Detailed information for compound 826143

Basic information

Technical information
  • TDR Targets ID: 826143
  • Name: 4-fluoro-N-[(2-methyl-1,3-thiazol-4-yl)methyl ]benzenesulfonamide
  • MW: 286.346 | Formula: C11H11FN2O2S2
  • H donors: 1 H acceptors: 3 LogP: 1.95 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)S(=O)(=O)NCc1csc(n1)C
  • InChi: 1S/C11H11FN2O2S2/c1-8-14-10(7-17-8)6-13-18(15,16)11-4-2-9(12)3-5-11/h2-5,7,13H,6H2,1H3
  • InChiKey: OMNYJUCZVIAMEB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-fluoro-N-[(2-methylthiazol-4-yl)methyl]benzenesulfonamide
  • 4-fluoro-N-[(2-methyl-4-thiazolyl)methyl]benzenesulfonamide
  • ZINC04251651

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis neuropeptide Y receptor 0.0065 0.0196 0.0196
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0039 0.5
Schistosoma mansoni biogenic amine receptor 0.0065 0.0196 0.0281
Brugia malayi neuropeptide F receptor 0.0065 0.0196 0.0307
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0065 0.0196 0.0307
Echinococcus multilocularis g protein coupled receptor 0.0065 0.0196 0.0196
Brugia malayi Dopamine receptor protein 1 0.0065 0.0196 0.0307
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0039 0.5
Schistosoma mansoni hypothetical protein 0.0065 0.0196 0.0281
Onchocerca volvulus 0.0047 0.0127 0.2941
Echinococcus granulosus biogenic amine 5HT receptor 0.0204 0.0705 0.0705
Onchocerca volvulus 0.0065 0.0196 0.4789
Brugia malayi RE15519p 0.0065 0.0196 0.0307
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0065 0.0196 0.0281
Loa Loa (eye worm) TYRA-2 protein 0.0065 0.0196 0.0307
Echinococcus multilocularis g protein coupled receptor 0.0065 0.0196 0.0196
Echinococcus multilocularis rhodopsin orphan GPCR 0.0065 0.0196 0.0196
Echinococcus granulosus fmrfamide receptor 0.0065 0.0196 0.0196
Echinococcus granulosus 7tm_1 domain containing protein 0.0065 0.0196 0.0196
Brugia malayi G protein-coupled receptor 0.0065 0.0196 0.0307
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0065 0.0196 0.0196
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0307
Echinococcus multilocularis neuropeptide Y receptor 0.0065 0.0196 0.0196
Schistosoma mansoni amine GPCR 0.0065 0.0196 0.0281
Loa Loa (eye worm) G-protein coupled receptor 0.0065 0.0196 0.0307
Echinococcus multilocularis G-protein coupled receptor, putative 0.0065 0.0196 0.0196
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0039 0.0061
Brugia malayi G protein-coupled receptor F59B2.13 0.0065 0.0196 0.0307
Echinococcus granulosus neuropeptides capa receptor 0.0065 0.0196 0.0196
Echinococcus multilocularis g-protein coupled receptor 0.0065 0.0196 0.0196
Schistosoma mansoni amine GPCR 0.0065 0.0196 0.0281
Echinococcus granulosus g protein coupled receptor 0.0065 0.0196 0.0196
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0039 0.0039
Brugia malayi G-protein coupled receptor 0.0065 0.0196 0.0307
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0307
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0307
Onchocerca volvulus 0.0065 0.0196 0.4789
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0307
Echinococcus multilocularis neuropeptide receptor A26 0.0065 0.0196 0.0196
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0065 0.0196 0.0196
Echinococcus multilocularis serotonin receptor 0.0204 0.0705 0.0705
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0026
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0026
Echinococcus multilocularis MAM 0.0017 0.0017 0.0017
Brugia malayi follicle stimulating hormone receptor 0.0065 0.0196 0.0307
Echinococcus multilocularis fmrfamide receptor 0.0065 0.0196 0.0196
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0118 0.0118
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0065 0.0196 0.0196
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0039 0.5
Echinococcus granulosus bifunctional protein NCOAT 0.1752 0.6402 0.6402
Schistosoma mansoni amine GPCR 0.0065 0.0196 0.0281
Loa Loa (eye worm) TK/ALK protein kinase 0.0141 0.0474 0.074
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0039 0.5
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0307
