TDR Targets

Basic information

Technical information

TDR Targets ID: 825511
Name: 2-[1-oxo-1-[4-[3-(trifluoromethyl)phenyl]pipe razin-1-yl]propan-2-yl]-1,2-benzothiazol-3-on e
MW: 435.463 | Formula: C21H20F3N3O2S
H donors: 0 H acceptors: 2 LogP: 3.86 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(C(n1sc2c(c1=O)cccc2)C)N1CCN(CC1)c1cccc(c1)C(F)(F)F
InChi: 1S/C21H20F3N3O2S/c1-14(27-20(29)17-7-2-3-8-18(17)30-27)19(28)26-11-9-25(10-12-26)16-6-4-5-15(13-16)21(22,23)24/h2-8,13-14H,9-12H2,1H3
InChiKey: KZEFDPZRWHJRKN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[1-methyl-2-oxo-2-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]ethyl]-1,2-benzothiazol-3-one
2-[1-methyl-2-oxo-2-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]ethyl]-1,2-benzothiazol-3-one
2-[2-keto-1-methyl-2-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]ethyl]-1,2-benzothiazol-3-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0121	0.0491
Loa Loa (eye worm)	hypothetical protein	0.001	0.0013	0.0051
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.001	0.0013	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0145	0.2466	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0769	0.3119
Schistosoma mansoni	serine/threonine protein kinase	0.001	0.0013	0.0104
Brugia malayi	Ras association domain family 1 isoform A	0.001	0.0013	0.0051
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.001	0.0013	0.0051
Loa Loa (eye worm)	hypothetical protein	0.001	0.0013	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0077	0.122	0.4947
Schistosoma mansoni	hypothetical protein	0.0035	0.0469	0.3847
Echinococcus granulosus	myotubularin protein 13	0.001	0.0013	0.0051
Entamoeba histolytica	diacylglycerol kinase, putative	0.001	0.0013	0.5
Schistosoma mansoni	protein kinase C mu	0.001	0.0013	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0121	0.0491
Schistosoma mansoni	serine/threonine protein kinase	0.001	0.0013	0.0104
Brugia malayi	diacylglycerol kinase	0.001	0.0013	0.0051
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0691	0.2802
Echinococcus granulosus	raf serine:threonine protein kinase	0.001	0.0013	0.0051
Echinococcus multilocularis	muscleblind protein	0.0145	0.2466	1
Echinococcus multilocularis	serine:threonine protein kinase MRCK beta	0.001	0.0013	0.0051
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0052	0.0769	0.3119
Brugia malayi	Muscleblind-like protein	0.0145	0.2466	1
Brugia malayi	protein kinase C3,putative	0.001	0.0013	0.0051
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0121	0.0491
Schistosoma mansoni	hypothetical protein	0.0016	0.0121	0.0992
Schistosoma mansoni	serine/threonine protein kinase	0.001	0.0013	0.0104
Echinococcus multilocularis	myotubularin protein 13	0.001	0.0013	0.0051
Brugia malayi	Protein kinase c protein 2	0.001	0.0013	0.0051
Echinococcus multilocularis	protein kinase c eta type	0.001	0.0013	0.0051
Loa Loa (eye worm)	AGC/PKC/IOTA protein kinase	0.001	0.0013	0.0051
Giardia lamblia	Rho GAP, putative	0.0066	0.1028	0.5
Schistosoma mansoni	diacylglycerol kinase theta	0.001	0.0013	0.0104
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0121	0.0491
Loa Loa (eye worm)	hypothetical protein	0.001	0.0013	0.0051
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.001	0.0013	0.0051
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0052	0.0769	0.3119
Schistosoma mansoni	serine/threonine protein kinase	0.001	0.0013	0.0104
Echinococcus granulosus	N chimaerin	0.0011	0.0015	0.0059
Echinococcus multilocularis	Rac GTPase activating protein 1	0.0077	0.122	0.4947
Schistosoma mansoni	hypothetical protein	0.001	0.0013	0.0104
Loa Loa (eye worm)	RasGEF domain-containing protein	0.001	0.0013	0.0051
Brugia malayi	RhoGEF domain containing protein	0.001	0.0013	0.0051
Loa Loa (eye worm)	Ras association domain family 1 isoform A	0.001	0.0013	0.0051
Echinococcus granulosus	Diacylglycerol kinase theta	0.001	0.0013	0.0051
Toxoplasma gondii	diacylglycerol kinase, putative	0.001	0.0013	0.5
Schistosoma mansoni	vav2	0.001	0.0013	0.0104
Echinococcus granulosus	Serine/threonine-protein kinase Genghis Khan	0.001	0.0013	0.0051
Echinococcus multilocularis	muscleblind protein 1	0.0145	0.2466	1
Brugia malayi	RhoGAP domain containing protein	0.0011	0.0015	0.0059
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0121	0.0491
Loa Loa (eye worm)	hypothetical protein	0.001	0.0013	0.0051
Echinococcus granulosus	unc 13 munc13	0.001	0.0013	0.0051
Schistosoma mansoni	protein kinase C mu	0.001	0.0013	0.0104
Brugia malayi	RhoGAP domain containing protein	0.0066	0.1028	0.417
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0052	0.0769	0.3119
