TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 427.495 | Formula: C26H25N3O3
H donors: 2 H acceptors: 3 LogP: 4.16 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Oc1ccccc1c1n[nH]c2c1C(c1ccc(cc1)C(C)(C)C)N(C2=O)Cc1ccco1
InChi: 1S/C26H25N3O3/c1-26(2,3)17-12-10-16(11-13-17)24-21-22(19-8-4-5-9-20(19)30)27-28-23(21)25(31)29(24)15-18-7-6-14-32-18/h4-14,24,30H,15H2,1-3H3,(H,27,28)
InChiKey: WOBPUSRDWMVJPI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	DNA polymerase kappa, putative	0.0032	0.0071	0.0938
Loa Loa (eye worm)	animal heme peroxidase	0.0027	0.0042	0.0054
Onchocerca volvulus	Peroxidasin homolog	0.0027	0.0042	0.0294
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0304	0.1697	0.3575
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0278	0.0362
Mycobacterium leprae	POSSIBLE PENICILLIN-BINDING LIPOPROTEIN	0.0311	0.1736	0.2935
Schistosoma mansoni	lipoxygenase	0.0086	0.0391	0.1194
Trypanosoma brucei	DNA polymerase kappa, putative	0.0032	0.0071	0.0938
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0042	0.0054
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0035	0.0084	0.1247
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0149	0.2218
Schistosoma mansoni	camp-specific cyclic nucleotide phosphodiesterase	0.0035	0.0084	0.0257
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0035	0.0084	0.0257
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0071	0.0216
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0084	0.0109
Echinococcus granulosus	histone lysine methyltransferase setb	0.0032	0.0071	0.105
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0035	0.0084	1
Loa Loa (eye worm)	glutaminase 2	0.0567	0.3271	0.4254
Giardia lamblia	Fructose-bisphosphate aldolase	0.0304	0.1697	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0043	0.0133	0.0832
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0035	0.0084	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.0133	0.1873
Plasmodium vivax	cyclic nucleotide phosphodiesterase, putative	0.0035	0.0084	1
Leishmania major	cAMP-specific phosphodiesterase, putative	0.0035	0.0084	0.1136
Leishmania major	hypothetical protein, conserved	0.0035	0.0084	0.1136
Loa Loa (eye worm)	hypothetical protein	0.127	0.7481	0.9731
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0149	0.2218
Mycobacterium ulcerans	penicillin-binding lipoprotein	0.0311	0.1736	0.1991
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0116	0.0569	0.1739
Echinococcus multilocularis	peroxidasin	0.0027	0.0042	0.0617
Mycobacterium ulcerans	glutaminase	0.0567	0.3271	0.3775
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.0035	0.0084	0.1247
Echinococcus multilocularis	transcription factor Dp 1	0.0077	0.0338	0.502
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0035	0.0084	0.1247
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0148	0.0766	0.1295
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0035	0.0084	0.1247
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0133	0.0673	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0043	0.0133	0.1873
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0225	0.1225	0.1594
Brugia malayi	Ets-domain containing protein	0.0078	0.0346	0.0451
Trypanosoma brucei	unspecified product	0.0036	0.0092	0.1255
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0035	0.0084	0.1247
Echinococcus granulosus	L aminoadipate semialdehyde	0.0086	0.0395	0.5867
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0304	0.1697	1
Mycobacterium ulcerans	bifunctional penicillin-binding protein 1A/1B PonA1	0.0788	0.4595	0.5315
Trypanosoma brucei	DNA polymerase IV, putative	0.0036	0.0092	0.1255
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0035	0.0084	0.0257
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0133	0.0673	1
Schistosoma mansoni	lipoxygenase	0.0123	0.0611	0.1869
Mycobacterium ulcerans	DNA polymerase IV	0.0043	0.0133	0.0128
Mycobacterium leprae	PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE	0.0788	0.4595	0.7834
Mycobacterium leprae	Probable penicillin-binding protein PbpA	0.0999	0.5859	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0035	0.0084	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.0133	0.1873
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0035	0.0084	0.0109
Loa Loa (eye worm)	animal heme peroxidase	0.0027	0.0042	0.0054
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0133	0.0673	0.3884
Echinococcus granulosus	dna polymerase kappa	0.0043	0.0133	0.1975
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.0035	0.0084	0.1247
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0116	0.0569	0.8451
Echinococcus granulosus	peroxidasin	0.0027	0.0042	0.0617
