036	0.0039	0.0049
Mycobacterium tuberculosis	Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3)	0.0081	0.0329	0.0784
Toxoplasma gondii	subtilisin SUB12	0.0081	0.0329	0.0299
Echinococcus multilocularis	integrin alpha ps	0.0225	0.1235	0.2507
Loa Loa (eye worm)	transcriptional regulator	0.0048	0.0118	0.0103
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	0.01	0.0443	0.0879
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0366	0.2122	0.7354
Echinococcus granulosus	tumor necrosis factor receptor superfamily	0.0044	0.009	0.0154
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0161	0.0829	0.1672
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0036	0.0039	0.0049
Plasmodium vivax	aspartyl protease, putative	0.0063	0.0214	0.0161
Trypanosoma cruzi	serine peptidase, clan SB, family S8-like protein	0.0081	0.0329	0.0696
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0063	0.0214	0.0205
Toxoplasma gondii	subtilisin SUB4	0.0081	0.0329	0.0299
Echinococcus granulosus	integrin alpha ps	0.0225	0.1235	0.2507
Schistosoma mansoni	intracisternal A-particle retropepsin (A02 family)	0.133	0.8204	1
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 3	0.0048	0.0118	0.0211
Brugia malayi	Palmitoyl-protein thioesterase 1 precursor	0.0086	0.0359	0.0559
Echinococcus granulosus	ribonucleoside diphosphate reductase subunit	0.0134	0.0658	0.1321
Echinococcus multilocularis	proprotein convertase subtilisin:kexin type 5	0.0081	0.0329	0.0644
Treponema pallidum	ribonucleotide-diphosphate reductase subunit alpha	0.0528	0.3143	1
Schistosoma mansoni	chromatin regulatory protein sir2	0.0048	0.0118	0.0088
Loa Loa (eye worm)	endoprotease bli-4	0.0081	0.0329	0.0314
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0081	0.0329	0.0773
Brugia malayi	Furin-like cysteine rich region family protein	0.0298	0.1696	0.2641
Loa Loa (eye worm)	hypothetical protein	0.0366	0.2122	0.211
Loa Loa (eye worm)	ribonucleotide reductase M2 B	0.0134	0.0658	0.0644
Plasmodium vivax	subtilisin-like protease 1	0.1166	0.7172	1
Plasmodium falciparum	plasmepsin I	0.01	0.0443	0.0484
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0042	0.0077	0.0127
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.0081	0.0329	0.0346
Echinococcus granulosus	Furin 1	0.0081	0.0329	0.0644
Trypanosoma brucei	SIR2-like protein 4, putative	0.0048	0.0118	0.0058
Schistosoma mansoni	cathepsin D (A01 family)	0.0192	0.1026	0.1201
Brugia malayi	aspartic protease BmAsp-1, identical	0.0063	0.0214	0.0334
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0081	0.0329	0.0773
Loa Loa (eye worm)	palmitoyl-protein thioesterase 1	0.0086	0.0359	0.0344
Loa Loa (eye worm)	reprolysin	0.0089	0.0374	0.0359
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.01	0.0443	0.0486
Echinococcus granulosus	NAD dependent deacetylase sirtuin 7	0.0048	0.0118	0.0211
Toxoplasma gondii	subtilisin SUB8	0.0081	0.0329	0.0299
Trichomonas vaginalis	conserved hypothetical protein	0.0081	0.0329	0.0773
Echinococcus granulosus	ribonucleoside diphosphate reductase large	0.0528	0.3143	0.6429
Brugia malayi	transcriptional regulator, Sir2 family protein	0.0048	0.0118	0.0184
Loa Loa (eye worm)	SRC-1	0.0042	0.0077	0.0062
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0081	0.0329	0.0773
Echinococcus multilocularis	neuroendocrine convertase 2	0.0081	0.0329	0.0644
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0042	0.0077	0.0127
Trypanosoma brucei	subtilisin peptidase	0.0081	0.0329	0.075
