TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 456.619 | Formula: C21H32N2O5S2
H donors: 1 H acceptors: 4 LogP: 3.55 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: COC(=O)c1c2CCN(Cc2sc1S(=O)(=O)NC1CCCCC1)C(=O)CCC(C)C
InChi: 1S/C21H32N2O5S2/c1-14(2)9-10-18(24)23-12-11-16-17(13-23)29-21(19(16)20(25)28-3)30(26,27)22-15-7-5-4-6-8-15/h14-15,22H,4-13H2,1-3H3
InChiKey: SIGCQSFFVKWEBL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	subtilisin SUB11	0.0078	0.0461	0.0496
Plasmodium falciparum	M17 leucyl aminopeptidase	0.0068	0.0374	0.0401
Schistosoma mansoni	site-1 peptidase (S08 family)	0.0078	0.0461	0.0461
Trichomonas vaginalis	conserved hypothetical protein	0.0078	0.0461	0.1154
Trypanosoma cruzi	epsilon tubulin, putative	0.004	0.0144	0.0316
Echinococcus multilocularis	tubulin alpha chain	0.004	0.0144	0.033
Schistosoma mansoni	alpha tubulin	0.004	0.0144	0.0144
Loa Loa (eye worm)	tubulin beta-1 chain	0.0104	0.0673	0.1535
Schistosoma mansoni	ribonucleoside-diphosphate reductase small chain	0.014	0.0975	0.0975
Leishmania major	beta tubulin	0.0104	0.0673	0.1535
Trypanosoma brucei	ribonucleoside-diphosphate reductase small chain	0.0047	0.0203	0.0452
Leishmania major	alpha tubulin	0.004	0.0144	0.0316
Mycobacterium ulcerans	leucyl aminopeptidase	0.0115	0.0763	0.1498
Trypanosoma brucei	epsilon tubulin	0.004	0.0144	0.0316
Giardia lamblia	Alpha-tubulin	0.004	0.0144	0.1043
Trypanosoma brucei	subtilisin peptidase	0.0078	0.0461	0.1046
Loa Loa (eye worm)	tubulin beta-2A chain	0.0104	0.0673	0.1535
Schistosoma mansoni	furin-1 (S08 family)	0.0078	0.0461	0.0461
Leishmania major	cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17	0.0068	0.0374	0.0846
Plasmodium vivax	tubulin epsilon chain, putative	0.004	0.0144	0.015
Echinococcus granulosus	beta tubulin	0.0104	0.0673	0.1547
Schistosoma mansoni	aminopeptidase A (M01 family)	0.0056	0.0276	0.0276
Leishmania major	alpha tubulin	0.004	0.0144	0.0316
Mycobacterium tuberculosis	Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein)	0.0496	0.3943	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0078	0.0461	0.1154
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0078	0.0461	0.1154
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0078	0.0461	0.1154
Trypanosoma brucei	alpha tubulin	0.004	0.0144	0.0316
Echinococcus multilocularis	tubulin alpha 3 chain	0.004	0.0144	0.033
Loa Loa (eye worm)	beta-tubulin	0.0104	0.0673	0.1535
Trichomonas vaginalis	tubulin gamma chain, putative	0.004	0.0144	0.0349
Leishmania major	beta tubulin	0.0104	0.0673	0.1535
Giardia lamblia	Gamma tubulin	0.004	0.0144	0.1043
Chlamydia trachomatis	ribonucleoside-diphosphate reductase subunit alpha	0.0545	0.4348	1
Echinococcus granulosus	eukaryotic initiation factor 4A	0.0024	0.0006	0.0015
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0056	0.0276	0.0622
Brugia malayi	Hypothetical subtilase-type proteinase F21H12.6 in chromosome II	0.0078	0.0461	0.1046
Schistosoma mansoni	family A2 unassigned peptidase (A02 family)	0.0222	0.166	0.166
Loa Loa (eye worm)	subtilase	0.0078	0.0461	0.1046
Echinococcus granulosus	membrane bound transcription factor site 1	0.0078	0.0461	0.106
Trypanosoma cruzi	metallo-peptidase, Clan MA(E) Family M1	0.0087	0.0536	0.122
Leishmania major	epsilon tubulin, putative	0.004	0.0144	0.0316
Brugia malayi	celfurPC protein	0.0078	0.0461	0.1046
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0078	0.0461	0.1154
Echinococcus granulosus	ribonucleoside diphosphate reductase subunit	0.014	0.0975	0.2242
Echinococcus granulosus	aminopeptidase N	0.0386	0.3027	0.6962
Toxoplasma gondii	beta-1 tubulin, putative	0.0104	0.0673	0.0727
Leishmania major	beta tubulin	0.0104	0.0673	0.1535
Loa Loa (eye worm)	leukotriene A4 hydrolase	0.0056	0.0276	0.0622
Plasmodium falciparum	subtilisin-like protease 2	0.0078	0.0461	0.0496
Trypanosoma cruzi	epsilon tubulin, putative	0.004	0.0144	0.0316
Loa Loa (eye worm)	hypothetical protein	0.004	0.0144	0.0316
Giardia lamblia	CDC72	0.0182	0.1324	1
