Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | tumor protein p53 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | tumor protein p63 | Get druggable targets OG5_140038 | All targets in OG5_140038 |
Echinococcus granulosus | tumor protein p63 | Get druggable targets OG5_140038 | All targets in OG5_140038 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | ceramide glucosyltransferase | 0.5527 | 0.8915 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.5984 | 1 | 1 |
Echinococcus multilocularis | non lysosomal glucosylceramidase | 0.4823 | 0.7242 | 0.7561 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.5527 | 0.8915 | 1 |
Giardia lamblia | Ceramide glucosyltransferase | 0.2505 | 0.1738 | 0.5 |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.5527 | 0.8915 | 1 |
Brugia malayi | Ceramide glucosyltransferase | 0.5527 | 0.8915 | 0.8634 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.4137 | 0.5615 | 0.1027 |
Echinococcus granulosus | bile acid beta glucosidase | 0.4823 | 0.7242 | 0.7561 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.5527 | 0.8915 | 0.8634 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.4137 | 0.5615 | 0.1027 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.5527 | 0.8915 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.5984 | 1 | 1 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.5984 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.5984 | 1 | 1 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.5527 | 0.8915 | 1 |
Echinococcus granulosus | non lysosomal glucosylceramidase | 0.4823 | 0.7242 | 0.7561 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.5984 | 1 | 1 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.3926 | 0.5113 | 0.5735 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.5984 | 1 | 1 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.4823 | 0.7242 | 0.7561 |
Echinococcus multilocularis | bile acid beta glucosidase | 0.4823 | 0.7242 | 0.7561 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.5984 | 1 | 1 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.4823 | 0.7242 | 0.7561 |
Loa Loa (eye worm) | hypothetical protein | 0.3255 | 0.3519 | 0.1841 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 10 um | PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.