Schistosoma mansoni	unc-13 (munc13)	0.001	0.0013	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0145	0.2466	1
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0011	0.0015	0.012
Schistosoma mansoni	hypothetical protein	0.0016	0.0121	0.0992
Schistosoma mansoni	hypothetical protein	0.0016	0.0121	0.0992
Brugia malayi	Protein kinase domain containing protein	0.001	0.0013	0.0051
Onchocerca volvulus		0.001	0.0013	1
Brugia malayi	Phorbol esters/diacylglycerol binding domain	0.001	0.0013	0.0051
Schistosoma mansoni	serine/threonine protein kinase	0.001	0.0013	0.0104
Echinococcus multilocularis	Diacylglycerol kinase theta	0.001	0.0013	0.0051
Onchocerca volvulus		0.001	0.0013	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0691	0.5665
Echinococcus multilocularis	N chimaerin	0.0011	0.0015	0.0059
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0691	0.2802
Schistosoma mansoni	hypothetical protein	0.0016	0.0121	0.0992
Brugia malayi	diacylglycerol kinase	0.001	0.0013	0.0051
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.001	0.0013	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0066	0.1028	0.417
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0048	0.0691	0.2802
Loa Loa (eye worm)	hypothetical protein	0.001	0.0013	0.0051
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0691	0.2802
Brugia malayi	Pleckstrin Homology Domain	0.001	0.0013	0.0051
Loa Loa (eye worm)	hypothetical protein	0.001	0.0013	0.0051
Loa Loa (eye worm)	raf kinase	0.001	0.0013	0.0051
Echinococcus granulosus	protein kinase c epsilon type	0.001	0.0013	0.0051
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0121	0.0491
Echinococcus multilocularis	raf serine:threonine protein kinase	0.001	0.0013	0.0051
Loa Loa (eye worm)	hypothetical protein	0.001	0.0013	0.0051
Loa Loa (eye worm)	hypothetical protein	0.001	0.0013	0.0051
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0048	0.0691	0.2802
Entamoeba histolytica	hypothetical protein	0.001	0.0013	0.5
Schistosoma mansoni	diacylglycerol kinase theta	0.001	0.0013	0.0104
Schistosoma mansoni	atypical protein kinase C	0.001	0.0013	0.0104
Loa Loa (eye worm)	hypothetical protein	0.001	0.0013	0.0051
Loa Loa (eye worm)	hypothetical protein	0.001	0.0013	0.0051
Schistosoma mansoni	serine/threonine protein kinase	0.001	0.0013	0.0104
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.001	0.0013	0.0051
Schistosoma mansoni	rac gtpase activating protein	0.0077	0.122	1
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.001	0.0013	0.0051
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0691	0.5665
Echinococcus granulosus	Protein kinase C brain isozyme	0.001	0.0013	0.0051
Echinococcus multilocularis	unc 13 (munc13)	0.001	0.0013	0.0051
Schistosoma mansoni	unc-13 (munc13)	0.001	0.0013	0.0104
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0011	0.0015	0.0059
Schistosoma mansoni	protein kinase C	0.001	0.0013	0.0104
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0121	0.0491
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0469	0.1903
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0121	0.0491
Loa Loa (eye worm)	hypothetical protein	0.001	0.0013	0.0051
Brugia malayi	C1-like domain containing protein	0.001	0.0013	0.0051
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.0469	0.1903
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0121	0.0491
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.001	0.0013	0.0051
Onchocerca volvulus		0.001	0.0013	1
Entamoeba histolytica	diacylglycerol kinase, putative	0.001	0.0013	0.5
Echinococcus granulosus	muscleblind protein	0.0145	0.2466	1
Echinococcus granulosus	protein kinase c iota type	0.001	0.0013	0.0051
Echinococcus granulosus	Rac GTPase activating protein 1	0.0077	0.122	0.4947
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0691	0.2802
Echinococcus multilocularis	protein kinase c epsilon type	0.001	0.0013	0.0051
Echinococcus granulosus	protein kinase c eta type	0.001	0.0013	0.0051
Brugia malayi	protein kinase C II.	0.001	0.0013	0.0051
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0011	0.0015	0.012
Brugia malayi	RhoGAP domain containing protein	0.0077	0.122	0.4947
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.001	0.0013	0.0051
Echinococcus multilocularis	protein kinase c iota type	0.001	0.0013	0.0051
Echinococcus granulosus	GPCR family 2	0.0016	0.0121	0.0491
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0691	0.5665
Brugia malayi	Variant SH3 domain containing protein	0.001	0.0013	0.0051
Mycobacterium ulcerans	urease subunit alpha	0.0557	1	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 825511