Loa Loa (eye worm)	TATA binding protein associated factor	0.0056	0.0276	0.0622
Loa Loa (eye worm)	alpha-tubulin	0.004	0.0144	0.0316
Echinococcus multilocularis	tubulin subunit beta	0.0104	0.0673	0.1547
Mycobacterium leprae	conserved hypothetical protein	0.0049	0.0212	0.0024
Plasmodium falciparum	glycylpeptide N-tetradecanoyltransferase	0.0182	0.1324	0.1438
Toxoplasma gondii	beta-tubulin, putative	0.0104	0.0673	0.0727
Leishmania major	puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.0056	0.0276	0.0622
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0078	0.0461	0.1154
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.0024	0.0006	0.0006
Brugia malayi	endoprotease bli-4 precursor	0.0078	0.0461	0.1046
Mycobacterium tuberculosis	Ribonucleoside-diphosphate reductase (beta chain) NrdF1 (ribonucleotide reductase small subunit) (R2F protein)	0.014	0.0975	0.2461
Loa Loa (eye worm)	tubulin gamma chain	0.004	0.0144	0.0316
Trypanosoma brucei	alpha tubulin	0.004	0.0144	0.0316
Leishmania major	gamma-tubulin	0.004	0.0144	0.0316
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.0144	0.1005	0.2301
Entamoeba histolytica	tubulin gamma chain	0.004	0.0144	0.1043
Echinococcus multilocularis	Furin 1	0.0078	0.0461	0.106
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0078	0.0461	0.1154
Echinococcus granulosus	furin	0.0078	0.0461	0.106
Echinococcus multilocularis	hypothetical protein	0.004	0.0144	0.033
Loa Loa (eye worm)	tubulin beta-4 chain	0.0104	0.0673	0.1535
Plasmodium vivax	glycylpeptide N-tetradecanoyltransferase, putative	0.0182	0.1324	0.1438
Echinococcus granulosus	tubulin alpha	0.004	0.0144	0.033
Brugia malayi	Membrane-bound transcription factor site-1 protease precursor	0.0078	0.0461	0.1046
Plasmodium vivax	tubulin alpha chain, putative	0.004	0.0144	0.015
Trypanosoma cruzi	aminopeptidase, putative	0.0144	0.1005	0.2301
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0078	0.0461	0.1154
Loa Loa (eye worm)	proprotein convertase 2	0.0078	0.0461	0.1046
Echinococcus multilocularis	tubulin alpha	0.004	0.0144	0.033
Echinococcus granulosus	neuroendocrine convertase 2	0.0078	0.0461	0.106
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0144	0.1005	0.2312
Mycobacterium ulcerans	proline rich membrane-anchored mycosin MycP5	0.0078	0.0461	0.069
Leishmania major	beta tubulin	0.0104	0.0673	0.1535
Echinococcus granulosus	tubulin subunit beta	0.0104	0.0673	0.1547
Echinococcus granulosus	tubulin beta 1 chain	0.0104	0.0673	0.1547
Echinococcus granulosus	Tubulin beta 2C chain	0.0104	0.0673	0.1547
Entamoeba histolytica	tubulin family protein	0.0104	0.0673	0.5059
Leishmania major	beta tubulin	0.0104	0.0673	0.1535
Brugia malayi	alpha-tubulin	0.004	0.0144	0.0316
Echinococcus multilocularis	leukotriene A 4 hydrolase	0.0056	0.0276	0.0635
Echinococcus granulosus	Tubulin beta 2C chain	0.0104	0.0673	0.1547
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0056	0.0276	0.0686
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0104	0.0673	0.1547
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0078	0.0461	0.1154
Plasmodium vivax	ribonucleotide reductase small subunit, putative	0.0047	0.0203	0.0214
Leishmania major	beta tubulin	0.0104	0.0673	0.1535
Schistosoma mansoni	subfamily S8B non-peptidase homologue (S08 family)	0.0078	0.0461	0.0461
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0144	0.1005	0.2312
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0536	0.122
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0276	0.0622
Echinococcus multilocularis	ribonucleoside diphosphate reductase large	0.0545	0.4348	1
Trypanosoma cruzi	ribonucleoside-diphosphate reductase small chain, putative	0.014	0.0975	0.2231
Entamoeba histolytica	glycylpeptide N-tetradecanoyltransferase, putative	0.0182	0.1324	1
Mycobacterium tuberculosis	Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase)	0.0178	0.1294	0.3271
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0078	0.0461	0.1154
