Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | carbonic anhydrase | 0.2523 | 0.5051 | 0.5051 |
Loa Loa (eye worm) | hypothetical protein | 0.0666 | 0.1157 | 0.1157 |
Schistosoma mansoni | hypothetical protein | 0.2523 | 0.5051 | 0.5051 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.2578 | 0.5166 | 0.6453 |
Loa Loa (eye worm) | hypothetical protein | 0.0666 | 0.1157 | 0.1157 |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.3629 | 0.7369 | 0.7369 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3929 | 0.7998 | 1 |
Echinococcus granulosus | carbonic anhydrase II | 0.4884 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3929 | 0.7998 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.1064 | 0.1992 | 0.1992 |
Loa Loa (eye worm) | hypothetical protein | 0.0666 | 0.1157 | 0.1157 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.2523 | 0.5051 | 0.5051 |
Echinococcus multilocularis | peroxidasin | 0.0666 | 0.1157 | 0.1157 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2578 | 0.5166 | 0.6442 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.1064 | 0.1992 | 0.1992 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.3629 | 0.7369 | 1 |
Brugia malayi | Ceramide glucosyltransferase | 0.3629 | 0.7369 | 0.7369 |
Loa Loa (eye worm) | hypothetical protein | 0.0666 | 0.1157 | 0.1157 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.2523 | 0.5051 | 0.5051 |
Schistosoma mansoni | carbonic anhydrase-related | 0.2523 | 0.5051 | 0.5051 |
Echinococcus granulosus | carbonic anhydrase | 0.2523 | 0.5051 | 0.5051 |
Schistosoma mansoni | carbonic anhydrase-related | 0.2523 | 0.5051 | 0.5051 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3929 | 0.7998 | 1 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.1064 | 0.1992 | 0.1992 |
Brugia malayi | Animal haem peroxidase family protein | 0.0666 | 0.1157 | 0.1157 |
Loa Loa (eye worm) | hypothetical protein | 0.0666 | 0.1157 | 0.1157 |
Brugia malayi | Peroxidasin | 0.0666 | 0.1157 | 0.1157 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.3167 | 0.64 | 0.64 |
Loa Loa (eye worm) | hypothetical protein | 0.2523 | 0.5051 | 0.5051 |
Loa Loa (eye worm) | hypothetical protein | 0.0666 | 0.1157 | 0.1157 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2578 | 0.5166 | 0.6442 |
Brugia malayi | hypothetical protein | 0.0666 | 0.1157 | 0.1157 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2578 | 0.5166 | 0.6442 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.1064 | 0.1992 | 0.1992 |
Echinococcus granulosus | carbonic anhydrase | 0.2523 | 0.5051 | 0.5051 |
Echinococcus granulosus | peroxidasin | 0.0666 | 0.1157 | 0.1157 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3929 | 0.7998 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.2523 | 0.5051 | 0.5051 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2578 | 0.5166 | 0.6442 |
Plasmodium falciparum | carbonic anhydrase | 0.2523 | 0.5051 | 0.5 |
Echinococcus granulosus | ceramide glucosyltransferase | 0.3629 | 0.7369 | 0.7369 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.4884 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0666 | 0.1157 | 0.1157 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2717 | 0.5457 | 0.6808 |
Loa Loa (eye worm) | hypothetical protein | 0.2523 | 0.5051 | 0.5051 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.4884 | 1 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.2523 | 0.5051 | 0.5051 |
Brugia malayi | Animal haem peroxidase family protein | 0.0666 | 0.1157 | 0.1157 |
Onchocerca volvulus | 0.0715 | 0.126 | 0.0166 | |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.4884 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0666 | 0.1157 | 0.1157 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.2523 | 0.5051 | 0.5051 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0666 | 0.1157 | 0.1157 |
Schistosoma mansoni | alpha-glucosidase | 0.1064 | 0.1992 | 0.1992 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.2523 | 0.5051 | 0.5051 |
Echinococcus multilocularis | carbonic anhydrase II | 0.4884 | 1 | 1 |
Echinococcus granulosus | non lysosomal glucosylceramidase | 0.3167 | 0.64 | 0.64 |
Loa Loa (eye worm) | hypothetical protein | 0.0666 | 0.1157 | 0.1157 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.3629 | 0.7369 | 0.7369 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0666 | 0.1157 | 0.1157 |
Loa Loa (eye worm) | hypothetical protein | 0.0666 | 0.1157 | 0.1157 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.3929 | 0.7998 | 0.7998 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.4884 | 1 | 0.5 |
Leishmania major | carbonic anhydrase-like protein | 0.4884 | 1 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0666 | 0.1157 | 0.1157 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.4884 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0666 | 0.1157 | 0.1157 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.1064 | 0.1992 | 0.1992 |
Brugia malayi | Animal haem peroxidase family protein | 0.0666 | 0.1157 | 0.1157 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.2523 | 0.5051 | 0.5051 |
Loa Loa (eye worm) | hypothetical protein | 0.0666 | 0.1157 | 0.1157 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2578 | 0.5166 | 0.6442 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0666 | 0.1157 | 0.1157 |
Schistosoma mansoni | peroxidasin | 0.0666 | 0.1157 | 0.1157 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.2523 | 0.5051 | 0.5051 |
Loa Loa (eye worm) | hypothetical protein | 0.2523 | 0.5051 | 0.5051 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.3929 | 0.7998 | 0.7998 |
Echinococcus multilocularis | non lysosomal glucosylceramidase | 0.3167 | 0.64 | 0.64 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0666 | 0.1157 | 0.1157 |
Schistosoma mansoni | alpha-glucosidase | 0.1064 | 0.1992 | 0.1992 |
Loa Loa (eye worm) | hypothetical protein | 0.2138 | 0.4242 | 0.4242 |
Loa Loa (eye worm) | hypothetical protein | 0.0666 | 0.1157 | 0.1157 |
Loa Loa (eye worm) | hypothetical protein | 0.0666 | 0.1157 | 0.1157 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3929 | 0.7998 | 1 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.3629 | 0.7369 | 0.7369 |
Echinococcus multilocularis | bile acid beta glucosidase | 0.3167 | 0.64 | 0.64 |
Echinococcus multilocularis | carbonic anhydrase | 0.2523 | 0.5051 | 0.5051 |
Loa Loa (eye worm) | hypothetical protein | 0.0666 | 0.1157 | 0.1157 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.3629 | 0.7369 | 0.7369 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.4884 | 1 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.2523 | 0.5051 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2717 | 0.5457 | 0.6808 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2578 | 0.5166 | 0.6442 |
Brugia malayi | Blistered cuticle protein 3 | 0.0666 | 0.1157 | 0.1157 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3929 | 0.7998 | 1 |
Giardia lamblia | Ceramide glucosyltransferase | 0.1645 | 0.321 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase | 0.2523 | 0.5051 | 0.5051 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2578 | 0.5166 | 0.6442 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.4884 | 1 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.2523 | 0.5051 | 0.5051 |
Echinococcus granulosus | bile acid beta glucosidase | 0.3167 | 0.64 | 0.64 |
Schistosoma mansoni | peroxidasin | 0.0666 | 0.1157 | 0.1157 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.3167 | 0.64 | 0.64 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.4884 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0666 | 0.1157 | 0.1157 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.