Echinococcus multilocularis	chromatin regulatory protein sir2	0.0048	0.0118	0.0211
Plasmodium vivax	aspartyl protease, putative	0.0063	0.0214	0.0161
Brugia malayi	Protein kinase domain containing protein	0.0096	0.042	0.0655
Schistosoma mansoni	ribonucleoside-diphosphate reductase small chain	0.0134	0.0658	0.0749
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0036	0.0039	0.0049
Echinococcus granulosus	peptidase s8 s53 subtilisin kexin sedolisin	0.0081	0.0329	0.0644
Chlamydia trachomatis	ribonucleoside-diphosphate reductase subunit beta	0.0134	0.0658	0.1793
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0042	0.0077	0.0127
Schistosoma mansoni	tyrosine kinase	0.0096	0.042	0.0458
Toxoplasma gondii	eukaryotic aspartyl protease superfamily protein	0.0063	0.0214	0.0136
Plasmodium falciparum	plasmepsin VIII, putative	0.0063	0.0214	0.0161
Trypanosoma brucei	Silent information regulator 2 related protein 3	0.0048	0.0118	0.0058
Brugia malayi	ADAM-TS Spacer 1 family protein	0.0052	0.0142	0.0221
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0081	0.0329	0.0773
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0042	0.0077	0.0127
Mycobacterium tuberculosis	Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4)	0.0081	0.0329	0.0784
Giardia lamblia	NAD-dependent histone deacetylase Sir2	0.0366	0.2122	1
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 7	0.0048	0.0118	0.0211
Echinococcus granulosus	furin	0.0081	0.0329	0.0644
Brugia malayi	neuroendocrine convertase 1 precursor	0.0081	0.0329	0.0512
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0081	0.0329	0.0773
Loa Loa (eye worm)	sirtuin 4	0.0048	0.0118	0.0103
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0081	0.0329	0.0773
Echinococcus multilocularis	Blood coagulation inhibitor, Disintegrin	0.0037	0.0047	0.0064
Brugia malayi	ribonucleoside-diphosphate reductase large chain, putative	0.0528	0.3143	0.4893
Brugia malayi	Subtilase family protein	0.0081	0.0329	0.0512
Trypanosoma cruzi	ribonucleoside-diphosphate reductase small chain, putative	0.0134	0.0658	0.1785
Brugia malayi	aspartic protease BmAsp-2, identical	0.0063	0.0214	0.0334
Schistosoma mansoni	chromatin regulatory protein sir2	0.0048	0.0118	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0792	0.4813	0.4805
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0042	0.0077	0.0127
Brugia malayi	angiogenesis inhibito	0.0052	0.0142	0.0221
Trichomonas vaginalis	conserved hypothetical protein	0.0081	0.0329	0.0773
Trypanosoma cruzi	subtilisin-like serine peptidase, putative	0.0081	0.0329	0.0696
Echinococcus multilocularis	integrin alpha ps	0.047	0.2777	0.5677
Plasmodium falciparum	plasmepsin X	0.0063	0.0214	0.0161
Echinococcus multilocularis	glycylpeptide N tetradecanoyltransferase	0.0183	0.097	0.1963
Plasmodium vivax	aspartyl protease, putative	0.0063	0.0214	0.0161
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.0048	0.0118	0.1077
Schistosoma mansoni	tripeptidyl-peptidase II (S08 family)	0.0081	0.0329	0.0346
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 1	0.0366	0.2122	0.433
Schistosoma mansoni	tyrosine kinase	0.0161	0.0829	0.0958
Brugia malayi	hypothetical protein	0.0116	0.0547	0.0851
Schistosoma mansoni	tyrosine kinase	0.0298	0.1696	0.2022
Mycobacterium tuberculosis	Ribonucleoside-diphosphate reductase (beta chain) NrdB (ribonucleotide reductase small chain)	0.0134	0.0658	0.1991
Loa Loa (eye worm)	TK/INSR protein kinase	0.0096	0.042	0.0406
Echinococcus granulosus	disintegrin and metalloproteinase	0.0037	0.0047	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0578	0.346	0.345