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0078	0.0461	0.1154
Trichomonas vaginalis	tubulin beta chain, putative	0.004	0.0144	0.0349
Brugia malayi	proprotein convertase 2	0.0078	0.0461	0.1046
Onchocerca volvulus		0.0386	0.3027	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0104	0.0673	0.1693
Wolbachia endosymbiont of Brugia malayi	ribonucleotide-diphosphate reductase subunit beta	0.014	0.0975	0.0667
Trypanosoma cruzi	subtilisin-like serine peptidase, putative	0.0078	0.0461	0.1046
Trichomonas vaginalis	tubulin beta chain, putative	0.0104	0.0673	0.1693
Echinococcus granulosus	tubulin alpha chain	0.004	0.0144	0.033
Plasmodium falciparum	subtilisin-like protease 1	0.1122	0.9168	1
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0144	0.1005	0.2538
Entamoeba histolytica	tubulin alpha-1 chain	0.004	0.0144	0.1043
Treponema pallidum	ribonucleotide-diphosphate reductase subunit beta	0.014	0.0975	0.2231
Trypanosoma cruzi	beta tubulin, putative	0.0104	0.0673	0.1535
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0078	0.0461	0.1154
Echinococcus granulosus	glycylpeptide N tetradecanoyltransferase	0.0182	0.1324	0.3044
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0276	0.0622
Echinococcus multilocularis	Tubulin beta 2C chain	0.0104	0.0673	0.1547
Plasmodium vivax	subtilisin-like protease 1	0.1122	0.9168	1
Trichomonas vaginalis	tubulin, putative	0.0104	0.0673	0.1693
Brugia malayi	hypothetical protein	0.0144	0.1005	0.2301
Plasmodium falciparum	ribonucleoside-diphosphate reductase large subunit, putative	0.0545	0.4348	0.4739
Loa Loa (eye worm)	hypothetical protein	0.033	0.2558	0.5876
Mycobacterium ulcerans	membrane-anchored serine protease (mycosin), MycP4	0.0078	0.0461	0.069
Leishmania major	alpha tubulin	0.004	0.0144	0.0316
Echinococcus granulosus	alpha tubulin	0.004	0.0144	0.033
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0078	0.0461	0.1154
Echinococcus multilocularis		0.0078	0.0461	0.106
Echinococcus multilocularis	Tubulin beta 2C chain	0.0104	0.0673	0.1547
Toxoplasma gondii	alpha tubulin TUBA1	0.004	0.0144	0.015
Echinococcus multilocularis	beta tubulin	0.0104	0.0673	0.1547
Loa Loa (eye worm)	ribonucleotide reductase M2 B	0.014	0.0975	0.2231
Trypanosoma brucei	beta tubulin	0.0104	0.0673	0.1535
Leishmania major	alpha tubulin	0.004	0.0144	0.0316
Loa Loa (eye worm)	tubulin alpha-2 chain	0.004	0.0144	0.0316
Entamoeba histolytica	tubulin alpha chain, putative	0.004	0.0144	0.1043
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0144	0.1005	0.2312
Mycobacterium ulcerans	ribonucleotide-diphosphate reductase subunit alpha	0.0496	0.3943	1
Toxoplasma gondii	aminopeptidase n, putative	0.0342	0.266	0.2897
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0078	0.0461	0.1154
Trypanosoma brucei	alpha tubulin	0.004	0.0144	0.0316
Trypanosoma brucei	ribonucleoside-diphosphate reductase small chain	0.014	0.0975	0.2231
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0144	0.1005	0.2312
Trypanosoma brucei	ribonucleoside-diphosphate reductase small chain, putative	0.014	0.0975	0.2231
Leishmania major	beta tubulin	0.0104	0.0673	0.1535
Echinococcus granulosus	Tubulin alpha 1 chain	0.004	0.0144	0.033
Mycobacterium tuberculosis	Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5)	0.0078	0.0461	0.1154
Echinococcus multilocularis	Tubulin alpha 1 chain	0.004	0.0144	0.033
Loa Loa (eye worm)	N-myristoyltransferase 2	0.0182	0.1324	0.3034
Trichomonas vaginalis	tubulin beta chain, putative	0.004	0.0144	0.0349
Trichomonas vaginalis	tubulin alpha chain, putative	0.004	0.0144	0.0349
Leishmania major	alpha tubulin	0.004	0.0144	0.0316
Toxoplasma gondii	alpha-tubulin I, putative	0.004	0.0144	0.015
Leishmania major	alpha tubulin	0.004	0.0144	0.0316
Echinococcus granulosus	Tubulin alpha 1 chain	0.004	0.0144	0.033
Brugia malayi	Tubulin alpha-2 chain	0.004	0.0144	0.0316
Plasmodium vivax	subtilisin-like serine protease, putative	0.0078	0.0461	0.0496
Schistosoma mansoni	tubulin subunit beta	0.0104	0.0673	0.0673
