Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0215 | 0.1458 | 0.5643 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0873 | 0.6309 | 1 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0028 | 0.0079 | 0.003 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0044 | 0.0198 | 0.0765 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0215 | 0.1458 | 0.2237 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0215 | 0.1458 | 0.5643 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0088 | 0.0521 | 0.2016 |
Echinococcus multilocularis | lamin dm0 | 0.0032 | 0.011 | 0.0425 |
Schistosoma mansoni | lamin | 0.0032 | 0.011 | 0.0425 |
Loa Loa (eye worm) | hypothetical protein | 0.0215 | 0.1458 | 0.5644 |
Echinococcus granulosus | GTP binding nuclear protein Ran | 0.0025 | 0.006 | 0.0229 |
Echinococcus granulosus | ubiquitin specific protease 41 | 0.0044 | 0.0198 | 0.0766 |
Trypanosoma brucei | beta lactamase | 0.0076 | 0.0434 | 0.2675 |
Brugia malayi | RNA, U transporter 1 | 0.0098 | 0.0595 | 0.408 |
Mycobacterium leprae | Probable lipase LipE | 0.0215 | 0.1458 | 0.2106 |
Onchocerca volvulus | 0.0215 | 0.1458 | 1 | |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0215 | 0.1458 | 0.2237 |
Echinococcus granulosus | snurportin 1 | 0.0368 | 0.2583 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0032 | 0.011 | 0.0756 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0028 | 0.0079 | 0.0136 |
Schistosoma mansoni | importin beta-1 | 0.0034 | 0.0127 | 0.0489 |
Mycobacterium tuberculosis | Probable conserved lipoprotein LpqF | 0.0076 | 0.0434 | 0.0274 |
Entamoeba histolytica | hypothetical protein | 0.0028 | 0.0079 | 0.137 |
Trichomonas vaginalis | importin beta-1, putative | 0.0028 | 0.0079 | 0.003 |
Mycobacterium ulcerans | beta-lactamase | 0.0215 | 0.1458 | 0.1949 |
Mycobacterium leprae | PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN | 0.0534 | 0.3807 | 0.5929 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0368 | 0.2583 | 1 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0028 | 0.0079 | 0.003 |
Leishmania major | hypothetical protein, conserved | 0.0215 | 0.1458 | 1 |
Treponema pallidum | penicillin-binding protein (pbp-2) | 0.0873 | 0.6309 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0215 | 0.1458 | 0.5644 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0044 | 0.0198 | 0.0221 |
Echinococcus granulosus | intermediate filament protein | 0.0032 | 0.011 | 0.0425 |
Brugia malayi | Inositol-1 | 0.0044 | 0.0198 | 0.1358 |
Plasmodium vivax | hypothetical protein, conserved | 0.0215 | 0.1458 | 1 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0044 | 0.0198 | 0.099 |
Echinococcus multilocularis | musashi | 0.0032 | 0.011 | 0.0425 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.0044 | 0.0198 | 1 |
Brugia malayi | beta-lactamase | 0.0215 | 0.1458 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0215 | 0.1458 | 0.2237 |
Wolbachia endosymbiont of Brugia malayi | cell division protein FtsI | 0.0817 | 0.59 | 1 |
Mycobacterium ulcerans | penicillin-binding lipoprotein | 0.0213 | 0.1444 | 0.1928 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0198 | 0.0768 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0044 | 0.0198 | 0.099 |
Mycobacterium tuberculosis | Conserved protein | 0.0215 | 0.1458 | 0.1316 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0215 | 0.1458 | 0.2237 |
Leishmania major | importin beta-1 subunit, putative | 0.0028 | 0.0079 | 0.0136 |
Schistosoma mansoni | inositol monophosphatase | 0.0044 | 0.0198 | 0.0765 |
Echinococcus granulosus | geminin | 0.0202 | 0.1365 | 0.5283 |
Mycobacterium tuberculosis | Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase | 0.0339 | 0.2375 | 0.2248 |
Mycobacterium tuberculosis | Conserved protein | 0.0215 | 0.1458 | 0.1316 |
Echinococcus multilocularis | Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 | 0.0044 | 0.0198 | 0.0766 |
Mycobacterium tuberculosis | Probable penicillin-binding protein PbpA | 0.0488 | 0.347 | 0.3361 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0127 | 0.049 |
