Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | ceramide glucosyltransferase | 0.4318 | 0.9063 | 1 |
Trypanosoma brucei | metallo-peptidase, Clan MF, Family M17 | 0.0873 | 0.0023 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | leucyl aminopeptidase | 0.0873 | 0.0023 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.129 | 0.1117 | 0.1117 |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.4318 | 0.9063 | 1 |
Echinococcus granulosus | ceramide glucosyltransferase | 0.4318 | 0.9063 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3232 | 0.6215 | 0.1027 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.4318 | 0.9063 | 1 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.3767 | 0.7619 | 0.7469 |
Onchocerca volvulus | 0.1521 | 0.1723 | 0.0279 | |
Giardia lamblia | Ceramide glucosyltransferase | 0.1957 | 0.2869 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.4674 | 1 | 1 |
Trypanosoma cruzi | metallo-peptidase, Clan MF, Family M17, putative | 0.0873 | 0.0023 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.4674 | 1 | 1 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.2144 | 0.3358 | 0.3689 |
Mycobacterium leprae | Probable cytosol aminopeptidase PepB | 0.0873 | 0.0023 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.4674 | 1 | 1 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.4674 | 1 | 1 |
Chlamydia trachomatis | cytosol aminopeptidase | 0.0873 | 0.0023 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.4674 | 1 | 1 |
Echinococcus granulosus | aminopeptidase N | 0.1521 | 0.1723 | 0.188 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.3067 | 0.5781 | 0.5653 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.2144 | 0.3358 | 0.3358 |
Mycobacterium ulcerans | leucyl aminopeptidase | 0.0873 | 0.0023 | 0.5 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.2144 | 0.3358 | 0.3689 |
Trypanosoma cruzi | cytosolic leucyl aminopeptidase, putative | 0.0873 | 0.0023 | 0.5 |
Plasmodium falciparum | M17 leucyl aminopeptidase | 0.0873 | 0.0023 | 0.5 |
Plasmodium vivax | M17 leucyl aminopeptidase, putative | 0.0873 | 0.0023 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.4674 | 1 | 1 |
Echinococcus multilocularis | non lysosomal glucosylceramidase | 0.3767 | 0.7619 | 0.8403 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.4674 | 1 | 1 |
Brugia malayi | Ceramide glucosyltransferase | 0.4318 | 0.9063 | 0.8868 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3232 | 0.6215 | 0.1027 |
Mycobacterium tuberculosis | Probable aminopeptidase PepB | 0.0873 | 0.0023 | 0.5 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.4318 | 0.9063 | 1 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.4318 | 0.9063 | 0.9063 |
Toxoplasma gondii | leucyl aminopeptidase LAP | 0.0873 | 0.0023 | 0.5 |
Echinococcus granulosus | bile acid beta glucosidase | 0.3767 | 0.7619 | 0.8403 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.1095 | 0.0606 | 0.0606 |
Leishmania major | cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 | 0.0873 | 0.0023 | 0.5 |
Echinococcus multilocularis | aminopeptidase N | 0.1521 | 0.1723 | 0.188 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.2144 | 0.3358 | 0.3689 |
Echinococcus multilocularis | bile acid beta glucosidase | 0.3767 | 0.7619 | 0.8403 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.3767 | 0.7619 | 0.7469 |
Loa Loa (eye worm) | hypothetical protein | 0.2543 | 0.4406 | 0.4406 |
Echinococcus granulosus | non lysosomal glucosylceramidase | 0.3767 | 0.7619 | 0.8403 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.2144 | 0.3358 | 0.1975 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.