Mycobacterium tuberculosis	Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen	0.0543	0.3125	0.5326
Leishmania major	phosphopantetheinyl transferase-like protein	0.0024	0.0023	0.0217
Loa Loa (eye worm)	fli-1 protein	0.0238	0.1301	0.1693
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.0035	0.0084	0.0109
Mycobacterium tuberculosis	Probable penicillin-binding protein PbpA	0.0999	0.5859	1
Loa Loa (eye worm)	calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase	0.0035	0.0084	0.0109
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.0133	0.1873
Echinococcus granulosus	transcription factor Dp 1	0.0077	0.0338	0.502
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0116	0.0569	0.8432
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0035	0.0084	1
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0035	0.0084	0.1247
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.0133	0.1873
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0042	0.0054
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0035	0.0084	0.0257
Loa Loa (eye worm)	blistered cuticle protein 3	0.0027	0.0042	0.0054
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0035	0.0084	0.1136
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0042	0.0054
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0043	0.0133	0.0832
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.1305	0.7688	1
Brugia malayi	Animal haem peroxidase family protein	0.0027	0.0042	0.0054
Schistosoma mansoni	gabp alpha	0.0078	0.0346	0.1059
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.0133	0.1873
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0035	0.0084	0.1247
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.0133	0.1873
Schistosoma mansoni	peroxidasin	0.0027	0.0042	0.0127
Brugia malayi	hypothetical protein	0.0027	0.0042	0.0054
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0133	0.0673	1
Trichomonas vaginalis	DNA polymerase eta, putative	0.0043	0.0133	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0071	0.0092
Echinococcus granulosus	high affinity cgmp specific 3' 5' cyclic	0.0035	0.0084	0.1247
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0084	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0042	0.0054
Onchocerca volvulus	Chorion peroxidase homolog	0.0027	0.0042	0.0294
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0149	0.0456
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0042	0.0054
Onchocerca volvulus		0.0086	0.0395	0.2797
Schistosoma mansoni	glutaminase	0.0567	0.3271	1
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0035	0.0084	0.0257
Brugia malayi	Fli-1 protein	0.0238	0.1301	0.1693
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0086	0.0395	0.5867
Trichomonas vaginalis	glutaminase, putative	0.0567	0.3271	0.7064
Echinococcus multilocularis	high affinity cgmp specific 3' 5' cyclic	0.0035	0.0084	0.1247
Mycobacterium leprae	Probable penicillin-binding membrane protein PbpB	0.0459	0.2627	0.4462
Mycobacterium tuberculosis	Probable penicillin-binding membrane protein PbpB	0.0459	0.2627	0.4476
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.0133	0.1873
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0304	0.1697	0.3575
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0035	0.0084	1
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0035	0.0084	0.0109
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsI	0.1691	1	1
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0032	0.0071	0.7829
Giardia lamblia	Hypothetical protein	0.0035	0.0084	0.0447
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0304	0.1697	0.3575
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0032	0.0071	0.105
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0035	0.0084	1
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0395	0.0514
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0123	0.0611	0.9086
Echinococcus granulosus	GA binding protein alpha chain	0.0078	0.0346	0.5147
Loa Loa (eye worm)	glutaminase	0.0567	0.3271	0.4254
Loa Loa (eye worm)	hypothetical protein	0.0359	0.2025	0.2634
Echinococcus granulosus	high affinity cAMP specific 3'5' cyclic	0.0035	0.0084	0.1247
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0133	0.0673	1
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0078	0.0346	0.0451
Echinococcus multilocularis	high affinity cAMP specific 3',5' cyclic	0.0035	0.0084	0.1247
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0035	0.0084	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0035	0.0084	1
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0035	0.0084	0.0257
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0042	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0071	0.0092