Onchocerca volvulus | 0.0215 | 0.1458 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0215 | 0.1458 | 0.5644 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0215 | 0.1458 | 1 |
Echinococcus multilocularis | geminin | 0.0202 | 0.1365 | 0.5283 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0215 | 0.1458 | 0.1316 |
Mycobacterium leprae | Probable penicillin-binding protein PbpA | 0.0488 | 0.347 | 0.5379 |
Mycobacterium leprae | POSSIBLE PENICILLIN-BINDING LIPOPROTEIN | 0.0213 | 0.1444 | 0.2083 |
Echinococcus granulosus | Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 | 0.0044 | 0.0198 | 0.0766 |
Toxoplasma gondii | ABC1 family protein | 0.0215 | 0.1458 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0044 | 0.0198 | 0.0765 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0044 | 0.0198 | 0.0992 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0034 | 0.0127 | 0.0479 |
Schistosoma mansoni | hypothetical protein | 0.0202 | 0.1365 | 0.5283 |
Trichomonas vaginalis | esterase, putative | 0.0215 | 0.1458 | 0.2237 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0044 | 0.0198 | 0.0222 |
Loa Loa (eye worm) | hypothetical protein | 0.0215 | 0.1458 | 0.5644 |
Mycobacterium tuberculosis | Class a beta-lactamase BlaC | 0.0158 | 0.1041 | 0.0892 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0215 | 0.1458 | 0.1949 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.0025 | 0.006 | 0.0409 |
Mycobacterium ulcerans | lipase LipD | 0.0215 | 0.1458 | 0.1949 |
Loa Loa (eye worm) | intermediate filament protein | 0.0032 | 0.011 | 0.0427 |
Mycobacterium ulcerans | penicillin-binding protein PbpA | 0.0488 | 0.347 | 0.5061 |
Plasmodium vivax | importin-beta 2, putative | 0.0034 | 0.0127 | 0.0479 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0106 | 0.041 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0215 | 0.1458 | 1 |
Mycobacterium ulcerans | bifunctional penicillin-binding protein 1A/1B PonA1 | 0.0873 | 0.6309 | 0.9454 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0215 | 0.1458 | 0.1316 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0215 | 0.1458 | 0.1316 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0215 | 0.1458 | 0.1316 |
Schistosoma mansoni | ran | 0.0025 | 0.006 | 0.0229 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0215 | 0.1458 | 0.1949 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0044 | 0.0198 | 0.0992 |
Mycobacterium ulcerans | bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 | 0.0534 | 0.3807 | 0.5583 |
Trypanosoma brucei | ubiquitin carboxyl-terminal hydrolase, putative | 0.0044 | 0.0198 | 0.0992 |
Mycobacterium tuberculosis | Probable penicillin-binding membrane protein PbpB | 0.0272 | 0.1878 | 0.1743 |
Treponema pallidum | penicillin-binding protein (pbp-1) | 0.0817 | 0.59 | 0.0472 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0044 | 0.0198 | 0.9972 |
Schistosoma mansoni | ran | 0.0025 | 0.006 | 0.0229 |
Mycobacterium leprae | conserved hypothetical protein | 0.0215 | 0.1458 | 0.2106 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0044 | 0.0198 | 0.099 |
Mycobacterium ulcerans | hypothetical protein | 0.0215 | 0.1458 | 0.1949 |
Mycobacterium tuberculosis | Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen | 0.0534 | 0.3807 | 0.3704 |
Mycobacterium tuberculosis | Conserved protein | 0.0215 | 0.1458 | 0.1316 |
Plasmodium falciparum | importin beta, putative | 0.0034 | 0.0127 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0215 | 0.1458 | 0.5644 |
Schistosoma mansoni | hypothetical protein | 0.0368 | 0.2583 | 1 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0034 | 0.0127 | 0.0489 |
Brugia malayi | beta-lactamase family protein | 0.0215 | 0.1458 | 1 |
Brugia malayi | Importin beta-1 subunit | 0.0034 | 0.0127 | 0.0869 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0034 | 0.0127 | 0.0479 |
Mycobacterium ulcerans | penicillin-binding membrane protein PbpB | 0.0815 | 0.588 | 0.879 |
Mycobacterium tuberculosis | Possible penicillin-binding lipoprotein | 0.0213 | 0.1444 | 0.1302 |