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0078	0.0461	0.1154
Mycobacterium leprae	PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3)	0.0078	0.0461	0.069
Trypanosoma cruzi	tubulin gamma chain	0.004	0.0144	0.0316
Loa Loa (eye worm)	BEN-1 protein	0.0104	0.0673	0.1535
Toxoplasma gondii	subtilisin SUB1	0.1122	0.9168	1
Leishmania major	beta tubulin	0.0104	0.0673	0.1535
Echinococcus granulosus	eukaryotic initiation factor 4A III	0.0024	0.0006	0.0015
Leishmania major	N-myristoyl transferase, putative	0.0182	0.1324	0.3034
Echinococcus granulosus	Tubulin alpha 1 chain	0.004	0.0144	0.033
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0078	0.0461	0.1154
Giardia lamblia	Alpha-tubulin	0.004	0.0144	0.1043
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0144	0.1005	0.1005
Leishmania major	alpha tubulin	0.004	0.0144	0.0316
Echinococcus multilocularis	proprotein convertase subtilisin:kexin type 5	0.0078	0.0461	0.106
Schistosoma mansoni	tubulin subunit beta	0.0104	0.0673	0.0673
Echinococcus granulosus	leukotriene A 4 hydrolase	0.0056	0.0276	0.0635
Echinococcus granulosus	ribonucleoside diphosphate reductase large	0.0545	0.4348	1
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0144	0.1005	0.2312
Trypanosoma cruzi	metallo-peptidase, Clan MA(E) Family M1	0.0056	0.0276	0.0622
Toxoplasma gondii	subtilisin SUB9	0.0078	0.0461	0.0496
Echinococcus multilocularis	neuroendocrine convertase 2	0.0078	0.0461	0.106
Trypanosoma cruzi	subtilisin peptidase	0.0078	0.0461	0.1046
Echinococcus multilocularis	Tubulin beta 2C chain	0.0104	0.0673	0.1547
Schistosoma mansoni	tubulin subunit beta	0.0104	0.0673	0.0673
Brugia malayi	Tubulin alpha-2 chain	0.004	0.0144	0.0316
Leishmania major	subtilisin-like serine peptidase	0.0078	0.0461	0.1046
Loa Loa (eye worm)	alpha-tubulin	0.004	0.0144	0.0316
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0078	0.0461	0.1154
Schistosoma mansoni	family M1 non-peptidase homologue (M01 family)	0.0087	0.0536	0.0536
Trypanosoma brucei	beta tubulin	0.004	0.0144	0.0316
Trypanosoma cruzi	N-myristoyl transferase, putative	0.0182	0.1324	0.3034
Leishmania major	beta tubulin	0.0104	0.0673	0.1535
Trypanosoma brucei	N-myristoyltransferase	0.0182	0.1324	0.3034
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.0078	0.0461	0.0461
Toxoplasma gondii	aminopeptidase N protein	0.0342	0.266	0.2897
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0144	0.1005	0.2538
Leishmania major	alpha tubulin	0.004	0.0144	0.0316
Trypanosoma cruzi	subtilisin-like serine peptidase, putative	0.0078	0.0461	0.1046
Trypanosoma cruzi	aminopeptidase, putative	0.0056	0.0276	0.0622
Brugia malayi	Tubulin gamma chain	0.004	0.0144	0.0316
Echinococcus multilocularis	ribonucleoside diphosphate reductase subunit	0.014	0.0975	0.2242
Toxoplasma gondii	subtilisin SUB5	0.0078	0.0461	0.0496
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0078	0.0461	0.1154
Plasmodium falciparum	subtilisin-like protease 3	0.0078	0.0461	0.0496
Echinococcus multilocularis	tubulin alpha chain	0.004	0.0144	0.033
Treponema pallidum	ribonucleotide-diphosphate reductase subunit alpha	0.0545	0.4348	1
Mycobacterium ulcerans	transcriptional regulator NrdR	0.0049	0.0212	0.0024
Trypanosoma brucei	ribonucleoside-diphosphate reductase small chain	0.014	0.0975	0.2231
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0078	0.0461	0.1154
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0144	0.1005	0.2312
Trypanosoma brucei	Aminopeptidase M1, putative	0.0144	0.1005	0.2301
Brugia malayi	beta-tubulin, identical	0.0104	0.0673	0.1535
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.004	0.0144	0.015
Trichomonas vaginalis	tubulin beta chain, putative	0.004	0.0144	0.0349
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0144	0.1005	0.2312
Echinococcus granulosus	tubulin alpha chain	0.004	0.0144	0.033
Trypanosoma brucei	epsilon tubulin	0.004	0.0144	0.0316
Trypanosoma brucei	ribonucleoside-diphosphate reductase large chain	0.0545	0.4348	1
Plasmodium falciparum	alpha tubulin 2	0.004	0.0144	0.015
