Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0305 | 0.169 | 0.3504 |
Treponema pallidum | penicillin-binding protein (pbp-2) | 0.0791 | 0.4591 | 0.4583 |
Brugia malayi | polk-prov protein | 0.0032 | 0.0062 | 0.0051 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0116 | 0.0561 | 0.8291 |
Loa Loa (eye worm) | glutaminase | 0.0285 | 0.1572 | 1 |
Onchocerca volvulus | 0.0247 | 0.1345 | 1 | |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0031 | 0.0055 | 0.0111 |
Chlamydia trachomatis | transglycolase/transpeptidase | 0.0773 | 0.4481 | 0.4473 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0123 | 0.0604 | 0.9002 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0116 | 0.0561 | 0.3336 |
Brugia malayi | glutaminase DH11.1 | 0.0285 | 0.1572 | 1 |
Treponema pallidum | penicillin-binding protein (pbp-1) | 0.1697 | 1 | 1 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0149 | 0.0758 | 0.1273 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0305 | 0.169 | 0.1678 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0305 | 0.169 | 1 |
Echinococcus granulosus | dna polymerase kappa | 0.0043 | 0.0125 | 0.1243 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0791 | 0.4591 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0125 | 0.1873 |
Mycobacterium leprae | PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE | 0.0791 | 0.4591 | 0.7834 |
Mycobacterium tuberculosis | Possible penicillin-binding lipoprotein | 0.0312 | 0.1729 | 0.2953 |
Mycobacterium ulcerans | bifunctional penicillin-binding protein 1A/1B PonA1 | 0.0791 | 0.4591 | 0.5315 |
Treponema pallidum | penicillin-binding protein (pbp-3) | 0.1467 | 0.8625 | 0.8623 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0043 | 0.0125 | 0.1873 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0043 | 0.0125 | 0.0128 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0133 | 0.0665 | 0.3884 |
Mycobacterium tuberculosis | holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie | 0.0024 | 0.0014 | 0.0025 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0087 | 0.0387 | 0.2188 |
Plasmodium falciparum | holo-[acyl-carrier-protein] synthase, putative | 0.0024 | 0.0014 | 0.5 |
Trichomonas vaginalis | set domain proteins, putative | 0.0247 | 0.1345 | 0.2731 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0032 | 0.0062 | 0.0938 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0133 | 0.0665 | 0.4023 |
Leishmania major | phosphopantetheinyl transferase-like protein | 0.0024 | 0.0014 | 0.0217 |
Mycobacterium ulcerans | penicillin-binding lipoprotein | 0.0312 | 0.1729 | 0.1991 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0305 | 0.169 | 0.3504 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0116 | 0.0561 | 0.0958 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0125 | 0.1873 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0116 | 0.0561 | 0.8432 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0125 | 0.1873 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0087 | 0.0387 | 0.5439 |
Mycobacterium leprae | Probable penicillin-binding membrane protein PbpB | 0.0461 | 0.2621 | 0.4462 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0043 | 0.0125 | 0.1873 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0305 | 0.169 | 0.3504 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0305 | 0.169 | 0.3504 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0133 | 0.0665 | 0.4023 |
Schistosoma mansoni | lipoxygenase | 0.0123 | 0.0604 | 0.3617 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0125 | 0.1873 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0108 | 0.0514 | 0.3029 |
Mycobacterium tuberculosis | Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase | 0.0247 | 0.134 | 0.2289 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0133 | 0.0665 | 0.4023 |
Mycobacterium ulcerans | bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 | 0.0545 | 0.3119 | 0.3606 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0116 | 0.0561 | 0.831 |
Mycobacterium tuberculosis | Probable penicillin-binding protein PbpA | 0.1003 | 0.5856 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0125 | 0.1873 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0133 | 0.0665 | 1 |
Loa Loa (eye worm) | glutaminase 2 | 0.0285 | 0.1572 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0305 | 0.169 | 0.3504 |
Wolbachia endosymbiont of Brugia malayi | cell division protein FtsI | 0.1697 | 1 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0123 | 0.0604 | 0.8991 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0087 | 0.0387 | 0.2188 |
Trypanosoma brucei | unspecified product | 0.0036 | 0.0083 | 0.1255 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0031 | 0.0055 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0217 | 0.1165 | 0.7321 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0032 | 0.0062 | 0.0938 |
Mycobacterium ulcerans | penicillin-binding membrane protein PbpB | 0.1467 | 0.8625 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0305 | 0.169 | 1 |
Mycobacterium leprae | Probable penicillin-binding protein PbpA | 0.1003 | 0.5856 | 1 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0133 | 0.0665 | 1 |
Onchocerca volvulus | 0.0087 | 0.0387 | 0.2574 | |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0125 | 0.1873 |
Mycobacterium leprae | POSSIBLE PENICILLIN-BINDING LIPOPROTEIN | 0.0312 | 0.1729 | 0.2935 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0024 | 0.0014 | 0.0217 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0125 | 0.1873 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0149 | 0.0758 | 0.1295 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0036 | 0.0083 | 0.1255 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0133 | 0.0665 | 1 |
Mycobacterium ulcerans | glutaminase | 0.0285 | 0.1572 | 0.1809 |
Mycobacterium leprae | PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN | 0.0545 | 0.3119 | 0.5315 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0305 | 0.169 | 0.3504 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0125 | 0.1873 |
Mycobacterium tuberculosis | Probable penicillin-binding membrane protein PbpB | 0.0461 | 0.2621 | 0.4476 |
Mycobacterium ulcerans | penicillin-binding protein PbpA | 0.1003 | 0.5856 | 0.6784 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0116 | 0.0561 | 0.0635 |
Echinococcus multilocularis | dna polymerase kappa | 0.0043 | 0.0125 | 0.1145 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0149 | 0.0758 | 0.0864 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0077 | 0.033 | 0.4505 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0305 | 0.169 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0305 | 0.169 | 0.3504 |
Brugia malayi | Pre-SET motif family protein | 0.0217 | 0.1165 | 0.7321 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.0387 | 0.2188 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0116 | 0.0561 | 0.0635 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0077 | 0.033 | 0.4566 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0116 | 0.0561 | 0.3336 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0133 | 0.0665 | 1 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0133 | 0.0665 | 1 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0087 | 0.0387 | 0.549 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0062 | 0.0051 |
Mycobacterium tuberculosis | Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen | 0.0545 | 0.3119 | 0.5326 |
Schistosoma mansoni | lipoxygenase | 0.0086 | 0.0382 | 0.216 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0305 | 0.169 | 0.3504 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0125 | 0.1873 |
Plasmodium vivax | SET domain protein, putative | 0.0031 | 0.0055 | 1 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0133 | 0.0665 | 1 |
Schistosoma mansoni | glutaminase | 0.0285 | 0.1572 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0043 | 0.0125 | 0.0128 |
Trichomonas vaginalis | glutaminase, putative | 0.0285 | 0.1572 | 0.324 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.