Echinococcus granulosus 7TM GPCR rhodopsin 0.0065 0.0196 0.0196
Echinococcus granulosus neuropeptide Y receptor 0.0065 0.0196 0.0196
Brugia malayi hypothetical protein 0.0065 0.0196 0.0307
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0118 0.0118
Echinococcus multilocularis neuropeptide FF receptor 2 0.0065 0.0196 0.0196
Brugia malayi hypothetical protein 0.0065 0.0196 0.0307
Schistosoma mansoni ap endonuclease 0.0023 0.0039 0.0034
Brugia malayi hypothetical protein 0.0065 0.0196 0.0307
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0307
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0118 0.0118
Brugia malayi hypothetical protein 0.0017 0.0017 0.0026
Echinococcus granulosus orexin receptor type 2 0.0065 0.0196 0.0196
Loa Loa (eye worm) hypothetical protein 0.0119 0.0392 0.0612
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0065 0.0196 0.0196
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0307
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0039 0.5
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0307
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0118 0.0185
Schistosoma mansoni amine GPCR 0.0065 0.0196 0.0281
Echinococcus multilocularis rhodopsin orphan GPCR 0.0065 0.0196 0.0196
Onchocerca volvulus 0.0065 0.0196 0.4789
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0307
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0065 0.0196 0.0281
Schistosoma mansoni hypothetical protein 0.0065 0.0196 0.0281
Loa Loa (eye worm) hypothetical protein 0.0229 0.0798 0.1246
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0065 0.0196 0.0196
Echinococcus granulosus tm gpcr rhodopsin 0.0065 0.0196 0.0196
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0307
Onchocerca volvulus Neuropeptide F receptor homolog 0.0065 0.0196 0.4789
Echinococcus granulosus alpha 1A adrenergic receptor 0.0065 0.0196 0.0196
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0307
Echinococcus granulosus survival motor neuron protein 1 0.0229 0.0798 0.0798
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0065 0.0196 0.4789
Echinococcus granulosus rhodopsin orphan GPCR 0.0065 0.0196 0.0196
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0065 0.0196 0.0281
Echinococcus granulosus hypothetical protein 0.0065 0.0196 0.0196
Loa Loa (eye worm) hypothetical protein 0.0744 0.2694 0.4208
Schistosoma mansoni neuropeptide receptor 0.0065 0.0196 0.0281
Echinococcus multilocularis neuropeptides capa receptor 0.0065 0.0196 0.0196
Onchocerca volvulus 0.0065 0.0196 0.4789
Brugia malayi hypothetical protein 0.0065 0.0196 0.0307
Echinococcus multilocularis fmrfamide receptor 0.0065 0.0196 0.0196
Echinococcus multilocularis rhodopsin orphan GPCR 0.0065 0.0196 0.0196
Echinococcus granulosus neuropeptide receptor 0.0065 0.0196 0.0196
Toxoplasma gondii exonuclease III APE 0.0023 0.0039 0.5
Echinococcus granulosus neuropeptide receptor 0.0065 0.0196 0.0196
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0039 0.0061
Echinococcus granulosus tm gpcr rhodopsin 0.0065 0.0196 0.0196
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0307
Loa Loa (eye worm) hypothetical protein 0.0123 0.0408 0.0637
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0039 0.5
Echinococcus multilocularis orexin receptor type 2 0.0065 0.0196 0.0196
Brugia malayi hypothetical protein 0.0119 0.0392 0.0612
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0039 0.5
Onchocerca volvulus Huntingtin homolog 0.0119 0.0392 1
Onchocerca volvulus 0.0065 0.0196 0.4789
Brugia malayi hypothetical protein 0.0065 0.0196 0.0307
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0307
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0307
Echinococcus multilocularis serotonin receptor 0.0204 0.0705 0.0705
Echinococcus multilocularis neuropeptide s receptor 0.0065 0.0196 0.0196
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0065 0.0196 0.0281
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0127 0.0199
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0065 0.0196 0.0281
Echinococcus granulosus neuropeptide Y receptor 0.0065 0.0196 0.0196
Schistosoma mansoni alpha-1 adrenergic receptor 0.0065 0.0196 0.0281