Trypanosoma brucei	serine peptidase, clan SB, family S8-like protein	0.0078	0.0461	0.1046
Echinococcus granulosus	peroxisome assembly protein 26	0.004	0.0144	0.033
Trichomonas vaginalis	tubulin alpha chain, putative	0.0104	0.0673	0.1693
Trypanosoma cruzi	metallo-peptidase, Clan MF, Family M17, putative	0.0068	0.0374	0.0846
Echinococcus multilocularis	glycylpeptide N tetradecanoyltransferase	0.0182	0.1324	0.3044
Echinococcus multilocularis	membrane bound transcription factor site 1	0.0078	0.0461	0.106
Echinococcus multilocularis	tubulin alpha 1C chain	0.004	0.0144	0.033
Echinococcus multilocularis	tubulin epsilon chain	0.004	0.0144	0.033
Trichomonas vaginalis	conserved hypothetical protein	0.0078	0.0461	0.1154
Brugia malayi	tubulin alpha-2 chain	0.004	0.0144	0.0316
Trichomonas vaginalis	conserved hypothetical protein	0.0078	0.0461	0.1154
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0078	0.0461	0.1154
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0144	0.1005	0.2301
Echinococcus multilocularis	tubulin beta 1 chain	0.0104	0.0673	0.1547
Trypanosoma brucei	metallo-peptidase, Clan MA(E) Family M1	0.0144	0.1005	0.2301
Leishmania major	beta tubulin	0.0104	0.0673	0.1535
Trichomonas vaginalis	N-myristoyl transferase, putative	0.012	0.0803	0.2025
Schistosoma mansoni	tripeptidyl-peptidase II (S08 family)	0.0078	0.0461	0.0461
Leishmania major	beta tubulin	0.0104	0.0673	0.1535
Echinococcus multilocularis	Tubulin alpha 1 chain	0.004	0.0144	0.033
Mycobacterium tuberculosis	Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3)	0.0078	0.0461	0.1154
Onchocerca volvulus		0.0056	0.0276	0.0894
Leishmania major	beta tubulin	0.0104	0.0673	0.1535
Echinococcus multilocularis	Peptidase M1, membrane alanine aminopeptidase, N terminal	0.0144	0.1005	0.2312
Mycobacterium leprae	Probable cytosol aminopeptidase PepB	0.0115	0.0763	0.1498
Plasmodium falciparum	ribonucleoside-diphosphate reductase small chain, putative	0.0047	0.0203	0.0214
Echinococcus granulosus	tubulin alpha 1C chain	0.004	0.0144	0.033
Trichomonas vaginalis	conserved hypothetical protein	0.0078	0.0461	0.1154
Leishmania major	beta tubulin	0.0104	0.0673	0.1535
Brugia malayi	Peptidase family M1 containing protein	0.0144	0.1005	0.2301
Loa Loa (eye worm)	hypothetical protein	0.0242	0.1829	0.4197
Echinococcus multilocularis	Tubulin beta 2C chain	0.0104	0.0673	0.1547
Giardia lamblia	Beta tubulin	0.0104	0.0673	0.5059
Leishmania major	beta tubulin	0.0104	0.0673	0.1535
Schistosoma mansoni	tubulin subunit epsilon	0.004	0.0144	0.0144
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0078	0.0461	0.1154
Echinococcus granulosus	leucine aminopeptidase protein	0.0115	0.0763	0.1755
Echinococcus granulosus	tubulin alpha chain	0.004	0.0144	0.033
Giardia lamblia	Beta tubulin	0.0104	0.0673	0.5059
Trichomonas vaginalis	tubulin beta chain, putative	0.004	0.0144	0.0349
Leishmania major	beta tubulin	0.0104	0.0673	0.1535
Mycobacterium ulcerans	aminopeptidase N PepN	0.0144	0.1005	0.2146
Brugia malayi	ribonucleotide reductase 2	0.014	0.0975	0.2231
Plasmodium vivax	tubulin alpha chain, putative	0.004	0.0144	0.015
Leishmania major	beta tubulin	0.0104	0.0673	0.1535
Plasmodium vivax	tubulin beta chain, putative	0.0104	0.0673	0.0727
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0276	0.0622
Toxoplasma gondii	ribonucleoside-diphosphate reductase large chain	0.0545	0.4348	0.4739
Leishmania major	beta tubulin	0.0104	0.0673	0.1535
Toxoplasma gondii	subtilisin SUB12	0.0078	0.0461	0.0496
Trypanosoma cruzi	N-myristoyl transferase, putative	0.0182	0.1324	0.3034
Echinococcus granulosus	proprotein convertase subtilisin:kexin type 5	0.0078	0.0461	0.106
Brugia malayi	Peptidase family M1 containing protein	0.0386	0.3027	0.6957
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0056	0.0276	0.0635
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0078	0.0461	0.1154
Mycobacterium ulcerans	aminopeptidase N PepN	0.0056	0.0276	0.0197
Schistosoma mansoni	cytosol alanyl aminopeptidase (M01 family)	0.0144	0.1005	0.1005