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.0048	0.0118	0.1077
Echinococcus granulosus	NAD dependent deacetylase sirtuin 6	0.0048	0.0118	0.0211
Schistosoma mansoni	chromatin regulatory protein sir2	0.0048	0.0118	0.0088
Loa Loa (eye worm)	proprotein convertase 2	0.0081	0.0329	0.0314
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0042	0.0077	0.0127
Plasmodium vivax	aspartyl proteinase, putative	0.01	0.0443	0.0484
Schistosoma mansoni	tyrosine kinase	0.0042	0.0077	0.0037
Brugia malayi	transcriptional regulator, Sir2 family protein	0.0048	0.0118	0.0184
Trypanosoma brucei	ribonucleoside-diphosphate reductase small chain	0.0134	0.0658	0.1832
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.0048	0.0118	0.1077
Brugia malayi	Integrin alpha pat-2 precursor	0.1048	0.6422	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0081	0.0329	0.0773
Toxoplasma gondii	ribonucleoside-diphosphate reductase large chain	0.0528	0.3143	0.4288
Plasmodium falciparum	transcriptional regulatory protein sir2a	0.0048	0.0118	0.0025
Mycobacterium tuberculosis	Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein)	0.048	0.2842	1
Echinococcus granulosus	neuroendocrine convertase 2	0.0081	0.0329	0.0644
Plasmodium vivax	glycylpeptide N-tetradecanoyltransferase, putative	0.0183	0.097	0.123
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0042	0.0077	0.0127
Toxoplasma gondii	subtilisin SUB6	0.0081	0.0329	0.0299
Brugia malayi	ADAMTS-like protease	0.0052	0.0142	0.0221
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0329	0.0314
Plasmodium falciparum	ribonucleoside-diphosphate reductase small chain, putative	0.0134	0.0658	0.0788
Schistosoma mansoni	chromatin regulatory protein sir2	0.0048	0.0118	0.0088
Loa Loa (eye worm)	TK protein kinase	0.0036	0.0039	0.0024
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0042	0.0077	0.0127
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0081	0.0329	0.0773
Brugia malayi	Reprolysin	0.0052	0.0142	0.0222
Echinococcus multilocularis	epidermal growth factor receptor	0.0298	0.1696	0.3454
Brugia malayi	protein-tyrosine kinase	0.0036	0.0039	0.0061
Echinococcus multilocularis	subfamily M12B unassigned peptidase	0.0089	0.0374	0.0737
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0081	0.0329	0.0773
Mycobacterium tuberculosis	Transcriptional regulatory protein	0.0048	0.0118	0.0011
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0081	0.0329	0.0773
Toxoplasma gondii	subtilisin SUB9	0.0081	0.0329	0.0299
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0081	0.0329	0.0773
Trypanosoma cruzi	subtilisin-like serine peptidase, putative	0.0081	0.0329	0.0696
Trypanosoma brucei	Silent information regulator 2 related protein 1	0.0048	0.0118	0.0058
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0063	0.0214	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0142	0.0127
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0042	0.0077	0.0127
Echinococcus multilocularis	ribonucleoside diphosphate reductase large	0.0528	0.3143	0.6429
Trichomonas vaginalis	N-myristoyl transferase, putative	0.012	0.0574	0.1673
Loa Loa (eye worm)	subtilase	0.0081	0.0329	0.0314
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0081	0.0329	0.0773
Echinococcus granulosus	NAD dependent deacetylase sirtuin 1	0.0366	0.2122	0.433
Loa Loa (eye worm)	hypothetical protein	0.01	0.0443	0.0428
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0081	0.0329	0.0773