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0307
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0039 0.5
Onchocerca volvulus 0.0065 0.0196 0.4789
Onchocerca volvulus 0.0065 0.0196 0.4789
Echinococcus multilocularis bifunctional protein NCOAT 0.1752 0.6402 0.6402
Echinococcus granulosus neuropeptides capa receptor 0.0065 0.0196 0.0196
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0065 0.0196 0.0196
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0065 0.0196 0.0307
Onchocerca volvulus 0.0065 0.0196 0.4789
Echinococcus granulosus somatostatin receptor 0.0065 0.0196 0.0196
Echinococcus granulosus rhodopsin orphan GPCR 0.0065 0.0196 0.0196
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0065 0.0196 0.0196
Onchocerca volvulus 0.0065 0.0196 0.4789
Echinococcus multilocularis rhodopsin orphan GPCR 0.0065 0.0196 0.0196
Echinococcus multilocularis dro:myosuppressin receptor 0.0065 0.0196 0.0196
Loa Loa (eye worm) melatonin receptor type 1A 0.0065 0.0196 0.0307
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0307
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0307
Brugia malayi Protein kinase domain containing protein 0.0141 0.0474 0.074
Brugia malayi putative neuropeptide receptor 0.0065 0.0196 0.0307
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0065 0.0196 0.0307
Echinococcus granulosus neuropeptide receptor A26 0.0065 0.0196 0.0196
Echinococcus multilocularis neuropeptide receptor 0.0065 0.0196 0.0196
Brugia malayi hypothetical protein 0.0065 0.0196 0.0307
Echinococcus granulosus g protein coupled receptor 0.0065 0.0196 0.0196
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0307
Brugia malayi GnHR receptor homolog 0.0065 0.0196 0.0307
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0307
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0065 0.0196 0.0196
Loa Loa (eye worm) hyaluronidase 0.1752 0.6402 1
Brugia malayi putative neuropeptide receptor NPR1 0.0065 0.0196 0.0307
Echinococcus multilocularis survival motor neuron protein 1 0.0229 0.0798 0.0798
Echinococcus granulosus g-protein coupled receptor 0.0065 0.0196 0.0196
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0307
Schistosoma mansoni opsin-like receptor 0.0065 0.0196 0.0281
Echinococcus multilocularis sex peptide receptor 0.0065 0.0196 0.0196
Echinococcus multilocularis rhodopsin orphan GPCR 0.0065 0.0196 0.0196
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0065 0.0196 0.0281
Brugia malayi Hyaluronidase family protein 0.1752 0.6402 1
Loa Loa (eye worm) neuropeptide F receptor 0.0065 0.0196 0.0307
Echinococcus multilocularis g protein coupled receptor 0.0065 0.0196 0.0196
Schistosoma mansoni hypothetical protein 0.0047 0.0127 0.0173
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0065 0.0196 0.0281
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0065 0.0196 0.0307
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0065 0.0196 0.0307
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0307
Brugia malayi larval opioid receptor 0.0065 0.0196 0.0307
Echinococcus multilocularis rhodopsin orphan GPCR 0.0065 0.0196 0.0196
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0307
Echinococcus granulosus dro:myosuppressin receptor 0.0065 0.0196 0.0196
Loa Loa (eye worm) hypothetical protein 0.0204 0.0705 0.1102
Brugia malayi neuropeptide F receptor 0.0065 0.0196 0.0307
Echinococcus granulosus rhodopsin orphan GPCR 0.0065 0.0196 0.0196
Schistosoma mansoni histamine h1 receptor 0.0065 0.0196 0.0281
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0065 0.0196 0.0196
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0307
Schistosoma mansoni myosin xvIII 0.0065 0.0196 0.0281
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0307
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0065 0.0196 0.0196
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0065 0.0196 0.0281
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0307
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0307
Schistosoma mansoni biogenic amine (5HT) receptor 0.0065 0.0196 0.0281
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0118 0.0159
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0065 0.0196 0.0281