Schistosoma mansoni | ubiquitin-specific peptidase 8 (C19 family) | 0.0044 | 0.0198 | 0.0766 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 8 | 0.0044 | 0.0198 | 0.0766 |
Loa Loa (eye worm) | inositol-1 | 0.0044 | 0.0198 | 0.0767 |
Mycobacterium leprae | PROBABLE CONSERVED LIPOPROTEIN LPQF | 0.0076 | 0.0434 | 0.0439 |
Echinococcus multilocularis | lamin | 0.0032 | 0.011 | 0.0425 |
Schistosoma mansoni | ubiquitin-specific peptidase 2 (C19 family) | 0.0044 | 0.0198 | 0.0766 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0032 | 0.011 | 0.0427 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0215 | 0.1458 | 0.1316 |
Mycobacterium ulcerans | multidrugs-transport integral membrane protein Mmr-like | 0.0921 | 0.6662 | 1 |
Mycobacterium ulcerans | multidrug-transport integral membrane protein Mmr | 0.0232 | 0.1583 | 0.2142 |
Echinococcus multilocularis | ubiquitin specific protease 41 | 0.0044 | 0.0198 | 0.0766 |
Echinococcus multilocularis | GTP binding nuclear protein Ran | 0.0025 | 0.006 | 0.0229 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0044 | 0.0198 | 0.0221 |
Brugia malayi | beta-lactamase family protein | 0.0215 | 0.1458 | 1 |
Chlamydia trachomatis | transglycolase/transpeptidase | 0.0817 | 0.59 | 1 |
Mycobacterium leprae | PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE | 0.0873 | 0.6309 | 1 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0044 | 0.0198 | 0.0765 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0215 | 0.1458 | 0.5643 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0044 | 0.0198 | 0.0222 |
Mycobacterium ulcerans | lipoprotein LpqF | 0.0076 | 0.0434 | 0.0365 |
Echinococcus granulosus | lamin | 0.0032 | 0.011 | 0.0425 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0215 | 0.1458 | 0.1316 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0044 | 0.0198 | 0.099 |
Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.0025 | 0.006 | 0.0231 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.0044 | 0.0198 | 1 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0215 | 0.1458 | 0.1316 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0044 | 0.0198 | 0.0222 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0034 | 0.0127 | 0.0479 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.011 | 0.0427 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0 | 0.0002 |
Brugia malayi | intermediate filament protein | 0.0032 | 0.011 | 0.0756 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0215 | 0.1458 | 0.5643 |
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | 0.0044 | 0.0198 | 0.0992 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0044 | 0.0198 | 0.0221 |
Echinococcus granulosus | lamin dm0 | 0.0032 | 0.011 | 0.0425 |
Echinococcus granulosus | importin subunit beta 1 | 0.0034 | 0.0127 | 0.0489 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0215 | 0.1458 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0032 | 0.011 | 0.0425 |
Onchocerca volvulus | 0.0215 | 0.1458 | 1 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0215 | 0.1458 | 1 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 8 | 0.0044 | 0.0198 | 0.0766 |
Mycobacterium leprae | Probable penicillin-binding membrane protein PbpB | 0.0272 | 0.1878 | 0.2789 |
Echinococcus granulosus | nuclear factor of activated T cells 5 | 0.0088 | 0.0521 | 0.2016 |
Schistosoma mansoni | hypothetical protein | 0.0202 | 0.1365 | 0.5283 |
Mycobacterium ulcerans | class a beta-lactamase, BlaC | 0.0158 | 0.1041 | 0.1305 |
Loa Loa (eye worm) | hypothetical protein | 0.0215 | 0.1458 | 0.5644 |
Schistosoma mansoni | lamin | 0.0032 | 0.011 | 0.0425 |
Echinococcus multilocularis | snurportin 1 | 0.0368 | 0.2583 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0215 | 0.1458 | 0.5644 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0044 | 0.0198 | 0.099 |
Loa Loa (eye worm) | beta-lactamase | 0.0215 | 0.1458 | 0.5644 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0215 | 0.1458 | 0.2237 |
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.0044 | 0.0198 | 0.1361 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.