Toxoplasma gondii	beta tubulin	0.0104	0.0673	0.0727
Schistosoma mansoni	alpha tubulin	0.004	0.0144	0.0144
Echinococcus granulosus	tubulin gamma 1 chain	0.004	0.0144	0.033
Echinococcus multilocularis	leucine aminopeptidase protein	0.0115	0.0763	0.1755
Entamoeba histolytica	aminopeptidase, putative	0.0144	0.1005	0.7585
Echinococcus granulosus	tubulin alpha 1C chain	0.004	0.0144	0.033
Brugia malayi	Tubulin beta-1 chain	0.0104	0.0673	0.1535
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0078	0.0461	0.1154
Giardia lamblia	Beta tubulin	0.0104	0.0673	0.5059
Echinococcus granulosus	tubulin alpha chain	0.004	0.0144	0.033
Trypanosoma cruzi	alpha tubulin, putative	0.004	0.0144	0.0316
Loa Loa (eye worm)	BEN-1 protein	0.0104	0.0673	0.1535
Brugia malayi	ribonucleoside-diphosphate reductase large chain, putative	0.0545	0.4348	1
Schistosoma mansoni	ribonucleoside-diphosphate reductase alpha subunit	0.0545	0.4348	0.4348
Trypanosoma brucei	epsilon tubulin	0.004	0.0144	0.0316
Echinococcus granulosus	Tubulin beta 2C chain	0.0104	0.0673	0.1547
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0144	0.1005	0.2312
Trypanosoma cruzi	Aminopeptidase M1, putative	0.0144	0.1005	0.2301
Trypanosoma brucei	tubulin gamma chain	0.004	0.0144	0.0316
Toxoplasma gondii	leucyl aminopeptidase LAP	0.0115	0.0763	0.0826
Plasmodium vivax	M1-family alanyl aminopeptidase, putative	0.0342	0.266	0.2897
Echinococcus multilocularis	aminopeptidase N	0.0386	0.3027	0.6962
Toxoplasma gondii	subtilisin SUB2	0.0078	0.0461	0.0496
Echinococcus granulosus	tubulin beta 4A class IVa	0.0104	0.0673	0.1547
Loa Loa (eye worm)	ribonucleoside-diphosphate reductase large subunit	0.0545	0.4348	1
Trypanosoma brucei	Aminopeptidase M1, putative	0.0144	0.1005	0.2301
Trypanosoma brucei	N-myristoyl transferase, putative	0.0182	0.1324	0.3034
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0078	0.0461	0.1154
Schistosoma mansoni	tubulin subunit alpha	0.004	0.0144	0.0144
Wolbachia endosymbiont of Brugia malayi	ribonucleotide-diphosphate reductase subunit alpha	0.0496	0.3943	1
Toxoplasma gondii	ribonucleoside-diphosphate reductase small subunit	0.014	0.0975	0.1057
Mycobacterium tuberculosis	Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like)	0.0078	0.0461	0.1154
Echinococcus granulosus	tubulin epsilon chain	0.004	0.0144	0.033
Mycobacterium tuberculosis	Ribonucleoside-diphosphate reductase (beta chain) NrdB (ribonucleotide reductase small chain)	0.014	0.0975	0.2461
Mycobacterium leprae	PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5)	0.0078	0.0461	0.069
Mycobacterium tuberculosis	Probable transcriptional regulatory protein NrdR	0.0049	0.0212	0.0522
Brugia malayi	TATA binding protein associated factor	0.0056	0.0276	0.0622
Plasmodium falciparum	tubulin gamma chain	0.004	0.0144	0.015
Echinococcus multilocularis	eukaryotic initiation factor 4A III	0.0024	0.0006	0.0015
Echinococcus multilocularis	tubulin alpha chain	0.004	0.0144	0.033
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0078	0.0461	0.1154
Brugia malayi	Peptidase family M1 containing protein	0.0056	0.0276	0.0622
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0461	0.1046
Trichomonas vaginalis	tubulin gamma chain, putative	0.004	0.0144	0.0349
Echinococcus multilocularis	peroxisome assembly protein 26	0.004	0.0144	0.033
Schistosoma mansoni	Tata binding protein associated factor (M01 family)	0.0056	0.0276	0.0276
Schistosoma mansoni	tubulin subunit beta	0.0104	0.0673	0.0673
Schistosoma mansoni	tubulin subunit beta	0.0104	0.0673	0.0673
Echinococcus multilocularis	Peptidase S8 S53, subtilisin kexin sedolisin	0.0078	0.0461	0.106
Echinococcus multilocularis	Tubulin alpha 1 chain	0.004	0.0144	0.033
Trypanosoma brucei	beta tubulin	0.0104	0.0673	0.1535
Onchocerca volvulus		0.0144	0.1005	0.3307
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0078	0.0461	0.1154
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0078	0.0461	0.1154
