Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.2144 | 0.3358 | 0.3689 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.1095 | 0.0606 | 0.0606 |
Leishmania major | cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 | 0.0873 | 0.0023 | 0.5 |
Echinococcus multilocularis | aminopeptidase N | 0.1521 | 0.1723 | 0.188 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.2144 | 0.3358 | 0.1975 |
Echinococcus granulosus | non lysosomal glucosylceramidase | 0.3767 | 0.7619 | 0.8403 |
Echinococcus multilocularis | bile acid beta glucosidase | 0.3767 | 0.7619 | 0.8403 |
Loa Loa (eye worm) | hypothetical protein | 0.2543 | 0.4406 | 0.4406 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.3767 | 0.7619 | 0.7469 |
Plasmodium vivax | M17 leucyl aminopeptidase, putative | 0.0873 | 0.0023 | 0.5 |
Plasmodium falciparum | M17 leucyl aminopeptidase | 0.0873 | 0.0023 | 0.5 |
Echinococcus multilocularis | non lysosomal glucosylceramidase | 0.3767 | 0.7619 | 0.8403 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.4674 | 1 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.2144 | 0.3358 | 0.3358 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.2144 | 0.3358 | 0.3689 |
Mycobacterium ulcerans | leucyl aminopeptidase | 0.0873 | 0.0023 | 0.5 |
Trypanosoma cruzi | cytosolic leucyl aminopeptidase, putative | 0.0873 | 0.0023 | 0.5 |
Mycobacterium tuberculosis | Probable aminopeptidase PepB | 0.0873 | 0.0023 | 0.5 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.4318 | 0.9063 | 1 |
Toxoplasma gondii | leucyl aminopeptidase LAP | 0.0873 | 0.0023 | 0.5 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.4318 | 0.9063 | 0.9063 |
Echinococcus granulosus | bile acid beta glucosidase | 0.3767 | 0.7619 | 0.8403 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.4674 | 1 | 1 |
Brugia malayi | Ceramide glucosyltransferase | 0.4318 | 0.9063 | 0.8868 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3232 | 0.6215 | 0.1027 |
Onchocerca volvulus | 0.1521 | 0.1723 | 0.0279 | |
Giardia lamblia | Ceramide glucosyltransferase | 0.1957 | 0.2869 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.4674 | 1 | 1 |
Trypanosoma cruzi | metallo-peptidase, Clan MF, Family M17, putative | 0.0873 | 0.0023 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.4674 | 1 | 1 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.2144 | 0.3358 | 0.3689 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.4318 | 0.9063 | 1 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.3767 | 0.7619 | 0.7469 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.4674 | 1 | 1 |
Chlamydia trachomatis | cytosol aminopeptidase | 0.0873 | 0.0023 | 0.5 |
Echinococcus granulosus | aminopeptidase N | 0.1521 | 0.1723 | 0.188 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.4674 | 1 | 1 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.3067 | 0.5781 | 0.5653 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.4674 | 1 | 1 |
Mycobacterium leprae | Probable cytosol aminopeptidase PepB | 0.0873 | 0.0023 | 0.5 |
Trypanosoma brucei | metallo-peptidase, Clan MF, Family M17 | 0.0873 | 0.0023 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | leucyl aminopeptidase | 0.0873 | 0.0023 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.129 | 0.1117 | 0.1117 |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.4318 | 0.9063 | 1 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.4318 | 0.9063 | 1 |
Echinococcus granulosus | ceramide glucosyltransferase | 0.4318 | 0.9063 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3232 | 0.6215 | 0.1027 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.