Echinococcus multilocularis rhodopsin orphan GPCR 0.0065 0.0196 0.0196
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0065 0.0196 0.0281
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0307
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0065 0.0196 0.0307
Schistosoma mansoni hypothetical protein 0.0065 0.0196 0.0281
Brugia malayi Tachykinin-like peptides receptor 99D 0.0065 0.0196 0.0307
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0307
Echinococcus granulosus tachykinin peptides receptor 99D 0.0065 0.0196 0.0196
Schistosoma mansoni survival motor neuron protein 0.0047 0.0127 0.0173
Brugia malayi Dopamine receptor protein 2 0.0065 0.0196 0.0307
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0118 0.0185
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0039 0.5
Schistosoma mansoni aminopeptidase P homologue (M24 family) 0.1752 0.6402 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0307
Echinococcus multilocularis G protein coupled receptor 139 0.0065 0.0196 0.0196
Onchocerca volvulus 0.0065 0.0196 0.4789
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0307
Brugia malayi Serotonin receptor 0.0065 0.0196 0.0307
Onchocerca volvulus 0.0065 0.0196 0.4789
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0307
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0307
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0307
Schistosoma mansoni neuropeptide F-like receptor 0.0065 0.0196 0.0281
Schistosoma mansoni neuropeptide receptor 0.0065 0.0196 0.0281
Brugia malayi sulfakinin receptor protein 0.0065 0.0196 0.0307
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0307
Brugia malayi Serotonin receptor 0.0065 0.0196 0.0307
Echinococcus granulosus allatostatin A receptor 0.0065 0.0196 0.0196
Onchocerca volvulus 0.0065 0.0196 0.4789
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0065 0.0196 0.0196
Schistosoma mansoni opsin-like receptor 0.0065 0.0196 0.0281
Schistosoma mansoni amine GPCR 0.0065 0.0196 0.0281
Echinococcus granulosus g protein coupled receptor 0.0065 0.0196 0.0196
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0065 0.0196 0.0196
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0307
Echinococcus granulosus serotonin receptor 0.0065 0.0196 0.0196
Brugia malayi hypothetical protein 0.0065 0.0196 0.0307
Loa Loa (eye worm) neuropeptide F receptor 0.0065 0.0196 0.0307
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0307
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0039 0.5
Brugia malayi ORL1-like opioid receptor 0.0065 0.0196 0.0307
Schistosoma mansoni biogenic amine (5HT) receptor 0.0204 0.0705 0.1078
Echinococcus granulosus peptide allatostatin:somatostatin 0.0065 0.0196 0.0196
Loa Loa (eye worm) hypothetical protein 0.0204 0.0705 0.1102
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0065 0.0196 0.0307
Schistosoma mansoni biogenic amine receptor 0.0065 0.0196 0.0281
Schistosoma mansoni growth hormone secretagogue receptor 0.0065 0.0196 0.0281
Echinococcus granulosus biogenic amine 5HT receptor 0.0065 0.0196 0.0196
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0039 0.5
Echinococcus granulosus neuropeptide s receptor 0.0065 0.0196 0.0196
Echinococcus multilocularis neuropeptides capa receptor 0.0065 0.0196 0.0196
Onchocerca volvulus 0.0065 0.0196 0.4789
Onchocerca volvulus 0.0065 0.0196 0.4789
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0065 0.0196 0.0281
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0065 0.0196 0.0281
Echinococcus multilocularis allatostatin A receptor 0.0065 0.0196 0.0196
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0039 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0065 0.0196 0.0281
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0118 0.0159
Schistosoma mansoni neuropeptide receptor 0.0065 0.0196 0.0281
Echinococcus granulosus sex peptide receptor 0.0065 0.0196 0.0196
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0039 0.5
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0307
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0065 0.0196 0.0281
Brugia malayi AKH receptor 0.0065 0.0196 0.0307