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0104	0.0673	0.1693
Trypanosoma brucei	beta tubulin	0.0104	0.0673	0.1535
Mycobacterium tuberculosis	Probable aminopeptidase PepB	0.0115	0.0763	0.1922
Trypanosoma brucei	ribonucleoside-diphosphate reductase small chain	0.014	0.0975	0.2231
Trypanosoma brucei	metallo-peptidase, Clan MF, Family M17	0.0068	0.0374	0.0846
Brugia malayi	tubulin alpha chain - mouse	0.004	0.0144	0.0316
Echinococcus multilocularis	eukaryotic initiation factor 4A	0.0024	0.0006	0.0015
Mycobacterium ulcerans	membrane-anchored mycosin MycP3	0.0078	0.0461	0.069
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.004	0.0144	0.0349
Echinococcus granulosus	Tubulin beta 2C chain	0.0104	0.0673	0.1547
Leishmania major	ribonucleoside-diphosphate reductase large chain, putative	0.0545	0.4348	1
Loa Loa (eye worm)	endoprotease bli-4	0.0078	0.0461	0.1046
Plasmodium falciparum	tubulin beta chain	0.0104	0.0673	0.0727
Toxoplasma gondii	subtilisin SUB6	0.0078	0.0461	0.0496
Schistosoma mansoni	tubulin subunit alpha	0.004	0.0144	0.0144
Schistosoma mansoni	site-1 peptidase (S08 family)	0.0078	0.0461	0.0461
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0087	0.0536	0.1233
Trichomonas vaginalis	tubulin epsilon chain, putative	0.004	0.0144	0.0349
Echinococcus multilocularis	Tubulin beta 2C chain	0.0104	0.0673	0.1547
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0078	0.0461	0.1154
Plasmodium vivax	M17 leucyl aminopeptidase, putative	0.0115	0.0763	0.0826
Trypanosoma brucei	beta tubulin	0.0104	0.0673	0.1535
Echinococcus granulosus	Tubulin beta 2C chain	0.0104	0.0673	0.1547
Trichomonas vaginalis	tubulin beta chain, putative	0.004	0.0144	0.0349
Brugia malayi	N-myristoyltransferase 2	0.0182	0.1324	0.3034
Trichomonas vaginalis	ribonucleoside-diphosphate reductase alpha chain, putative	0.0496	0.3943	1
Echinococcus multilocularis	tubulin alpha 3 chain	0.004	0.0144	0.033
Leishmania major	beta tubulin	0.0104	0.0673	0.1535
Brugia malayi	Subtilase family protein	0.0078	0.0461	0.1046
Trypanosoma cruzi	cytosolic leucyl aminopeptidase, putative	0.0068	0.0374	0.0846
Toxoplasma gondii	subtilisin SUB8	0.0078	0.0461	0.0496
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0461	0.1046
Echinococcus granulosus	tubulin alpha chain	0.004	0.0144	0.033
Echinococcus multilocularis	tubulin subunit TubB	0.004	0.0144	0.033
Entamoeba histolytica	tubulin family protein	0.0104	0.0673	0.5059
Mycobacterium leprae	Possible secreted protease	0.0078	0.0461	0.069
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0078	0.0461	0.1154
Schistosoma mansoni	leukotriene A4 hydrolase (M01 family)	0.0056	0.0276	0.0276
Leishmania major	alpha tubulin	0.004	0.0144	0.0316
Loa Loa (eye worm)	tubulin beta chain	0.0104	0.0673	0.1535
Plasmodium falciparum	ribonucleoside-diphosphate reductase small chain, putative	0.014	0.0975	0.1057
Trichomonas vaginalis	tubulin beta chain, putative	0.004	0.0144	0.0349
Plasmodium vivax	M1-family alanyl aminopeptidase, putative	0.0056	0.0276	0.0295
Schistosoma mansoni	tubulin subunit beta	0.0104	0.0673	0.0673
Trichomonas vaginalis	conserved hypothetical protein	0.0078	0.0461	0.1154
Onchocerca volvulus		0.0078	0.0461	0.1504
Echinococcus granulosus	tubulin subunit TubB	0.004	0.0144	0.033
Trypanosoma cruzi	ribonucleoside-diphosphate reductase small chain, putative	0.014	0.0975	0.2231
Plasmodium falciparum	M1-family alanyl aminopeptidase	0.0342	0.266	0.2897
Echinococcus multilocularis	tubulin gamma 1 chain	0.004	0.0144	0.033
Toxoplasma gondii	subtilisin SUB10	0.0078	0.0461	0.0496
Leishmania major	ribonucleoside-diphosphate reductase small chain, putative	0.014	0.0975	0.2231
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.0024	0.0006	0.0006
Echinococcus multilocularis	tubulin alpha chain	0.004	0.0144	0.033
Loa Loa (eye worm)	peptidase family M1 containing protein	0.0299	0.2298	0.5278
Plasmodium falciparum	alpha tubulin 1	0.004	0.0144	0.015
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0078	0.0461	0.1154