Trypanosoma brucei	serine peptidase, clan SB, family S8-like protein	0.0081	0.0329	0.075
Plasmodium falciparum	subtilisin-like protease 3	0.0081	0.0329	0.0323
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0042	0.0077	0.0127
Echinococcus multilocularis	TNFR CD27 30 40 95 cysteine rich region	0.0044	0.009	0.0154
Toxoplasma gondii	subtilisin SUB5	0.0081	0.0329	0.0299
Schistosoma mansoni	tyrosine kinase	0.0158	0.0811	0.0937
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0042	0.0077	0.0127
Echinococcus granulosus	integrin alpha ps	0.047	0.2777	0.5677
Mycobacterium tuberculosis	Ribonucleoside-diphosphate reductase (beta chain) NrdF1 (ribonucleotide reductase small subunit) (R2F protein)	0.0134	0.0658	0.1991
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0063	0.0214	0.0205
Mycobacterium leprae	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN)	0.048	0.2842	1
Echinococcus granulosus	palmitoyl protein thioesterase 1	0.0086	0.0359	0.0706
Echinococcus granulosus	NAD dependent deacetylase sirtuin 3	0.0048	0.0118	0.0211
Schistosoma mansoni	site-1 peptidase (S08 family)	0.0081	0.0329	0.0346
Echinococcus granulosus	membrane bound transcription factor site 1	0.0081	0.0329	0.0644
Trypanosoma brucei	ribonucleoside-diphosphate reductase small chain	0.0134	0.0658	0.1832
Schistosoma mansoni	tyrosine kinase	0.0096	0.042	0.0458
Toxoplasma gondii	subtilisin SUB7	0.0081	0.0329	0.0299
Echinococcus multilocularis	palmitoyl protein thioesterase 1	0.0086	0.0359	0.0706
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0042	0.0077	0.0127
Mycobacterium leprae	conserved hypothetical protein	0.0048	0.0115	0.0053
Plasmodium falciparum	subtilisin-like protease 2	0.0081	0.0329	0.0323
Schistosoma mansoni	chromatin regulatory protein sir2	0.0048	0.0118	0.0088
Mycobacterium tuberculosis	Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like)	0.0081	0.0329	0.0784
Echinococcus granulosus	chromatin regulatory protein sir2	0.0048	0.0118	0.0211
Brugia malayi	Eukaryotic aspartyl protease family protein	0.0063	0.0214	0.0334
Schistosoma mansoni	tyrosine kinase	0.0158	0.0811	0.0937
Loa Loa (eye worm)	ribonucleoside-diphosphate reductase large subunit	0.0528	0.3143	0.3132
Echinococcus multilocularis	tumor necrosis factor receptor superfamily	0.0044	0.009	0.0154
Mycobacterium ulcerans	Sir2-like regulatory protein	0.0048	0.0118	0.0064
Trypanosoma cruzi	ribonucleoside-diphosphate reductase small chain, putative	0.0134	0.0658	0.1785
Trypanosoma cruzi	ribonucleoside-diphosphate reductase large chain, putative	0.0528	0.3143	1
Plasmodium vivax	ribonucleoside-diphosphate reductase large chain, putative	0.0528	0.3143	0.4302
Mycobacterium ulcerans	transcriptional regulator NrdR	0.0048	0.0115	0.0053
Echinococcus granulosus	adam	0.0116	0.0547	0.1092
Loa Loa (eye worm)	hypothetical protein	0.0318	0.1818	0.1806
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0081	0.0329	0.0773
Echinococcus multilocularis	epidermal growth factor receptor	0.0161	0.0829	0.1672
Trypanosoma brucei	ribonucleoside-diphosphate reductase large chain	0.0528	0.3143	1
Schistosoma mansoni	palmitoyl-protein thioesterase	0.0086	0.0359	0.0383
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0214	0.0199
Plasmodium falciparum	plasmepsin V	0.0063	0.0214	0.0161
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0081	0.0329	0.0773
Brugia malayi	hypothetical protein	0.0063	0.0214	0.0334
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0081	0.0329	0.0773
