Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Possible penicillin-binding protein | Get druggable targets OG5_149948 | All targets in OG5_149948 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | ceramide glucosyltransferase | 0.4625 | 0.8856 | 1 |
Giardia lamblia | Ceramide glucosyltransferase | 0.2096 | 0.1286 | 0.5 |
Echinococcus granulosus | ceramide glucosyltransferase | 0.4625 | 0.8856 | 1 |
Echinococcus multilocularis | non lysosomal glucosylceramidase | 0.4035 | 0.7091 | 0.7251 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.5007 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3462 | 0.5375 | 0.1027 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.4625 | 0.8856 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.5007 | 1 | 1 |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.4625 | 0.8856 | 1 |
Brugia malayi | Ceramide glucosyltransferase | 0.4625 | 0.8856 | 0.8487 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3462 | 0.5375 | 0.1027 |
Echinococcus granulosus | bile acid beta glucosidase | 0.4035 | 0.7091 | 0.7251 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.4625 | 0.8856 | 0.8487 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.4625 | 0.8856 | 1 |
Echinococcus granulosus | non lysosomal glucosylceramidase | 0.4035 | 0.7091 | 0.7251 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.5007 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.5007 | 1 | 1 |
Echinococcus multilocularis | bile acid beta glucosidase | 0.4035 | 0.7091 | 0.7251 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.5007 | 1 | 1 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.4035 | 0.7091 | 0.7251 |
Loa Loa (eye worm) | hypothetical protein | 0.2724 | 0.3165 | 0.0963 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.5007 | 1 | 1 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.3285 | 0.4845 | 0.5471 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.4035 | 0.7091 | 0.7251 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.5007 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 15.8489 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.