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0065 0.0196 0.0281
Schistosoma mansoni biogenic amine receptor 0.0065 0.0196 0.0281
Echinococcus granulosus MAM 0.0017 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0119 0.0392 0.0612
Echinococcus granulosus neuropeptide FF receptor 2 0.0065 0.0196 0.0196
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0065 0.0196 0.0196
Schistosoma mansoni hypothetical protein 0.0065 0.0196 0.0281
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0026
Brugia malayi hypothetical protein 0.0229 0.0798 0.1246
Schistosoma mansoni neuropeptide f receptor 76f 0.0065 0.0196 0.0281
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0118 0.0118
Brugia malayi hypothetical protein 0.0065 0.0196 0.0307
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0065 0.0196 0.0281
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0307
Brugia malayi hypothetical protein 0.0065 0.0196 0.0307
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0065 0.0196 0.0196
Echinococcus granulosus rhodopsin orphan GPCR 0.0065 0.0196 0.0196
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0065 0.0196 0.0196
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0307
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0065 0.0196 0.0196
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0065 0.0196 0.0307
Onchocerca volvulus 0.0065 0.0196 0.4789
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0065 0.0196 0.0281
Loa Loa (eye worm) G-protein coupled receptor 0.0065 0.0196 0.0307
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0065 0.0196 0.0281
Schistosoma mansoni opsin-like receptor 0.0065 0.0196 0.0281
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0065 0.0196 0.0307
Echinococcus granulosus rhodopsin orphan GPCR 0.0065 0.0196 0.0196
Brugia malayi Dopamine receptor 0.0065 0.0196 0.0307
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0307
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0307
Onchocerca volvulus 0.0065 0.0196 0.4789
Schistosoma mansoni adenoreceptor 0.0065 0.0196 0.0281
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0307
Echinococcus granulosus rhodopsin orphan GPCR 0.0065 0.0196 0.0196
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0065 0.0196 0.0281
Brugia malayi hypothetical protein 0.0065 0.0196 0.0307
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.2729 1 1
Echinococcus granulosus G protein coupled receptor 139 0.0065 0.0196 0.0196
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0118 0.0159
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0065 0.0196 0.0196
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0065 0.0196 0.0281
Echinococcus multilocularis neuropeptide receptor 0.0065 0.0196 0.0196
Onchocerca volvulus Huntingtin homolog 0.0119 0.0392 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0039 0.0039
Brugia malayi Melatonin receptor type 1A 0.0065 0.0196 0.0307
Brugia malayi G-protein coupled receptor 0.0065 0.0196 0.0307
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0065 0.0196 0.0307
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0307
Schistosoma mansoni Hyaluronidase 0.1752 0.6402 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0065 0.0196 0.0196
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0065 0.0196 0.0196
Schistosoma mansoni neuropeptide F-like receptor 0.0065 0.0196 0.0281
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0065 0.0196 0.0281
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0039 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0065 0.0196 0.0196
Schistosoma mansoni neuropeptide receptor 0.0065 0.0196 0.0281
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0065 0.0196 0.0281
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0065 0.0196 0.0196
Echinococcus multilocularis somatostatin receptor 0.0065 0.0196 0.0196
Onchocerca volvulus 0.0065 0.0196 0.4789
Schistosoma mansoni ap endonuclease 0.0023 0.0039 0.0034

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 5.9728 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) = 100 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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