Trypanosoma cruzi	ribonucleoside-diphosphate reductase large chain, putative	0.0147	0.0744	0.2068
Mycobacterium ulcerans	NAD-dependent deacetylase	0.0048	0.0118	0.0064
Trypanosoma brucei	ribonucleoside-diphosphate reductase small chain	0.0134	0.0658	0.1832
Schistosoma mansoni	integrin alpha	0.1048	0.6422	0.7816
Plasmodium falciparum	plasmepsin II	0.01	0.0443	0.0484
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0214	0.0199
Mycobacterium tuberculosis	Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5)	0.0081	0.0329	0.0784
Echinococcus multilocularis		0.0092	0.0395	0.078
Trichomonas vaginalis	Clan AA, family A1, cathepsin D-like aspartic peptidase	0.01	0.0443	0.1192
Echinococcus granulosus	proprotein convertase subtilisin:kexin type 5	0.0081	0.0329	0.0644
Leishmania major	N-myristoyl transferase, putative	0.0183	0.097	0.2817
Toxoplasma gondii	aspartyl protease ASP1	0.01	0.0443	0.046
Entamoeba histolytica	hypothetical protein, conserved	0.0048	0.0118	0.1077
Schistosoma mansoni	subfamily S8B non-peptidase homologue (S08 family)	0.0081	0.0329	0.0346
Plasmodium falciparum	ribonucleoside-diphosphate reductase large subunit, putative	0.0528	0.3143	0.4302
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0096	0.042	0.0833
Brugia malayi	N-myristoyltransferase 2	0.0183	0.097	0.1511
Schistosoma mansoni	chromatin regulatory protein sir2	0.0048	0.0118	0.0088
Echinococcus granulosus	epidermal growth factor receptor	0.0298	0.1696	0.3454
Brugia malayi	transcriptional regulator, Sir2 family protein	0.0048	0.0118	0.0184
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0063	0.0214	0.0205
Echinococcus multilocularis	ribonucleoside diphosphate reductase subunit	0.0134	0.0658	0.1321
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	0.01	0.0443	0.0879
Plasmodium falciparum	glycylpeptide N-tetradecanoyltransferase	0.0183	0.097	0.123
Mycobacterium ulcerans	proline rich membrane-anchored mycosin MycP5	0.0081	0.0329	0.0832
Trichomonas vaginalis	conserved hypothetical protein	0.0081	0.0329	0.0773
Echinococcus granulosus	integrin alpha 3	0.0803	0.488	1
Echinococcus granulosus	insulin receptor	0.0096	0.042	0.0833
Loa Loa (eye worm)	transcriptional regulator	0.0048	0.0118	0.0103
Leishmania major	subtilisin-like serine peptidase	0.0081	0.0329	0.0696
Schistosoma mansoni	subfamily M12B unassigned peptidase (M12 family)	0.0089	0.0374	0.0401
Plasmodium vivax	ribonucleoside-diphosphate reductase small chain, putative	0.0134	0.0658	0.0788
Schistosoma mansoni	hypothetical protein	0.0225	0.1235	0.1456
Echinococcus granulosus	glycylpeptide N tetradecanoyltransferase	0.0183	0.097	0.1963
Brugia malayi	Integrin alpha cytoplasmic region family protein	0.0792	0.4813	0.7494
Loa Loa (eye worm)	aspartic protease BmAsp-2	0.01	0.0443	0.0428
Trichomonas vaginalis	conserved hypothetical protein	0.0081	0.0329	0.0773
Mycobacterium leprae	PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5)	0.0081	0.0329	0.0832
Schistosoma mansoni	tyrosine kinase	0.0042	0.0077	0.0037
Entamoeba histolytica	glycylpeptide N-tetradecanoyltransferase, putative	0.0183	0.097	1
Loa Loa (eye worm)	hypothetical protein	0.0822	0.5002	0.4995
Echinococcus multilocularis	disintegrin and metalloproteinase	0.0037	0.0047	0.0064
Echinococcus multilocularis	membrane bound transcription factor site 1	0.0081	0.0329	0.0644
Toxoplasma gondii	aspartyl proteinase (eimepsin), putative	0.01	0.0443	0.046
Echinococcus multilocularis	adam	0.0116	0.0547	0.1092

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 814556