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0304	0.1697	0.3575
Mycobacterium ulcerans	penicillin-binding protein PbpA	0.0999	0.5859	0.6784
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0148	0.0766	0.0864
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0035	0.0084	1
Trypanosoma brucei	cAMP phosphodiesterase A, putative	0.0035	0.0084	0.1136
Treponema pallidum	penicillin-binding protein (pbp-3)	0.1462	0.8626	0.8623
Schistosoma mansoni	ets-related	0.0238	0.1301	0.3979
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0042	0.0054
Plasmodium falciparum	phosphodiesterase delta, putative	0.0035	0.0084	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0149	0.0456
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0043	0.0133	0.0832
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0035	0.0084	1
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0148	0.0766	0.1273
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0304	0.1697	0.3575
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative	0.0035	0.0084	0.0109
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0035	0.0084	1
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0031	0.0064	0.0944
Trypanosoma brucei	DNA polymerase IV, putative	0.0043	0.0133	0.1873
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0116	0.0569	0.0635
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0035	0.0084	0.1136
Brugia malayi	Animal haem peroxidase family protein	0.0027	0.0042	0.0054
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0149	0.0194
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0035	0.0084	1
Plasmodium vivax	holo-[acyl-carrier-protein] synthase, putative	0.0024	0.0023	0.2721
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0035	0.0084	0.1136
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0086	0.0395	0.1207
Trypanosoma brucei	cAMP-specific phosphodiesterase, putative	0.0035	0.0084	0.1136
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0042	0.0054
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0116	0.0569	0.074
Loa Loa (eye worm)	animal heme peroxidase	0.0027	0.0042	0.0054
Onchocerca volvulus		0.0027	0.0042	0.0294
Onchocerca volvulus		0.0032	0.0071	0.05
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0304	0.1697	0.3575
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	0.0035	0.0084	0.0447
Plasmodium vivax	phosphodiesterase gamma, putative	0.0035	0.0084	1
Treponema pallidum	penicillin-binding protein (pbp-2)	0.0788	0.4595	0.4583
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0133	0.0673	0.2058
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0035	0.0084	0.1247
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0108	0.0522	0.0679
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0149	0.0456
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0042	0.0054
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0116	0.0569	0.8451
Chlamydia trachomatis	transglycolase/transpeptidase	0.077	0.4486	0.4473
Loa Loa (eye worm)	animal heme peroxidase	0.0027	0.0042	0.0054
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0071	0.0216
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0149	0.2218
Brugia malayi	Animal haem peroxidase family protein	0.0027	0.0042	0.0054
Mycobacterium tuberculosis	Possible penicillin-binding lipoprotein	0.0311	0.1736	0.2953
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0116	0.0569	0.0635
Brugia malayi	Animal haem peroxidase family protein	0.0027	0.0042	0.0054
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0304	0.1697	0.3575
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0035	0.0084	1
Mycobacterium tuberculosis	Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase	0.0246	0.1348	0.2289
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0035	0.0084	0.0257
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0035	0.0084	0.0257
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0035	0.0084	1
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0084	0.1136
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0032	0.0071	0.0216
Loa Loa (eye worm)	hypothetical protein	0.1305	0.7688	1
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0123	0.0611	0.9086
Plasmodium falciparum	phosphodiesterase gamma, putative	0.0035	0.0084	1
Brugia malayi	Pre-SET motif family protein	0.0032	0.0071	0.0092
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0116	0.0569	0.0958
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0042	0.0054
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0035	0.0084	1
Trichomonas vaginalis	set domain proteins, putative	0.0256	0.1412	0.2943
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0071	0.0216