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0078	0.0461	0.1154
Echinococcus granulosus	Furin 1	0.0078	0.0461	0.106
Brugia malayi	hypothetical protein	0.0056	0.0276	0.0622
Echinococcus granulosus	tubulin alpha 3 chain	0.004	0.0144	0.033
Plasmodium vivax	tubulin gamma chain, putative	0.004	0.0144	0.015
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0078	0.0461	0.1154
Brugia malayi	Guanylate kinase family protein	0.0026	0.002	0.0031
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0056	0.0276	0.0635
Trichomonas vaginalis	tubulin epsilon chain, putative	0.004	0.0144	0.0349
Echinococcus multilocularis	tubulin alpha chain	0.004	0.0144	0.033
Echinococcus granulosus	beta tubulin	0.0104	0.0673	0.1547
Trypanosoma cruzi	ribonucleoside-diphosphate reductase large chain, putative	0.0545	0.4348	1
Echinococcus multilocularis	tubulin alpha 1C chain	0.004	0.0144	0.033
Leishmania major	alpha tubulin	0.004	0.0144	0.0316
Plasmodium falciparum	M1-family alanyl aminopeptidase, putative	0.0056	0.0276	0.0295
Schistosoma mansoni	alpha tubulin	0.004	0.0144	0.0144
Trypanosoma brucei	aminopeptidase, putative	0.0056	0.0276	0.0622
Leishmania major	aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.0144	0.1005	0.2301
Schistosoma mansoni	N-myristoyltransferase	0.0182	0.1324	0.1324
Echinococcus granulosus	peptidase s8 s53 subtilisin kexin sedolisin	0.0078	0.0461	0.106
Trichomonas vaginalis	tubulin gamma chain, putative	0.0104	0.0673	0.1693
Chlamydia trachomatis	ribonucleoside-diphosphate reductase subunit beta	0.014	0.0975	0.1845
Trichomonas vaginalis	N-myristoyl transferase, putative	0.0182	0.1324	0.3346
Chlamydia trachomatis	cytosol aminopeptidase	0.0115	0.0763	0.1332
Trypanosoma cruzi	puromycin-sensitive aminopeptidase-like protein, putative	0.0056	0.0276	0.0622
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0144	0.1005	0.2312
Brugia malayi	neuroendocrine convertase 1 precursor	0.0078	0.0461	0.1046
Loa Loa (eye worm)	tubulin alpha chain	0.004	0.0144	0.0316
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0078	0.0461	0.1154
Loa Loa (eye worm)	tubulin alpha chain	0.004	0.0144	0.0316
Echinococcus granulosus	tubulin alpha 3 chain	0.004	0.0144	0.033
Brugia malayi	Tubulin alpha chain	0.004	0.0144	0.0316
Toxoplasma gondii	subtilisin SUB4	0.0078	0.0461	0.0496
Trypanosoma cruzi	ribonucleoside-diphosphate reductase large chain, putative	0.0152	0.1076	0.2463
Plasmodium vivax	subtilisin-like protease 2, putative	0.0078	0.0461	0.0496
Schistosoma mansoni	tubulin subunit alpha	0.004	0.0144	0.0144
Toxoplasma gondii	subtilisin SUB7	0.0078	0.0461	0.0496
Trypanosoma brucei	alpha tubulin	0.004	0.0144	0.0316
Leishmania major	alpha tubulin	0.004	0.0144	0.0316
Leishmania major	ribonucleoside-diphosphate reductase small chain, putative	0.014	0.0975	0.2231
Leishmania major	alpha tubulin	0.004	0.0144	0.0316
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0536	0.122
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.0056	0.0276	0.0622
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.0078	0.0461	0.0461
Mycobacterium leprae	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN)	0.0496	0.3943	1
Mycobacterium tuberculosis	Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4)	0.0078	0.0461	0.1154
Loa Loa (eye worm)	aminopeptidase N	0.0144	0.1005	0.2301
Toxoplasma gondii	aminopeptidase N, putative	0.0342	0.266	0.2897
Schistosoma mansoni	tubulin subunit gamma	0.004	0.0144	0.0144
Plasmodium vivax	ribonucleoside-diphosphate reductase small chain, putative	0.014	0.0975	0.1057
Trypanosoma cruzi	serine peptidase, clan SB, family S8-like protein	0.0078	0.0461	0.1046
Plasmodium falciparum	tubulin epsilon chain, putative	0.004	0.0144	0.015
Echinococcus multilocularis	beta tubulin	0.0104	0.0673	0.1547
Plasmodium vivax	ribonucleoside-diphosphate reductase large chain, putative	0.0545	0.4348	0.4739
Trypanosoma cruzi	puromycin-sensitive aminopeptidase-like protein, putative	0.0056	0.0276	0.0622

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 814568