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0035	0.0084	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0035	0.0084	1
Mycobacterium ulcerans	bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2	0.0543	0.3125	0.3606
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0149	0.2218
Onchocerca volvulus		0.0027	0.0042	0.0294
Plasmodium falciparum	holo-[acyl-carrier-protein] synthase, putative	0.0024	0.0023	0.2721
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0035	0.0084	0.0257
Plasmodium vivax	SET domain protein, putative	0.0032	0.0071	0.842
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0304	0.1697	0.3575
Schistosoma mansoni	peroxidasin	0.0027	0.0042	0.0127
Trichomonas vaginalis	conserved hypothetical protein	0.0788	0.4595	1
Leishmania major	cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100	0.0035	0.0084	0.1136
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0035	0.0084	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0042	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0042	0.0054
Brugia malayi	glutaminase DH11.1	0.0567	0.3271	0.4254
Schistosoma mansoni	calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase	0.0035	0.0084	0.0257
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0084	0.0109
Brugia malayi	Peroxidasin	0.0027	0.0042	0.0054
Loa Loa (eye worm)	PDE1B protein	0.0035	0.0084	0.0109
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.0133	0.1873
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0035	0.0084	1
Brugia malayi	Ets-domain containing protein	0.0078	0.0346	0.0451
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0035	0.0084	0.1136
Onchocerca volvulus		0.0027	0.0042	0.0294
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0042	0.0054
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0133	0.0673	1
Treponema pallidum	penicillin-binding protein (pbp-1)	0.1691	1	1
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0035	0.0084	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0035	0.0084	1
Echinococcus multilocularis	GA binding protein alpha chain	0.0078	0.0346	0.5147
Mycobacterium leprae	PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN	0.0543	0.3125	0.5315
Brugia malayi	polk-prov protein	0.0032	0.0071	0.0092
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0035	0.0084	1
Brugia malayi	Pre-SET motif family protein	0.0225	0.1225	0.1594
Onchocerca volvulus		0.0256	0.1412	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0149	0.0194
Mycobacterium ulcerans	penicillin-binding membrane protein PbpB	0.1462	0.8626	1
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0035	0.0084	0.1247
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0133	0.0673	1
Brugia malayi	Blistered cuticle protein 3	0.0027	0.0042	0.0054
Onchocerca volvulus	Peroxidase homolog	0.0027	0.0042	0.0294
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0043	0.0133	0.0832
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0035	0.0084	1
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0043	0.0133	0.0109
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0035	0.0084	0.0109
Giardia lamblia	hypothetical protein	0.0035	0.0084	0.0447
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0035	0.0084	0.1247
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.0133	0.1873
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0035	0.0084	0.1247
Mycobacterium ulcerans	DNA polymerase IV	0.0043	0.0133	0.0128
Brugia malayi	hypothetical protein	0.0138	0.0701	0.0912
Brugia malayi	Animal haem peroxidase family protein	0.0027	0.0042	0.0054
Trypanosoma brucei	hypothetical protein, conserved	0.0024	0.0023	0.0217
Leishmania major	hypothetical protein, conserved	0.0035	0.0084	0.1136
Onchocerca volvulus	Peroxidasin homolog	0.0027	0.0042	0.0294
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0133	0.0673	0.0875
Mycobacterium tuberculosis	holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie	0.0024	0.0023	0.0025
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.0035	0.0084	0.0257
Treponema pallidum	fructose-bisphosphate aldolase	0.0304	0.1697	0.1678
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0035	0.0084	1
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0032	0.0071	0.105
Onchocerca volvulus	Dual oxidase homolog	0.0027	0.0042	0.0294
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0133	0.0673	0.0875
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0042	0.0054
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0086	0.0395	0.0514
Onchocerca volvulus	Peroxidase homolog	0.0027	0.0042	0.0294
Echinococcus multilocularis	dna polymerase kappa	0.0043	0.0133	0.1975
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0304	0.1697	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 822664